simvastatin and Colonic Neoplasms

Topics: Animals; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclin-Dependent Kinase 4; Diabetes Mellitus, Type 2; Drug Repositioning; Female; Humans; Male; Simvastatin

Topics: Animals; Caspase 1; Colonic Neoplasms; Disease Models, Animal; HCT116 Cells; Humans; Mice; Mice, Nude; Phosphate-Binding Proteins; Pore Forming Cytotoxic Proteins; Pyroptosis; Reactive Oxygen Species; Simvastatin

Topics: Animals; Antineoplastic Agents; Apoptosis; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; HCT116 Cells; Humans; Hydrogen-Ion Concentration; Male; Microspheres; Particle Size; Polymethacrylic Acids; Rabbits; Simvastatin

Topics: Animals; Colonic Neoplasms; HCT116 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Proto-Oncogene Proteins c-mdm2; Radiation Tolerance; Random Allocation; Simvastatin; Tumor Stem Cell Assay; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cholesterol; Cimicifuga; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Rats; Real-Time Polymerase Chain Reaction; Saponins; Signal Transduction; Simvastatin; Transcriptome; Triterpenes

Topics: Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; HCT116 Cells; Humans; MicroRNAs; rab GTP-Binding Proteins; Signal Transduction; Simvastatin

Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyclic S-Oxides; Cyclooxygenase 2; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Humans; Inhibitory Concentration 50; Proto-Oncogene Proteins c-bcl-2; Simvastatin; Thiazines; Up-Regulation

Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Phenothiazines; Simvastatin

Topics: Cell Proliferation; Colonic Neoplasms; Down-Regulation; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Transcription Factors; Mutation; Neoplasm Invasiveness; Simvastatin; Tumor Suppressor Protein p53; Up-Regulation

Topics: Apoptosis; Cell Movement; Cell Proliferation; Chemokine CCL17; Colonic Neoplasms; HT29 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Polyisoprenyl Phosphates; Prenylation; Receptors, CCR4; rhoA GTP-Binding Protein; Simvastatin

Topics: Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Intracellular Signaling Peptides and Proteins; Neoplasm Proteins; Simvastatin

Topics: Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Heme Oxygenase-1; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MAP Kinase Signaling System; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Simvastatin

Topics: Animals; Apoptosis; bcl-X Protein; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Cell Growth Processes; Cell Line, Tumor; Colitis; Colonic Neoplasms; Down-Regulation; Drug Synergism; Enzyme Activation; HCT116 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-bcl-2; Simvastatin; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Colonic Neoplasms; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Oligopeptides; Oxidative Stress; Polyisoprenyl Phosphates; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Simvastatin

Topics: Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Proliferation; Colonic Neoplasms; CpG Islands; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Methylation; Mice; Mice, Inbred Strains; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Xenograft Model Antitumor Assays

Topics: Colonic Neoplasms; Doxorubicin; Drug Synergism; Gene Silencing; HT29 Cells; Humans; NF-kappa B; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Simvastatin

Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogens; Cholesterol; Colonic Neoplasms; Dimethylhydrazines; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Mice, Inbred ICR; Pravastatin; Simvastatin