simvastatin has been researched along with Cognitive Decline in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (76.92) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Bian, H; Chao, Y; Ding, X; Feng, H; Li, Y; Liu, B; Meng, Q; Tong, H; Wu, L; Zhang, C; Zhang, Q; Zhang, S; Zhu, W | 1 |
| Hamel, E; Royea, J; Tong, XK; Trigiani, LJ | 1 |
| Alves, OL; Carmo, GMD; Cordenonsi, LM; Davies, S; de Oliveira, AL; Lorenzoni, R; Mezzomo, NJ; Raffin, RP; Rech, VC; Vaucher, RA; Viçosa, JADS | 1 |
| Alberici, LC; Cárnio, EC; Catalão, CHR; da Costa, LHA; Rocha, MJA; Santos-Junior, NN; Sebollela, A; Souza, AO | 1 |
| Binks, S; Cardoso, MJ; Chan, D; Chataway, J; Frost, C; Nicholas, JM; Nicholas, R; Ourselin, S; Wilkie, D | 1 |
| Feinstein, A | 1 |
| Ji, J; Liu, W; Zhang, X; Zhao, Y | 1 |
| Ekladious, ST; El Sayed, NS | 1 |
| Adeli, S; Ansari Dezfouli, M; Zahmatkesh, M | 1 |
| Aisen, PS; Donohue, MC; Edland, SD; Galasko, D; Moghadam, SH; Petersen, RC; Rissman, RA; Roe, AD; Sano, M; Sun, CK; Thomas, RG | 1 |
| Boutté, AM; Gilsdorf, J; Lu, XC; Mountney, A; Shear, DA; Tortella, FC | 1 |
| de Silva, V; Hanwella, R; Suraweera, C | 1 |
| Ademola, T; Caslake, M; Cooper, SA; Douglas, E; Evans, J; Greenlaw, N; Haig, C; Hassiotis, A; Jahoda, A; McConnachie, A; Morrison, J; Ring, H; Sirisena, C; Starr, J; Stiles, C; Sullivan, F | 1 |
3 trial(s) available for simvastatin and Cognitive Decline
| Article | Year |
|---|---|
Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial.
Topics: Adult; Cognitive Dysfunction; Double-Blind Method; Executive Function; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Memory Disorders; Middle Aged; Multiple Sclerosis, Chronic Progressive; Outcome Assessment, Health Care; Quality of Life; Simvastatin | 2017 |
Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Biomarkers; Blood Chemical Analysis; Cognitive Dysfunction; Disease Progression; Donepezil; Female; Heterozygote; Humans; Indans; Longitudinal Studies; Male; Nootropic Agents; Peptide Fragments; Piperidines; Severity of Illness Index; Simvastatin; Vitamin E | 2015 |
Towards onset prevention of cognition decline in adults with Down syndrome (The TOP-COG study): A pilot randomised controlled trial.
Topics: Adult; Cognitive Dysfunction; Double-Blind Method; Down Syndrome; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Pilot Projects; Prospective Studies; Simvastatin | 2016 |
10 other study(ies) available for simvastatin and Cognitive Decline
| Article | Year |
|---|---|
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Topics: Animals; Cognitive Dysfunction; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Humans; Lipids; Mice; Postmenopause; Simvastatin | 2023 |
Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia.
Topics: Animals; Cerebrovascular Circulation; Cognitive Dysfunction; Dementia; Disease Models, Animal; Inflammation; Mice; Microglia; Physical Conditioning, Animal; Simvastatin | 2019 |
Lipid-core nanocapsules containing simvastatin improve the cognitive impairment induced by obesity and hypercholesterolemia in adult rats.
Topics: Animals; Cognitive Dysfunction; Hypercholesterolemia; Lipids; Nanocapsules; Obesity; Rats; Simvastatin | 2020 |
Simvastatin Prevents Long-Term Cognitive Deficits in Sepsis Survivor Rats by Reducing Neuroinflammation and Neurodegeneration.
Topics: Animals; Brain; Cognitive Dysfunction; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Neurodegenerative Diseases; Rats; Rats, Wistar; Sepsis; Simvastatin | 2020 |
Multiple sclerosis: Treatment of cognitive impairment in secondary progressive MS.
Topics: Clinical Trials, Phase II as Topic; Cognitive Dysfunction; Depression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Multiple Sclerosis, Chronic Progressive; Simvastatin | 2017 |
Simvastatin ameliorates cognitive impairments via inhibition of oxidative stress‑induced apoptosis of hippocampal cells through the ERK/AKT signaling pathway in a rat model of senile dementia.
Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Apoptosis; Cells, Cultured; Cognitive Dysfunction; Hippocampus; Male; MAP Kinase Signaling System; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin | 2018 |
Effect of pioglitazone and simvastatin in lipopolysaccharide-induced amyloidogenesis and cognitive impairment in mice: possible role of glutamatergic pathway and oxidative stress.
Topics: Amyloid beta-Peptides; Animals; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Glutamic Acid; Lipopolysaccharides; Male; Maze Learning; Mice; Neuroprotective Agents; Nitrates; Oxidative Stress; Peptide Fragments; Pioglitazone; Recognition, Psychology; Signal Transduction; Simvastatin | 2019 |
Simvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive Impairment
Topics: Animals; Cell Shape; Cognitive Dysfunction; Gene Expression Regulation, Enzymologic; Hippocampus; Male; Matrix Metalloproteinase 9; Maze Learning; Memory; Motor Activity; Neurons; Pyramidal Cells; Rats, Wistar; Simvastatin; Streptozocin | 2019 |
Intravenous Administration of Simvastatin Improves Cognitive Outcome following Severe Traumatic Brain Injury in Rats.
Topics: Administration, Intravenous; Animals; Behavior, Animal; Biomarkers; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; Head Injuries, Penetrating; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rats; Rats, Sprague-Dawley; Simvastatin | 2016 |
Simvastatin-induced cognitive dysfunction: two case reports.
Topics: Adult; Cognitive Dysfunction; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Memory Disorders; Middle Aged; Simvastatin | 2016 |