Page last updated: 2024-08-23

simvastatin and Cirrhosis

simvastatin has been researched along with Cirrhosis in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (26.67)29.6817
2010's25 (55.56)24.3611
2020's8 (17.78)2.80

Authors

AuthorsStudies
Bae, E; Han, SW; Kim, JE; Kim, YS; Lee, S; Moon, JJ; Park, DJ; Yang, SH; Yu, MY1
DiSanto, ME; Li, Y; Liu, D; Liu, J; Wang, Z; Yang, S; Zhang, X; Zhou, Y1
Eslahi, A; Karbalay-Doust, S; Khoshnood, O; Noorafshan, A; Shirazi, M1
Aartsma-Rus, A; Bull, D; Cappellari, O; Hildyard, JCW; Nnorom, S; Plomp, JJ; Tanganyika-de Winter, CL; Verhaart, IEC; Wells, DJ; Wells, KE1
Bai, L; Li, R; Li, S; Liu, Q; Liu, Y; Wang, Y; Wen, Y1
Cai, C; Kilari, S; Korley, JN; Misra, S; Simeon, M; Singh, A; von Recum, HA; Zhao, C; Zuckerman, ST1
Liao, SL; Wang, CC; Wang, SH; Wei, YH; Yang, CH1
Albrecht, J; Aytaman, A; Baffy, G; Bajaj, J; Garcia-Tsao, G; Hernaez, R; Hunt, K; Ioannou, G; Johnson, K; Kanwal, F; Kaplan, DE; Lee, TH; Mehta, R; Monto, A; Pandya, P; Schaubel, D; Taddei, TH1
Ekinci, A; Erdoğan, AS; Kesici, H; Koc, S1
Adams, ME; Bible, KL; Froehner, SC; Kim, MJ; Regnier, M; Whitehead, NP1
Altavilla, D; Bagnato, G; Bitto, A; Cinquegrani, M; Irrera, N; Matucci Cerinic, M; Pizzino, G; Roberts, WN; Saitta, A; Sangari, D; Squadrito, F1
Han, L; Liu, ZH; Qi, H; Yang, X; Zhao, C; Zou, C1
Gao, Q; Shen, S; Wang, Y; Xia, Yj; Yi, L; Zhang, C; Zhang, X1
Acikgoz, A; Acikgoz, Y; Bek, K; Can, B; Genç, G; Ozkaya, O; Sarikaya, S1
Alcala, SE; Anderson, J; Benton, AS; Damsker, J; Freishtat, RJ; Hayes, K; Hoffman, EP; Kureshi, S; Lee, AJ; Nagaraju, K; Reeves, EM; Rose, MC; Wang, Z; Watson, AM; Williams, AM1
Bedi, A; Davis, ME; Gumucio, JP; Harning, JA; Korn, MA; Mendias, CL; Saripalli, AL1
Chu, W; Duan, W; Liu, Z; Lu, Y; Qile, M; Qiu, F; Sun, F; Zhang, L; Zhang, Y; Zhao, D1
Al-Manee, RZ; Al-Oteibi, MM; Al-Rasheed, NM; Al-Shareef, SA; Hasan, IH; Mahmoud, AM; Mohamad, RA1
Boskabady, MH; Golchoobian, R; Jahromi, GP; Kashani, IR; Mohammadian, M; Nejad, AK; Omidi, A; Sadeghipour, HR1
Cao, Y; Chen, C; Li, Z; Qi, R; Tuerdi, N; Wang, Y; Xu, L; Zhang, Q; Zhu, B1
Chung, KJ; Kim, TG; Kim, YH; Lee, JH; Park, KR1
Ajitkumar, S; Murugan Girija, D; Ranga Rao, S; Subbarayan, R1
Chade, AR; Grande, JP; Krier, JD; Lerman, A; Lerman, LO; Zhu, XY1
Carvajal-González, G; Egido, J; Mezzano, S; Ortiz, A; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M; Sánchez-López, E; Selgas, R1
Hong, MK; Kang, DH; Kim, JJ; Kim, YH; Lee, CW; Lee, SW; Park, DW; Park, SJ; Park, SW; Song, JK1
McDaniel, MC; Samady, H1
Narahara, H; Nasu, K; Tsuno, A; Yuge, A1
Chade, AR; Lavi, R; Lerman, A; Lerman, LO; Lin, J; Zhu, XY1
Du, J; He, JQ; Qin, YW; Sheng, L; Wang, LY; Ye, P1
Chen, T; Chen, Z; Pan, L; Xu, Y; Zhang, J; Zhao, R1
Civantos, E; Egido, J; Lavoz, C; Mezzano, S; Ortiz, A; Rayego-Mateos, S; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M1
Fukuda, N; Jumabay, M; Matsumoto, K; Matsumoto, T; Saito, K; Shimosawa, T; Soma, M; Ueno, T; Yamamoto, C1
Cheng, CF; Cheng, WT; Kikuchi, T; Lian, WS; Lin, H1
Abe, Y; Higuchi, K; Inoue, T; Ishida, K; Kakimoto, K; Kawakami, K; Kuramoto, T; Morita, E; Murano, M; Murano, N; Narabayashi, K; Okada, T; Umegaki, E1
Garcia-Garcia, HM; Okamura, T; Serruys, PW; Shin, ES1
Bai, W; Li, H; Zheng, X; Zhou, L1
Doi, K; Fujita, T; Hamasaki, Y; Ijichi, H; Maeda-Mamiya, R; Noiri, E; Okamoto, K; Seki, G1
Almeida-Leite, CM; Bahia, MT; Leite, R; Shrestha-Bajracharya, D; Silva, RR; Talvani, A1
Babal, P; Gvozdjakova, A; Krajcirovicova, K; Kucharska, J; Luptak, I; Matuskova, J; Pechanova, O; Simko, F1
Dellê, H; Fujihara, CK; Mantovani, E; Noronha, IL; Rodrigues, LT; Vieira, JM; Zatz, R1
Zhang, GG; Zhang, SD1
Ding, MX; Fu, Q; Li, GX; Li, ZL; Liu, YF; Xu, L; Zhao, LY; Zhao, X; Zhao, YQ1
Abbate, M; Banfi, C; Bellosta, S; Brioschi, M; Canavesi, M; Gelosa, P; Gianella, A; Guerrini, U; Mussoni, L; Nobili, E; Remuzzi, G; Rottoli, D; Sironi, L; Tremoli, E; Zoja, C1
Boltan, DD; Bouffard, JP; Khetan, A; Lachar, W; Roberts, WC1
Göze, F; Gümüş, C; Kiliç, E; Ozeç, I1

Trials

3 trial(s) available for simvastatin and Cirrhosis

ArticleYear
SACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation.
    Contemporary clinical trials, 2021, Volume: 104

    Topics: Esophageal and Gastric Varices; Fibrosis; Gastrointestinal Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Cirrhosis; Liver Neoplasms; Prospective Studies; Retrospective Studies; Simvastatin

2021
Effects of statin treatments on coronary plaques assessed by volumetric virtual histology intravascular ultrasound analysis.
    JACC. Cardiovascular interventions, 2009, Volume: 2, Issue:7

    Topics: Aged; Calcinosis; Coronary Angiography; Coronary Artery Disease; Female; Fibrosis; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Necrosis; Predictive Value of Tests; Pyrimidines; Rosuvastatin Calcium; Severity of Illness Index; Simvastatin; Sulfonamides; Time Factors; Treatment Outcome; Ultrasonography, Interventional; User-Computer Interface

2009
[Effect of simvastatin on cardiac fibrosis in patients with essential hypertension].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2005, Volume: 30, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzazepines; Drug Therapy, Combination; Female; Fibrosis; Humans; Hypertension; Male; Middle Aged; Myocardium; Simvastatin

2005

Other Studies

42 other study(ies) available for simvastatin and Cirrhosis

ArticleYear
Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy.
    Cells, 2022, 02-22, Volume: 11, Issue:5

    Topics: Angiotensin II; Animals; Atherosclerosis; Endothelial Cells; Fibrosis; Humans; Hypertension, Renal; Interleukin-18; Kruppel-Like Transcription Factors; Mice; Nephritis; RNA, Messenger; Simvastatin; Transcription Factors

2022
Simvastatin Improves Benign Prostatic Hyperplasia: Role of Peroxisome-Proliferator-Activated Receptor-γ and Classic WNT/β-Catenin Pathway.
    International journal of molecular sciences, 2023, Mar-03, Volume: 24, Issue:5

    Topics: Aged; Animals; beta Catenin; Cell Proliferation; Fibrosis; Humans; Male; Peroxisomes; PPAR gamma; Prostatic Hyperplasia; Rats; Simvastatin; Wnt Signaling Pathway

2023
Comparison of the effects of pentoxifylline, simvastatin, tamoxifen, and losartan on cavernous bodies after penile fracture in rats: a stereological study.
    International journal of impotence research, 2020, Volume: 32, Issue:3

    Topics: Animals; Fibrosis; Losartan; Male; Penile Diseases; Pentoxifylline; Rats; Simvastatin; Tamoxifen

2020
Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy.
    Journal of neuromuscular diseases, 2021, Volume: 8, Issue:5

    Topics: Animals; Disease Models, Animal; Fibrosis; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Animal; Muscular Dystrophy, Duchenne; Simvastatin

2021
Simvastatin Enhances Muscle Regeneration Through Autophagic Defect-Mediated Inflammation and mTOR Activation in G93ASOD1 Mice.
    Molecular neurobiology, 2021, Volume: 58, Issue:4

    Topics: Animals; Autophagy; Denervation; Female; Fibrosis; Inflammation; Mice, Transgenic; Motor Activity; Muscle Development; Muscle, Skeletal; Muscular Atrophy; Mutation; Neuromuscular Junction; Phenotype; Protein Aggregates; Regeneration; Signal Transduction; Simvastatin; Superoxide Dismutase; TOR Serine-Threonine Kinases

2021
Periadventitial Delivery of Simvastatin-Loaded Microparticles Attenuate Venous Neointimal Hyperplasia Associated With Arteriovenous Fistula.
    Journal of the American Heart Association, 2020, 12-15, Volume: 9, Issue:24

    Topics: Animals; Anticholesteremic Agents; Arteriovenous Fistula; Chemokine CCL2; Cyclodextrins; Drug Delivery Systems; Fibrosis; Graft Occlusion, Vascular; Hyperplasia; Inflammation; Kidney Failure, Chronic; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Models, Animal; Neointima; Simvastatin; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Vascular Remodeling; Veins

2020
Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves' Ophthalmopathy-Derived Orbital Fibroblasts
    Frontiers in endocrinology, 2020, Volume: 11

    Topics: Adult; Amides; Cell Differentiation; Female; Fibrosis; Graves Ophthalmopathy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; MAP Kinase Signaling System; Middle Aged; Myofibroblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Primary Cell Culture; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Transforming Growth Factor beta

2020
Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats.
    International journal of pediatric otorhinolaryngology, 2018, Volume: 105

    Topics: Alkylating Agents; Animals; Anticholesteremic Agents; Female; Fibrosis; Inflammation; Laryngostenosis; Larynx; Mitomycin; Prospective Studies; Rats; Simvastatin; Single-Blind Method; Trachea; Tracheal Stenosis; Tracheotomy

2018
Simvastatin provides long-term improvement of left ventricular function and prevents cardiac fibrosis in muscular dystrophy.
    Physiological reports, 2019, Volume: 7, Issue:6

    Topics: Animals; Autonomic Nervous System; Calcium-Binding Proteins; Cardiomyopathies; Disease Models, Animal; Fibrosis; Heart; Heart Rate; Male; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Myocytes, Cardiac; Phosphorylation; Recovery of Function; Simvastatin; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2019
Simvastatin attenuates the development of pulmonary and cutaneous fibrosis in a murine model of systemic sclerosis.
    Rheumatology (Oxford, England), 2013, Volume: 52, Issue:8

    Topics: Animals; Biopsy, Needle; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Immunohistochemistry; Mice; Mice, Inbred BALB C; Pulmonary Fibrosis; Random Allocation; Reactive Oxygen Species; Scleroderma, Systemic; Sensitivity and Specificity; Simvastatin; Skin Diseases; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

2013
Simvastatin activates the PPARγ-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling.
    Texas Heart Institute journal, 2013, Volume: 40, Issue:2

    Topics: Animals; Disease Models, Animal; Fibrosis; Heart Failure; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Myocardium; PPAR gamma; Rabbits; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Simvastatin; Transcription Factor RelA; Ultrasonography

2013
Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats.
    Human reproduction (Oxford, England), 2013, Volume: 28, Issue:11

    Topics: Animals; Dehydroepiandrosterone; Female; Fibrosis; Hypoglycemic Agents; Hypolipidemic Agents; Metformin; Ovarian Diseases; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Simvastatin; Transforming Growth Factor beta; Uterine Diseases

2013
The effect of simvastatin and erythropoietin on renal fibrosis in rats with unilateral ureteral obstruction.
    Renal failure, 2014, Volume: 36, Issue:2

    Topics: Animals; Epoetin Alfa; Erythropoietin; Fibroblast Growth Factor 2; Fibronectins; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Kidney; Male; NF-kappa B; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Simvastatin; Transforming Growth Factor beta; Ureteral Obstruction

2014
Mitotic asynchrony induces transforming growth factor-β1 secretion from airway epithelium.
    American journal of respiratory cell and molecular biology, 2014, Volume: 51, Issue:3

    Topics: Aphidicolin; Asthma; Bronchi; Cells, Cultured; Culture Media, Conditioned; Dexamethasone; Epithelial Cells; Epithelium; Fibrosis; Humans; Inflammation; Mitosis; Respiratory Mucosa; Simvastatin; Time Factors; Transforming Growth Factor beta1

2014
Simvastatin reduces fibrosis and protects against muscle weakness after massive rotator cuff tear.
    Journal of shoulder and elbow surgery, 2015, Volume: 24, Issue:2

    Topics: Acetyl-CoA C-Acetyltransferase; Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; CCAAT-Binding Factor; Chronic Disease; Extracellular Matrix Proteins; Fibrosis; Gene Expression; Inflammation; Male; Muscle Contraction; Muscle Fibers, Skeletal; Muscle Weakness; Myosin Heavy Chains; PPAR gamma; Rats; Rats, Sprague-Dawley; Regeneration; Rotator Cuff; Rotator Cuff Injuries; Rupture; Shoulder Pain; Simvastatin

2015
Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression.
    British journal of pharmacology, 2015, Volume: 172, Issue:15

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Survival; Cells, Cultured; Echocardiography; Fibrosis; Gene Knockdown Techniques; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; MAP Kinase Signaling System; Mice; Myocardial Infarction; Proteoglycans; Receptors, Transforming Growth Factor beta; Simvastatin; Up-Regulation

2015
Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Animals; Biomarkers; Cardiomegaly; Creatine Kinase, MB Form; Cytoprotection; Disease Models, Animal; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Isoproterenol; Janus Kinases; Lipids; Male; Myocytes, Cardiac; NF-kappa B; Phosphorylation; Rats, Wistar; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Troponin I

2015
Evaluation of Simvastatin and Bone Marrow-Derived Mesenchymal Stem Cell Combination Therapy on Airway Remodeling in a Mouse Asthma Model.
    Lung, 2016, Volume: 194, Issue:5

    Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cell Movement; Collagen; Combined Modality Therapy; Disease Models, Animal; Eosinophils; Fibrosis; Goblet Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; Leukocyte Count; Male; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Pneumonia; Simvastatin

2016
Preventive effects of simvastatin nanoliposome on isoproterenol-induced cardiac remodeling in mice.
    Nanomedicine : nanotechnology, biology, and medicine, 2016, Volume: 12, Issue:7

    Topics: Animals; Atrial Remodeling; Fibrosis; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoproterenol; Liposomes; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Simvastatin

2016
Simvastatin Reduces Capsular Fibrosis around Silicone Implants.
    Journal of Korean medical science, 2016, Volume: 31, Issue:8

    Topics: Administration, Oral; Animals; Breast; Breast Implants; Connective Tissue Growth Factor; Fibrosis; Gamma Rays; Male; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Silicone Gels; Simvastatin; Transforming Growth Factor beta1

2016
4PBA strongly attenuates endoplasmic reticulum stress, fibrosis, and mitochondrial apoptosis markers in cyclosporine treated human gingival fibroblasts.
    Journal of cellular physiology, 2018, Volume: 233, Issue:1

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Cells, Cultured; Cyclosporine; Cytoprotection; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fibroblasts; Fibrosis; Gingiva; Gingival Overgrowth; Humans; Melatonin; Mitochondria; Phenylbutyrates; Signal Transduction; Simvastatin

2018
Simvastatin abates development of renal fibrosis in experimental renovascular disease.
    Journal of hypertension, 2008, Volume: 26, Issue:8

    Topics: Animals; Atherosclerosis; Blood Pressure; Disease Models, Animal; Epithelial Cells; Fibrosis; Glomerular Filtration Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Renal; Mesenchymal Stem Cells; Renal Artery Obstruction; Renal Circulation; Simvastatin; Sus scrofa

2008
Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways.
    Pharmaceutical research, 2008, Volume: 25, Issue:10

    Topics: Angiotensin II; Atorvastatin; Cell Line; Cell Transdifferentiation; Connective Tissue Growth Factor; Epithelial Cells; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase Kinases; Phenotype; Protein Kinase Inhibitors; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Time Factors; Transfection

2008
Can statins alter coronary plaque composition assessed by radiofrequency backscatter intravascular ultrasound?
    JACC. Cardiovascular interventions, 2009, Volume: 2, Issue:7

    Topics: Calcinosis; Coronary Artery Disease; Fatty Acids, Monounsaturated; Fibrosis; Fluorobenzenes; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Necrosis; Observer Variation; Predictive Value of Tests; Pyrimidines; Radiography; Rosuvastatin Calcium; Severity of Illness Index; Simvastatin; Sulfonamides; Time Factors; Treatment Outcome; Ultrasonography, Interventional; User-Computer Interface

2009
Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.
    Fertility and sterility, 2009, Volume: 92, Issue:6

    Topics: Cell Division; Cells, Cultured; Collagen; Endometriosis; Female; Fibrosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Simvastatin; Stromal Cells

2009
Simvastatin decreases endothelial progenitor cell apoptosis in the kidney of hypertensive hypercholesterolemic pigs.
    Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:5

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cell Survival; Disease Models, Animal; Endothelial Cells; Fibrosis; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension, Renovascular; Inflammation; Kidney; Lipoproteins, LDL; Macrophages; Oxidative Stress; Renal Circulation; Simvastatin; Stem Cells; Sus scrofa

2010
Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:10

    Topics: Animals; Apolipoproteins E; Cardiomegaly; Cathepsins; Cholesterol; Diet; Dietary Fats; Fibrosis; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; Simvastatin

2010
Effect of simvastatin on collagen I deposition in non-infarcted myocardium: role of NF-κB and osteopontin.
    Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:11

    Topics: Animals; Collagen Type I; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Infarction; Myocardium; NF-kappa B; NF-kappa B p50 Subunit; Osteopontin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Ventricular Function, Left

2010
Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
    PloS one, 2010, Nov-30, Volume: 5, Issue:11

    Topics: Angiotensin II; Animals; Aorta; Atorvastatin; Blotting, Western; Cells, Cultured; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Simvastatin; Smad Proteins; Transforming Growth Factor beta; Vasoconstrictor Agents

2010
Protective effects of statin on cardiac fibrosis and apoptosis in adrenomedullin-knockout mice treated with angiotensin II and high salt loading.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2011, Volume: 34, Issue:3

    Topics: Actins; Adrenomedullin; Angiotensin II; Animals; Antigens, Ly; Apoptosis; Capillaries; Coronary Vessels; Fibrosis; Glycoproteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Membrane Proteins; Mice; Mice, Knockout; Myocardium; Proto-Oncogene Proteins c-kit; Simvastatin; Sodium Chloride, Dietary; Treatment Outcome

2011
Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy.
    Journal of biomedical science, 2011, Apr-15, Volume: 18

    Topics: Animals; Disease Models, Animal; Endothelial Cells; Fibrosis; Granulocyte Colony-Stimulating Factor; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iron; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocarditis; Simvastatin; Thrombosis; Tirofiban; Tyrosine

2011
Simvastatin attenuates intestinal fibrosis independent of the anti-inflammatory effect by promoting fibroblast/myofibroblast apoptosis in the regeneration/healing process from TNBS-induced colitis.
    Digestive diseases and sciences, 2012, Volume: 57, Issue:2

    Topics: Animals; Apoptosis; Body Weight; Cicatrix, Hypertrophic; Colitis; Disease Models, Animal; Fibroblasts; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Intestines; Male; Mice; Mice, Inbred Strains; Myofibroblasts; Simvastatin; Wound Healing

2012
Effect of statins on coronary bifurcation atherosclerosis: an intravascular ultrasound virtual histology study.
    The international journal of cardiovascular imaging, 2012, Volume: 28, Issue:7

    Topics: Aged; Chi-Square Distribution; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Disease Progression; Female; Fibrosis; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Logistic Models; Male; Middle Aged; Necrosis; Odds Ratio; Plaque, Atherosclerotic; Predictive Value of Tests; Pyrimidines; Retrospective Studies; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Time Factors; Treatment Outcome; Ultrasonography, Interventional; Vascular Calcification

2012
Prostaglandin E1 dose-dependently promotes stability of atherosclerotic plaque in a rabbit model.
    Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:2

    Topics: Alprostadil; Angioplasty, Balloon; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Cardiovascular Agents; Chemokine CCL2; Cholesterol, Dietary; Cytokines; Daboia; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Down-Regulation; Fibrosis; Histamine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Lipid Metabolism; Macrophages; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Plaque, Atherosclerotic; Rabbits; RNA, Messenger; Simvastatin; Viper Venoms

2012
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor simvastatin ameliorates renal fibrosis through HOXA13-USAG-1 pathway.
    Laboratory investigation; a journal of technical methods and pathology, 2012, Volume: 92, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Line; Dogs; Female; Fibrosis; Homeodomain Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Mice; Mice, Inbred C57BL; Models, Biological; Polymerase Chain Reaction; Promoter Regions, Genetic; Protective Agents; Signal Transduction; Simvastatin

2012
Short-term therapy with simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease.
    Memorias do Instituto Oswaldo Cruz, 2012, Volume: 107, Issue:4

    Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Disease Models, Animal; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Myocarditis; Simvastatin; Time Factors; Tumor Necrosis Factor-alpha

2012
Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension.
    Life sciences, 2004, Jan-23, Volume: 74, Issue:10

    Topics: Animals; Aorta; Blood Pressure; Body Weight; Coenzymes; DNA; Enzyme Inhibitors; Fibrosis; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Rats; Rats, Wistar; Simvastatin; Ubiquinone; Ventricular Remodeling

2004
Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:8

    Topics: Actins; Animals; Cell Differentiation; Chemokine CCL2; Collagen; Fibroblast Growth Factor 2; Fibronectins; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Tubules; Male; Nephritis, Interstitial; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Simvastatin; Transforming Growth Factor beta; Ureteral Obstruction

2005
[Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2006, Volume: 26, Issue:2

    Topics: Animals; Animals, Newborn; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Female; Fibroblasts; Fibrosis; Hypolipidemic Agents; Male; Mevalonic Acid; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Simvastatin; Time Factors

2006
Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats.
    The American journal of pathology, 2007, Volume: 170, Issue:4

    Topics: Actins; Animals; Blood Pressure; Blotting, Western; Collagen; Disease Progression; Fibrinogen; Fibrinolysin; Fibrosis; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Kidney; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microscopy, Electron; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Podocytes; Proteinuria; Pyrimidines; Rats; Rats, Inbred SHR; Rosuvastatin Calcium; Simvastatin; Stroke; Sulfonamides

2007
Fatal and widespread skeletal myopathy confirmed morphologically years after initiation of simvastatin therapy.
    The American journal of cardiology, 2007, Apr-15, Volume: 99, Issue:8

    Topics: Calcinosis; Deglutition Disorders; Dysarthria; Dyspnea; Fatal Outcome; Fibrosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Middle Aged; Muscle Fibers, Skeletal; Muscle Weakness; Muscular Diseases; Necrosis; Simvastatin

2007
Effect of local simvastatin application on mandibular defects.
    The Journal of craniofacial surgery, 2007, Volume: 18, Issue:3

    Topics: Animals; Anticholesteremic Agents; Bone Density; Bone Regeneration; Connective Tissue; Fibrosis; Gelatin Sponge, Absorbable; Hemostatics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mandible; Mandibular Diseases; Osteogenesis; Rats; Rats, Wistar; Simvastatin; Tomography, X-Ray Computed; Wound Healing

2007