simvastatin has been researched along with Chronic Disease in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (11.11) | 18.2507 |
| 2000's | 18 (40.00) | 29.6817 |
| 2010's | 18 (40.00) | 24.3611 |
| 2020's | 4 (8.89) | 2.80 |
| Authors | Studies |
|---|---|
| Brody, SL; Farrell, NF; Goldstein, BJ; Huang, T; Pan, J; Piccirillo, JF | 1 |
| Arancón-Monge, JM; Campos-Díaz, L; de Castro-Cuenca, A; Del Cura-González, I; Rodríguez Barrientos, R; Serrano-Vázquez, Á | 1 |
| Fras, Z; Mikhailidis, DP | 1 |
| Blom, D; Guler, R; Günther, G; Kengne, AP; Motaung, B; Mukasa, S; Nepolo, E; Ozturk, M; Sabeel, S; Schacht, C; Sliwa, K; Thienemann, F; Wilkinson, RJ | 1 |
| Anoopkumar-Dukie, S; Davey, AK; McFarland, AJ | 1 |
| Ong, HX; Pisano, E; Scalia, S; Traini, D; Tulbah, AS; Young, PM | 1 |
| Esmaillzadeh, A; Larijani, B; Milajerdi, A | 1 |
| Del Rio, R; Haack, KK; Marcus, NJ; Schultz, HD; Zucker, IH | 1 |
| Bedi, A; Davis, ME; Gumucio, JP; Harning, JA; Korn, MA; Mendias, CL; Saripalli, AL | 1 |
| Chura, OV; Denisova, NN; Fedulaev, YN; Khairetdinova, GA; Logunova, IY; Pinchuk, TV | 1 |
| Goyal, RK; Jhala, MK; Joshi, CG; Patel, AK; Rana, DG | 1 |
| Archer-Chicko, C; Bagiella, E; Girgis, RE; Hassoun, PM; Horn, EM; Kawut, SM; Lederer, DJ; Mathai, SC; Matura, LA; Palevsky, HI; Pinder, D; Roberts, KE; Tracy, RP; Ventetuolo, CE | 1 |
| Acharya, AB; Surve, SM; Thakur, SL | 1 |
| Ivanovska, J; Jain, A; Jankov, RP; Kantores, C; Wong, MJ | 1 |
| Castillo, C; Cramer, A; González-Herrera, F; Kemmerling, U; Liempi, A; Machado, FS; Maya, JD; Pimentel, P | 1 |
| Fujii, M; Horie, M; Kawahara, C; Nishiyama, K; Tsutamoto, T; Yamaji, M; Yamamoto, T | 1 |
| Al'tman, DA; Davydova, EV; Ermak, EM; Pirogov, AL | 1 |
| Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A | 1 |
| Adachi, S; Hirao, K; Isobe, M; Ito, H; Maejima, Y; Nobori, K; Ono, Y; Suzuki, J | 1 |
| Komuro, I; Sanada, S | 1 |
| Hou, X; Lin, Z; Lu, D; Na, M; Qiao, W; Song, Y; Sun, J; Wei, L; Xie, C | 1 |
| Azor, MH; da Silva Duarte, AJ; de Brito, CA; dos Santos, JC; Futata, EA; Maruta, CW; Rivitti, EA; Sato, MN | 1 |
| Adami, M; Cabrini, DA; Horinouchi, CD; Mendes, DA; Otuki, MF; Prudente, Ada S | 1 |
| Fsadni, P; Montefort, S; Psaila, M | 1 |
| Anstey, AV; Holme, SA; Pearse, AD | 1 |
| Cornish, KG; Pliquett, RU; Zucker, IH | 1 |
| Garcia, JG; Girgis, RE; Hassoun, PM; Johns, RA; Li, D; Tuder, RM; Zhan, X | 1 |
| Andreassen, AK; Aukrust, P; Gullestad, L; Hognestad, A; Holm, T; Kjekshus, JK; Semb, AG; Stokke, O; Wergeland, R | 1 |
| Boulday, G; Charreau, B; Coupel, S; Leboeuf, F; Soulillou, JP | 1 |
| Chen, MS; Luo, JD; Wang, YZ; Xu, FP; Yi, Q; Zhang, GP; Zhang, HQ | 1 |
| Altmann, P; Armitage, J; Baigent, C; Baxter, A; Cairns, HS; Collins, R; Foley, RN; Frighi, V; Kourellias, K; Landray, M; Leaper, C; Ratcliffe, PJ; Rogerson, M; Scoble, JE; Tomson, CR; Warwick, G; Wheeler, DC | 1 |
| Krane, V; Wanner, C | 1 |
| Frampton, C; O'Donnell, JL; Smyth, D | 1 |
| Choe, KH; Kim, EK; Kim, SE; Lee, DS; Lee, JH; Lee, SD; Lee, YS; Oh, YM; Shim, TS | 1 |
| Garcia, JG; Girgis, RE; Grigoryev, DN; Hassoun, PM; Johns, RA; Li, D; Ma, SF; Tuder, RM; Ye, S | 1 |
| Adu, D; Altmann, P; Armitage, J; Baigent, C; Ball, S; Baxter, A; Blackwell, L; Cairns, HS; Carr, S; Collins, R; Kourellias, K; Landray, M; Leaper, C; Rogerson, M; Scoble, JE; Tomson, CR; Warwick, G; Wheeler, DC | 1 |
| Chade, AR; Lerman, A; Lerman, LO; Mushin, OP; Napoli, C; Zhu, X | 1 |
| Carpi, A; Consani, C; Filippi, C; Giovannini, L; Manca-Rizza, G; Mantuano, E; Panichi, V; Paoletti, S; Santi, S; Tramonti, G | 1 |
| Adamus, J; Bak, A; Janczak, J; Kałka, D; Kopka, L; Korzeniowska, J; Marciniak, W; Popielewicz-Kautz, A; Sobieszczańska, M; Zawadzka-Bartczak, E | 1 |
| Rebrov, AP; Tolstov, CN | 1 |
| Kazumi, T; Maeda, E; Matsushita, M; Morita, M; Murata, Y; Nagata, K; Naka, Y; Yoshino, G | 1 |
| Gorrie, MJ; MacGregor, MS; Rodger, RS | 1 |
| Angelin, B; Juliusson, G; Vitols, S | 1 |
| Cruces, MJ; de la Torre, C; Granados, MT; Piñeiro, G | 1 |
| Kruse, W; Schlierf, G; Weber, E | 1 |
1 review(s) available for simvastatin and Chronic Disease
| Article | Year |
|---|---|
Statins influence biomarkers of low grade inflammation in apparently healthy people or patients with chronic diseases: A systematic review and meta-analysis of randomized clinical trials.
Topics: Adult; Atorvastatin; Biomarkers; C-Reactive Protein; Chronic Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Male; Middle Aged; Randomized Controlled Trials as Topic; Simvastatin | 2019 |
11 trial(s) available for simvastatin and Chronic Disease
| Article | Year |
|---|---|
Have We Learnt all from IMPROVE-IT? Part I. Core Results and Subanalyses on the Effects of Ezetimibe Added to Statin Therapy Related to Age, Gender and Selected Chronic Diseases (Kidney Disease, Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease).
Topics: Aged; Anticholesteremic Agents; Chronic Disease; Diabetes Mellitus; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Male; Non-alcoholic Fatty Liver Disease; Simvastatin; Treatment Outcome | 2021 |
Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension.
Topics: Administration, Oral; Aspirin; Biomarkers; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Interleukin-6; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Pulmonary Wedge Pressure; Quality of Life; Simvastatin; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Effect of simvastatin vs. rosuvastatin on adiponectin and haemoglobin A1c levels in patients with non-ischaemic chronic heart failure.
Topics: Adiponectin; Aged; C-Reactive Protein; Chronic Disease; Female; Fluorobenzenes; Glycated Hemoglobin; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Male; Middle Aged; Natriuretic Peptide, Brain; Pyrimidines; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2009 |
[Pleiotropic effects of small dozes simvastatin in patients of senile age with chronic heart failure].
Topics: Aged, 80 and over; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Female; Heart Failure; Humans; Hypolipidemic Agents; Lipids; Male; Simvastatin; Treatment Outcome; Ultrasonography; Vasodilation | 2009 |
Synergistic effect of combined HMG-CoA reductase inhibitor and angiotensin-II receptor blocker therapy in patients with chronic heart failure: the HF-COSTAR trial.
Topics: Aged; Angiotensin Receptor Antagonists; Chronic Disease; Drug Synergism; Drug Therapy, Combination; Electrocardiography; Female; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Losartan; Male; Middle Aged; Prospective Studies; Renin-Angiotensin System; Simvastatin; Treatment Outcome; Ventricular Dysfunction, Left | 2011 |
Effects of conventional and aggressive statin treatment on markers of endothelial function and inflammation.
Topics: Arteriosclerosis; Atorvastatin; C-Reactive Protein; Chronic Disease; Coronary Artery Disease; E-Selectin; Female; Fibrinogen; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Middle Aged; Nitric Oxide; Pyrroles; Simvastatin; Treatment Outcome | 2004 |
First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease.
Topics: Adult; Aged; Alanine Transaminase; Aspirin; Cardiovascular Diseases; Cholesterol, LDL; Chronic Disease; Creatine Kinase; Creatine Kinase, MM Form; Creatinine; Diabetic Nephropathies; Disease Progression; Feasibility Studies; Female; Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Isoenzymes; Kidney Diseases; Kidney Transplantation; Lipids; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Renal Dialysis; Renal Replacement Therapy; Simvastatin; Single-Blind Method; Thrombophilia; Treatment Outcome | 2005 |
The second United Kingdom Heart and Renal Protection (UK-HARP-II) Study: a randomized controlled study of the biochemical safety and efficacy of adding ezetimibe to simvastatin as initial therapy among patients with CKD.
Topics: Anticholesteremic Agents; Azetidines; Chronic Disease; Drug Therapy, Combination; Ezetimibe; Female; Humans; Kidney Diseases; Male; Middle Aged; Simvastatin | 2006 |
[Effect of long-term cardiac training on lipids concentration in patients with chronic heart ischemic disease treated with simvastatin].
Topics: Aged; Cholesterol, HDL; Cholesterol, LDL; Chronic Disease; Exercise; Exercise Therapy; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipid Metabolism; Lipids; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Simvastatin; Treatment Outcome; Triglycerides | 2007 |
Simvastatin impairs mitogen-induced proliferation of malignant B-lymphocytes from humans--in vitro and in vivo studies.
Topics: Adult; Aged; B-Lymphocytes; Cell Division; Cholesterol; Chronic Disease; Disease Progression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Leukemia, Lymphoid; Lipids; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Mitogens; Pravastatin; Simvastatin; Thymidine; Tumor Cells, Cultured | 1997 |
Monitoring compliance in clinical trials.
Topics: Anticholesteremic Agents; Chronic Disease; Clinical Trials as Topic; Humans; Hyperlipoproteinemia Type II; Lovastatin; Microcomputers; Patient Compliance; Simvastatin | 1990 |
33 other study(ies) available for simvastatin and Chronic Disease
| Article | Year |
|---|---|
Simvastatin as a topical anti-inflammatory: Effect on airway epithelial cell homeostasis.
Topics: Anti-Inflammatory Agents; Chronic Disease; Epithelial Cells; Humans; Respiratory System; Rhinitis; Simvastatin | 2023 |
[Effects of changing the appearance of medications in safety and adherence in chronic patients over 65 years of age in primary care. CAMBIMED Study].
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Chronic Disease; Drug Labeling; Drug Packaging; Enalapril; Female; Follow-Up Studies; Humans; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Longitudinal Studies; Male; Medication Adherence; Medication Errors; Primary Health Care; Prospective Studies; Simvastatin | 2020 |
Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases.
Topics: Adult; Atorvastatin; Chronic Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Meta-Analysis as Topic; Simvastatin; Systematic Reviews as Topic | 2020 |
Statins Reduce Lipopolysaccharide-Induced Cytokine and Inflammatory Mediator Release in an In Vitro Model of Microglial-Like Cells.
Topics: Anti-Inflammatory Agents; Antioxidants; Atorvastatin; Cell Proliferation; Chronic Disease; Dinoprostone; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Inflammation; Interleukin-1beta; Lipids; Lipopolysaccharides; Microglia; Monocytes; Nitric Oxide; Pravastatin; Quinolines; Reactive Oxygen Species; Rosuvastatin Calcium; Simvastatin; THP-1 Cells; Tumor Necrosis Factor-alpha | 2017 |
Inhaled simvastatin nanoparticles for inflammatory lung disease.
Topics: Administration, Inhalation; Anti-Inflammatory Agents; Biological Transport; Chemistry, Pharmaceutical; Chronic Disease; Drug Carriers; Drug Liberation; Epithelial Cells; Humans; Inflammation; Lactic Acid; Lung Diseases; Mucus; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Simvastatin; Surface Properties | 2017 |
Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure.
Topics: Animals; Arrhythmias, Cardiac; Carotid Body; Chronic Disease; Disease Models, Animal; Heart Failure; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Transcription Factors; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Respiration; Simvastatin; Sleep Apnea Syndromes | 2014 |
Simvastatin reduces fibrosis and protects against muscle weakness after massive rotator cuff tear.
Topics: Acetyl-CoA C-Acetyltransferase; Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; CCAAT-Binding Factor; Chronic Disease; Extracellular Matrix Proteins; Fibrosis; Gene Expression; Inflammation; Male; Muscle Contraction; Muscle Fibers, Skeletal; Muscle Weakness; Myosin Heavy Chains; PPAR gamma; Rats; Rats, Sprague-Dawley; Regeneration; Rotator Cuff; Rotator Cuff Injuries; Rupture; Shoulder Pain; Simvastatin | 2015 |
Anti-inflammatory effects of simvastatin in patients with chronic heart failure.
Topics: Aged; Anti-Inflammatory Agents; Chronic Disease; Female; Heart Failure; Humans; Inflammation Mediators; Male; Middle Aged; Simvastatin | 2014 |
Alteration in the expression of exon IIC transcripts of brain-derived neurotrophic factor gene by simvastatin [correction of simvastain] in chronic mild stress in mice: a possible link with dopaminergic pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Bromocriptine; Chronic Disease; Dopamine; Dopamine Agents; Eating; Exons; Haloperidol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Levodopa; Lipid Metabolism; Male; Mice; Signal Transduction; Simvastatin; Stress, Psychological; Sucrose; Transcription, Genetic | 2014 |
Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing.
Topics: Administration, Buccal; Adult; Atorvastatin; Case-Control Studies; Chronic Disease; Dental Scaling; Gels; Gingival Crevicular Fluid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1alpha; Middle Aged; Periodontitis; Root Planing; Simvastatin; Treatment Outcome | 2015 |
Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling.
Topics: Animals; Animals, Newborn; Biosynthetic Pathways; Blood Pressure; Cholesterol; Chronic Disease; Female; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; Myelin Sheath; Nitric Oxide Synthase Type III; Organ Size; Physical Conditioning, Animal; Polyisoprenyl Phosphates; Pulmonary Artery; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Sesquiterpenes; Signal Transduction; Simvastatin; Vascular Remodeling | 2016 |
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
Topics: Animals; Anticholesteremic Agents; Arachidonate 5-Lipoxygenase; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; E-Selectin; Endothelium; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Lipoxins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Myocardium; Nitroimidazoles; Parasitemia; Simvastatin; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vascular Cell Adhesion Molecule-1 | 2017 |
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Epithelial Cells; Epithelium; Lung; Male; Mice; Mice, Inbred BALB C; Mucus; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrosation; Pneumonia; Simvastatin; Stress, Physiological | 2011 |
Costarring statins with ARBs: going to be a smash hit?
Topics: Angiotensin Receptor Antagonists; Chronic Disease; Drug Therapy, Combination; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Losartan; Renin-Angiotensin System; Simvastatin; Treatment Outcome | 2011 |
Administration of simvastatin after kainic acid-induced status epilepticus restrains chronic temporal lobe epilepsy.
Topics: Animals; Anticholesteremic Agents; Behavior, Animal; Chronic Disease; Cytokines; Enzyme-Linked Immunosorbent Assay; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Wistar; Simvastatin; Status Epilepticus | 2011 |
Statin effects on regulatory and proinflammatory factors in chronic idiopathic urticaria.
Topics: Adaptive Immunity; Adult; Aged; Cell Cycle; Cell Proliferation; Chemokine CCL3; Chronic Disease; Female; Humans; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-10; Interleukin-17; Interleukin-6; Leukocytes, Mononuclear; Lovastatin; Male; Middle Aged; Phytohemagglutinins; RNA, Messenger; Simvastatin; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; T-Lymphocytes; Th1 Cells; Th2 Cells; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Urticaria; Young Adult | 2011 |
Simvastatin ointment, a new treatment for skin inflammatory conditions.
Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dermatitis, Irritant; Disease Models, Animal; Female; Mice; Ointments; Peroxidase; Proliferating Cell Nuclear Antigen; Simvastatin; Tetradecanoylphorbol Acetate | 2012 |
Chronic cough as a complication of treatment with statins: a case report.
Topics: Aged, 80 and over; Chronic Disease; Cough; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Simvastatin | 2012 |
Chronic actinic dermatitis secondary to simvastatin.
Topics: Chronic Disease; Diagnosis, Differential; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Neck; Photosensitivity Disorders; Simvastatin | 2002 |
Statin therapy restores sympathovagal balance in experimental heart failure.
Topics: Animals; Atropine; Baroreflex; Cardiac Output, Low; Chronic Disease; Heart Rate; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metoprolol; Rabbits; Simvastatin; Sympathetic Nervous System; Sympatholytics; Vagus Nerve | 2003 |
Attenuation of chronic hypoxic pulmonary hypertension by simvastatin.
Topics: Animals; Chronic Disease; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypoxia; Lung; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Simvastatin | 2003 |
RhoA activation mediates phosphatidylinositol 3-kinase-dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft nephropathy.
Topics: Cell Division; Chronic Disease; Cytoskeleton; Endothelium, Vascular; Gene Expression; Genes, MHC Class I; Humans; Kidney Diseases; Kidney Transplantation; Phosphatidylinositol 3-Kinases; Protein Prenylation; rhoA GTP-Binding Protein; Simvastatin; Transplantation Immunology | 2004 |
Statins initiated after hypertrophy inhibit oxidative stress and prevent heart failure in rats with aortic stenosis.
Topics: Animals; Aortic Coarctation; Aortic Valve Stenosis; Apoptosis; Atrial Natriuretic Factor; Cardiac Output, Low; Caspase 3; Caspases; Chronic Disease; Heart Ventricles; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Male; Myocytes, Cardiac; Oxidative Stress; Rats; RNA, Messenger; Simvastatin; Superoxides | 2004 |
Statins and aspirin in chronic kidney disease: what does the UK-HARP-I trial tell us?
Topics: Aspirin; Cardiovascular Diseases; Cholesterol; Chronic Disease; Disease Progression; Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Kidney Transplantation; Peritoneal Dialysis; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Renal Dialysis; Research Design; Simvastatin; Treatment Outcome | 2005 |
Prioritizing health-care funding.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Chronic Disease; Cost Allocation; Drug Costs; Female; Financial Management; Health Care Rationing; Health Expenditures; Health Priorities; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infliximab; New Zealand; Simvastatin; Stroke; Tumor Necrosis Factor-alpha | 2005 |
Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs.
Topics: Administration, Oral; Analysis of Variance; Animals; Biopsy; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Nitric Oxide Synthase; Pulmonary Artery; Pulmonary Emphysema; Rats; Rats, Sprague-Dawley; Risk Factors; Simvastatin; Smoking; Time Factors | 2005 |
Differential gene expression in chronic hypoxic pulmonary hypertension: effect of simvastatin treatment.
Topics: Animals; Chronic Disease; Gene Expression; Hypertension, Pulmonary; Hypoxia; Microarray Analysis; Rats; Rats, Sprague-Dawley; Simvastatin | 2005 |
Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia.
Topics: Angiogenic Proteins; Animals; Blood Pressure; Chronic Disease; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Kidney Diseases; Microcirculation; Neovascularization, Physiologic; Renal Artery Obstruction; Simvastatin; Swine; Transglutaminases | 2006 |
Simvastatin and fluvastatin reduce interleukin-6 and interleukin-8 lipopolysaccharide (LPS) stimulated production by isolated human monocytes from chronic kidney disease patients.
Topics: Cardiovascular Diseases; Cells, Cultured; Chronic Disease; Cytokines; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Indoles; Interleukin-6; Interleukin-8; Kidney Diseases; Lipopolysaccharides; Monocytes; Simvastatin | 2007 |
[Clinico-diagnostic significance of cytokine activation and changes of morphofunctional parameters of the heart in patients with chronic heart failure and possibilities of correction of revealed disturbances with simvastatin].
Topics: Chronic Disease; Cytokines; Female; Heart Failure; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Simvastatin | 2007 |
Effect of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor on triglyceride kinetics in chronically streptozotocin-diabetic rats.
Topics: Animals; Cholesterol; Chronic Disease; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipids; Lovastatin; Male; Rats; Rats, Wistar; Reference Values; Simvastatin; Triglycerides | 1993 |
Acute on chronic renal failure induced by simvastatin.
Topics: Acute Disease; Cardiovascular Diseases; Chronic Disease; Humans; Lovastatin; Male; Middle Aged; Renal Insufficiency; Simvastatin | 1996 |
Chronic actinic dermatitis due to simvastatin.
Topics: Aged; Chronic Disease; Dermatitis, Phototoxic; Drug Eruptions; Humans; Hypolipidemic Agents; Male; Simvastatin | 1998 |