Page last updated: 2024-08-23

simvastatin and Chemical and Drug Induced Liver Injury

simvastatin has been researched along with Chemical and Drug Induced Liver Injury in 58 studies

Research

Studies (58)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (13.79)	18.2507
2000's	14 (24.14)	29.6817
2010's	29 (50.00)	24.3611
2020's	7 (12.07)	2.80

Authors

Authors	Studies
Ahmad, S; Barrish, JC; Bird, E; Bisaha, S; Blanar, MA; Chang, M; Chen, BC; Chen, X; Cuff, CA; Darienzo, CJ; Giancarli, M; Harrity, T; Huang, C; Janovitz, E; Kennedy, LJ; Li, T; Madsen, CS; Monshizadegan, H; Ngu, K; Nguyen-Tran, V; Reeves, RA; Robl, JA; Ryan, CS; Search, D; Setters, R; Sitkoff, D; Stein, PD; Yin, X; Zahler, R; Zhang, R; Zhao, R; Zhuang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Abd El Reheem, MH; Ahmed, SA; Elbahy, DA	1
Li, XY; Mao, YM; Zhong, W	1
Armas Flórez, CD; Concepción-Zavaleta, MJ; Gonzáles Yovera, JG; Moreno Marreros, DM	1
Carubbi, F; Nascimbeni, F; Onfiani, G	1
Albrahim, T; Alonazi, MA	1
Abdelsalam, RM; Abo-Zalam, HB; El-Denshary, ES; Hamzawy, MA; Khalil, IA; Khattab, MM	1
Alanazi, NS; Alenazi, TS; Alenzi, KA	1
Duan, F; Guo, Z; Liu, Y; Xian, Z; Xiao, H; Xu, W	1
Cui, R; Feng, Y; Liang, H; Liu, C; Qiu, M; Zhang, J	1
Aschmann, HE; Kaufmann, M; Puhan, MA; Yebyo, HG	1
Mikiewicz, M; Otrocka-Domagała, I; Paździor-Czapula, K	1
Ahmed, EA; Ali, MF; Hareedy, MS	1
El-Boghdady, NA; Ibrahim, SA; Motawi, TK; Teleb, ZA	1
Also, MA; Bastida, C; Letang, E; Miró, JM; Pericas, JM; Tuset, M	1
Peña-Irún, Á	1
Majeed, A; Muneera, KE; Naveed, AK	1
Beck-Peccoz, P; Campi, I; Covelli, D; Currò, N; D'Ambrosio, R; Gianelli, U; Maggioni, M; Salvi, M; Vannucchi, G	1
Lopez, JL; Tayek, JA	1
Fang, RF; Gao, SQ; Li, JH; Pan, YT; Zhan, SY; Zhang, J	1
Björnsson, ES	1
Daly, AK	2
Björnsson, E; Jacobsen, EI; Kalaitzakis, E	1
Bing, N; de Souza, PL; Goodman, VL; King, KS; McCann, LA; Mooser, VE; Pandite, LN; Spraggs, CF; Xu, CF; Xue, Z	1
Abraldes, JG; Bosch, J; García-Pagán, JC; Gracia-Sancho, J; Hide, D; La Mura, V; Meireles, CZ; Miquel, R; Pasarín, M; Rodríguez-Vilarrupla, A	1
Itakura, H; Kita, T; Mabuchi, H; Matsuzaki, M; Matsuzawa, Y; Nakaya, N; Oikawa, S; Saito, Y; Sasaki, J; Shimamoto, K	1
Ashar, U; Bhaduri, A; Desai, D	1
Blazing, M; Braunwald, E; Califf, R; Cannon, CP; de Lemos, JA; McCabe, CH; Murphy, SA; Wiviott, SD	1
Guirguis, A; Ricaurte, B; Taylor, HC; Zabriskie, D	1
Guthrie, RM	1
Alican, I; Ercan, F; Gedik, N; Işeri, S; Yüksel, M	1
Alsheikh-Ali, AA; Karas, RH	1
Arkad'eva, AV; Baĭdiuk, EV; Morozov, VI; Okovityĭ, SV; Sakuta, GA; Shiriaeva, AP	1
Alsheikh-Ali, AA; Han, H; Karas, RH; Maddukuri, PV	1
Chudy, B; Lata, S	1
Fehmers, MC; Koornstra, JJ; Ottervanger, JP; Stricker, BH	1
Lee, TH	1
Bataille, L; Hamoir, V; Horsmans, Y; Nakad, A; Sempoux, C	1
Gabbert, HE; Gerards, H; Heuer, T; Pauw, M; Reis, HE	1
Caldwell, SH; Hespenheide, EE; von Borstel, RW	1
Byrd, RP; Fields, CL; Kanathur, N; Mathai, MG; Roy, TM	1
Baziz, A; Becot, F; Piquemal, A; Roblin, X	1
Walker, JF	1
Ballaré, M; Bordin, G; Campanini, M; Catania, E; Monteverde, A; Zaccala, G	1
Bogomoletz, WV; Feydy, P	1

Reviews

8 review(s) available for simvastatin and Chemical and Drug Induced Liver Injury

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis, and network meta-analysis of randomized trials with 94,283 participants. American heart journal, 2019, Volume: 210 Topics: Atorvastatin; Cardiovascular Diseases; Cause of Death; Chemical and Drug Induced Liver Injury; Double-Blind Method; Fluvastatin; Headache; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Lovastatin; Middle Aged; Muscular Diseases; Nausea; Neoplasms; Network Meta-Analysis; Placebos; Pravastatin; Randomized Controlled Trials as Topic; Risk Assessment; Rosuvastatin Calcium; Simvastatin; Withholding Treatment	2019
Voriconazole-Induced Hepatitis via Simvastatin- and Lansoprazole-Mediated Drug Interactions: A Case Report and Review of the Literature. Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:1 Topics: Adult; Antifungal Agents; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Dyslipidemias; Gastroesophageal Reflux; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Jaundice, Obstructive; Lansoprazole; Liver; Male; Polypharmacy; Proton Pump Inhibitors; Pulmonary Aspergillosis; Simvastatin; Voriconazole	2016
Hepatotoxicity of statins and other lipid-lowering agents. Liver international : official journal of the International Association for the Study of the Liver, 2017, Volume: 37, Issue:2 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Simvastatin	2017
Genome-wide association studies in pharmacogenomics. Nature reviews. Genetics, 2010, Volume: 11, Issue:4 Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2C9; Drug-Related Side Effects and Adverse Reactions; Floxacillin; Genome-Wide Association Study; Humans; Interferon-alpha; Mixed Function Oxygenases; Muscular Diseases; Pharmacogenetics; Platelet Aggregation Inhibitors; Simvastatin; Vitamin K Epoxide Reductases	2010
Using genome-wide association studies to identify genes important in serious adverse drug reactions. Annual review of pharmacology and toxicology, 2012, Volume: 52 Topics: Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2C8; Drug-Related Side Effects and Adverse Reactions; Exanthema; Genetic Predisposition to Disease; Genome-Wide Association Study; Genome, Human; Genotype; HLA-A Antigens; Humans; Hypersensitivity; Liver; Pharmacogenetics; Polymorphism, Genetic; Risk Factors; Simvastatin	2012
How safe is aggressive statin therapy? Progress in cardiovascular nursing, 2006,Summer, Volume: 21, Issue:3 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Muscular Diseases; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides	2006
Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials. Journal of the American College of Cardiology, 2007, Jul-31, Volume: 50, Issue:5 Topics: Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Liver Diseases; Lovastatin; Neoplasms; Pravastatin; Rhabdomyolysis; Simvastatin	2007

Trials

3 trial(s) available for simvastatin and Chemical and Drug Induced Liver Injury

Article	Year
Influence of simvastatin on hepatocytes - histopathological and immunohistochemical study. Polish journal of veterinary sciences, 2019, Volume: 22, Issue:2 Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Hepatocytes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Random Allocation; Simvastatin; Swine; Swine Diseases	2019
HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment. European heart journal, 2013, Volume: 34, Issue:17 Topics: Arterial Occlusive Diseases; Chemical and Drug Induced Liver Injury; Death, Sudden, Cardiac; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Hypolipidemic Agents; Indoles; Male; Middle Aged; Muscular Diseases; Myocardial Infarction; Myocardial Reperfusion; Niacin; Simvastatin; Stroke	2013
Worldwide experience with simvastatin/lovastatin. European heart journal, 1992, Volume: 13 Suppl B Topics: Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Coronary Artery Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Long-Term Care; Lovastatin; Rhabdomyolysis; Simvastatin	1992

Other Studies

47 other study(ies) available for simvastatin and Chemical and Drug Induced Liver Injury

Article	Year
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with Journal of medicinal chemistry, 2008, May-08, Volume: 51, Issue:9 Topics: Administration, Oral; Animals; Biological Availability; Chemical and Drug Induced Liver Injury; Cholesterol; Crystallography, X-Ray; Dogs; Female; Guinea Pigs; Haplorhini; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Liver; Models, Molecular; Muscle Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Triazoles	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
l-Carnitine ameliorates the osteoporotic changes and protects against simvastatin induced myotoxicity and hepatotoxicity in glucocorticoid-induced osteoporosis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 152 Topics: Animals; Carnitine; Chemical and Drug Induced Liver Injury; Glucocorticoids; Myotoxicity; Osteoporosis; Rats; Rats, Wistar; Simvastatin	2022
[Statin-related drug-induced liver injury]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2023, Jun-20, Volume: 31, Issue:6 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Simvastatin	2023
Statins in liver cirrhosis in a developing country: benefits overweigh the risk? Expert opinion on drug safety, 2020, Volume: 19, Issue:12 Topics: Chemical and Drug Induced Liver Injury; Contraindications, Drug; Developing Countries; Hepatitis, Viral, Human; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver Cirrhosis; Meta-Analysis as Topic; Non-alcoholic Fatty Liver Disease; Obesity; Peru; Risk Assessment; Simvastatin	2020
A case of statin-induced liver injury with positive rechallenge with a second statin. Is there a class effect? Journal of basic and clinical physiology and pharmacology, 2021, Apr-22, Volume: 32, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Simvastatin	2021
Lycopene corrects metabolic syndrome and liver injury induced by high fat diet in obese rats through antioxidant, anti-inflammatory, antifibrotic pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 141 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Chemical and Drug Induced Liver Injury; Cytokines; Diet, High-Fat; Fibrinolytic Agents; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Lipid Metabolism; Lipids; Liver Cirrhosis; Lycopene; Male; Metabolic Syndrome; Obesity; Rats; Rats, Wistar; Simvastatin; Weight Gain	2021
Therapeutic advancement of simvastatin-loaded solid lipid nanoparticles (SV-SLNs) in treatment of hyperlipidemia and attenuating hepatotoxicity, myopathy and apoptosis: Comprehensive study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 139 Topics: Animals; Apoptosis; Biological Availability; Chemical and Drug Induced Liver Injury; Drug Carriers; Drug Delivery Systems; Hyperlipidemias; Lipids; Male; Muscular Diseases; Nanoparticles; Particle Size; Rats; Rats, Wistar; Simvastatin	2021
Hepatotoxicity Induced by Fluvastatin: A Reversible Acute Cholestatic Liver Injury. The American journal of case reports, 2021, Aug-12, Volume: 22 Topics: Aged; Chemical and Drug Induced Liver Injury; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Simvastatin	2021
The Anti-hyperlipidemia Effects of Raw Polygonum multiflorum Extract in Vivo. Biological & pharmaceutical bulletin, 2017, Volume: 40, Issue:11 Topics: Acetyl-CoA Carboxylase; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal; Fallopia multiflora; Fatty Acid Synthase, Type I; Hepatocytes; Humans; Hydroxymethylglutaryl CoA Reductases; Hyperlipidemias; Hypolipidemic Agents; Lipid Metabolism; Liver; Male; Medicine, Chinese Traditional; Rats, Sprague-Dawley; Simvastatin; Triglycerides	2017
Simvastatin protects against acetaminophen-induced liver injury in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 98 Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidative Stress; Protective Agents; Simvastatin; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2018
Montelukast modifies simvastatin-induced myopathy and hepatotoxicity. Drug development research, 2019, Volume: 80, Issue:7 Topics: Acetates; Albumins; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Creatine Kinase; Cyclopropanes; Drug Interactions; Globulins; Liver Function Tests; Male; Muscular Diseases; Myoglobin; Quinolines; Rats; Simvastatin; Sulfides	2019
Effect of simvastatin and naringenin coadministration on rat liver DNA fragmentation and cytochrome P450 activity: an in vivo and in vitro study. Journal of physiology and biochemistry, 2014, Volume: 70, Issue:1 Topics: Alanine Transaminase; Animals; Anticholesteremic Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; DNA Fragmentation; Drug Evaluation, Preclinical; Drug Interactions; Female; Flavanones; Glutathione; Liver; Malondialdehyde; Microsomes, Liver; Rats; Rats, Wistar; Simvastatin; Superoxide Dismutase	2014
[Rhabdomyolysis and severe hepatotoxicity due to a drug-drug interaction between ritonavir and simvastatin. Could we use the most cost-effective statin in all human immunodeficiency virus-infected patients?]. Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32, Issue:9 Topics: Antiretroviral Therapy, Highly Active; Atorvastatin; Chemical and Drug Induced Liver Injury; Comorbidity; Contraindications; Cost-Benefit Analysis; Cytochrome P-450 CYP3A Inhibitors; Drug Substitution; Drug Synergism; Dyslipidemias; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Tubular Necrosis, Acute; Middle Aged; Rhabdomyolysis; Ritonavir; Simvastatin	2014
[Drug-induced liver injury caused by simvastatin associated with antinuclear antibodies]. Medicina clinica, 2015, Feb-20, Volume: 144, Issue:4 Topics: Aged; Antibodies, Antinuclear; Chemical and Drug Induced Liver Injury; Female; Hepatitis, Autoimmune; Humans; Hypolipidemic Agents; Simvastatin	2015
Comparative evaluation of Nigella sativa (Kalonji) and simvastatin for the treatment of hyperlipidemia and in the induction of hepatotoxicity. Pakistan journal of pharmaceutical sciences, 2015, Volume: 28, Issue:2 Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cholesterol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Nigella sativa; Phytotherapy; Rats; Rats, Sprague-Dawley; Simvastatin; Triglycerides	2015
Statins may increase the risk of liver dysfunction in patients treated with steroids for active graves' orbitopathy. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:5 Topics: Chemical and Drug Induced Liver Injury; Female; Glucocorticoids; Graves Ophthalmopathy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Methylprednisolone; Middle Aged; Simvastatin	2015
[Association between statins use and liver injury based on prescription sequence symmetry analysis]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2016, Volume: 37, Issue:7 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Prescription Drugs; Simvastatin	2016
Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing. Journal of hepatology, 2012, Volume: 56, Issue:2 Topics: Adverse Drug Reaction Reporting Systems; Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrroles; Simvastatin; Sweden; Time Factors	2012
Concomitant use of pazopanib and simvastatin increases the risk of transaminase elevations in patients with cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:9 Topics: Alanine Transaminase; Anticholesteremic Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Interactions; Humans; Hypercholesterolemia; Incidence; Indazoles; Neoplasm Proteins; Neoplasms; Polymorphism, Single Nucleotide; Pyrimidines; Reference Values; Simvastatin; Sulfonamides	2012
Effects of simvastatin administration on rodents with lipopolysaccharide-induced liver microvascular dysfunction. Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:3 Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Liver; Liver Circulation; Male; Microcirculation; Rats; Rats, Wistar; Simvastatin; Vascular Resistance	2013
Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatment with minimum side effects in 51,321 Japanese hypercholesterolemic patients. Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:4 Topics: Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Cholesterol; Cohort Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Male; Middle Aged; Musculoskeletal Diseases; Osmolar Concentration; Simvastatin	2003
Flutamide-induced hepatotoxicity with possible potentiation by simvastatin. The Journal of the Association of Physicians of India, 2003, Volume: 51 Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Synergism; Flutamide; Humans; Male; Prostatic Neoplasms; Simvastatin	2003
A tale of two trials: a comparison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22. Circulation, 2006, Mar-21, Volume: 113, Issue:11 Topics: Aged; Angina, Unstable; Atorvastatin; C-Reactive Protein; Cardiovascular Diseases; Case Management; Chemical and Drug Induced Liver Injury; Comorbidity; Confounding Factors, Epidemiologic; Dose-Response Relationship, Drug; Endpoint Determination; Female; Heptanoic Acids; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Life Tables; Lipids; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Ischemia; Myocardial Revascularization; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Risk; Risk Factors; Simvastatin; Stroke; Tirofiban; Treatment Outcome; Tyrosine	2006
Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity. The Annals of pharmacotherapy, 2006, Volume: 40, Issue:4 Topics: Aged; Amiodarone; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Male; Rhabdomyolysis; Simvastatin; Treatment Outcome; Uremia	2006
Simvastatin attenuates cisplatin-induced kidney and liver damage in rats. Toxicology, 2007, Feb-12, Volume: 230, Issue:2-3 Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Bilirubin; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Cisplatin; Creatinine; Female; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; L-Lactate Dehydrogenase; Liver Diseases; Male; Malondialdehyde; Peroxidase; Rats; Rats, Sprague-Dawley; Serum Albumin; Simvastatin	2007
Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system). The American journal of cardiology, 2007, Feb-01, Volume: 99, Issue:3 Topics: Adverse Drug Reaction Reporting Systems; Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Prescriptions; Drug Therapy, Combination; Dyslipidemias; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Liver Diseases; Lovastatin; Niacin; Pravastatin; Prevalence; Pyrroles; Retrospective Studies; Rhabdomyolysis; Risk Factors; Simvastatin; United States; United States Food and Drug Administration	2007
[Hepatocyte mitochondrion respiratory chain in rats with experimental toxic hepatitis]. Tsitologiia, 2007, Volume: 49, Issue:2 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochromes c; Dinitrophenols; Electron Transport; Ethanol; Hepatocytes; Malates; Male; Mitochondria; Oxygen Consumption; Pyruvic Acid; Rats; Rats, Wistar; Rotenone; Simvastatin	2007
[Acute cholestatic hepatitis caused by simvastatine in a 67-year-old patient]. Przeglad lekarski, 2006, Volume: 63 Suppl 7 Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Humans; Hyperbilirubinemia; Jaundice, Obstructive; Male; Prednisone; Pruritus; Simvastatin; Treatment Outcome	2006
[Clinically manifest liver lesions during use of simvastatin]. Nederlands tijdschrift voor geneeskunde, 1996, Apr-13, Volume: 140, Issue:15 Topics: Aged; Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Jaundice; Lovastatin; Male; Middle Aged; Simvastatin	1996
I take Zocor for high cholesterol. My doctor checks my lipid levels every six months and they have been pretty good for a few years now. But he also checks my liver-function tests, because liver damage is one of the side effects of this drug. How worried Harvard heart letter : from Harvard Medical School, 1998, Volume: 9, Issue:1 Topics: Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Liver Function Tests; Simvastatin	1998
Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin. Lancet (London, England), 1999, May-22, Volume: 353, Issue:9166 Topics: Aged; Anticholesteremic Agents; Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Pyrroles; Simvastatin	1999
[Toxic liver damage caused by HMG-CoA reductase inhibitor]. Medizinische Klinik (Munich, Germany : 1983), 2000, Nov-15, Volume: 95, Issue:11 Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver Function Tests; Male; Middle Aged; Pravastatin; Simvastatin	2000
Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simvastatin. Digestive diseases and sciences, 2001, Volume: 46, Issue:2 Topics: Aged; Anticholesteremic Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Disease Progression; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypoglycemic Agents; Liver Cirrhosis; Myositis; Simvastatin; Thiazoles; Thiazolidinediones; Troglitazone	2001
Simvastatin-diltiazem drug interaction resulting in rhabdomyolysis and hepatitis. Tennessee medicine : journal of the Tennessee Medical Association, 2001, Volume: 94, Issue:9 Topics: Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Diltiazem; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Rhabdomyolysis; Simvastatin	2001
[Simvastatin-induced hepatitis]. Gastroenterologie clinique et biologique, 1992, Volume: 16, Issue:1 Topics: Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin	1992
Acute cholestatic hepatitis during simvastatin administration. Recenti progressi in medicina, 1991, Volume: 82, Issue:4 Topics: Acute Disease; Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Middle Aged; Simvastatin	1991
Pravastatin and simvastatin for hypercholesterolemia. The Medical letter on drugs and therapeutics, 1991, Mar-08, Volume: 33, Issue:839 Topics: Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Therapy, Combination; Heptanoic Acids; Humans; Hypercholesterolemia; Lovastatin; Muscular Diseases; Naphthalenes; Pravastatin; Simvastatin	1991
[A case of hepatitis caused by simvastatin]. Gastroenterologie clinique et biologique, 1991, Volume: 15, Issue:1 Topics: Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Humans; Lovastatin; Male; Middle Aged; Simvastatin	1991