simvastatin has been researched along with Cardiomegaly in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 14 (60.87) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, P; Chen, X; Cheng, Y; Duan, Y; Kuang, Y; Li, H; Liu, J; Liu, Z; Shen, Y; Tomlinson, B; Wang, X; Wang, Y; Yu, Z; Zhang, L; Zhang, Q; Zhang, Y; Zhao, Z; Zhuang, T | 1 |
| Han, Q; Liu, Q; Lu, M; Tang, F; Wang, H; Zhang, H; Zhang, Y | 1 |
| Al-Manee, RZ; Al-Oteibi, MM; Al-Rasheed, NM; Al-Shareef, SA; Hasan, IH; Mahmoud, AM; Mohamad, RA | 1 |
| Bonney, W; Cheema, FH; Gonzalez, AM; Homma, S; Kinnear, C; Liao, JK; Mahmut, N; Martens, TP; Mital, S; Osorio, JC | 1 |
| Liu, J; Wu, Y | 1 |
| Guo, WG; Li, RY; Liu, XT; Lu, ZF; Shi, XQ; Shu, Q; Su, FF; Yang, GD; Yuan, LJ; Zheng, QS | 1 |
| Chen, X; Wu, Y; Yang, HC | 1 |
| Cramariuc, D; Gerdts, E; Rieck, AE; Tuseth, N; Wachtell, K | 1 |
| Du, J; He, JQ; Qin, YW; Sheng, L; Wang, LY; Ye, P | 1 |
| Anegawa, T; Hirooka, Y; Imaizumi, T; Kai, H; Kajimoto, H; Koga, M; Kudo, H; Mori, T; Takayama, N; Yasuoka, S | 1 |
| Li, J; Lu, Z; Ou, D; Shi, M; Su, F; Yan, Z; Zheng, Q | 1 |
| Jensen, KS; Liao, JK; Nakagami, H | 1 |
| Arai, H; Matsuo, K; Miura, S; Nishikawa, H; Saku, K; Shimomura, H; Tsuchiya, Y; Zhang, B | 1 |
| Wang, YX | 1 |
| Lang, B; Shang, F; Wang, L; Wang, X; Wu, L; Zhao, L; Zheng, Q | 1 |
| Geng, B; Tang, CS; Wu, XS; Yao, HM; Zhang, J | 1 |
| Delbosc, S; Jover, B; Mimran, A; Rugale, C | 1 |
| Liu, J; Shen, Q; Wu, Y | 1 |
| Haneda, T; Kashiwagi, Y; Kawabe, J; Kikuchi, K; Nakamura, Y; Oi, S; Osaki, J | 1 |
| Abdellatif, M; Entman, ML; Kopelen, HA; Lutucuta, S; Marian, AJ; Nagueh, SF; Patel, R; Quinones, MA; Roberts, R; Tsybouleva, N; Zoghbi, WA | 1 |
| Grimm, M; Kitakaze, M; Liao, JK; Liao, Y; Nakagami, H; Node, K; Takemoto, M; Takemoto, Y | 1 |
| Cristol, JP; Delbosc, S; Jover, B; Mimran, A | 1 |
| Böhm, M; Kilter, H; Konkol, C; Laufs, U; Nickenig, G; Wassmann, S | 1 |
2 review(s) available for simvastatin and Cardiomegaly
| Article | Year |
|---|---|
A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms.
Topics: Antioxidants; Cardiomegaly; GTP-Binding Proteins; Heart; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardium; NADPH Oxidases; Oxidation-Reduction; Protein Prenylation; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; Simvastatin; Superoxides | 2003 |
Cardiovascular functional phenotypes and pharmacological responses in apolipoprotein E deficient mice.
Topics: Angiotensin II; Animals; Aortic Diseases; Apolipoproteins E; Arteriosclerosis; Cardiac Output, High; Cardiomegaly; Cardiovascular System; Enzyme Inhibitors; Estradiol; Hypercholesterolemia; Hyperglycemia; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Phenotype; Simvastatin | 2005 |
21 other study(ies) available for simvastatin and Cardiomegaly
| Article | Year |
|---|---|
Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling.
Topics: Animals; Anticholesteremic Agents; Cardiomegaly; Cell Survival; Cells, Cultured; Endothelial Cells; Forkhead Transcription Factors; Heart Failure; Kruppel-Like Transcription Factors; Male; Mice; Mice, Inbred C57BL; Repressor Proteins; Simvastatin; Transforming Growth Factor beta; Ventricular Remodeling | 2021 |
Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-κB (NF-κB).
Topics: Animals; Calpain; Cardiomegaly; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Inflammation; Intercellular Adhesion Molecule-1; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Simvastatin; Streptozocin; Vascular Cell Adhesion Molecule-1 | 2019 |
Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway.
Topics: Animals; Biomarkers; Cardiomegaly; Creatine Kinase, MB Form; Cytoprotection; Disease Models, Animal; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Isoproterenol; Janus Kinases; Lipids; Male; Myocytes, Cardiac; NF-kappa B; Phosphorylation; Rats, Wistar; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Troponin I | 2015 |
Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor.
Topics: Animals; Blood Pressure; Cardiomegaly; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Signal Transduction; Simvastatin; Stroke Volume; Ultrasonography | 2008 |
[Simvastatin attenuated cardiac hypertrophy via inhibiting JAK-STAT pathways].
Topics: Animals; Cardiomegaly; Cytokines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Janus Kinases; Male; Myocardium; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; STAT Transcription Factors | 2008 |
Simvastatin inhibits angiotensin II-induced cardiac cell hypertrophy: role of Homer 1a.
Topics: Angiotensin II; Animals; Animals, Newborn; Anticholesteremic Agents; Cardiomegaly; Carrier Proteins; Cell Line; Drug Interactions; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Homer Scaffolding Proteins; Myocytes, Cardiac; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Simvastatin; Transfection; Up-Regulation | 2010 |
[The effects of simvastatin on cardiac hypertrophy and association on calcium channel modulation in rats with myocardial hypertrophy induced by abdominal aortic constriction].
Topics: Animals; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiomegaly; Male; Myocardium; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin | 2009 |
Asymmetric septal hypertrophy - a marker of hypertension in aortic stenosis (a SEAS substudy).
Topics: Aortic Valve Stenosis; Azetidines; Biomarkers; Cardiomegaly; Cardiomyopathy, Hypertrophic; Ezetimibe; Female; Heart Atria; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Simvastatin | 2010 |
Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels.
Topics: Animals; Apolipoproteins E; Cardiomegaly; Cathepsins; Cholesterol; Diet; Dietary Fats; Fibrosis; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; Simvastatin | 2010 |
Simvastatin prevents large blood pressure variability induced aggravation of cardiac hypertrophy in hypertensive rats by inhibiting RhoA/Ras-ERK pathways.
Topics: Animals; Blood Pressure; Cardiomegaly; Carotid Sinus; Cell Enlargement; Cholesterol; Denervation; Extracellular Signal-Regulated MAP Kinases; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lipoproteins, HDL; Male; Monomeric GTP-Binding Proteins; Myocytes, Cardiac; Rats; Rats, Inbred SHR; rhoA GTP-Binding Protein; Simvastatin; Treatment Outcome; Triglycerides; Ventricular Remodeling | 2011 |
Simvastatin modulates remodeling of Kv4.3 expression in rat hypertrophied cardiomyocytes.
Topics: Animals; Calcineurin; Cardiomegaly; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Male; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Shal Potassium Channels; Simvastatin | 2012 |
Statins induce the regression of left ventricular mass in patients with angina.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Cardiomegaly; Case-Control Studies; Constriction, Pathologic; Drug Evaluation; Female; Heart Ventricles; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Pravastatin; Retrospective Studies; Simvastatin | 2004 |
Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK-STAT pathway in cultured cardiomyocytes.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Cell Size; Cells, Cultured; Cytokines; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocytes, Cardiac; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Simvastatin; STAT Transcription Factors | 2006 |
[Simvastatin inhibits hypertension-induced cardiac hypertrophy in rats through activation of heme oxygenase-1/carbon monoxide pathway].
Topics: Angiotensins; Animals; Carbon Monoxide; Cardiomegaly; Cell Enlargement; Heme Oxygenase-1; Hypertension; Male; Myocytes, Cardiac; Rats; Rats, Wistar; Signal Transduction; Simvastatin | 2006 |
Simvastatin reverses target organ damage and oxidative stress in Angiotensin II hypertension: comparison with apocynin, tempol, and hydralazine.
Topics: Acetophenones; Albuminuria; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Cardiomegaly; Carotid Arteries; Cyclic N-Oxides; Hydralazine; Hypertension; Hypolipidemic Agents; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Spin Labels; Superoxides; Tunica Media | 2007 |
Simvastatin prevents cardiac hypertrophy in vitro and in vivo via JAK/STAT pathway.
Topics: Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cell Size; Cytokines; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Janus Kinases; Male; Myocytes, Cardiac; Organ Size; Rats; Rats, Sprague-Dawley; Simvastatin; STAT Transcription Factors | 2008 |
Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells.
Topics: Angiotensin II; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cell Division; Cell Membrane; Cells, Cultured; DNA; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Myocardium; Naphthalenes; Pravastatin; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; RNA; Simvastatin | 1999 |
Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy.
Topics: Animals; Animals, Genetically Modified; Cardiomegaly; Cardiomyopathy, Hypertrophic; Cell Line; Disease Models, Animal; Echocardiography; Echocardiography, Doppler; Endomyocardial Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Myocardium; Myosin Heavy Chains; Phenotype; Rabbits; ras Proteins; Remission Induction; rhoA GTP-Binding Protein; Simvastatin; Ventricular Function, Left | 2001 |
Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.
Topics: Angiotensin II; Animals; Antioxidants; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Heart; Mice; Myocardium; Oxidation-Reduction; Promoter Regions, Genetic; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Simvastatin; Superoxides | 2001 |
[Simvastatin attenuates cardiovascular effects and oxidative stress induced by angiotensin II].
Topics: Angiotensin II; Animals; Anticholesteremic Agents; Blood Pressure; Cardiomegaly; Hypertension; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin | 2001 |
Impact of HMG CoA reductase inhibition on small GTPases in the heart.
Topics: Angiotensin II; Animals; Atorvastatin; Atrial Natriuretic Factor; Cardiac Myosins; Cardiomegaly; Cell Membrane; Cells, Cultured; Gene Expression Regulation; GTP Phosphohydrolases; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Myocardium; Myosin Light Chains; Pyrroles; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; RNA, Messenger; Simvastatin | 2002 |