Compounds > simvastatin
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simvastatin and Carcinoma, Non-Small Cell Lung

simvastatin has been researched along with Carcinoma, Non-Small Cell Lung in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's8 (57.14)24.3611
2020's5 (35.71)2.80

Authors

AuthorsStudies
Qing, C; Tu, X; Wu, X; Xu, Z; Yuan, W; Zhang, J1
Cantarini, M; Fetterolf, J; Harvey, RD; Masson, E; Ramalingam, SS; So, K; Vishwanathan, K1
Casado, E; Colmenarejo, G; Fernández, LP; Gómez de Cedrón, M; Merino, M; Moreno-Rubio, J; Quijada-Freire, A; Ramírez de Molina, A; Reglero, G; Sánchez-Martínez, R; Sereno, M1
Asrorov, AM; Chen, B; Gao, Y; He, Y; Huang, Y; Liu, T; Shi, M; Tu, B; Wang, Y1
Aksoy, HN; Ceylan, C1
Jin, X; Lang, Y; Li, X; Liu, W; Ma, J; Ning, J; Wang, F; Wang, J; Wang, X; Xu, S; Yang, F; Zhu, K1
Hwang, KE; Jeong, ET; Kim, BR; Kim, HR; Kim, YS; Kwon, SJ; Park, DS; Yoon, KH1
Cha, BK; Hwang, KE; Jeong, ET; Jung, JW; Kim, HR; Kim, YS; Kwon, SJ; Oh, SH; Park, DS; Yoon, KH1
Kang, HH; Kim, IK; Lee, HI; Lee, HY; Lee, SH; Mo, JY; Moon, HS; Yeo, CD1
Go, YJ; Han, JY; Joo, J; Lee, GK; Lee, JS; Lee, KH; Lee, SH; Lee, Y; Lim, KY1
Sundermeyer, M; Veeraputhiran, M1
Choi, JY; Han, JY; Kim, JY; Park, IH1
Han, JY; Hyung, LS; Kim, HT; Lee, JS; Lee, SH; Moon, YJ; Yoo, NJ; Yun, T1
Busceti, MT; Caraglia, M; Falcone, D; Fratto, D; Gallelli, L; Maselli, R; Pelaia, G; Renda, T; Savino, R; Terracciano, R; Vatrella, A1

Trials

3 trial(s) available for simvastatin and Carcinoma, Non-Small Cell Lung

ArticleYear
Impact of Disease and Treatment Response in Drug-Drug Interaction Studies: Osimertinib and Simvastatin in Advanced Non-Small Cell Lung Cancer.
    Clinical and translational science, 2020, Volume: 13, Issue:1

    Topics: Acrylamides; Administration, Oral; Adult; Aged; Aged, 80 and over; Aniline Compounds; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Drug Interactions; Female; Follow-Up Studies; Humans; Liver; Liver Function Tests; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Retrospective Studies; Simvastatin; Tomography, X-Ray Computed; Treatment Outcome; Tumor Burden; Young Adult

2020
Randomized Phase II Study of Afatinib Plus Simvastatin Versus Afatinib Alone in Previously Treated Patients with Advanced Nonadenocarcinomatous Non-small Cell Lung Cancer.
    Cancer research and treatment, 2017, Volume: 49, Issue:4

    Topics: Adult; Afatinib; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Metastasis; Neoplasm Staging; Quinazolines; Retreatment; Simvastatin; Survival Analysis; Treatment Outcome

2017
A randomized phase II study of gefitinib plus simvastatin versus gefitinib alone in previously treated patients with advanced non-small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Mar-15, Volume: 17, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Middle Aged; Mutation; Quinazolines; Simvastatin; Treatment Outcome

2011

Other Studies

11 other study(ies) available for simvastatin and Carcinoma, Non-Small Cell Lung

ArticleYear
Simvastatin Enhanced Anti-tumor Effects of Bevacizumab against Lung Adenocarcinoma A549 Cells
    Anti-cancer agents in medicinal chemistry, 2023, Volume: 23, Issue:19

    Topics: A549 Cells; Adenocarcinoma of Lung; Animals; beta Catenin; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Mice; Mice, Nude; Simvastatin; Wnt Signaling Pathway

2023
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer.
    Molecular oncology, 2020, Volume: 14, Issue:12

    Topics: Aged; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coenzyme A Ligases; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Precision Medicine; Prognosis; Simvastatin; Survival Analysis

2020
Deformable liposomal codelivery of vorinostat and simvastatin promotes antitumor responses through remodeling tumor microenvironment.
    Biomaterials science, 2020, Dec-15, Volume: 8, Issue:24

    Topics: Carcinoma, Non-Small-Cell Lung; Humans; Liposomes; Lung Neoplasms; Simvastatin; Tumor Microenvironment; Vorinostat

2020
Comparison of the Effects of Statins on A549 Nonsmall-Cell Lung Cancer Cell Line Lipids Using Fourier Transform Infrared Spectroscopy: Rosuvastatin Stands Out.
    Lipids, 2021, Volume: 56, Issue:3

    Topics: A549 Cells; Atorvastatin; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lovastatin; Lung Neoplasms; Pravastatin; Rosuvastatin Calcium; Simvastatin; Spectroscopy, Fourier Transform Infrared

2021
Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis.
    International journal of biological sciences, 2018, Volume: 14, Issue:4

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Lung Neoplasms; Mice; Pyroptosis; Simvastatin; Xenograft Model Antitumor Assays

2018
Effect of simvastatin on the resistance to EGFR tyrosine kinase inhibitors in a non-small cell lung cancer with the T790M mutation of EGFR.
    Experimental cell research, 2014, May-01, Volume: 323, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Catenins; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Inhibitor of Apoptosis Proteins; Mutation, Missense; Protein Kinase Inhibitors; Quinazolines; Simvastatin; Survivin

2014
Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells.
    Oncotarget, 2015, Oct-06, Volume: 6, Issue:30

    Topics: Adenine; AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lung Neoplasms; Macrolides; Mesothelioma; Mesothelioma, Malignant; Mice, Nude; Microtubule-Associated Proteins; Pemetrexed; Pepstatins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Simvastatin; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

2015
The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells.
    Experimental lung research, 2016, Volume: 42, Issue:1

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; MAP Kinase Signaling System; Quinazolines; Simvastatin; Up-Regulation

2016
Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatin.
    Clinical lung cancer, 2008, Volume: 9, Issue:4

    Topics: Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atenolol; Azetidines; Carcinoma, Non-Small-Cell Lung; Coronary Artery Disease; Drug Interactions; Erlotinib Hydrochloride; Ezetimibe; Female; Humans; Hyperlipidemias; Hypertension; Lung Neoplasms; Neoplasm Recurrence, Local; Protein Kinase Inhibitors; Quinazolines; Rhabdomyolysis; Simvastatin; Tomography, X-Ray Computed

2008
Simvastatin enhances irinotecan-induced apoptosis in human non-small cell lung cancer cells by inhibition of proteasome activity.
    Investigational new drugs, 2011, Volume: 29, Issue:5

    Topics: Apoptosis; Benzimidazoles; Blotting, Western; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Synergism; Flow Cytometry; Humans; I-kappa B Proteins; Irinotecan; Lung Neoplasms; NF-kappa B; NF-KappaB Inhibitor alpha; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Simvastatin; Staining and Labeling; Substrate Specificity

2011
Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells.
    Cell proliferation, 2012, Volume: 45, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Lung Neoplasms; MAP Kinase Signaling System; Phosphorylation; Quinolones; Simvastatin

2012