Page last updated: 2024-08-23

simvastatin and Cancer of Prostate

simvastatin has been researched along with Cancer of Prostate in 44 studies

Research

Studies (44)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.27)	18.2507
2000's	14 (31.82)	29.6817
2010's	21 (47.73)	24.3611
2020's	8 (18.18)	2.80

Authors

Authors	Studies
Aghamir, SMK; Akbari, MR; Khatami, F; Mirzaei, A; Rashedi, S	1
Gademann, G; Gawish, A; Korte, V; Ochel, HJ	1
d'Hose, D; Gallez, B; Hamelin, L; Jordan, BF; Mignion, L; Sonveaux, P	1
Cao, Z; Chen, M; He, Y; Huang, J; Lou, D; Yao, J; Zhang, Y; Zhou, X; Zhou, Z	1
Miyazawa, Y; Nakayama, H; Nakazawa, S; Oka, D; Sekine, Y; Suzuki, K; Tsuji, Y	1
Bouchal, J; Eder, IE; Jöhrer, K; Kharaishvili, G; Klocker, H; Neuwirt, H; Pitterl, F; Ploner, C; Weber, A	1
Bruzzese, F; Budillon, A; Ciardiello, C; Ciliberto, G; Costantini, S; De Rienzo, S; Di Gennaro, E; Grumetti, L; Iannelli, F; Leone, A; Lombardi, R; Mancini, R; Milone, MR; Moccia, T; Pucci, B; Roca, MS; Sorice, A; Vitagliano, C	1
Ahn, KS; Alharbi, SA; Chinnathambi, A; Jung, YY; Ko, JH; Sethi, G; Um, JY	1
Chung, KH; Jung, EJ; Kim, CW	1
Bontkes, HJ; de Gruijl, TD; Huijts, CM; Reijm, M; Schneiders, FL; van der Vliet, HJ; Verheul, HMW	1
El-Sherbiny, IM; Khalil, IA; Sedki, M	1
Karnewar, S; Kotamraju, S; Mallappa, S; Neeli, PK	1
Al-Husein, B; Goc, A; Somanath, PR	1
Davis, RA; Liberio, MS; Nelson, CC; Sadowski, MC; Soekmadji, C	1
Freedland, SJ; Fung, KZ; Hoffman, RM; Shi, Y; Tang, VL; Walter, LC	1
Brannon, M; Chakraborty, K; Kalra, S; Krishnan, K; Lightner, J; Moukharskaya, J; Niyazi, M; Palau, VE; Rogers, M; Stone, WL	1
Arnold, RS; Petros, JA; Sun, CQ; Sun, Q	1
Bläuer, M; Murtola, TJ; Pennanen, P; Syvälä, H; Tammela, TL	1
Alfaqih, MA; Barry, WT; Dambal, SK; Dewhirst, MW; Freedland, AR; Freedland, SJ; Freeman, MR; Macias, E; Masko, EM; Muehlbauer, MJ; Newgard, CB; Phillips, TE; Pizzo, SV; Poulton, SH; Sanders, SE; Solomon, KR; Sun, S; Valilis, NA	1
Ravnskov, U	1
Alberici, LC; Castilho, RF; Oliveira, KA; Vercesi, AE; Zecchin, KG	1
Aberg, M; Johnell, M; Siegbahn, A; Wickström, M; Widunder, A	1
Freedland, SJ; Goldberg, KC; Hamilton, RJ; Platz, EA	1
Bläuer, M; Murtola, TJ; Pennanen, P; Syvälä, H; Tammela, TL; Ylikomi, T	1
Amling, CL; Aronson, WJ; Banez, LL; Freedland, SJ; Hamilton, RJ; Kane, CJ; Platz, EA; Presti, JC; Terris, MK	1
Demosky, SJ; Furuya, Y; Koike, H; Remaley, AT; Sekine, Y; Stonik, JA; Suzuki, K	1
Al-Husein, B; Goc, A; Kochuparambil, ST; Soliman, S; Somanath, PR	1
Atkinson, BJ; Pagliaro, LC; Watkins, JL	1
Balink, H; de Graaf, W; Grond, J; Hemmelder, MH	1
D'Avolio, LW; Farwell, WR; Gaziano, JM; Lawler, EV; Scranton, RE	1
Bläuer, M; Murtola, TJ; Pennanen, P; Solakivi, T; Syvälä, H; Tammela, TL; Ylikomi, T	2
Al-Azayzih, A; Al-Husein, B; Goc, A; Kochuparambil, ST; Mohammad, S; Somanath, PR	1
Kim, HH; Ku, JH; Kwak, C; Lee, E; Park, YH; Seo, SY	1
Haller, DG; Itakura, H; O'Dwyer, PJ; Vaughn, D	1
Ashar, U; Bhaduri, A; Desai, D	1
Ahamed, E; Bissett, D	1
Adam, RM; Freeman, MR; Kim, J; Solomon, KR; Zhuang, L	1
Kim, CW; Kim, YN; Li, YC; Park, MJ; Ye, SK	1
Adamovich, E; Allen, ZA; Butler, EG; Butler, WM; Galbreath, RW; Merrick, GS; Moyad, MA; Wallner, KE	1
Abbas, T; Dutta, A; Sivaprasad, U	1
Chen, H; Hoque, A; Xu, XC	1
Furuya, Y; Koike, H; Matsui, H; Nishii, M; Sekine, Y; Suzuki, K	1
Benraad, TJ; Kloppenborg, PW; Smals, AG; Weusten, JJ	1

Reviews

1 review(s) available for simvastatin and Cancer of Prostate

Article	Year
Association Between Statin Exposure and Incidence and Prognosis of Prostate Cancer: A Meta-analysis Based on Observational Studies. American journal of clinical oncology, 2023, 07-01, Volume: 46, Issue:7 Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Prognosis; Prostatic Neoplasms; Simvastatin	2023

Other Studies

43 other study(ies) available for simvastatin and Cancer of Prostate

Article	Year
Combined anticancer effects of simvastatin and arsenic trioxide on prostate cancer cell lines via downregulation of the VEGF and OPN isoforms genes. Journal of cellular and molecular medicine, 2022, Volume: 26, Issue:9 Topics: Apoptosis; Arsenic Trioxide; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Prostatic Neoplasms; Protein Isoforms; Simvastatin; Vascular Endothelial Growth Factor A	2022
Modulation of radiosensitivity of DU145 prostate carcinoma cells by simvastatin. Journal of cancer research and clinical oncology, 2023, Volume: 149, Issue:8 Topics: Carcinoma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Prostate; Prostatic Neoplasms; Radiation Tolerance; Simvastatin	2023
Statins Alleviate Tumor Hypoxia in Prostate Cancer Models by Decreasing Oxygen Consumption: An Opportunity for Radiosensitization? Biomolecules, 2022, Oct-03, Volume: 12, Issue:10 Topics: Animals; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Oxygen; Oxygen Consumption; Prostatic Neoplasms; Simvastatin; Superoxides; Tumor Hypoxia	2022
Simvastatin Induces Autophagy and Inhibits Proliferation in Prostate Cancer Cells. Anticancer research, 2023, Volume: 43, Issue:12 Topics: Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Prostate; Prostatic Neoplasms; Simvastatin; Sirolimus	2023
Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis. Cell communication and signaling : CCS, 2020, 01-24, Volume: 18, Issue:1 Topics: Aged; Benzamides; Biosynthetic Pathways; Cancer-Associated Fibroblasts; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholesterol; Culture Media, Conditioned; Disease Progression; Drug Resistance, Neoplasm; Extracellular Matrix; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Models, Biological; Molecular Sequence Annotation; Nitriles; Phenotype; Phenylthiohydantoin; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Simvastatin; Spheroids, Cellular; Up-Regulation	2020
Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition. Journal of experimental & clinical cancer research : CR, 2020, Oct-08, Volume: 39, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Docetaxel; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Prostatic Neoplasms; Simvastatin; Transcription Factors; Tumor Cells, Cultured; Valproic Acid; Xenograft Model Antitumor Assays	2020
LDL cholesterol promotes the proliferation of prostate and pancreatic cancer cells by activating the STAT3 pathway. Journal of cellular physiology, 2021, Volume: 236, Issue:7 Topics: Anticholesteremic Agents; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cholesterol, LDL; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 1; Janus Kinase 2; Male; Pancreas; Pancreatic Neoplasms; Prostate; Prostatic Neoplasms; RNA Interference; RNA, Small Interfering; Signal Transduction; Simvastatin; STAT3 Transcription Factor	2021
Identification of simvastatin-regulated targets associated with JNK activation in DU145 human prostate cancer cell death signaling. BMB reports, 2017, Volume: 50, Issue:9 Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Docetaxel; Gene Expression Regulation, Neoplastic; Heterogeneous-Nuclear Ribonucleoprotein K; Humans; JNK Mitogen-Activated Protein Kinases; Male; Phosphorylation; Prostatic Neoplasms; Proteomics; Signal Transduction; Simvastatin; Taxoids	2017
The effects of systemic treatment with aminobisphosphonates and statins on circulating Vγ9Vδ2-T cells in patients with advanced cancer. Immunobiology, 2018, Volume: 223, Issue:2 Topics: Acute-Phase Reaction; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Drug-Related Side Effects and Adverse Reactions; Female; Granzymes; HLA-DR Antigens; Humans; Immunophenotyping; Lymphocyte Activation; Male; Middle Aged; Perforin; Pilot Projects; Prostatic Neoplasms; Receptors, Antigen, T-Cell, gamma-delta; Simvastatin; T-Lymphocytes	2018
Hybrid nanocarrier system for guiding and augmenting simvastatin cytotoxic activity against prostate cancer. Artificial cells, nanomedicine, and biotechnology, 2018, Volume: 46, Issue:sup3 Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cytotoxins; Drug Carriers; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Male; Neoplasm Proteins; Polylactic Acid-Polyglycolic Acid Copolymer; Prostatic Neoplasms; Simvastatin	2018
Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in chemosensitization. Molecular carcinogenesis, 2019, Volume: 58, Issue:7 Topics: Acetylcysteine; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily G; Cyclic AMP Response Element-Binding Protein; Doxorubicin; Drug Resistance, Neoplasm; Glutathione; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Nude; Prostatic Neoplasms; RNA Interference; RNA, Small Interfering; Simvastatin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2019
Suppression of interactions between prostate tumor cell-surface integrin and endothelial ICAM-1 by simvastatin inhibits micrometastasis. Journal of cellular physiology, 2013, Volume: 228, Issue:11 Topics: beta Catenin; Cell Communication; Cell Line, Tumor; Cell Membrane; Endothelial Cells; Gene Expression Regulation, Neoplastic; Humans; Integrin alphaVbeta3; Intercellular Adhesion Molecule-1; Male; Models, Biological; Neoplasm Micrometastasis; Neovascularization, Pathologic; Prostatic Neoplasms; Protein Binding; Protein Stability; Simvastatin	2013
Differential effects of tissue culture coating substrates on prostate cancer cell adherence, morphology and behavior. PloS one, 2014, Volume: 9, Issue:11 Topics: Actins; Androgens; Cell Adhesion; Cell Count; Cell Culture Techniques; Cell Movement; Cell Survival; Collagen; Fibronectins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Laminin; Male; Peptides; Polylysine; Prostatic Neoplasms; Simvastatin; Tumor Cells, Cultured	2014
Statin medications are associated with a lower probability of having an abnormal screening prostate-specific antigen result. Urology, 2014, Volume: 84, Issue:5 Topics: Aged; Aged, 80 and over; Biopsy; Cohort Studies; Cross-Sectional Studies; Hospitals, Veterans; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Poisson Distribution; Probability; Prostate-Specific Antigen; Prostatic Neoplasms; Risk; Simvastatin; Treatment Outcome; United States	2014
Synergistic growth inhibition of PC3 prostate cancer cells with low-dose combinations of simvastatin and alendronate. Anticancer research, 2015, Volume: 35, Issue:4 Topics: Alendronate; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Simvastatin	2015
A mitochondrial DNA mutation influences the apoptotic effect of statins on prostate cancer. The Prostate, 2015, Volume: 75, Issue:16 Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Disease Progression; DNA, Mitochondrial; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mutation; Prostatic Neoplasms; Simvastatin	2015
Additive inhibitory effects of simvastatin and enzalutamide on androgen-sensitive LNCaP and VCaP prostate cancer cells. Biochemical and biophysical research communications, 2016, Dec-02, Volume: 481, Issue:1-2 Topics: Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Simvastatin; Treatment Outcome	2016
Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model. The Prostate, 2017, Volume: 77, Issue:5 Topics: Animals; Anticholesteremic Agents; Cell Line, Tumor; Cell Proliferation; Cholesterol; Drug Therapy, Combination; Ezetimibe; Feedback, Physiological; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Simvastatin; Tumor Burden; Xenograft Model Antitumor Assays	2017
Re: The association between statins and cancer incidence in a veterans population. Journal of the National Cancer Institute, 2008, Jul-02, Volume: 100, Issue:13 Topics: Anticholesteremic Agents; Antineoplastic Agents; Bias; Colorectal Neoplasms; Confounding Factors, Epidemiologic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Lung Neoplasms; Male; Neoplasms; Pravastatin; Prostatic Neoplasms; Simvastatin; United States; Veterans	2008
Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction. Journal of bioenergetics and biomembranes, 2008, Volume: 40, Issue:4 Topics: Apoptosis; Calcineurin; Cell Line, Tumor; Cell Proliferation; Humans; Male; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Prostatic Neoplasms; Simvastatin	2008
Simvastatin reduces the production of prothrombotic prostasomes in human prostate cancer cells. Thrombosis and haemostasis, 2008, Volume: 100, Issue:4 Topics: Anticholesteremic Agents; Apoptosis; Cell Line, Tumor; Culture Media, Conditioned; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Humans; Male; Particle Size; Prostatic Neoplasms; Simvastatin; Thromboplastin; Venous Thrombosis	2008
The influence of statin medications on prostate-specific antigen levels. Journal of the National Cancer Institute, 2008, Nov-05, Volume: 100, Issue:21 Topics: Aged; Atorvastatin; Biomarkers, Tumor; Cholesterol, HDL; Cholesterol, LDL; Early Diagnosis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Indoles; Linear Models; Longitudinal Studies; Lovastatin; Male; Middle Aged; Multivariate Analysis; Pravastatin; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrroles; Risk Assessment; Simvastatin; Veterans	2008
Effects of simvastatin, acetylsalicylic acid, and rosiglitazone on proliferation of normal and cancerous prostate epithelial cells at therapeutic concentrations. The Prostate, 2009, Jun-15, Volume: 69, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Cell Line, Transformed; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Epithelial Cells; Growth Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Prostate; Prostatic Neoplasms; Rosiglitazone; Simvastatin; Thiazolidinediones	2009
Statin medication use and the risk of biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) Database. Cancer, 2010, Jul-15, Volume: 116, Issue:14 Topics: Anticholesteremic Agents; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; Recurrence; Risk; Simvastatin	2010
High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent mechanism. Molecular cancer research : MCR, 2010, Volume: 8, Issue:9 Topics: Androgens; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholesterol; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Intracellular Space; Lipoproteins, HDL; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; RNA, Messenger; RNA, Small Interfering; Simvastatin	2010
Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 336, Issue:2 Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Neoplasm Invasiveness; Phosphorylation; Prostate-Specific Antigen; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; RNA, Messenger; Simvastatin; Xenograft Model Antitumor Assays	2011
Rhabdomyolysis in a Prostate Cancer Patient Taking Ketoconazole and Simvastatin: Case Report and Review of the Literature. The Annals of pharmacotherapy, 2011, Volume: 45, Issue:2 Topics: Acute Kidney Injury; Aged; Antineoplastic Agents; Drug Interactions; Drug Therapy, Combination; Fenofibrate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketoconazole; Male; Prostatic Neoplasms; Renal Dialysis; Rhabdomyolysis; Simvastatin	2011
Scintigraphic diagnosis of Erdheim-Chester disease. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Jun-01, Volume: 29, Issue:16 Topics: Aged; Amlodipine; Antihypertensive Agents; Diabetes Mellitus, Type 2; Drug Combinations; Erdheim-Chester Disease; Gated Blood-Pool Imaging; Humans; Hydrochlorothiazide; Hypoglycemic Agents; Hypolipidemic Agents; Imidazoles; Knee Joint; Losartan; Male; Metformin; Positron-Emission Tomography; Prostatic Neoplasms; Simvastatin	2011
Statins and prostate cancer diagnosis and grade in a veterans population. Journal of the National Cancer Institute, 2011, Jun-08, Volume: 103, Issue:11 Topics: Aged; Aged, 80 and over; Anticarcinogenic Agents; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Biomarkers, Tumor; Cholesterol; Confounding Factors, Epidemiologic; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Indoles; Lipids; Lovastatin; Male; Middle Aged; Multivariate Analysis; New England; Pravastatin; Proportional Hazards Models; Prostatic Neoplasms; Pyrroles; Risk Assessment; Severity of Illness Index; Simvastatin; Veterans	2011
Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL. European journal of pharmacology, 2011, Dec-30, Volume: 673, Issue:1-3 Topics: Apoptosis; Cell Cycle; Cell Line; Cell Line, Tumor; Cellular Senescence; Cholesterol, LDL; Dose-Response Relationship, Drug; Epithelial Cells; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Prostate; Prostatic Neoplasms; Pyrimidines; Rosuvastatin Calcium; Simvastatin; Sulfonamides	2011
The importance of LDL and cholesterol metabolism for prostate epithelial cell growth. PloS one, 2012, Volume: 7, Issue:6 Topics: ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cell Count; Cell Line; Cell Proliferation; Cholesterol; Epithelial Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Lipoproteins, LDL; Male; Prostate; Prostatic Neoplasms; Receptors, LDL; Simvastatin; Sterol Regulatory Element Binding Protein 2	2012
Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis. BMC cancer, 2012, Sep-14, Volume: 12 Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Docetaxel; Fas Ligand Protein; Humans; Male; Mice; Mice, Nude; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Receptors, Death Domain; Signal Transduction; Simvastatin; Taxoids	2012
Simvastatin induces apoptosis in castrate resistant prostate cancer cells by deregulating nuclear factor-κB pathway. The Journal of urology, 2013, Volume: 189, Issue:4 Topics: Apoptosis; Drug Resistance, Neoplasm; Humans; Male; NF-kappa B; Prostatic Neoplasms; Signal Transduction; Simvastatin; Tumor Cells, Cultured	2013
Rhabdomyolysis from cytochrome p-450 interaction of ketoconazole and simvastatin in prostate cancer. The Journal of urology, 2003, Volume: 169, Issue:2 Topics: Aged; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketoconazole; Male; Prostatic Neoplasms; Rhabdomyolysis; Simvastatin	2003
Flutamide-induced hepatotoxicity with possible potentiation by simvastatin. The Journal of the Association of Physicians of India, 2003, Volume: 51 Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Synergism; Flutamide; Humans; Male; Prostatic Neoplasms; Simvastatin	2003
Rhabdomyolysis in prostate cancer--caution in prescribing cyproterone acetate with statins. Clinical oncology (Royal College of Radiologists (Great Britain)), 2004, Volume: 16, Issue:8 Topics: Aged; Anticholesteremic Agents; Antineoplastic Agents; Cyproterone Acetate; Drug Interactions; Humans; Hypercholesterolemia; Male; Prostatic Neoplasms; Rhabdomyolysis; Simvastatin	2004
Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. The Journal of clinical investigation, 2005, Volume: 115, Issue:4 Topics: Animals; Anticholesteremic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cholesterol; Enzyme Activation; Humans; Male; Membrane Microdomains; Mice; Mice, SCID; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Simvastatin; Transplantation, Heterologous	2005
Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. The American journal of pathology, 2006, Volume: 168, Issue:4 Topics: Apoptosis; bcl-X Protein; beta-Cyclodextrins; Breast Neoplasms; Carcinoma, Squamous Cell; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; Cholesterol; Down-Regulation; Enzyme Activation; ErbB Receptors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Membrane Microdomains; Neoplasms; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Simvastatin	2006
Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer. Urologic nursing, 2006, Volume: 26, Issue:4 Topics: Aged; Atorvastatin; Biopsy; Brachytherapy; Cause of Death; Chemotherapy, Adjuvant; Chi-Square Distribution; Disease-Free Survival; Fatty Acids, Monounsaturated; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Neoplasm Staging; Pravastatin; Proportional Hazards Models; Prostatic Neoplasms; Pyrroles; Retrospective Studies; Simvastatin; Survival Analysis	2006
Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells. Molecular cancer therapeutics, 2006, Volume: 5, Issue:9 Topics: Cell Cycle; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase 2; Fatty Acids, Monounsaturated; Fluvastatin; G1 Phase; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; p21-Activated Kinases; Phosphorylation; Pravastatin; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Simvastatin	2006
Statin induces apoptosis and cell growth arrest in prostate cancer cells. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:1 Topics: Apoptosis; Blotting, Western; Cell Cycle; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; In Vitro Techniques; Lovastatin; Male; Prostatic Neoplasms; Simvastatin; Tumor Cells, Cultured	2008
Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. Biochemical and biophysical research communications, 2008, Jul-25, Volume: 372, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Prostatic Neoplasms; Receptor, IGF Type 1; RNA, Small Interfering; Simvastatin	2008
The HMG-CoA reductase inhibitor simvastatin suppresses human testicular testosterone synthesis in vitro by a selective inhibitory effect on 17-ketosteroid-oxidoreductase enzyme activity. The Journal of steroid biochemistry and molecular biology, 1991, Volume: 38, Issue:4 Topics: 17-Hydroxysteroid Dehydrogenases; Aged; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Oxidoreductases; Prostatic Neoplasms; Simvastatin; Steroids; Testis; Testosterone	1991