Page last updated: 2024-08-23

simvastatin and Brain Ischemia

simvastatin has been researched along with Brain Ischemia in 50 studies

Research

Studies (50)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.00)	18.2507
2000's	24 (48.00)	29.6817
2010's	23 (46.00)	24.3611
2020's	2 (4.00)	2.80

Authors

Authors	Studies
Chen, H; Hu, Y; Qin, X; Wang, M; Wang, S; Wu, J; Wu, T; Wu, Y; Yang, R; Yu, H	1
Isaka, Y; Nakamura, T; Nakayama, S; Taguchi, N; Tanaka, M	1
Alahmari, A; Almalki, ZS; Alotaibi, N; Guo, JJ; Thaibah, H	1
Liu, H; Xu, X	1
Campos-Martorell, M; Hernandez-Guillamón, M; Montaner, J; Simats, A; Solé, M; Sun, P; Unzeta, M	1
de Leeuw, FE; Koopman, A; Meijer, F	1
Chen, Z; Liu, L; Liu, Z; Zhang, Z; Zhao, B	1
Anderson, DC; Boden, WE; Chaitman, BR; Cruz-Flores, S; Goldstein, LB; Grant, S; Kostuk, WJ; Padley, RJ; Sila, CA; Teo, KK; Weintraub, WS	1
Barlinn, K; Bodechtel, U; Gahn, G; Gehrisch, S; Grählert, X; Heinke, D; Kepplinger, J; Puetz, V; Reichmann, H; Schwanebeck, U; Siepmann, T	1
Kirkpatrick, PJ; Turner, CL	1
Britz, GW; Lombard, F; Warner, DS	1
Corbett, AM; Flannery, T; Lizzi, J; Sanghvi, S; Sibbit, B; Sieber, S; Wyatt, N	1
Guo, J; He, L; Li, J; Qin, F; Wu, B; Zhang, S; Zhou, D; Zhou, M	1
Bradamante, V; Kelava, M; Konjevoda, P; Lovrić, J; Macan, M; Štambuk, N; Vrkić, N; Vukšić, A; Žunec, S	1
Chicoine, M; Derdeyn, CP; Dhar, R; Diringer, MN; Powers, WJ; Scalfani, M; Zazulia, AR	1
Campos-Martorell, M; Cano-Sarabia, M; Hernández-Guillamon, M; Maspoch, D; Montaner, J; Rosell, A; Simats, A	1
Bravo, Y; Bustamante, A; Cánovas, D; Corbeto, N; de Arce, A; de la Torre, J; Delgado, P; Delgado-Mederos, R; Freijo, M; García-Matas, S; Giralt, D; Jiménez, C; Lago, A; Martínez-Zabaleta, M; Masjuán, J; Moniche, F; Montaner, J; Ribó, M; Rubio, FR; Segura, T; Tejada, J; Vives-Pastor, B	1
Chen, J; Chopp, M; Cui, X; Zacharek, A	1
Beyer, C; Heid, F; Kerz, T; Reisch, R; Trapp, I; Victor, A	1
Shabanzadeh, AP; Shuaib, A; Wang, CX	2
Czosnyka, M; Hutchinson, PJ; Kirkpatrick, PJ; Pickard, JD; Richards, HK; Tseng, MY; Turner, CL	1
Coert, BA; Geskus, RB; Horn, J; Meijers, JC; Roos, YB; Stroes, ES; van der Poll, T; Vergouwen, MD; Vermeulen, M	1
de Haan, RJ; Kruyt, ND; Roos, YB; van Geloven, N; Vergouwen, MD; Vermeulen, M	1
Chen, J; Chopp, M; Cui, X; Lu, M; Roberts, C; Shehadah, A	1
Boaz, M; Gilad, R; Lampl, Y; Lorberboym, M; Sadeh, M; Tikozky, A; Vysberg, I	1
Guluma, KZ; Lapchak, PA	1
Beretta, S; Cattalini, A; de Curtis, M; Ferrarese, C; Librizzi, L; Pastori, C; Piazza, F; Sala, G	1
Anderson, T; Boden, WE; Chaitman, BR; Desvignes-Nickens, P; Koprowicz, K; McBride, R; Probstfield, JL; Teo, K; Weintraub, W	1
Du, D; Liu, M; Shen, L; Wang, J; Xia, C; Zhu, D; Zhu, M	1
Chan, KY; Lee, MW; Liang, M; Po, YC; Poon, WS; Tan, H; Wong, GK	1
Asdente, M; Balduini, W; Calvio, AM; Cimino, M; Guerrini, U; Lodetti, B; Paoletti, R; Sironi, L; Tremoli, E	1
Audebert, H; Haberl, RL	1
Armitage, J; Collins, R; Parish, S; Peto, R; Sleight, P	1
Coull, BM	1
Amin-Hanjani, S; Asahi, M; Huang, PL; Huang, Z; Liao, JK; Lo, EH; Mori, T; Moskowitz, MA; Qiu, J; Sumii, T; Thomas, S; Yoshimura, S	1
Balduini, W; Carloni, S; Cimino, M; Gelosa, P; Guerrini, U; Sironi, L; Tremoli, E	1
Alexander, MJ; Blessing, R; Coon, AL; Floyd, J; Friedman, AH; Graffagnino, C; Laskowitz, DT; Lynch, JR; McGirt, MJ; Wang, H; Warner, DS	1
Ovbiagele, B	1
Banfi, C; Brioschi, M; Cimino, M; Gelosa, P; Gianella, A; Guerrini, U; Nobili, E; Paoletti, R; Sironi, L; Tremoli, E	1
Carod-Artal, FJ	1
Gao, F; Song, T; Wu, JM; Zhang, J; Zhou, FY	1
Cakmak, A; Dalkara, T; Dinçer, D; Köksoy, C; Yazgan, U; Yemişçi, M	1
Kanorskiĭ, SG; Shevelev, VI; Zafiraki, VK; Zingilevskiĭ, KB	1
Guyton, JR; Laskowitz, DT; Lynch, JR; Mace, B; Song, P; Wang, H; Warner, DS; Yang, HJ; Yates, RB	1
Bassi, A; Caltagirone, C; Colivicchi, F; Santini, M	1
Alvarez-Sabín, J; Chacón, P; Hereu, P; Krupinski, J; Millán, M; Molina, CA; Montaner, J; Quintana, M; Rubio, F	1
Bleck, TP; Dumont, AS; Gurka, MJ; Kassell, NF; Kramer, AH; Nathan, B	1
Thomas, U	1

Reviews

5 review(s) available for simvastatin and Brain Ischemia

Article	Year
Effect of simvastatin in patients with aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis. The American journal of emergency medicine, 2017, Volume: 35, Issue:12 Topics: Anticholesteremic Agents; Brain Ischemia; Humans; Intracranial Aneurysm; Randomized Controlled Trials as Topic; Simvastatin; Subarachnoid Hemorrhage; Treatment Outcome	2017
Cholesterol-reducing agents for aneurysmal subarachnoid haemorrhage. The Cochrane database of systematic reviews, 2013, Apr-30, Issue:4 Topics: Anticholesteremic Agents; Brain Ischemia; Humans; Incidence; Randomized Controlled Trials as Topic; Simvastatin; Subarachnoid Hemorrhage; Treatment Outcome	2013
[Secondary prevention after stroke: healthy life style, oral anticoagulation]. MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2 Topics: Administration, Oral; Adult; Anticholesteremic Agents; Anticoagulants; Antihypertensive Agents; Blood Coagulation Disorders; Brain Ischemia; Carotid Artery, Internal; Carotid Stenosis; Cerebral Infarction; Clinical Trials as Topic; Contraceptives, Oral; Embolism; Endarterectomy, Carotid; Exercise; Female; Humans; Hypertension; Hypolipidemic Agents; Ischemic Attack, Transient; Life Style; Male; Phenprocoumon; Platelet Aggregation Inhibitors; Recurrence; Simvastatin; Smoking Cessation; Stroke	2003
Statin therapy after acute ischemic stroke in the heart protection study: is the role in recurrent stroke prevention now defined? Stroke, 2004, Volume: 35, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brain Ischemia; Cerebral Hemorrhage; Comorbidity; Coronary Disease; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Prospective Studies; Randomized Controlled Trials as Topic; Recurrence; Risk; Risk Factors; Simvastatin; Vitamins	2004
Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia. Neurotoxicology, 2005, Volume: 26, Issue:5 Topics: Aging; Animals; Animals, Newborn; Brain Ischemia; Disease Models, Animal; Enzyme Activation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Nitric Oxide Synthase Type III; Simvastatin; Stroke	2005

Trials

13 trial(s) available for simvastatin and Brain Ischemia

Article	Year
Cost-Effectiveness of Simvastatin Plus Ezetimibe for Cardiovascular Prevention in Patients With a History of Acute Coronary Syndrome: Analysis of Results of the IMPROVE-IT Trial. Heart, lung & circulation, 2018, Volume: 27, Issue:6 Topics: Acute Coronary Syndrome; Anticholesteremic Agents; Brain Ischemia; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ezetimibe; Female; Follow-Up Studies; Forecasting; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Quality-Adjusted Life Years; Saudi Arabia; Simvastatin; Treatment Outcome	2018
Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial. Stroke, 2013, Volume: 44, Issue:10 Topics: Aged; Atherosclerosis; Brain Ischemia; Delayed-Action Preparations; Female; Follow-Up Studies; Humans; Hypolipidemic Agents; Lipoproteins, HDL; Male; Metabolic Syndrome; Middle Aged; Niacin; Simvastatin; Stroke; Thrombosis; Triglycerides	2013
Interaction of clopidogrel and statins in secondary prevention after cerebral ischaemia - a randomized, double-blind, double-dummy crossover study. British journal of clinical pharmacology, 2014, Volume: 78, Issue:5 Topics: Aged; Brain Ischemia; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP3A; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Simvastatin; Substrate Specificity; Ticlopidine	2014
Effect of High-Dose Simvastatin on Cerebral Blood Flow and Static Autoregulation in Subarachnoid Hemorrhage. Neurocritical care, 2016, Volume: 25, Issue:1 Topics: Aged; Brain Ischemia; Cerebrovascular Circulation; Female; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Positron-Emission Tomography; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial	2016
Combination of Thrombolysis and Statins in Acute Stroke Is Safe: Results of the STARS Randomized Trial (Stroke Treatment With Acute Reperfusion and Simvastatin). Stroke, 2016, Volume: 47, Issue:11 Topics: Aged; Aged, 80 and over; Brain Ischemia; Double-Blind Method; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Outcome Assessment, Health Care; Simvastatin; Stroke; Tissue Plasminogen Activator	2016
Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009, Volume: 29, Issue:8 Topics: Blood Coagulation; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Cholesterol, LDL; Double-Blind Method; Female; Humans; Hypolipidemic Agents; Intracranial Aneurysm; Magnetic Resonance Angiography; Male; Middle Aged; Prospective Studies; Simvastatin; Subarachnoid Hemorrhage; Time Factors; Treatment Outcome	2009
Increased cortisol levels are associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Neurocritical care, 2010, Volume: 12, Issue:3 Topics: Adult; Aged; Blood Glucose; Brain Ischemia; Combined Modality Therapy; Double-Blind Method; Embolization, Therapeutic; Endothelium, Vascular; Female; Glasgow Coma Scale; Humans; Hydrocortisone; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hypertension; Male; Middle Aged; Neurologic Examination; Prognosis; Simvastatin; Subarachnoid Hemorrhage, Traumatic; Surgical Instruments; von Willebrand Factor	2010
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24 Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Kaplan-Meier Estimate; Male; Medication Adherence; Middle Aged; Muscular Diseases; Niacin; Proportional Hazards Models; Simvastatin; Treatment Failure; Triglycerides	2011
High-dose simvastatin for aneurysmal subarachnoid hemorrhage: a multicenter, randomized, controlled, double-blind clinical trial protocol. Neurosurgery, 2013, Volume: 72, Issue:5 Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Brain Ischemia; China; Comorbidity; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Prevalence; Risk Factors; Simvastatin; Subarachnoid Hemorrhage; Treatment Outcome; Young Adult	2013
Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions. Lancet (London, England), 2004, Mar-06, Volume: 363, Issue:9411 Topics: Adult; Aged; Anticholesteremic Agents; Arterial Occlusive Diseases; Brain Ischemia; Cerebrovascular Disorders; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Female; Humans; Incidence; Male; Middle Aged; Peripheral Nervous System Diseases; Placebos; Simvastatin; Stroke; Treatment Outcome	2004
Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. Stroke, 2005, Volume: 36, Issue:9 Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Brain; Brain Ischemia; Creatine Kinase; Double-Blind Method; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Middle Aged; Models, Statistical; Pilot Projects; Simvastatin; Subarachnoid Hemorrhage; Time Factors; Treatment Outcome; Vascular Diseases; Vasospasm, Intracranial	2005
[Prevention of ischemic stroke in middle aged patients with atrial fibrillation. Effect of sinus rhythm maintenance, aspirin, warfarin, and simvastatin]. Kardiologiia, 2007, Volume: 47, Issue:1 Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Heart Rate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Contraction; Platelet Aggregation Inhibitors; Simvastatin; Sinoatrial Node; Treatment Outcome; Warfarin	2007
Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial. European journal of neurology, 2008, Volume: 15, Issue:1 Topics: Acute Disease; Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infections; Inflammation Mediators; Male; Middle Aged; Pilot Projects; Simvastatin; Stroke; Treatment Outcome	2008

Other Studies

32 other study(ies) available for simvastatin and Brain Ischemia

Article	Year
Is statin therapy after ischaemic stroke associated with increased intracerebral hemorrhage? The association may be dependent on intensity of statin therapy. International journal of stroke : official journal of the International Stroke Society, 2023, Volume: 18, Issue:8 Topics: Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Stroke; Rosuvastatin Calcium; Simvastatin; Stroke	2023
Combined Treatment with Hydrophilic and Lipophilic Statins Improves Neurological Outcomes Following Experimental Cardiac Arrest in Mice. Neurocritical care, 2020, Volume: 33, Issue:1 Topics: Animals; Behavior, Animal; Blood Gas Analysis; Brain Edema; Brain Ischemia; CA1 Region, Hippocampal; Cardiopulmonary Resuscitation; Cytokines; Heart Arrest; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Neuroprotective Agents; Pravastatin; Random Allocation; Simvastatin; Survival Rate	2020
Simvastatin blocks soluble SSAO/VAP-1 release in experimental models of cerebral ischemia: Possible benefits for stroke-induced inflammation control. Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:2 Topics: Amine Oxidase (Copper-Containing); Animals; Brain; Brain Ischemia; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Disease Models, Animal; E-Selectin; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Wistar; Simvastatin; Stroke; Vascular Cell Adhesion Molecule-1	2018
CT perfusion hypervolemia: brain ischemia or stroke mimic? Neuroradiology, 2019, Volume: 61, Issue:4 Topics: Aged; Angiography, Digital Subtraction; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Clopidogrel; Computed Tomography Angiography; Contrast Media; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Drug Therapy, Combination; Female; Humans; Hypolipidemic Agents; Magnetic Resonance Angiography; Platelet Aggregation Inhibitors; Simvastatin; Stroke; Water-Electrolyte Imbalance	2019
Simvastatin in subarachnoid haemorrhage: beyond the short-term--authors' reply. The Lancet. Neurology, 2014, Volume: 13, Issue:11 Topics: Brain Ischemia; Female; Humans; Male; Simvastatin; Subarachnoid Hemorrhage	2014
Simvastatin in subarachnoid haemorrhage: beyond the short-term. The Lancet. Neurology, 2014, Volume: 13, Issue:11 Topics: Brain Ischemia; Female; Humans; Male; Simvastatin; Subarachnoid Hemorrhage	2014
Increasing neurogenesis with fluoxetine, simvastatin and ascorbic Acid leads to functional recovery in ischemic stroke. Recent patents on drug delivery & formulation, 2015, Volume: 9, Issue:2 Topics: Animals; Ascorbic Acid; Brain; Brain Ischemia; Drug Therapy, Combination; Female; Fluoxetine; Male; Neurogenesis; Rats; Rats, Long-Evans; Rats, Wistar; Recovery of Function; Simvastatin; Stroke	2015
Statin treatment reduces the risk of poststroke seizures. Neurology, 2015, Aug-25, Volume: 85, Issue:8 Topics: Aged; Aged, 80 and over; Atorvastatin; Brain Ischemia; Cohort Studies; Epilepsy; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Rosuvastatin Calcium; Seizures; Simvastatin; Stroke; Time Factors; Treatment Outcome	2015
Effects of simvastatin on malondialdehyde level and esterase activity in plasma and tissue of normolipidemic rats. Pharmacological reports : PR, 2015, Volume: 67, Issue:5 Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Carotid Artery, Common; Cytokines; Diabetes Mellitus, Experimental; Glutamic Acid; Hippocampus; Male; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Pioglitazone; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Simvastatin; Thiazolidinediones	2015
Charge effect of a liposomal delivery system encapsulating simvastatin to treat experimental ischemic stroke in rats. International journal of nanomedicine, 2016, Volume: 11 Topics: Animals; Biological Availability; Blood-Brain Barrier; Brain; Brain Ischemia; Drug Delivery Systems; Infarction, Middle Cerebral Artery; Kidney; Liposomes; Liver; Lung; Male; Rats, Wistar; Simvastatin; Spleen; Stroke; Tissue Distribution	2016
Increasing Ang1/Tie2 expression by simvastatin treatment induces vascular stabilization and neuroblast migration after stroke. Journal of cellular and molecular medicine, 2009, Volume: 13, Issue:7 Topics: Angiopoietin-1; Animals; Blood Vessels; Blood-Brain Barrier; Brain Ischemia; Cell Movement; Doublecortin Domain Proteins; Doublecortin Protein; Endothelial Cells; Gene Expression Regulation; Male; Membrane Proteins; Microtubule-Associated Proteins; Neovascularization, Physiologic; Neurons; Neuropeptides; Occludin; Rats; Rats, Wistar; Receptor, TIE-2; Simvastatin; Stroke	2009
A case control study of statin and magnesium administration in patients after aneurysmal subarachnoid hemorrhage: incidence of delayed cerebral ischemia and mortality. Neurological research, 2008, Volume: 30, Issue:9 Topics: Anticholesteremic Agents; Brain Ischemia; Case-Control Studies; Female; Humans; Magnesium; Male; Middle Aged; Retrospective Studies; Simvastatin; Subarachnoid Hemorrhage; Survival Rate; Treatment Outcome	2008
Reduction of ischemic brain injury in rats with normothermic and hyperthermic conditions. Journal of neurosurgery, 2008, Volume: 109, Issue:3 Topics: Animals; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Combined Modality Therapy; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Male; Rats; Rats, Sprague-Dawley; Simvastatin	2008
Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhage. Neurosurgery, 2008, Volume: 63, Issue:6 Topics: Brain Ischemia; Cohort Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Retrospective Studies; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial	2008
Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. Journal of the neurological sciences, 2010, Jul-15, Volume: 294, Issue:1-2 Topics: Amyloid beta-Protein Precursor; Animals; Axons; Brain; Brain Ischemia; Calcium-Binding Proteins; Delayed-Action Preparations; Disease Models, Animal; Drug Therapy, Combination; GPI-Linked Proteins; Infarction, Middle Cerebral Artery; Male; Microfilament Proteins; Microglia; Myelin Proteins; Neuroprotective Agents; Niacin; Nogo Receptor 1; Random Allocation; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Peptide; Simvastatin; Stroke; Treatment Outcome	2010
Early outcome of acute ischemic stroke in hyperlipidemic patients under atorvastatin versus simvastatin. Clinical neuropharmacology, 2010, Volume: 33, Issue:3 Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hyperlipidemias; Lipids; Male; Medical Records; Middle Aged; Neuroprotective Agents; Pyrroles; Retrospective Studies; Severity of Illness Index; Simvastatin; Statistics as Topic; Stroke; Stroke Rehabilitation; Treatment Outcome	2010
Comparison of the post-embolization effects of tissue-plasminogen activator and simvastatin on neurological outcome in a clinically relevant rat model of acute ischemic stroke. Brain research, 2010, Oct-01, Volume: 1354 Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Fibrinolytic Agents; Hypolipidemic Agents; Rats; Simvastatin; Statistics, Nonparametric; Stroke; Tissue Plasminogen Activator; Treatment Outcome	2010
Acute lipophilicity-dependent effect of intravascular simvastatin in the early phase of focal cerebral ischemia. Neuropharmacology, 2011, Volume: 60, Issue:6 Topics: Animals; Brain Ischemia; Disease Models, Animal; Electrophysiology; Guinea Pigs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Infusions, Intravenous; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Oxidation-Reduction; Proto-Oncogene Proteins c-akt; Simvastatin; Solubility; Vascular Resistance	2011
Upregulation of protein phosphatase 2A and NR3A-pleiotropic effect of simvastatin on ischemic stroke rats. PloS one, 2012, Volume: 7, Issue:12 Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Gene Expression Regulation; Genetic Pleiotropy; Infarction, Middle Cerebral Artery; Male; Okadaic Acid; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Simvastatin; Stroke; Up-Regulation	2012
Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arteriosclerosis, thrombosis, and vascular biology, 2003, Feb-01, Volume: 23, Issue:2 Topics: Animals; Brain Chemistry; Brain Damage, Chronic; Brain Injuries; Brain Ischemia; Brain Mapping; Cerebral Arteries; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation	2003
Statins after ischemic stroke and transient ischemic attack: an advisory statement from the Stroke Council, American Heart Association, and American Stroke Association. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:4 Topics: Brain Ischemia; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome	2004
Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:6 Topics: Animals; Atorvastatin; Brain Ischemia; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Embolism; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyrroles; Simvastatin; Stroke; Tissue Plasminogen Activator	2005
Simvastatin reduced ischemic brain injury and perfusion deficits in an embolic model of stroke. Brain research, 2005, Apr-25, Volume: 1042, Issue:1 Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Intracranial Embolism; Male; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion; Simvastatin; Stroke; Treatment Outcome	2005
HMG-CoA reductase inhibitors improve acute ischemic stroke outcome. Stroke, 2005, Volume: 36, Issue:11 Topics: Brain Ischemia; Cholesterol, LDL; Cohort Studies; Coronary Artery Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Prospective Studies; Simvastatin; Stroke; Treatment Outcome	2005
Activation of NF-kB and ERK1/2 after permanent focal ischemia is abolished by simvastatin treatment. Neurobiology of disease, 2006, Volume: 22, Issue:2 Topics: Animals; Brain; Brain Ischemia; Chemokine CCL2; Disease Models, Animal; Down-Regulation; Encephalitis; Enzyme Activation; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Interleukin-1; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; NF-kappa B; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation	2006
Statins and cerebral vasomotor reactivity: implications for a new therapy? Stroke, 2006, Volume: 37, Issue:10 Topics: Adult; Animals; Arginine; Atorvastatin; Brain Ischemia; Cerebrovascular Circulation; Clinical Trials, Phase II as Topic; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Intracranial Aneurysm; Mice; Middle Cerebral Artery; Nitric Oxide; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Simvastatin; Stroke; Subarachnoid Hemorrhage; Ultrasonography, Doppler, Transcranial; Vasodilation; Vasomotor System; Vasospasm, Intracranial	2006
[Effects of xuezhikang and simvastatin on cerebral ischemia-reperfusion injury in rat]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:17 Topics: Animals; Brain; Brain Ischemia; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin	2006
Statin pre-treatment protects brain against focal cerebral ischemia in diabetic mice. The Journal of surgical research, 2007, Volume: 138, Issue:2 Topics: Animals; Brain; Brain Ischemia; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Mice; Motor Activity; Neurologic Examination; Simvastatin	2007
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Experimental neurology, 2007, Volume: 206, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Brain Edema; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Cognition Disorders; Cytokines; Disease Models, Animal; Encephalitis; Endothelial Cells; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Pyrroles; Recovery of Function; RNA, Messenger; Simvastatin; Treatment Outcome	2007
Discontinuation of statin therapy and clinical outcome after ischemic stroke. Stroke, 2007, Volume: 38, Issue:10 Topics: Aged; Atorvastatin; Brain Ischemia; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Pyrroles; Simvastatin; Stroke; Substance Withdrawal Syndrome	2007
Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhage. Neurosurgery, 2008, Volume: 62, Issue:2 Topics: Brain Ischemia; Cohort Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Retrospective Studies; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial	2008
Switching statins: can we do harm? The New Zealand medical journal, 1998, Jan-23, Volume: 111, Issue:1058 Topics: Brain Ischemia; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; National Health Programs; New Zealand; Simvastatin; Therapeutic Equivalency	1998