simvastatin has been researched along with Brain Injuries in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (43.33) | 29.6817 |
| 2010's | 15 (50.00) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Q; Chen, Z; Feng, H; Hao, N; Li, W; Shi, X; Wu, Y; Zhang, J | 1 |
| Abdel-Rafei, MK; Moustafa, EM; Rashed, ER; Thabet, NM | 1 |
| Abrahamson, EE; Dekosky, ST; Foley, LM; Hitchens, TK; Ho, C; Ikonomovic, MD; Kochanek, PM | 1 |
| Akyüz, F; Çomunoğlu, N; Iş, M; Üzüm, G; Yavuz, Ö; Yıldırım, HA; Yüksel, H | 1 |
| Anderson, GD; Bammler, TK; Elmore, BE; Farin, FM; Hoane, MR; Kantor, ED; MacDonald, JW; Moore, LH; Vonder Haar, C; Wright, AM | 1 |
| Chopp, M; Darwish, H; Mahmood, A; Schallert, T; Therrien, B | 1 |
| Chen, HJ; Cho, CL; Liang, CL; Liliang, PC; Lu, K; Tsai, YD; Wang, KW | 1 |
| Chen, HJ; Cho, CL; Liang, CL; Liliang, PC; Lu, K; Tsai, YD; Wang, HK; Wang, KW | 1 |
| Cong, D; Huang, Q; Liang, H; Wang, X; Wang, Y; Xie, C; Zhang, X | 1 |
| Dobakhti, F; Madani, S; Mazloomzadeh, S; Naghibi, T | 1 |
| Besson, VC; Beziaud, T; Chen, XR; Marchand-Leroux, C; Plotkine, M | 1 |
| Doolen, S; Holmberg, E; Kluge, BR; Sarmiere, PD; White, JT; Zhang, SX | 1 |
| Chopp, M; Jiang, H; Li, B; Lu, D; Mahmood, A; Qu, C; Wu, H; Xiong, Y; Zhou, D | 1 |
| Chopp, M; Goussev, A; Kazmi, H; Lu, D; Mahmood, A; Qu, C; Xiong, Y | 1 |
| Ai, J; Chen, G; Hang, C; Qi, M; Shi, J; Zhang, S | 1 |
| Allard, M; Hyong, A; Jadhav, V; Lee, S; Lekic, T; Martin, R; Stier, G; Zhang, J | 1 |
| Chopp, M; Li, B; Lu, D; Mahmood, A; Qu, C; Wu, H; Xiong, Y | 1 |
| Chopp, M; Goussev, A; Kazmi, H; Lu, D; Mahmood, A; Qu, C | 1 |
| Abrahamson, EE; DeKosky, ST; Dixon, CE; Ikonomovic, MD | 1 |
| Chopp, M; Jiang, H; Lu, D; Mahmood, A; Wu, H; Xiong, Y; Zhou, D | 1 |
| Chauhan, NB; Gatto, R | 2 |
| Chopp, M; Jiang, H; Lu, D; Mahmood, A; Qu, C; Wu, H; Xiong, Y; Zhou, D | 1 |
| Beray-Berthat, V; Besson, VC; Béziaud, T; El Shafey, N; Fréchou, M; Marchand-Leroux, C; Margaill, I; Palmier, B; Plotkine, M; Ru Chen, X; Soustrat, M; Teng, F | 1 |
| Dawson, HN; Indraswari, F; James, ML; Kernagis, D; Laskowitz, DT; Lei, B; Wang, H; Warner, DS | 1 |
| Chopp, M; Mahmood, A; Qu, C; Wu, H; Xiong, Y | 1 |
| Asdente, M; Balduini, W; Calvio, AM; Cimino, M; Guerrini, U; Lodetti, B; Paoletti, R; Sironi, L; Tremoli, E | 1 |
| Laskowitz, DT; Lynch, JR; McGirt, MJ; Woodworth, GF | 1 |
| Guyton, JR; Laskowitz, DT; Lynch, JR; Mace, B; Song, P; Wang, H; Warner, DS; Yang, HJ; Yates, RB | 1 |
| Chen, J; Chopp, M; Goussev, A; Jiang, H; Li, Y; Lu, C; Lu, D; Mahmood, A; Qu, C; Schallert, T | 1 |
1 trial(s) available for simvastatin and Brain Injuries
| Article | Year |
|---|---|
Simvastatin and environmental enrichment effect on recognition and temporal order memory after mild-to-moderate traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Environment, Controlled; Humans; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Rats; Rats, Wistar; Recognition, Psychology; Simvastatin; Synaptic Transmission | 2014 |
29 other study(ies) available for simvastatin and Brain Injuries
| Article | Year |
|---|---|
Simvastatin Upregulates Lipoxin A4 and Accelerates Neuroinflammation Resolution After Intracerebral Hemorrhage.
Topics: Animals; bcl-2-Associated X Protein; Brain Injuries; Cerebral Hemorrhage; Male; Myeloid Cell Leukemia Sequence 1 Protein; Neuroinflammatory Diseases; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Simvastatin | 2022 |
Modulation of the Nitric Oxide/BH4 Pathway Protects Against Irradiation-Induced Neuronal Damage.
Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Biopterins; Brain; Brain Injuries; Cranial Irradiation; Depression; Fluoxetine; Gamma Rays; Inflammation; Male; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Rats; Signal Transduction; Sildenafil Citrate; Simvastatin | 2021 |
Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Brain; Brain Injuries; Cerebrovascular Circulation; Gene Knock-In Techniques; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Risk Factors; Simvastatin | 2013 |
Simvastatin reduces VEGF and NO levels in acute stages of experimental traumatic brain injury.
Topics: Acute Disease; Animals; Anticholesteremic Agents; Brain Injuries; Male; Nitric Oxide; Rats; Rats, Wistar; Simvastatin; Vascular Endothelial Growth Factor A | 2013 |
Comparison of the effect of minocycline and simvastatin on functional recovery and gene expression in a rat traumatic brain injury model.
Topics: Animals; Brain Injuries; Disease Models, Animal; Male; Minocycline; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Recovery of Function; Simvastatin; Transcriptome | 2014 |
Simvastatin attenuates the cerebral vascular endothelial inflammatory response in a rat traumatic brain injury.
Topics: Animals; Blotting, Western; Brain Injuries; Cerebrum; Endothelium, Vascular; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Male; Rats, Sprague-Dawley; Simvastatin; Staining and Labeling; Time Factors | 2014 |
Simvastatin combined with antioxidant attenuates the cerebral vascular endothelial inflammatory response in a rat traumatic brain injury.
Topics: Animals; Antioxidants; Brain Injuries; Cerebral Veins; Drug Combinations; Endothelial Cells; Humans; Inflammation; Nitric Oxide Synthase; Rats; Simvastatin | 2014 |
The effect of simvastatin treatment on proliferation and differentiation of neural stem cells after traumatic brain injury.
Topics: Amyloid Precursor Protein Secretases; Animals; Brain; Brain Injuries; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Male; Nestin; Neural Stem Cells; Neurogenesis; Neurons; Neuroprotective Agents; Random Allocation; Rats, Wistar; Receptor, Notch1; Recovery of Function; Simvastatin; Time Factors; Treatment Outcome | 2015 |
Simvastatin's effects on survival and outcome in traumatic braininjury patients: a comparative study.
Topics: Brain Injuries; Glasgow Coma Scale; Humans; Intensive Care Units; Retrospective Studies; Simvastatin; Treatment Outcome | 2016 |
Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Drug Therapy, Combination; Fenofibrate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; PPAR alpha; Rats; Rats, Sprague-Dawley; Simvastatin | 2008 |
Statins decrease chondroitin sulfate proteoglycan expression and acute astrocyte activation in central nervous system injury.
Topics: Animals; Astrocytes; Blotting, Western; Brain Injuries; Cells, Cultured; Cerebral Cortex; Chondroitin Sulfate Proteoglycans; Glial Fibrillary Acidic Protein; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Male; Motor Activity; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin; Spinal Cord Injuries | 2008 |
Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury.
Topics: Animals; Apoptosis; Brain Injuries; Cell Survival; Forkhead Transcription Factors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; I-kappa B Proteins; In Situ Nick-End Labeling; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Recovery of Function; Signal Transduction; Simvastatin; Trauma Severity Indices | 2008 |
Long-lasting benefits after treatment of traumatic brain injury (TBI) in rats with combination therapy of marrow stromal cells (MSCs) and simvastatin.
Topics: Animals; Bone Marrow Transplantation; Brain Injuries; Combined Modality Therapy; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rats; Rats, Wistar; Recovery of Function; Simvastatin; Stromal Cells; Time Factors; Treatment Outcome | 2008 |
Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-kappaB pathway.
Topics: Analysis of Variance; Animals; Apoptosis; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cytokines; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Male; Movement Disorders; NF-kappa B; Rats; Rats, Wistar; Rotarod Performance Test; Signal Transduction; Simvastatin; Time Factors; Toll-Like Receptor 4 | 2009 |
Simvastatin treatment in surgically induced brain injury in rats.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Capillary Permeability; Disease Models, Animal; Dose-Response Relationship, Drug; Frontal Lobe; Functional Laterality; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neurologic Examination; Rats; Rats, Sprague-Dawley; Simvastatin | 2008 |
Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury.
Topics: Analysis of Variance; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Brain Injuries; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Male; Microglia; Rats; Rats, Wistar; Simvastatin; Time Factors | 2009 |
Long-term benefits after treatment of traumatic brain injury with simvastatin in rats.
Topics: Animals; Brain Injuries; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neurons; Rats; Rats, Wistar; Simvastatin; Time Factors | 2009 |
Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain Injuries; Disease Models, Animal; Hippocampus; Humans; Maze Learning; Mice; Neuroprotective Agents; Postural Balance; Risk Factors; Simvastatin; Tissue Distribution | 2009 |
Attenuation of astrogliosis and modulation of endothelial growth factor receptor in lipid rafts by simvastatin after traumatic brain injury.
Topics: Animals; Astrocytes; Brain Injuries; Caveolin 1; Cell Hypoxia; Cell Survival; Cells, Cultured; Disease Models, Animal; Gliosis; Glucose; Interleukin-1; Male; Membrane Microdomains; Neurons; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar; Receptors, Vascular Endothelial Growth Factor; Simvastatin | 2010 |
Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury.
Topics: Animals; Antimetabolites; Axons; Brain; Brain Injuries; Bromodeoxyuridine; Cell Proliferation; Cognition; Drug Synergism; Erythropoietin; Hematocrit; Hemoglobins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Nerve Regeneration; Recombinant Proteins; Recovery of Function; Simvastatin | 2010 |
Induction of angiogenesis and modulation of vascular endothelial growth factor receptor-2 by simvastatin after traumatic brain injury.
Topics: Angiogenic Proteins; Animals; Brain Injuries; Cell Line; Cells, Cultured; Male; Neovascularization, Physiologic; Random Allocation; Rats; Rats, Wistar; Simvastatin; Up-Regulation; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Restoration of cognitive deficits after statin feeding in TBI.
Topics: Animals; Antibodies, Monoclonal; Brain Injuries; Cognition Disorders; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Learning; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Random Allocation; Recovery of Function; Simvastatin | 2011 |
Simvastatin in traumatic brain injury: effect on brain edema mechanisms.
Topics: Animals; Antigens, CD; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cadherins; Claudin-5; Endothelial Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Male; Matrix Metalloproteinase 9; Membrane Proteins; Neutrophils; Rats; Rats, Sprague-Dawley; Simvastatin | 2011 |
Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach.
Topics: Animals; Brain Damage, Chronic; Brain Injuries; Disease Models, Animal; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Hemorrhages; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Pyrimidines; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Translational Research, Biomedical; Treatment Outcome | 2012 |
Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons.
Topics: Animals; Axons; Brain Injuries; Cells, Cultured; Cerebral Cortex; Male; Neurites; Neurons; Rats; Rats, Wistar; Simvastatin | 2012 |
Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage.
Topics: Animals; Brain Chemistry; Brain Damage, Chronic; Brain Injuries; Brain Ischemia; Brain Mapping; Cerebral Arteries; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation | 2003 |
Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol lowering.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Awards and Prizes; Brain Injuries; Heptanoic Acids; Hypercholesterolemia; Immunoblotting; Interleukin-6; Internship and Residency; Mice; Pyrroles; Research; RNA, Messenger; Simvastatin; Spinal Cord Injuries; Subarachnoid Hemorrhage | 2004 |
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Brain Edema; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Cognition Disorders; Cytokines; Disease Models, Animal; Encephalitis; Endothelial Cells; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Pyrroles; Recovery of Function; RNA, Messenger; Simvastatin; Treatment Outcome | 2007 |
Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury.
Topics: Animals; Atorvastatin; Brain Injuries; Cell Proliferation; Dentate Gyrus; Dose-Response Relationship, Drug; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Maze Learning; Memory Disorders; Neovascularization, Physiologic; Nerve Degeneration; Nerve Regeneration; Neuronal Plasticity; Neurons; Neuroprotective Agents; Pyrroles; Rats; Rats, Wistar; Recovery of Function; Simvastatin; Stem Cells; Treatment Outcome | 2007 |