simvastatin has been researched along with Bone Loss, Osteoclastic in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 12 (52.17) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, HS; Ke, K; Kim, JE; Suh, JH; Sul, OJ | 1 |
| Gonçalves, RV; Maldonado, IRSC; Novaes, RD; Oliveira, MGA; Oliveira, TT; Pinto, AS; Sequetto, PL | 1 |
| Bak, EJ; Cha, JH; Kim, A; Kim, AR; Kim, JH; Sohn, Y; Yoo, YJ | 1 |
| Chang, JZ; Chen, MH; Hong, CY; Kok, SH; Lai, EH; Lin, SK; Shun, CT; Wang, HW; Yang, CN; Yang, H | 1 |
| AlSwafeeri, H; ElKenany, W; Karam, S; Mowafy, M | 1 |
| Akiyama, S; Chiba, H; Ishimi, Y; Kim, H; Matsumoto, A; Suzuki, K; Uehara, M | 1 |
| Amorim, RF; Chaves, SB; Ferreira, VM; Freitas, KM; Vieira, GM | 1 |
| Chen, S; Chu, Q; Saghatelian, A; Schwaid, AG; Wan, Y; Wang, X; Wei, W | 1 |
| Engqvist, H; Karlsson Ott, M; Melhus, H; Montazerolghaem, M; Rasmusson, A | 1 |
| Atsuta, I; Ayukawa, Y; Jinno, Y; Kihara, M; Koyano, K; Moriyama, Y; Ogino, Y; Tsukiyama, Y | 1 |
| Chen, ZQ; Dang, GT; Leng, HJ; Li, X; Liu, ZJ; Song, CL; Song, QS; Wang, JY | 1 |
| Arana-Chavez, VE; Bradaschia-Correa, V; Maciel-Oliveira, N | 1 |
| Kiriliuk, IN; Kochetkova, EA; Semisotova, EF | 1 |
| Feyen, JH; French, MH; Frith, JC; Güngör, T; Harrity, TW; Rogers, MJ; Staal, A; Swartz, J; Tamasi, J | 1 |
| Alexander, JM; Bab, I; Chorev, M; Fish, S; Müller, R; von Stechow, D; Yahalom, D | 1 |
| Andreassen, TT; Oxlund, H | 1 |
| Bereiter, H; Heckelei, A; Henschke, F; Hilken, G; Löer, F; Saxler, G; Sprecher, C; von Knoch, F; von Knoch, M; Wedemeyer, C | 1 |
| Chihara, K; Kaji, H; Kanatani, M; Sugimoto, T | 1 |
| Garbyal, RS; Saraf, SK; Singh, A; Singh, V | 1 |
| Crockett, JC; Hughes, A; Idris, AI; Rogers, MJ | 1 |
| Chen, J; Clark, RA; Downey, KJ; Funk, JL | 1 |
| Farnier, M; Mercuri, M; Stein, EA; Waldstreicher, J | 1 |
| Conradie, MM; Gopal, R; Hough, S; Hulley, PA; Maritz, FJ | 1 |
1 trial(s) available for simvastatin and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Effects of statins on biomarkers of bone metabolism: a randomised trial.
Topics: Adult; Aged; Alkaline Phosphatase; Anticholesteremic Agents; Atorvastatin; Biomarkers; Bone and Bones; Bone Development; Bone Resorption; Collagen; Collagen Type I; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Middle Aged; Peptides; Pyrroles; Simvastatin | 2001 |
22 other study(ies) available for simvastatin and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Atherogenic diet-induced bone loss is primarily due to increased osteoclastogenesis in mice.
Topics: Animals; Anticholesteremic Agents; Bone Resorption; Cell Differentiation; Cholesterol; Diet, Atherogenic; Lipoproteins, LDL; Macrophages; Male; Mice; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Osteogenesis; RANK Ligand; Simvastatin | 2020 |
Low Doses of Simvastatin Potentiate the Effect of Sodium Alendronate in Inhibiting Bone Resorption and Restore Microstructural and Mechanical Bone Properties in Glucocorticoid-Induced Osteoporosis.
Topics: Alendronate; Alkaline Phosphatase; Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Bone Resorption; Calcium; Dexamethasone; Drug Synergism; Osteoporosis; Phosphorus; Rats; Rats, Wistar; Simvastatin; Urea | 2017 |
Simvastatin attenuates tibial bone loss in rats with type 1 diabetes and periodontitis.
Topics: Alveolar Bone Loss; Animals; Blood Glucose; Body Weight; Bone Morphogenetic Proteins; Bone Resorption; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fasting; Genetic Markers; Lipoproteins, LDL; Male; Osteoclasts; Periodontitis; Rats, Inbred F344; Simvastatin; Tibia; Triglycerides | 2018 |
Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of mitophagy-related osteoblast apoptosis.
Topics: Animals; Apoptosis; Bone Resorption; Humans; Mitophagy; Osteoblasts; Periapical Periodontitis; Rats; Simvastatin | 2019 |
Effect of local administration of simvastatin on orthodontic tooth movement in rabbits.
Topics: Alveolar Bone Loss; Animals; Bone Remodeling; Bone Resorption; Male; Mandible; Models, Animal; Nickel; Orthodontic Appliances; Orthodontic Wires; Osteoclasts; Rabbits; Simvastatin; Titanium; Tooth Movement Techniques | 2019 |
Hesperidin prevents androgen deficiency-induced bone loss in male mice.
Topics: Androgens; Animals; Bone Density; Bone Resorption; Calcium; Cholesterol; Femur; Hesperidin; Male; Mice; Mice, Inbred Strains; Orchiectomy; Organ Size; Seminal Vesicles; Simvastatin; Triglycerides | 2014 |
The effect of simvastatin on relapse of tooth movement and bone mineral density in rats measured by a new method using microtomography.
Topics: Animals; Bone Density; Bone Remodeling; Bone Resorption; Densitometry; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Maxilla; Rats, Wistar; Recurrence; Reproducibility of Results; Secondary Prevention; Simvastatin; Time Factors; Tooth Migration; Tooth Movement Techniques; Tooth Root; Treatment Outcome; X-Ray Microtomography | 2015 |
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects.
Topics: Animals; Binding Sites; Bone Resorption; Cell Differentiation; Cell Line; Cholesterol; Diphosphonates; ERRalpha Estrogen-Related Receptor; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ligands; Macrophages; Male; Mice, Inbred C57BL; Muscle, Skeletal; Osteoclasts; Protein Binding; Protein Domains; Receptors, Estrogen; Simvastatin | 2016 |
Simvastatin-doped pre-mixed calcium phosphate cement inhibits osteoclast differentiation and resorption.
Topics: Animals; Bone Cements; Bone Marrow Cells; Bone Resorption; Calcium; Calcium Phosphates; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Liberation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Materials Testing; Mice; Osteoclasts; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin | 2016 |
Simvastatin enhances bone formation around titanium implants in rat tibiae.
Topics: Acid Phosphatase; Animals; Anticholesteremic Agents; Biomarkers; Bone Density; Bone Marrow; Bone Resorption; Colorimetry; Dental Implants; Dental Materials; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Isoenzymes; Osseointegration; Osteocalcin; Osteogenesis; Rats; Simvastatin; Tartrate-Resistant Acid Phosphatase; Tibia; Time Factors; Titanium | 2010 |
Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ERα expression and uterine wet weight in ovariectomized rats.
Topics: Absorptiometry, Photon; Animals; Biomechanical Phenomena; Blotting, Western; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Estrogen Receptor alpha; Female; Immunohistochemistry; Lumbar Vertebrae; Ovariectomy; Rats; Rats, Sprague-Dawley; Simvastatin; Uterus | 2011 |
Early alveolar bone regeneration in rats after topical administration of simvastatin.
Topics: Administration, Topical; Alveolar Bone Loss; Alveolar Process; Animals; Bone Marrow; Bone Matrix; Bone Regeneration; Bone Resorption; Collagen; Gels; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Male; Mandible; Mandibular Diseases; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Osteoblasts; Osteogenesis; Osteopontin; Rats; Rats, Wistar; Simvastatin; Time Factors | 2011 |
[Experience with simvastatin therapy for the achievement of osteoprotective effects in women with hyperlipidemia].
Topics: Absorptiometry, Photon; Biological Availability; Biomarkers; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Collagen; Diet, Fat-Restricted; Drug Monitoring; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipids; Middle Aged; Osteocalcin; Peptide Fragments; Protective Agents; Simvastatin; Treatment Outcome | 2012 |
The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity.
Topics: Animals; Bone Resorption; Calcium; Female; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Male; Osteoclasts; Osteogenesis; Parathyroidectomy; Pravastatin; Protein Prenylation; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Simvastatin; Thyroidectomy | 2003 |
Does simvastatin stimulate bone formation in vivo?
Topics: Animals; Bone Resorption; Drug Administration Routes; Female; Femur; Injections, Subcutaneous; Intubation, Gastrointestinal; Mice; Osteocalcin; Osteogenesis; Ovariectomy; Ovary; Parathyroid Hormone; Simvastatin | 2003 |
Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation.
Topics: Animals; Biomarkers; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Female; Organ Size; Ovariectomy; Rats; Rats, Wistar; Simvastatin; Stress, Mechanical | 2004 |
[A comparison of the antiresorptive effects of bisphosphonates and statins on polyethylene particle-induced osteolysis].
Topics: Animals; Bone Resorption; Diphosphonates; Female; Foreign-Body Reaction; Imidazoles; Male; Mice; Mice, Inbred C57BL; Osteolysis; Particle Size; Polyethylenes; Simvastatin; Skull; Treatment Outcome; Zoledronic Acid | 2005 |
Statins modulate the levels of osteoprotegerin/receptor activator of NFkappaB ligand mRNA in mouse bone-cell cultures.
Topics: Animals; Bone Resorption; Calcitriol; Carrier Proteins; Cell Differentiation; Cells, Cultured; Glycoproteins; Lovastatin; Membrane Glycoproteins; Mice; Mice, Inbred ICR; Osteoclasts; Osteogenesis; Osteoprotegerin; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; RNA, Messenger; Simvastatin | 2005 |
Effect of simvastatin on fracture healing--an experimental study.
Topics: Animals; Bone Resorption; Bony Callus; Femur; Fracture Healing; Fractures, Bone; Rabbits; Radiography; Simvastatin; Stress, Mechanical; Time Factors | 2007 |
A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo.
Topics: Anabolic Agents; Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Cells, Cultured; Disease Models, Animal; Female; Hydrophobic and Hydrophilic Interactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred BALB C; Osteoclasts; Osteoporosis; Ovariectomy; Pravastatin; Protein Prenylation; Pyridines; Rabbits; rap1 GTP-Binding Proteins; Signal Transduction; Simvastatin; Water | 2007 |
Bone protective effect of simvastatin in experimental arthritis.
Topics: Animals; Arthritis, Experimental; Bone Density; Bone Resorption; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Rats; Rats, Inbred Lew; Simvastatin | 2008 |
Effect of statins on bone mineral density and bone histomorphometry in rodents.
Topics: Animals; Atorvastatin; Bone Density; Bone Development; Bone Resorption; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ovariectomy; Pravastatin; Pyrroles; Radiography; Rats; Rats, Sprague-Dawley; Simvastatin | 2001 |