simvastatin has been researched along with Bone Cancer in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, Q; Li, Y; Xian, M; Yang, B; Ying, M | 1 |
| Bontkes, HJ; de Gruijl, TD; Huijts, CM; Reijm, M; Schneiders, FL; van der Vliet, HJ; Verheul, HMW | 1 |
| Hanschen, M; Kalbitz, M; Kany, S; Kneip, N; Relja, B; Sturm, R; Woschek, M | 1 |
| Fernández-Pérez, L; García-Castellano, JM; Guerra, B; Hernández-Perera, O; Sánchez-Gómez, M; Sandoval-Usme, MC; Umaña-Pérez, A | 1 |
| Babcook, MA; Daneshgari, F; Flask, CA; Fu, P; Gupta, S; Lindner, DJ; MacLennan, GT; Molter, JP; Oak, CZ; Parker, Y; Puchowicz, MA; Shukla, S; Vazquez, EJ | 1 |
| Fukuchi, Y; Kamel, WA; Maki, K; Matsuo, K; Muto, A; Nobusue, H; Onishi, N; Saya, H; Shimizu, T; Sugihara, E; Yamaguchi-Iwai, S | 1 |
| Choudhury, GG; Ghosh-Choudhury, N; Mandal, CC; Yoneda, T | 1 |
| Chen, Y; Li, W; Li, Y; Liu, H; Wang, Z | 1 |
| de Gortázar, AR; Esbrit, P; Guillén, C | 1 |
| Abe, K; Asami, S; Kodama, T; Konishi, K; Oikawa, S; Sugiyama, M | 1 |
10 other study(ies) available for simvastatin and Bone Cancer
| Article | Year |
|---|---|
Inhibition of KLF4 by Statins Reverses Adriamycin-Induced Metastasis and Cancer Stemness in Osteosarcoma Cells.
Topics: Animals; Antibiotics, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Down-Regulation; Doxorubicin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Neoplastic Stem Cells; Osteosarcoma; RNA Interference; RNA, Small Interfering; Simvastatin; Transcription Factors; Transplantation, Heterologous | 2017 |
The effects of systemic treatment with aminobisphosphonates and statins on circulating Vγ9Vδ2-T cells in patients with advanced cancer.
Topics: Acute-Phase Reaction; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Drug-Related Side Effects and Adverse Reactions; Female; Granzymes; HLA-DR Antigens; Humans; Immunophenotyping; Lymphocyte Activation; Male; Middle Aged; Perforin; Pilot Projects; Prostatic Neoplasms; Receptors, Antigen, T-Cell, gamma-delta; Simvastatin; T-Lymphocytes | 2018 |
Simvastatin exerts anticancer effects in osteosarcoma cell lines via geranylgeranylation and c-Jun activation.
Topics: Apoptosis; Bone Neoplasms; Cell Cycle Checkpoints; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; MAP Kinase Kinase 4; Mevalonic Acid; Osteosarcoma; Polyisoprenyl Phosphates; Prenylation; Proto-Oncogene Proteins c-jun; Sesquiterpenes; Simvastatin | 2018 |
Simvastatin impairs growth hormone-activated signal transducer and activator of transcription (STAT) signaling pathway in UMR-106 osteosarcoma cells.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Growth Hormone; Humans; Janus Kinases; Osteosarcoma; Rats; Rats, Inbred BUF; Signal Transduction; Simvastatin; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription, Genetic; Transcriptional Activation | 2014 |
Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer.
Topics: Animals; Anticholesteremic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Movement; Drug Synergism; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Neoplasm Metastasis; Prostatic Neoplasms, Castration-Resistant; Simvastatin | 2014 |
Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Xenograft Model Antitumor Assays | 2017 |
Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.
Topics: Amino Acid Substitution; Animals; Anticholesteremic Agents; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Mice; Mice, Nude; Mutation, Missense; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Osteolysis; Simvastatin; Transcription, Genetic; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2011 |
Simvastatin prevents proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo.
Topics: Acyl Coenzyme A; Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Bone Neoplasms; Cell Proliferation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Tumor Cells, Cultured | 2013 |
The interleukin-6/soluble interleukin-6 receptor system induces parathyroid hormone-related protein in human osteoblastic cells.
Topics: Aged; Alkaline Phosphatase; Alkyl and Aryl Transferases; Bone Neoplasms; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; MAP Kinase Signaling System; Osteoblasts; Osteocalcin; Osteogenesis; Osteosarcoma; Parathyroid Hormone-Related Protein; ras Proteins; Receptors, Interleukin; Receptors, Interleukin-6; Recombinant Fusion Proteins; RNA, Messenger; Simvastatin; Tumor Cells, Cultured; Up-Regulation | 2004 |
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells.
Topics: Anti-Bacterial Agents; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Bone Neoplasms; Cloning, Molecular; Disulfides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Indole Alkaloids; Lovastatin; Mevalonic Acid; Osteoporosis; Osteosarcoma; Pravastatin; Promoter Regions, Genetic; RNA, Messenger; Simvastatin; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |