Page last updated: 2024-08-23

simvastatin and Body Weight

simvastatin has been researched along with Body Weight in 71 studies

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (14.08)18.2507
2000's29 (40.85)29.6817
2010's27 (38.03)24.3611
2020's5 (7.04)2.80

Authors

AuthorsStudies
Asiimwe, IG; Blockman, M; Cohen, K; Cupido, C; Hutchinson, C; Jacobson, B; Jorgensen, AL; Lamorde, M; Morgan, J; Mouton, JP; Nakagaayi, D; Okello, E; Pirmohamed, M; Schapkaitz, E; Sekaggya-Wiltshire, C; Semakula, JR; Waitt, C; Zhang, EJ1
Abdelfattah, MS; Aldin, DE; Aleid, GM; Fareid, MA; Hameed, RA; Khaled, AM; Moneim, AEA; Othman, MS1
Hong, S; Hou, C; Jiang, X; Lin, Q; Sheng, W; Wang, T; Ye, X; Zhang, Y; Zhao, J1
Florean, EOPT; Guedes, MIF; Holanda, MO; Lima, CLS; Lira, SM; Marques, MMM; Mendes, FNP; Moura, LFWG; Oriá, RB; Paim, RTT; Rodrigues, PAS; Silva, BBD; Silva, JYGD; Vieira, IGP1
He, W; Mei, X; Wang, Y; Wei, W; Yang, M1
Cai, S; Gao, H; Hou, B; Wang, C; Wang, W1
Al-Ajmi, HN; Al-Amin, MA; Al-Rasheed, NM; Bassiouni, YA; Hasan, IH; Mahmoud, AM1
André, A; Barros, S; Capitão, A; Montes, R; Neuparth, T; Quintana, JB; Rodil, R; Santos, MM; Soares, J1
Bak, EJ; Cha, JH; Kim, A; Kim, AR; Kim, JH; Sohn, Y; Yoo, YJ1
Ahmad, A; Al Musaddi, SA; Alkhatib, MH; Alkreathy, HM; Balamash, KSA; Osman, NN1
Asafo-Adjei, T; Castro-Núñez, J; Cunningham, LL; Dziubla, TD; Liyanage, ADT; Puleo, DA; Venkatesan, N1
Fan, S; Ge, J; Hu, K; Jia, L; Jin, X; Liu, X; Ma, X; Sun, A; Wang, C; Wang, K; Wang, S; Zhao, B; Zhao, H; Zhao, J; Zhao, T; Zhu, H; Zou, Y1
Glück, B; Meerbach, A; Schmidtke, M; Walther, M; Wutzler, P1
Jang, SB; Lee, D; Lim, LA; Park, K; Roh, H; Son, H1
Gao, F; Kong, J; Liu, FF; Meng, X; Yang, JM; Zhang, C; Zhang, K; Zhang, Y1
Qin, S; Sang, H; Si, Y; Wang, J; Xu, X; Yang, N; Yao, S; Zhai, L; Zhang, Y; Zu, D1
Bastiaansen-Jenniskens, YM; Bierma-Zeinstra, SM; Botter, SM; Clockaerts, S; Gierman, LM; Kloppenburg, M; van Osch, GJ; Verhaar, JA; Wei, W; Weinans, H; Zuurmond, AM1
Augusti, PR; Conte, L; da Veiga, ML; Denardin, IT; Duarte, MM; Emanuelli, T; Figueiredo, CG; Kasten, J; Quatrin, A; Roehrs, M; Ruviaro, AR; Somacal, S1
Abdelsalam, RM; Ahmed, LA; Amin, HA; Darwish, HA1
Jiang, X; Li, P; Sun, B; Sun, W; Wang, J; Wang, P; Yuan, L; Zhang, L1
Gao, L; Guan, Q; Li, J; Wang, Y; Yu, C; Zhang, X; Zhao, J; Zhou, X; Zuo, C1
Han, W; Li, J; Sun, L; Tang, H1
Abuelezz, SA; Atalla, SS; El Aziz, LFA; Gorge, SS; Mohamed, MT1
Butterweck, V; Derendorf, H; Frye, R; Galloway, C; Zdrojewski, I1
Brufau, G; Dallinga-Thie, GM; Dasselaar, M; Mensink, RP; Plat, J1
Dai, DZ; Dai, Y; Luo, L; Zheng, YF1
Bowsman, M; Chen, M; Cordover, D; Fordstrom, P; Hale, C; Helmering, J; Kaufman, SA; Lloyd, DJ; Véniant, MM; Wang, M; Zhou, M1
Li, A; Li, S; Lv, S; Ma, H; Piao, H; Sun, C; Yu, Z; Zhang, N; Zhang, Y; Zhao, H1
Ashfaq, H; Bregman, DB; Chirinos, JA; Iqbal, N; Khayyam, U; Williams, MM1
Kalonia, H; Kumar, A; Kumar, P1
Chen, ZQ; Dang, GT; Leng, HJ; Li, X; Liu, ZJ; Song, CL; Song, QS; Wang, JY1
Huang, C; Liu, Z; Shen, Z; Wang, Z; Zhu, J1
Abe, Y; Higuchi, K; Inoue, T; Ishida, K; Kakimoto, K; Kawakami, K; Kuramoto, T; Morita, E; Murano, M; Murano, N; Narabayashi, K; Okada, T; Umegaki, E1
Derosa, G; Fogari, R; Lazzari, P; Maffioli, P; Mugellini, A; Zoppi, A1
Constantin-Teodosiu, D; Davies, WJ; Glaves, PD; Greenhaff, PL; Mallinson, JE; Martin, EA; Sidaway, JE; Westwood, FR1
Yan, H; Zhang, W1
Bonetti, PO; Holmes, DR; Lerman, A; Lerman, LO; Rodriguez-Porcel, M; Wilson, SH1
Cristol, JP; Delbosc, S; Descomps, B; Jover, B; Mimran, A1
Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG; Qiu, D; Vaszar, LT1
Balduini, W; Carloni, S; Cimino, M; De Simoni, MG; Mazzoni, E; Perego, C; Sironi, L1
Davis, NA; Inman, SR; Lukaszek, VA; Olson, KM1
Babal, P; Gvozdjakova, A; Krajcirovicova, K; Kucharska, J; Luptak, I; Matuskova, J; Pechanova, O; Simko, F1
Andreassen, TT; Oxlund, H1
Andreasen, F; Buus, NH; Heickendorff, L; Larsen, ML; Mosekilde, L; Rejnmark, L; Vestergaard, P1
Aktan, F; Ceylan, A; Karasu, C; Ozansoy, G1
Abe, K; Deguchi, K; Hayashi, T; Nagano, I; Nagotani, S; Sato, K; Shoji, M; Zhang, W1
Cheng, X; Ge, H; Guo, Z; Li, B; Liao, YH; Liu, Y; Lu, B; Wang, M; Yang, Y; Zhang, J; Zhang, L1
Ichihara, K; Kanda, M; Kasai, T; Keimatsu, N; Satoh, K; Sun, F; Takaguri, A1
Bayorh, MA; Eatman, D; Feuerstein, GZ; Ganafa, AA; Walton, M1
Ahn, HC; Ku, SK; Lee, HS1
Lee, SD; Man, D; Risovic, V; Sivak, O; Wasan, KM1
Parle, M; Singh, N1
Chumark, P; Khunawat, P; Morales, NP; Phivthong-Ngam, L; Phornchirasilp, S; Pongrapeeporn, KU; Ratanachamnong, P; Sanvarinda, Y; Srisawat, S1
Kamata, K; Kobayashi, T; Matsumoto, T; Takenouchi, Y1
Akgun, A; Alkanat, M; Baytan, SH; Ekinci, M; Gedikli, E; Okuyan, M; Ozeren, M1
Johansson, J; Lithell, H; Ohrvall, M; Vessby, B1
Benhizia, F; Griglio, S; Lagrange, D; Malewiak, MI1
Alsina, J; Andrés, E; Castelao, AM; Castiñeiras, MJ; Galcerán, JM; Gilvernet, S; González, MT; Griñó, JM; Roca, M; Serón, D1
Assie, N; Bruniquel, F; Degryse, AD; Delhon, A; Oms, P; van Haverbeke, G1
Giroux, I; Jacques, H; Lavigne, C; Moorjani, S1
Dhir, S; Gopaul, N; Palmer, AM; Poston, L; Thomas, CR; Tribe, RM1
Asenjo-Barrón, JC; Cárdenas-Vázquez, R; Díaz-Zagoya, JC; Juárez-Oropeza, MA; Martínez, F1
Gylling, H; Miettinen, TA; Strandberg, TE1
Aubourg, P; Cartier, N; Guidoux, S; Rocchiccioli, F1
Beinlich, CJ; Ichihara, K; Morgan, HE; Satoh, K; Shirota, F; Tsunajima, T1
Balduini, W; Cimino, M; De Angelis, V; Mazzoni, E1
de Bravo, MG; Polo, M1
Abbate, M; Cattaneo, D; Corna, D; Remuzzi, G; Rottoli, D; Tomasoni, S; Zanchi, C; Zoja, C1
Escousse, A; Goudonnet, H; Mercenne, F; Mounie, J; Truchot, RC1
Fukuzumi, H; Hase, K; Ishida, F; Kamei, T; Sato, A; Watanabe, K1
Desager, JP; Harvengt, C; Horsmans, Y1

Trials

8 trial(s) available for simvastatin and Body Weight

ArticleYear
Development of a pharmacokinetic interaction model for co-administration of simvastatin and amlodipine.
    Drug metabolism and pharmacokinetics, 2014, Volume: 29, Issue:2

    Topics: Administration, Oral; Adult; Age Factors; Amlodipine; Biological Availability; Body Weight; Calcium Channel Blockers; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Genotype; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Models, Biological; Phenotype; Polymorphism, Genetic; Polypharmacy; Republic of Korea; Simvastatin

2014
A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients.
    The Journal of nutrition, 2009, Volume: 139, Issue:6

    Topics: Apolipoproteins; Beverages; Body Weight; Cholesterol Ester Transfer Proteins; Cholesterol, LDL; Cholesterol, VLDL; DNA-Binding Proteins; Drug Therapy, Combination; Fatty Acids, Nonesterified; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver X Receptors; Metabolic Syndrome; Orphan Nuclear Receptors; PPAR alpha; Receptors, Cytoplasmic and Nuclear; Simvastatin; Sitosterols; Triglycerides; Yogurt

2009
Efficacy of cholesterol uptake inhibition added to statin therapy among subjects following a low-carbohydrate diet: a randomized controlled trial.
    American heart journal, 2010, Volume: 159, Issue:5

    Topics: Aged; Anticholesteremic Agents; Azetidines; Body Weight; Diet, Carbohydrate-Restricted; Double-Blind Method; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Prospective Studies; Simvastatin; Triglycerides

2010
Effects of losartan and amlodipine alone or combined with simvastatin in hypertensive patients with nonalcoholic hepatic steatosis.
    European journal of gastroenterology & hepatology, 2012, Volume: 24, Issue:2

    Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Body Mass Index; Body Weight; Double-Blind Method; Drug Therapy, Combination; Fatty Liver; Female; Glucose Clamp Technique; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Inflammation Mediators; Insulin Resistance; Lipids; Losartan; Male; Middle Aged; Simvastatin; Ultrasonography

2012
Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2004, Volume: 19, Issue:5

    Topics: Aged; Alkaline Phosphatase; Anticholesteremic Agents; Biomarkers; Body Composition; Body Weight; Bone and Bones; Bone Density; Bone Remodeling; Cholesterol; Collagen; Collagen Type I; Double-Blind Method; Female; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Longitudinal Studies; Middle Aged; Osteocalcin; Osteoporosis, Postmenopausal; Parathyroid Hormone; Peptides; Simvastatin; Triglycerides

2004
A comparison between the effects of gemfibrozil and simvastatin on insulin sensitivity in patients with non-insulin-dependent diabetes mellitus and hyperlipoproteinemia.
    Metabolism: clinical and experimental, 1995, Volume: 44, Issue:2

    Topics: Aged; Body Weight; Diabetes Complications; Diabetes Mellitus; Double-Blind Method; Female; Gemfibrozil; Glucose Tolerance Test; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Insulin; Lipoprotein Lipase; Lipoprotein(a); Lipoproteins, LDL; Lipoproteins, VLDL; Lovastatin; Male; Middle Aged; Simvastatin

1995
HMGCoA reductase inhibitors lovastatin and simvastatin in the treatment of hypercholesterolemia after renal transplantation.
    Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 2

    Topics: Adult; Anticholesteremic Agents; Apolipoproteins; Body Mass Index; Body Weight; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunosuppression Therapy; Kidney Transplantation; Lipids; Lipoproteins; Lovastatin; Male; Postoperative Complications; Proteinuria; Simvastatin; Triglycerides

1993
Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:5

    Topics: Anticholesteremic Agents; Body Weight; Cholestanol; Cholesterol; Coronary Disease; Desmosterol; Humans; Phytosterols; Placebos; Simvastatin; Sitosterols; Sterols

2000

Other Studies

63 other study(ies) available for simvastatin and Body Weight

ArticleYear
Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm.
    CPT: pharmacometrics & systems pharmacology, 2022, Volume: 11, Issue:1

    Topics: Adult; Africa South of the Sahara; Age Factors; Algorithms; Anticoagulants; Body Weight; Drug Dosage Calculations; Female; HIV Infections; Humans; International Normalized Ratio; Machine Learning; Male; Middle Aged; Models, Biological; Reproducibility of Results; Sex Factors; Simvastatin; Warfarin

2022
Evaluation of antiobesity and hepatorenal protective activities of Salvia officinalis extracts pre-treatment in high-fat diet-induced obese rats.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:49

    Topics: Animals; Antioxidants; Biomarkers; Body Weight; Creatinine; Diet, High-Fat; Flavonoids; Inflammation Mediators; Insulins; Interleukin-1beta; Leptin; Lipids; NF-E2-Related Factor 2; Nitric Oxide; Obesity; Oxidative Stress; Plant Extracts; PPAR gamma; Rats; Salvia officinalis; Simvastatin; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Urea

2022
Xinmaikang (XMK) tablets alleviate atherosclerosis by regulating the SREBP2-mediated NLRP3/ASC/Caspase-1 signaling pathway.
    Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 2

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Body Weight; Caspase 1; Caspases; Cholesterol, LDL; Chromatography, Liquid; Interleukin-6; Mice; Mice, Knockout, ApoE; Molecular Docking Simulation; NLR Family, Pyrin Domain-Containing 3 Protein; Plaque, Atherosclerotic; Signal Transduction; Simvastatin; Tandem Mass Spectrometry; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2024
Hypolipidemic and reduced nitrergic effects of p-hydroxycinnamic diesters extracted from Copernicia prunifera in mice challenged by a high-fat diet.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 142

    Topics: Administration, Oral; Animals; Arecaceae; Biomarkers; Body Weight; Coumaric Acids; Diet, High-Fat; Disease Models, Animal; Female; Hyperlipidemias; Hypolipidemic Agents; Inflammation; Interleukin-1beta; Lipid Metabolism; Lipids; Liver; Liver X Receptors; Male; Mice, Inbred C57BL; Plant Extracts; Simvastatin

2021
Exenatide Attenuates Obesity-Induced Mitochondrial Dysfunction by Activating SIRT1 in Renal Tubular Cells.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Line; Diet, High-Fat; Down-Regulation; Exenatide; Humans; Hypoglycemic Agents; In Vitro Techniques; Kidney Tubules; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Obesity; Palmitates; Reactive Oxygen Species; Simvastatin; Sirtuin 1

2021
Effects of aqueous extract of Arctium lappa L. roots on serum lipid metabolism.
    The Journal of international medical research, 2018, Volume: 46, Issue:1

    Topics: Animals; Arctium; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Diet, High-Fat; Encyclopedias as Topic; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Hypolipidemic Agents; Lipid Metabolism; Male; Molecular Sequence Annotation; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Simvastatin; Solvents; Triglycerides; Water

2018
Simvastatin ameliorates diabetic nephropathy by attenuating oxidative stress and apoptosis in a rat model of streptozotocin-induced type 1 diabetes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 105

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Caspase 3; Collagen; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Models, Animal; Down-Regulation; Hyperglycemia; Hypertrophy; Kidney; Kidney Function Tests; Male; Oxidative Stress; Rats, Wistar; Simvastatin; Streptozocin

2018
Chronic environmentally relevant levels of simvastatin disrupt embryonic development, biochemical and molecular responses in zebrafish (Danio rerio).
    Aquatic toxicology (Amsterdam, Netherlands), 2018, Volume: 201

    Topics: Animals; Body Weight; Cholesterol; Dose-Response Relationship, Drug; Embryonic Development; Female; Gene Expression Regulation, Developmental; Liver; Male; Reproduction; RNA, Messenger; Simvastatin; Survival Analysis; Tail; Triglycerides; Water Pollutants, Chemical; Zebrafish

2018
Simvastatin attenuates tibial bone loss in rats with type 1 diabetes and periodontitis.
    Journal of translational medicine, 2018, 11-09, Volume: 16, Issue:1

    Topics: Alveolar Bone Loss; Animals; Blood Glucose; Body Weight; Bone Morphogenetic Proteins; Bone Resorption; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fasting; Genetic Markers; Lipoproteins, LDL; Male; Osteoclasts; Periodontitis; Rats, Inbred F344; Simvastatin; Tibia; Triglycerides

2018
Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma.
    Clinical and experimental pharmacology & physiology, 2019, Volume: 46, Issue:5

    Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma, Ehrlich Tumor; Disease Models, Animal; Doxorubicin; Drug Carriers; Drug Synergism; Emulsions; Female; Kidney; Liver; Mice; Nanostructures; Simvastatin; Survival Rate

2019
Biodegradable polymerized simvastatin stimulates bone formation.
    Acta biomaterialia, 2019, 07-15, Volume: 93

    Topics: Absorbable Implants; Angiogenesis Inducing Agents; Animals; Body Weight; Bone Morphogenetic Protein 2; Bone Regeneration; Cholesterol; Core Binding Factor Alpha 1 Subunit; Cytokines; Cytoskeletal Proteins; Drug Delivery Systems; Drug Liberation; Male; Models, Animal; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Simvastatin; Skull; Tissue Scaffolds

2019
Naoxintong protects against atherosclerosis through lipid-lowering and inhibiting maturation of dendritic cells in LDL receptor knockout mice fed a high-fat diet.
    Current pharmaceutical design, 2013, Volume: 19, Issue:33

    Topics: Animals; Atherosclerosis; Body Weight; Cytokines; Dendritic Cells; Diet, High-Fat; Drugs, Chinese Herbal; Hypolipidemic Agents; Lipids; Male; Mice; Mice, Knockout; Receptors, LDL; Simvastatin

2013
Simvastatin treatment showed no prophylactic effect in influenza virus-infected mice.
    Journal of medical virology, 2013, Volume: 85, Issue:11

    Topics: Animals; Body Weight; Chemoprevention; Disease Models, Animal; Female; Immunologic Factors; Influenza A virus; Lung; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Simvastatin; Survival Analysis; Trachea; Viral Load

2013
Simvastatin increases Prolyl-4-Hydroxylase α1 expression in atherosclerotic plaque and ox-LDL-stimulated human aortic smooth muscle cells via p38 MAPK and ERK1/2 signaling.
    Journal of molecular and cellular cardiology, 2013, Volume: 65

    Topics: Animals; Aorta; Body Weight; Collagen; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Lipids; Lipoproteins, LDL; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plaque, Atherosclerotic; Prolyl Hydroxylases; Simvastatin; Time Factors

2013
Celastrus orbiculatus Thunb. ameliorates high-fat diet-induced non-alcoholic fatty liver disease in guinea pigs.
    Die Pharmazie, 2013, Volume: 68, Issue:10

    Topics: Animals; Body Weight; Celastrus; Cholesterol; Cholesterol, LDL; Diet, High-Fat; Fatty Liver; Guinea Pigs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Liver; Liver Function Tests; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Organ Size; Real-Time Polymerase Chain Reaction; Simvastatin; Superoxide Dismutase

2013
Statins and fibrates do not affect development of spontaneous cartilage damage in STR/Ort mice.
    Osteoarthritis and cartilage, 2014, Volume: 22, Issue:2

    Topics: Animals; Arthritis, Experimental; Biomarkers; Body Weight; Cartilage, Articular; Diet; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fenofibrate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Inflammation Mediators; Male; Mice; Mice, Inbred Strains; Osteoarthritis; Simvastatin; X-Ray Microtomography

2014
The antiatherogenic effect of bixin in hypercholesterolemic rabbits is associated to the improvement of lipid profile and to its antioxidant and anti-inflammatory effects.
    Molecular and cellular biochemistry, 2015, Volume: 403, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Atherosclerosis; Body Weight; Carotenoids; Hypercholesterolemia; Lipids; Male; Oxidation-Reduction; Plaque, Atherosclerotic; Rabbits; Simvastatin; Sulfhydryl Compounds; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha; Tunica Intima

2015
Role of Rho Kinase Inhibition in the Protective Effect of Fasudil and Simvastatin Against 3-Nitropropionic Acid-Induced Striatal Neurodegeneration and Mitochondrial Dysfunction in Rats.
    Molecular neurobiology, 2016, Volume: 53, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; bcl-2-Associated X Protein; Behavior, Animal; Body Weight; Caspase 3; Corpus Striatum; Male; Membrane Potential, Mitochondrial; Mitochondria; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitro Compounds; Organ Size; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Propionates; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; rho-Associated Kinases; Simvastatin; Succinate Dehydrogenase; Tumor Necrosis Factor-alpha

2016
Effect of Simvastatin on 5-HT and 5-HTT in a Rat Model of Pulmonary Artery Hypertension.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 37, Issue:5

    Topics: Animals; Blood Pressure; Body Weight; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Simvastatin; Smoking

2015
SIMVASTATIN DECREASES SEX HORMONE LEVELS IN MALE RATS.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:2

    Topics: Animals; Body Weight; Cholesterol; Estradiol; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intubation, Gastrointestinal; Lipids; Liver Function Tests; Luteinizing Hormone; Male; Rats; Rats, Sprague-Dawley; Simvastatin; Testosterone; Triglycerides

2017
Treatment of obese asthma in a mouse model by simvastatin is associated with improving dyslipidemia and decreasing leptin level.
    Biochemical and biophysical research communications, 2017, 03-04, Volume: 484, Issue:2

    Topics: Animals; Asthma; Blood Glucose; Body Weight; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dyslipidemias; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leptin; Leukocyte Count; Lipids; Lung; Mice; Mice, Inbred C57BL; Obesity; Simvastatin

2017
The anti-osteoporotic and anti-atherogenic effects of alendronate and simvastatin in ovariectomized rats fed high fat diet: A comparative study of combination therapy versus monotherapy.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89

    Topics: Alendronate; Alkaline Phosphatase; Animals; Atherosclerosis; Body Weight; Bone and Bones; Bone Density; Combined Modality Therapy; Diet, High-Fat; Female; Osteocalcin; Osteoporosis; Ovariectomy; Rats; Simvastatin

2017
Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days.
    Planta medica, 2009, Volume: 75, Issue:11

    Topics: Animals; Beverages; Body Weight; Cholesterol; Citrus paradisi; Drug Interactions; Male; Organ Size; Rats; Rats, Sprague-Dawley; Simvastatin

2009
Hypercholesterolaemia induces early renal lesions characterized by upregulation of MMP-9 and iNOS and ET(A)R: alleviated by a dual endothelin receptor antagonist CPU0213 and simvastatin.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:6

    Topics: Animals; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Endothelin A Receptor Antagonists; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Kidney; Kidney Diseases; Male; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Messenger; Simvastatin; Triglycerides; Up-Regulation

2009
Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis.
    Diabetes, obesity & metabolism, 2009, Volume: 11, Issue:7

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adipose Tissue; Animals; Atherosclerosis; Blood Glucose; Body Composition; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; Dyslipidemias; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Male; Metabolic Syndrome; Mice; Mice, Knockout; Rosiglitazone; Simvastatin; Thiazolidinediones; Triglycerides

2009
Simvastatin attenuates hypomyelination induced by hypoxia-ischemia in neonatal rats.
    Neurological research, 2010, Volume: 32, Issue:9

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weight; CD11b Antigen; Demyelinating Diseases; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Myelin Basic Protein; Rats; Rats, Sprague-Dawley; Simvastatin

2010
Comparative neuroprotective profile of statins in quinolinic acid induced neurotoxicity in rats.
    Behavioural brain research, 2011, Jan-01, Volume: 216, Issue:1

    Topics: Analysis of Variance; Animals; Atorvastatin; Behavior, Animal; Body Weight; Corpus Striatum; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipid Peroxidation; Male; Mitochondria; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Nitrites; Oxidative Stress; Pyrroles; Quinolinic Acid; Rats; Rats, Wistar; Rotarod Performance Test; Simvastatin; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2011
Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ERα expression and uterine wet weight in ovariectomized rats.
    Journal of bone and mineral metabolism, 2011, Volume: 29, Issue:4

    Topics: Absorptiometry, Photon; Animals; Biomechanical Phenomena; Blotting, Western; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Estrogen Receptor alpha; Female; Immunohistochemistry; Lumbar Vertebrae; Ovariectomy; Rats; Rats, Sprague-Dawley; Simvastatin; Uterus

2011
Simvastatin prevents ERK activation in myocardial hypertrophy of spontaneously hypertensive rats.
    Scandinavian cardiovascular journal : SCJ, 2010, Volume: 44, Issue:6

    Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Blotting, Western; Body Weight; Disease Progression; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Heart Ventricles; Hypertrophy, Left Ventricular; Male; Myocardium; Rats; Rats, Inbred SHR; Rats, Wistar; Signal Transduction; Simvastatin; Time Factors

2010
Simvastatin attenuates intestinal fibrosis independent of the anti-inflammatory effect by promoting fibroblast/myofibroblast apoptosis in the regeneration/healing process from TNBS-induced colitis.
    Digestive diseases and sciences, 2012, Volume: 57, Issue:2

    Topics: Animals; Apoptosis; Body Weight; Cicatrix, Hypertrophic; Colitis; Disease Models, Animal; Fibroblasts; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Intestines; Male; Mice; Mice, Inbred Strains; Myofibroblasts; Simvastatin; Wound Healing

2012
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
    The Journal of physiology, 2012, Dec-15, Volume: 590, Issue:24

    Topics: Acetylcarnitine; Animals; Body Weight; Carbohydrate Metabolism; Cathepsin L; Cytoprotection; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Enzyme Activation; Enzyme Activators; Female; Forkhead Transcription Factors; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Necrosis; Oxidation-Reduction; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; RNA, Messenger; Simvastatin; SKP Cullin F-Box Protein Ligases; Time Factors

2012
Simvastatin increases circulating endothelial progenitor cells and reduces the formation and progression of diabetic retinopathy in rats.
    Experimental eye research, 2012, Volume: 105

    Topics: Angiopoietin-1; Angiopoietin-2; Animals; Blood Glucose; Blood-Retinal Barrier; Body Weight; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Progression; Endothelium, Vascular; Flow Cytometry; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Retinal Vessels; RNA, Messenger; Simvastatin; Stem Cells; Vascular Endothelial Growth Factor A

2012
Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering.
    Journal of the American College of Cardiology, 2002, Aug-07, Volume: 40, Issue:3

    Topics: Animals; Anticholesteremic Agents; Body Weight; Capillary Permeability; Cholesterol, HDL; Cholesterol, LDL; Coronary Vessels; Disease Models, Animal; Female; Hemodynamics; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Models, Cardiovascular; Myocardial Ischemia; Random Allocation; Simvastatin; Stroke Volume; Swine; Tomography, X-Ray Computed; Treatment Outcome; Ultrasonography

2002
Simvastatin prevents angiotensin II-induced cardiac alteration and oxidative stress.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:2

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Body Weight; Creatinine; Dose-Response Relationship, Drug; Eating; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Myocardium; Neutrophils; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Simvastatin; Sodium

2002
Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.
    American journal of respiratory and critical care medicine, 2002, Nov-15, Volume: 166, Issue:10

    Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Disease Models, Animal; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Organ Size; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Treatment Outcome; Tunica Intima

2002
Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does
    Stroke, 2003, Volume: 34, Issue:8

    Topics: Animals; Animals, Newborn; Body Weight; Brain; Brain Chemistry; Cholesterol; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Interleukin-1; Male; Maze Learning; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha

2003
Simvastatin attenuates renal ischemia/reperfusion injury in rats administered cyclosporine A.
    The American journal of the medical sciences, 2003, Volume: 326, Issue:3

    Topics: Analysis of Variance; Animals; Body Weight; Cyclosporine; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Hemodynamics; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Iohexol; Ischemia; Kidney; Male; Microcirculation; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Time Factors; Vasoconstrictor Agents

2003
Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension.
    Life sciences, 2004, Jan-23, Volume: 74, Issue:10

    Topics: Animals; Aorta; Blood Pressure; Body Weight; Coenzymes; DNA; Enzyme Inhibitors; Fibrosis; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Rats; Rats, Wistar; Simvastatin; Ubiquinone; Ventricular Remodeling

2004
Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation.
    Bone, 2004, Volume: 34, Issue:4

    Topics: Animals; Biomarkers; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Female; Organ Size; Ovariectomy; Rats; Rats, Wistar; Simvastatin; Stress, Mechanical

2004
Simvastatin treatment restores vasoconstriction and the inhibitory effect of LPC on endothelial relaxation via affecting oxidizing metabolism in diabetic rats.
    Diabetes, nutrition & metabolism, 2004, Volume: 17, Issue:4

    Topics: Animals; Aorta; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; Hypolipidemic Agents; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Simvastatin; Streptozocin; Triglycerides; Vasodilation

2004
Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress.
    Stroke, 2005, Volume: 36, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Atorvastatin; Blood Pressure; Body Weight; Deoxyguanosine; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Infarction, Middle Cerebral Artery; Lipids; Lysine; Oxidative Stress; Pyrroles; Quinolines; Rats; Rats, Inbred SHR; Simvastatin; Survival Analysis

2005
Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction.
    Cardiovascular drugs and therapy, 2005, Volume: 19, Issue:1

    Topics: Animals; Blotting, Western; Body Weight; Collagen Type I; Cytokines; Disease Models, Animal; Echocardiography; Female; Gene Expression; Heart; Hemodynamics; Immunohistochemistry; Lipids; Myocardial Infarction; Myocardium; Organ Size; Polymerase Chain Reaction; Rats; Rats, Wistar; Simvastatin; Ventricular Remodeling

2005
HMG-CoA reductase inhibitors do not improve glucose intolerance in spontaneously diabetic Goto-Kakizaki rats.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:11

    Topics: Animals; Atorvastatin; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Glucose Intolerance; Glucose Tolerance Test; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Resistance; Male; Pravastatin; Pyrroles; Rats; Rats, Wistar; Simvastatin

2005
Simvastatin and losartan enhance nitric oxide and reduce oxidative stress in salt-induced hypertension.
    American journal of hypertension, 2005, Volume: 18, Issue:11

    Topics: Acetylcholine; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Body Weight; Drug Therapy, Combination; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Kidney; Losartan; Male; Mesenteric Arteries; Myocardium; Nitric Oxide; Organ Size; Oxidative Stress; Prostaglandins; Rats; Rats, Inbred Dahl; Simvastatin; Sodium Chloride, Dietary; Superoxides; Thromboxane A2; Treatment Outcome; Vasoconstriction; Vasodilator Agents

2005
Hypolipemic effect of water extracts of Picrorrhiza rhizoma in PX-407 induced hyperlipemic ICR mouse model with hepatoprotective effects: a prevention study.
    Journal of ethnopharmacology, 2006, May-24, Volume: 105, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cholesterol; Hyperlipidemias; Hypolipidemic Agents; Liver; Male; Mice; Mice, Inbred ICR; Organ Size; Phytotherapy; Picrorhiza; Plant Extracts; Simvastatin; Triglycerides

2006
Assessing lipid lowering and plasma cholesteryl ester transfer protein activity of simvastatin following administration to rabbits fed a high fat/cholesterol diet.
    Drug development and industrial pharmacy, 2006, Volume: 32, Issue:5

    Topics: Algorithms; Animals; Apolipoproteins B; Body Weight; Carrier Proteins; Cholesterol Ester Transfer Proteins; Cholesterol, Dietary; Cholesterol, HDL; Coconut Oil; Diet; Dietary Fats; Drinking; Eating; Glycoproteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lipids; Male; Plant Oils; Rabbits; Simvastatin; Triglycerides

2006
Reversal of memory deficits by Atorvastatin and Simvastatin in rats.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2007, Volume: 127, Issue:7

    Topics: Alprazolam; Amnesia; Animals; Atorvastatin; Body Weight; Cholesterol; Dietary Fats; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Maze Learning; Memory; Pyrroles; Rats; Rats, Wistar; Reaction Time; Scopolamine; Simvastatin; Stimulation, Chemical

2007
The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves.
    Journal of ethnopharmacology, 2008, Mar-28, Volume: 116, Issue:3

    Topics: Animals; Antioxidants; Atherosclerosis; Biphenyl Compounds; Body Weight; Cholesterol; Cholesterol, Dietary; Humans; Hypolipidemic Agents; Lipids; Lipoproteins, LDL; Male; Moringa oleifera; Picrates; Plant Extracts; Plant Leaves; Rabbits; Simvastatin; Thiobarbituric Acid Reactive Substances; Vitamin E; Water

2008
Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice.
    Journal of pharmacological sciences, 2008, Volume: 106, Issue:4

    Topics: Adrenomedullin; Animals; Aorta; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clonidine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Male; Mice; Mice, Inbred ICR; Nitrates; Nitrites; Nitroprusside; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Simvastatin; Vasodilation; Vasodilator Agents

2008
Simvastatin impairs spatial memory in rats at a specific dose level.
    The Tohoku journal of experimental medicine, 2008, Volume: 214, Issue:4

    Topics: Animals; Anticholesteremic Agents; Body Weight; Dose-Response Relationship, Drug; Maze Learning; Memory; Motor Activity; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Simvastatin; Space Perception

2008
In vivo regulation of hepatic lipase activity and mRNA levels by diets which modify cholesterol influx to the liver.
    Biochimica et biophysica acta, 1994, Mar-03, Volume: 1211, Issue:2

    Topics: Animals; Body Weight; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Cholic Acid; Cholic Acids; Diet; Female; Hydroxymethylglutaryl CoA Reductases; Lipase; Lipid Metabolism; Lipids; Liver; Lovastatin; Rats; Rats, Zucker; RNA, Messenger; Simvastatin

1994
Biochemical changes and morphological alterations of liver and kidney in hamsters after administration of the HMG-coenzyme A reductase inhibitor, simvastatin: prevention and reversibility by mevalonate.
    Pharmacology & toxicology, 1995, Volume: 77, Issue:6

    Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cricetinae; Dietary Fats; Eating; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Liver; Lovastatin; Male; Mevalonic Acid; Necrosis; Simvastatin

1995
Simvastatin further enhances the hypocholesterolemic effect of soy protein in rabbits.
    Journal of the American College of Nutrition, 1997, Volume: 16, Issue:2

    Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Drug Synergism; Eating; Enzyme Inhibitors; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Liver; Lovastatin; Male; Rabbits; Simvastatin; Soybean Proteins; Triglycerides

1997
Endothelial dysfunction in streptozotocin-diabetic rats is not reversed by dietary probucol or simvastatin supplementation.
    Diabetologia, 1998, Volume: 41, Issue:2

    Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diet; Dinoprost; Eating; Endothelium, Vascular; F2-Isoprostanes; Hypolipidemic Agents; Lipid Peroxidation; Lipids; Male; Mesenteric Arteries; Muscle Relaxation; Oxidative Stress; Probucol; Rats; Rats, Sprague-Dawley; Simvastatin; Tissue Distribution

1998
Comparative toxicity of high doses of vastatins currently used by clinicians, in CD-1 male mice fed with a hypercholesterolemic diet.
    Life sciences, 1999, Volume: 65, Issue:9

    Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Cholesterol, Dietary; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipids; Liver; Lovastatin; Male; Mice; Mice, Inbred Strains; Organ Size; Pravastatin; Simvastatin; Time Factors; Transaminases; Triglycerides

1999
Simvastatin does not normalize very long chain fatty acids in adrenoleukodystrophy mice.
    FEBS letters, 2000, Aug-04, Volume: 478, Issue:3

    Topics: Adrenal Glands; Adrenoleukodystrophy; Animals; Body Weight; Brain; Cholesterol; Fatty Acids; Liver; Male; Mice; Mice, Inbred C57BL; Myocardium; Simvastatin; Time Factors

2000
Limitation of heart growth in neonatal piglets by simvastatin and atorvastatin: comparison with pravastatin.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6

    Topics: Administration, Oral; Animals; Animals, Newborn; Atorvastatin; Blood Pressure; Body Weight; DNA; Heart; Heart Rate; Heart Ventricles; Heptanoic Acids; Mitogen-Activated Protein Kinases; Myocardium; Organ Size; Pravastatin; Proteins; Pyrroles; RNA; Simvastatin; Swine; Water

2001
Simvastatin protects against long-lasting behavioral and morphological consequences of neonatal hypoxic/ischemic brain injury.
    Stroke, 2001, Volume: 32, Issue:9

    Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Choice Behavior; Disease Models, Animal; Hypoxia-Ischemia, Brain; Male; Maze Learning; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Simvastatin

2001
Simvastatin effects on a human lung carcinoma and cholesterol homeostasis of host and non-host mice.
    Archives of physiology and biochemistry, 2001, Volume: 109, Issue:5

    Topics: Animals; Anticholesteremic Agents; Body Weight; Carcinoma, Mucoepidermoid; Cholesterol; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Liver; Lung Neoplasms; Mice; Mice, Nude; Microsomes, Liver; Neoplasm Transplantation; Simvastatin

2001
Effect of combining ACE inhibitor and statin in severe experimental nephropathy.
    Kidney international, 2002, Volume: 61, Issue:5

    Topics: Alanine Transaminase; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartate Aminotransferases; Blood Pressure; Body Weight; CD4-Positive T-Lymphocytes; Chemokine CCL2; Cholesterol; Disease Models, Animal; Drug Therapy, Combination; Eating; Glomerulonephritis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Lisinopril; Male; Proteinuria; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Triglycerides

2002
Effects of simvastatin, a lipoprotein-lowering drug, on the hepatic enzymes involved in drug metabolism in the Wistar rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1991, Volume: 21, Issue:7

    Topics: Animals; Body Weight; Enzyme Induction; Epoxide Hydrolases; Fatty Acids; Glycerolphosphate Dehydrogenase; Hypolipidemic Agents; In Vitro Techniques; Liver; Lovastatin; Male; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phosphatidylcholines; Rats; Rats, Inbred Strains; Simvastatin; Subcellular Fractions

1991
Effect of simvastatin (MK-733) on plasma triacylglycerol levels in rats.
    Biochemical pharmacology, 1991, Apr-15, Volume: 41, Issue:8

    Topics: Adipose Tissue; Animals; Body Weight; Clofibrate; Energy Intake; Lipoprotein Lipase; Lipoproteins; Liver; Lovastatin; Male; Muscles; Organ Size; Rats; Rats, Inbred Strains; Simvastatin; Triglycerides

1991
Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin (HMG CoA reductase-inhibitor).
    Pharmacology & toxicology, 1990, Volume: 67, Issue:4

    Topics: Aminopyrine N-Demethylase; Animals; Bile Ducts; Body Weight; Cholesterol; Colestipol; Cytochrome P-450 Enzyme System; Eating; Guinea Pigs; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Male; Necrosis; Simvastatin

1990