simvastatin has been researched along with Blood Pressure, High in 146 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (6.85) | 18.2507 |
| 2000's | 71 (48.63) | 29.6817 |
| 2010's | 63 (43.15) | 24.3611 |
| 2020's | 2 (1.37) | 2.80 |
| Authors | Studies |
|---|---|
| Cysewski, D; Grochot-Przęczek, A; Józkowicz, A; Klóska, D; Kopacz, A; Kraszewska, I; Lenartowicz, M; Nowak, W; Piechota-Polańczyk, A; Przepiórska, K; Łoboda, A | 1 |
| Arancón-Monge, JM; Campos-Díaz, L; de Castro-Cuenca, A; Del Cura-González, I; Rodríguez Barrientos, R; Serrano-Vázquez, Á | 1 |
| Bonsu, KO; Buabeng, KO; Kadirvelu, A; Owusu, IK; Reidpath, DD | 1 |
| Deska, P; Nowicki, M | 1 |
| Carvalho, V; Castro-Faria-Neto, HC; Estato, V; Freitas, F; Lessa, MA; Reis, P; Tibirica, E; Torres, R | 1 |
| Abd-Eldayem, AM; Abdel-Zaher, AO; El-Refaiy, AEM; Farghaly, HSM | 1 |
| Bang, CN; Boman, K; Devereux, RB; Egstrup, K; Greve, AM; Nienaber, C; Okin, PM; Ray, S; Rossebø, AB; Wachtell, K | 1 |
| Cruz-Angeles, J; Martínez, LM; Martínez-Jiménez, C; Videa, M | 1 |
| Christopher-Stine, L; Isackson, PJ; Kitzmiller, JP; Luzum, JA; Ma, C; Nguyen, LM; Ochs-Balcom, HM; Peltier, W; Tarnopolsky, M; Vladutiu, GD; Weisman, M; Wortmann, RL | 1 |
| Bae, J; Kryzhanovski, VA; LeNarz, LA; Sponseller, CA; Zhao, Z; Zhu, Y | 1 |
| Abdel-Zaher, AO; Abudahab, LH; Elbakry, MH; Elkoussi, AE; Elsayed, EA | 2 |
| Desai, KM; Farrah, R; Glick, RM; Lovett, E; Low Dog, T | 1 |
| Correa, V; Fuchs, FD; Fuchs, SC; Gerhardt, M; Gus, M; Monteggia, RG; Moreira, LB; Sloczinski, CR | 1 |
| Chang, CF; Cheng, PW; Cheng, WH; Ho, WY; Hong, LZ; Hsiao, M; Lu, PJ; Sun, GC; Tseng, CJ; Yeh, TC | 1 |
| Gerdts, E; Gohlke-Bärwolf, C; Jander, N; Minners, J; Pedersen, TR; Ray, S; Wachtell, K | 1 |
| Chaturvedula, A; Lee, H; Sale, ME | 1 |
| Billot, L; Bompoint, S; Brown, A; Burch, C; Burke, H; Cass, A; Hayman, N; Hillis, GS; Jan, S; Molanus, B; Neal, B; Patel, A; Peiris, D; Rafter, N; Reid, CM; Rodgers, A; Shiel, L; Togni, S; Tonkin, A; Usherwood, T; Webster, R | 1 |
| de Tena Gómez, MD; García Aroca, MÁ; López Soberón, E; Navarro Suay, R | 1 |
| Lindelof, M; Skovbølling, SL | 1 |
| Ghushchyan, V; Nair, K; Saseen, JJ; Tuchscherer, RM | 1 |
| Aleksandrowicz, M; Drapala, A; Kozniewska, E; Sikora, M; Skrzypecki, J; Ufnal, M; Zera, T | 1 |
| Chamnansua, M; Kaewdang, N; Lohitnavy, M; Methaneethorn, J | 1 |
| Choudhry, NK; Gagne, JJ; Kesselheim, AS; Landon, J; Wang, B | 1 |
| Han, SH; Hayashi, T; Kim, EY; Koh, KK; Lee, Y; Oh, PC; Park, YM; Sakuma, I; Shin, EK | 1 |
| D'Angelo, A; Derosa, G; Maffioli, P; Mugellini, A; Pesce, RM | 1 |
| Chang, YH; Chien, LN; Chuang, MT; Lin, CF; Liu, JC | 1 |
| Foerster, J; Schetz, D; Sein Anand, J | 1 |
| Ahlquist, P; Bagdat, D; Blegvad, J; Christensen, R; Christensen, TG; Colic, A; Ellingsen, T; Emmertsen, H; Fredberg, U; Giraldi, A; Graugaard, C; Hansen, IM; Hørslev-Petersen, K; Jensen, HS; Løgstrup, BB; Persson, F; Sheetal, E; Svendsen, L; Svensson, AL; Thygesen, T | 1 |
| Chang, CC; Chou, HC; Hsu, YH; Juan, SH; Lee, YG | 1 |
| Boman, K; Greve, AM; Kesäniemi, YA; Nielsen, OW; Nienaber, CA; Olsen, MH; Pedersen, TR; Sabbah, M; Sajadieh, A; Wachtell, K; Willenheimer, R | 1 |
| Adams-Huet, B; Ahmad, Z; Khine, H; Yuet, WC | 1 |
| Bangalore, S; DeMicco, DA; Fayyad, R; Kastelein, JJ; Laskey, R; Messerli, FH; Waters, DD | 1 |
| Agarwal, I; Ferket, BS; Fleischmann, KE; Hunink, MG; Khanji, M; Petersen, SE | 1 |
| Sundermeyer, M; Veeraputhiran, M | 1 |
| Arima, S; Kai, T; Kanamasa, K; Nakabou, M; Taniyama, Y | 1 |
| Baranova, E; Ferber, P; Kandra, A; Okopien, B; Rump, LC; Weisskopf, M | 1 |
| Chodick, G; Gerber, Y; Heymann, AD; Kokia, E; Shalev, V; Silber, H; Simah, V | 1 |
| Avorn, J; Brookhart, MA; Brown, TV; Choudhry, NK; Glynn, RJ; Jolda, C; Lee, TH; Schneeweiss, S; Shrank, WH; Snedden, TM; Solomon, DH; Spetman, M | 1 |
| Bilbao, I; Blanco, L; Caralt, M; Castells, L; Charco, R; Dopazo, C; Lázaro, JL; Sapisochin, G | 1 |
| Boffi, L; Capra, A; Corsi, D; Failla, M; Fantini, E; Gentile, G; Giannattasio, C; Maestroni, S; Mancia, G; Meles, E; Scotti, V | 1 |
| Ambrosioni, E; Borghi, C; Cicero, AF; Di Gregori, V; Prandin, MG; Veronesi, M | 1 |
| Godman, B; Granath, F; Hasselström, J; Norman, C; Wettermark, B; Zarrinkoub, R | 1 |
| Kaminsky, Y; Kosenko, E; Suslikov, A | 1 |
| Imig, JD; Knight, SF; Roy, S; Yuan, J | 1 |
| de Haan, RJ; Kruyt, ND; Roos, YB; van Geloven, N; Vergouwen, MD; Vermeulen, M | 1 |
| Almeida, S; Dal-Pizzol, F; Lima, LO; Rosendo, AB | 1 |
| Ji, YR; Lai, CL; Li, YF; Liu, XH; Zhao, JQ | 1 |
| Nilsson, PM | 1 |
| Cohen, C; Hu, S; Miteva, M; Romanelli, P; Torchia, D | 1 |
| Cramariuc, D; Gerdts, E; Rieck, AE; Tuseth, N; Wachtell, K | 1 |
| Eckel, RH | 1 |
| Cramariuc, D; Gerdts, E; Gohlke-Bärwolf, C; Lund, BP; Rieck, AE; Rossebø, AB | 1 |
| Foody, JM; Liu, LZ; Mendys, PM; Simpson, RJ | 1 |
| Ambrosius, WT; Chew, EY; Cushman, WC; Danis, RP; Davis, MD; Elam, MB; Esser, BA; Fine, LJ; Gangaputra, S; Genuth, S; Gerstein, HC; Ginsberg, HN; Goff, DC; Greven, CM; Hubbard, L; Lovato, JF; Perdue, LH; Schubart, U | 1 |
| Chen, JH; Guan, YY; Liu, YJ; Lv, XF; Tang, YB; Wang, XG; Zhou, JG | 1 |
| Choi, JW; Kim, SH; Lee, H; Lee, SJ; Lim, HE; Park, CG | 1 |
| Abramczyk, P; Bidiuk, J; Ciarka, A; Dobosiewicz, A; Gaciong, Z; Lewandowski, J; Siński, M | 1 |
| Anegawa, T; Hirooka, Y; Imaizumi, T; Kai, H; Kajimoto, H; Koga, M; Kudo, H; Mori, T; Takayama, N; Yasuoka, S | 1 |
| Flett, AS; Godman, BB; Grosso, AM; Moon, JC; Wierzbicki, AS | 1 |
| Kaminsky, Y; Kosenko, E; Suslikov, A; Tikhonova, L | 1 |
| Hu, M; Mak, VW; Tomlinson, B | 1 |
| Ferreira-Sae, MC; Franchini, KG; Geloneze, B; Grespan-Magossi, AM; Nadruz, W; Pio-Magalhães, JA; Schreiber, R; Souza, FA; Velloso, LA | 1 |
| Kageji, T; Kanematsu, Y; Kinouchi, T; Kitazato, KT; Matsushita, N; Nagahiro, S; Satomi, J; Shimada, K; Tada, Y; Yagi, K | 1 |
| He, WK; He, ZC; Lai, Q; Liang, LY; Lu, DF; Luo, JD; Pan, XD; Wang, W; Wen, YH; Xiao, AY; Zeng, ZH | 1 |
| Derosa, G; Fogari, R; Lazzari, P; Maffioli, P; Mugellini, A; Zoppi, A | 1 |
| Drapala, A; Sikora, M; Szczepanska-Sadowska, E; Ufnal, M | 1 |
| Guan, YY; Li, SY; Ma, MM; Wang, M | 1 |
| Armendaris, MK; Beck, AL; D'Avila, LB; Netto, FM; Otto, ME; Sposito, AC | 1 |
| Boman, K; Cramariuc, D; Gerdts, E; Gohlke-Bärwolf, C; Lønnebakken, MT; Rieck, ÅE; Rossebø, AB; Staal, EM | 1 |
| Afzal, R; Gao, P; Pais, P; Sigamani, A; Teo, KK; Xavier, D; Yusuf, S | 1 |
| Morris, JK; Wald, DS; Wald, NJ | 1 |
| Gugssa, SA; Johnston, JC | 1 |
| Floras, JS; McGowan, CL; Millar, PJ; Morris, BL; Murai, H; Notarius, CF | 1 |
| Bots, ML; Grobbee, DE; Lafeber, M; Rodgers, A; Spiering, W; Thom, S; Visseren, FL; Webster, R | 1 |
| Hoogwerf, BJ; Nambi, V; Sprecher, DL | 1 |
| Chollet, ME; Pérez, J; Tristano, A | 1 |
| George, A; Shakib, S | 1 |
| Ito, MK; Pieper, JA; Talbert, RL | 1 |
| Diener, HC | 1 |
| Audebert, H; Haberl, RL | 1 |
| Can, L; Danaoğlu, Z; Kayikçioğlu, M; Kültürsay, H; Payzin, S | 1 |
| Akdemir, O | 1 |
| Iqbal, P; Jamil, S | 1 |
| Babal, P; Gvozdjakova, A; Krajcirovicova, K; Kucharska, J; Luptak, I; Matuskova, J; Pechanova, O; Simko, F | 1 |
| Arai, H; Matsuo, K; Miura, S; Nishikawa, H; Saku, K; Shimomura, H; Tsuchiya, Y; Zhang, B | 1 |
| Davalos, A; Fisher, M | 1 |
| Bizien, MD; Cusack, B; Jue, SG; Panning, C; Peterson, T | 1 |
| Iwasaka, T; Nishikawa, M; Nomura, S; Omoto, S; Shouzu, A | 1 |
| Li, Q; Liu, L; Xiao, J; Xu, Z; Zhao, S | 1 |
| Ahn, JY; Chung, WJ; Han, SH; Jin, DK; Kang, WC; Kim, DS; Kim, HS; Koh, KK; Seo, YH; Shin, EK; Son, JW | 1 |
| Kiselevich, A; London, D; Magen, E; Priluk, R; Viskoper, RJ; Volchek, L; Yosefy, C | 1 |
| Cesari, M; Pessina, AC | 1 |
| Borghi, C; Dormi, A; Gaddi, A; Sangiorgi, Z; Veronesi, M | 1 |
| Hryszko, T; Malyszko, J; Malyszko, JS; Mysliwiec, M | 1 |
| Hayashi, M; Ichihara, A; Kaneshiro, Y; Koura, Y; Saruta, T; Tada, Y | 1 |
| Desai, MY; Gautam, S; Lai, S; Lima, JA; Steen, H; Warren, WP | 1 |
| Hayashi, H; Ishizaki, T; Kosuge, K; Nishio, S; Ohashi, K; Satoh, H; Uchida, S; Watanabe, H; Yamada, H | 1 |
| Ahn, JY; Ahn, TH; Choi, IS; Chung, WJ; Han, SH; Kang, MH; Koh, KK; Quon, MJ; Seo, YH; Shin, EK | 1 |
| Cartwright, MS; Donofrio, PD; Jeffery, DR; Nuss, GR | 1 |
| Bezerra, DG; Mandarim-de-Lacerda, CA | 1 |
| Cremonesi, B; Gelosa, P; Gianazza, E; Gianella, A; Guerrini, U; Nobili, E; Paoletti, R; Sironi, L; Tremoli, E | 1 |
| Fukuhara, S; Iwasaka, T; Nishikawa, M; Nomura, S; Omoto, S; Shouzu, A | 1 |
| Alvarez de Sotomayor, M; Herrera, MD; Marhuenda, E; Márquez-Martín, A; Pérez-Guerrero, C | 1 |
| Chen, YQ; Li, AG; Shang, FJ; Wang, B; Xue, YS; Zhao, LY; Zheng, QS | 1 |
| Zhang, GG; Zhang, SD | 1 |
| Hayashi, H; Kosuge, K; Nishio, S; Ohashi, K; Uchida, S; Watanabe, H | 1 |
| Field, KM | 1 |
| Bayorh, MA; Eatman, D; Feuerstein, GZ; Ganafa, AA; Walton, M | 1 |
| Laverty, R; Ledingham, JM | 1 |
| Gruzdeva, OV; Karpov, RS; Koshel'skaia, OA; Suslova, TE; Zhuravleva, OA | 1 |
| Han, SH; Koh, KK; Lee, Y; Quon, MJ; Shin, EK | 1 |
| Blanche, PJ; Hulley, SB; Krauss, RM; Lin, F; Nickerson, DA; Rotter, JI; Saad, M; Shiboski, S; Simon, JA; Waters, D; Yang, H | 1 |
| Itakura, H; Kita, T; Mabuchi, H; Matsuzaki, M; Matsuzawa, Y; Nakaya, N; Oikawa, S; Saito, Y; Sasaki, J; Shimamoto, K | 1 |
| Geng, B; Tang, CS; Wu, XS; Yao, HM; Zhang, J | 1 |
| Kalliomäki, T; Makkonen, N; Olkinuora, JT; Vanhanen, H; Viikari, J | 1 |
| Carod-Artal, FJ | 1 |
| Kirby, M; Pearmain, H; Ramsbottom, T; Usher-Smith, JA | 1 |
| Glazer, R; Jia, Y; Kariisa, M; Pitt, B; Prescott, MF; Radauceanu, A; Rajagopalan, S; Zannad, F | 1 |
| Bayorh, MA; Eatman, D; Feuerstein, GZ; Layas, MF; Mann, G | 1 |
| Gvozdjáková, A; Kucharská, J; Simko, F | 1 |
| Delbosc, S; Jover, B; Mimran, A; Rugale, C | 1 |
| Borgström, F; Jönsson, B; Kanis, JA; Ström, O; Zethraeus, N | 1 |
| Kirby, M; Pearmain, H; Ramsbottom, T; Usher-Smith, J | 1 |
| Acín, S; Arbonés-Mainar, JM; Carnicer, R; Guillén, N; Navarro, MA; Osada, J; Surra, JC | 1 |
| Cappelleri, JC; Dubois, RW; Messerli, FH; Pinto, L; Sichrovsky, T; Tang, SS; Thakker, KM | 1 |
| Ang, PS; Su, DH; Tow, SL | 1 |
| Criqui, MH; Dimsdale, JE; Golomb, BA; Ritchie, JB; White, HL | 1 |
| Chin, JP; Dart, AM | 1 |
| Chan, P; Huang, TY; Lee, C; Lee, YS; Tomlinson, B | 1 |
| Smit, AJ | 1 |
| Hasnain, S; McLay, JS; Webster, J | 1 |
| Chua, TP; Fox, KM; Saia, F | 1 |
| Ciancio, L; Manzari, M; Merlo, M; Nazzaro, P; Pirrelli, A; Scarano, A; Triggiani, R | 1 |
| Beggs, PW; Clark, DW; Coulter, DM; Williams, SM | 1 |
| Alvarez de Sotomayor, M; Herrera, MD; Marhuenda, E; Pérez-Guerrero, C | 1 |
| Ambrosioni, E; Bacchelli, S; Borghi, C; Costa, FV; Degli Esposti, D; Prandin, MG | 1 |
| Angius, MF; Brizzi, P; Carboni, A; Cherchi, GM; Ciccarese, M; Formato, M; Maioli, M; Melis, MG; Tonolo, G | 1 |
| Cook, T; Kjekshus , J; Pedersen, T; Pyörälä, K; Wedel, H; Wilhelmsen, L | 1 |
| Cristol, JP; Delbosc, S; Jover, B; Mimran, A | 1 |
| Alvarez de Sotomayor, M; Bravo, L; Carneado, J; Herrera, MD; Jimenez, L; Marhuenda, E; Martin-Sanz, MD; Miranda, M; Pamies, E; Perez-Guerrero, C; Stiefel, P | 1 |
| Bentivoglio, M; Berioli, S; Conti, R; Corea, L; Osanna, RA; Savino, K; Zollino, L | 1 |
| Anderson, A; Hopper, J; Macaskill, G; McDonald, P; Morgan, T | 1 |
12 review(s) available for simvastatin and Blood Pressure, High
| Article | Year |
|---|---|
Natural history of mild and of moderate aortic stenosis-new insights from a large prospective European study.
Topics: Anticholesteremic Agents; Aortic Valve; Aortic Valve Stenosis; Azetidines; Calcinosis; Comorbidity; Disease Progression; Drug Therapy, Combination; Ezetimibe; Humans; Hypertension; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Risk Factors; Severity of Illness Index; Simvastatin; Treatment Outcome | 2013 |
[Study of arterial distensibility in man. Modulating mechanisms, pathological conditions and effects of treatment].
Topics: Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Arteries; Arteriosclerosis; Compliance; Diabetes Mellitus; Diuretics; Drug Therapy, Combination; Elasticity; Heart Failure; Humans; Hypercholesterolemia; Hypertension; Risk Factors; Simvastatin; Treatment Outcome | 2003 |
Papuloerythroderma 2009: two new cases and systematic review of the worldwide literature 25 years after its identification by Ofuji et al.
Topics: Aged, 80 and over; Female; Furosemide; Humans; Hydroxyzine; Hypercholesterolemia; Hypertension; Male; Middle Aged; Simvastatin; Skin Diseases, Papulosquamous; Triamcinolone | 2010 |
Syphilitic aortic aneurysm with spastic paraparesis: a novel presentation and review of the literature.
Topics: Aorta, Thoracic; Aortic Aneurysm, Thoracic; Atenolol; Disease Outbreaks; Disease Progression; Drug Therapy, Combination; HIV Infections; Humans; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; Paraparesis, Spastic; Penicillins; Simvastatin; Spinal Cord Compression; Syphilis; Time Factors | 2012 |
A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia.
Topics: Angiotensin-Converting Enzyme Inhibitors; Female; Humans; Hyperinsulinism; Hypertension; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Male; Metabolic Syndrome; Metformin; Motor Activity; Obesity; Simvastatin; Thiazoles; Thiazolidinediones; Weight Loss | 2002 |
Choosing a drug from within a class.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Aspirin; Australia; Decision Making; Drug Costs; Drug Therapy, Combination; Drug Utilization; Drugs, Generic; Family Practice; Female; Humans; Hypertension; Indoles; Myocardial Infarction; Practice Patterns, Physicians'; Severity of Illness Index; Simvastatin | 2003 |
[Secondary prevention after stroke: healthy life style, oral anticoagulation].
Topics: Administration, Oral; Adult; Anticholesteremic Agents; Anticoagulants; Antihypertensive Agents; Blood Coagulation Disorders; Brain Ischemia; Carotid Artery, Internal; Carotid Stenosis; Cerebral Infarction; Clinical Trials as Topic; Contraceptives, Oral; Embolism; Endarterectomy, Carotid; Exercise; Female; Humans; Hypertension; Hypolipidemic Agents; Ischemic Attack, Transient; Life Style; Male; Phenprocoumon; Platelet Aggregation Inhibitors; Recurrence; Simvastatin; Smoking Cessation; Stroke | 2003 |
Emerging therapies for cerebrovascular disorders.
Topics: Angiotensin-Converting Enzyme Inhibitors; Atorvastatin; Cerebrovascular Circulation; Cerebrovascular Disorders; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Intracranial Aneurysm; Pyrroles; Randomized Controlled Trials as Topic; Risk; Simvastatin; Therapeutics; Tissue Plasminogen Activator; Treatment Outcome | 2004 |
Combined antihypertensive and lipid-lowering treatment.
Topics: Anticholesteremic Agents; Antihypertensive Agents; Arteriosclerosis; Cardiovascular Diseases; Comorbidity; Drug Therapy, Combination; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Nifedipine; Pyridines; Simvastatin | 2004 |
Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on high-sensitivity C-reactive protein levels.
Topics: Animals; Atherosclerosis; Atorvastatin; C-Reactive Protein; Cardiovascular Diseases; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Metabolic Syndrome; Pravastatin; Pyrroles; Risk Factors; Simvastatin | 2005 |
Impact of systemic hypertension on the cardiovascular benefits of statin therapy--a meta-analysis.
Topics: Aged; Atorvastatin; Cardiovascular Diseases; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Indoles; Male; Middle Aged; Pravastatin; Prognosis; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Therapeutics | 2008 |
Vastatin trials: lessons from hypertension history.
Topics: Aged; Anticholesteremic Agents; Controlled Clinical Trials as Topic; Humans; Hypertension; Pravastatin; Simvastatin; Treatment Outcome | 1998 |
56 trial(s) available for simvastatin and Blood Pressure, High
| Article | Year |
|---|---|
Short-term changes of serum potassium concentration induced by physical exercise in patient with arterial hypertension treated with angiotensin-converting enzyme inhibitor alone or in combination with statin.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Cross-Over Studies; Drug Therapy, Combination; Exercise; Exercise Test; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Potassium; Ramipril; Simvastatin; Single-Blind Method | 2017 |
Antihypertensive Treatment With β-Blockade in Patients With Asymptomatic Aortic Stenosis and Association With Cardiovascular Events.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Aged, 80 and over; Anticholesteremic Agents; Aortic Valve Stenosis; Asymptomatic Diseases; Blood Pressure; Cause of Death; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Echocardiography, Doppler; Ezetimibe; Female; Heart Ventricles; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Morbidity; Propensity Score; Simvastatin; Survival Rate; United States | 2017 |
Effect of simvastatin on the antihypertensive activity of losartan in hypertensive hypercholesterolemic animals and patients: role of nitric oxide, oxidative stress, and high-sensitivity C-reactive protein.
Topics: Adult; Aged; Animals; Anticholesteremic Agents; Antihypertensive Agents; Aorta; Blood Pressure; C-Reactive Protein; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Hypertension; In Vitro Techniques; Isometric Contraction; Losartan; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Rabbits; Rats, Wistar; Simvastatin; Treatment Outcome | 2014 |
Blood pressure-lowering effect of simvastatin: a placebo-controlled randomized clinical trial with 24-h ambulatory blood pressure monitoring.
Topics: Blood Pressure Monitoring, Ambulatory; Brazil; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Placebos; Simvastatin; Treatment Outcome | 2014 |
Genetic algorithm guided population pharmacokinetic model development for simvastatin, concurrently or non-concurrently co-administered with amlodipine.
Topics: Adult; Aged; Algorithms; Amlodipine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Models, Biological; Simvastatin | 2014 |
A pragmatic randomized trial of a polypill-based strategy to improve use of indicated preventive treatments in people at high cardiovascular disease risk.
Topics: Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aspirin; Atenolol; Australia; Biomarkers; Blood Pressure; Cardiovascular Diseases; Cholesterol; Drug Combinations; Drugs, Generic; Female; General Practice; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Lisinopril; Male; Middle Aged; Platelet Aggregation Inhibitors; Polypharmacy; Primary Prevention; Prospective Studies; Risk Factors; Simvastatin; Sodium Chloride Symporter Inhibitors; Tablets; Time Factors; Treatment Outcome | 2015 |
Perindopril and barnidipine alone or combined with simvastatin on hepatic steatosis and inflammatory parameters in hypertensive patients.
Topics: Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Hypolipidemic Agents; Male; Nifedipine; Non-alcoholic Fatty Liver Disease; Obesity; Perindopril; Simvastatin | 2015 |
Multifactorial intervention to prevent cardiovascular disease in patients with early rheumatoid arthritis: protocol for a multicentre randomised controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cardiovascular Diseases; Denmark; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Lipoproteins, LDL; Male; Middle Aged; Prospective Studies; Research Design; Risk Factors; Severity of Illness Index; Simvastatin; Young Adult | 2016 |
Assessing Optimal Blood Pressure in Patients With Asymptomatic Aortic Valve Stenosis: The Simvastatin Ezetimibe in Aortic Stenosis Study (SEAS).
Topics: Aged; Anticholesteremic Agents; Aortic Valve Stenosis; Blood Pressure; Double-Blind Method; Ezetimibe; Follow-Up Studies; Humans; Hypertension; Middle Aged; Simvastatin | 2016 |
Comparison of the effect of lipophilic and hydrophilic statins on serum adiponectin levels in patients with mild hypertension and dyslipidemia: Kinki Adiponectin Interventional (KAI) Study.
Topics: Adiponectin; Adipose Tissue; Adult; Aged; Aged, 80 and over; C-Reactive Protein; Cholesterol; Dyslipidemias; Female; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Pravastatin; Prospective Studies; Simvastatin | 2008 |
Coadministration of valsartan 160 and 320 mg and simvastatin 20 and 40 mg in patients with hypertension and hypercholesterolemia: a multicenter, 12-week, double-blind, double-dummy, parallel-group superiority study.
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypertension; Lipoproteins, LDL; Male; Middle Aged; Simvastatin; Tetrazoles; Valine; Valsartan | 2008 |
Rationale and design of the Study Assessing the Effect of Cardiovascular Medications Provided as Low-cost, Evidence-based Generic Samples (SAMPLES) trial.
Topics: Diuretics; Drug Costs; Drug Prescriptions; Drugs, Generic; Humans; Hydrochlorothiazide; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Pennsylvania; Physicians, Family; Prescription Drugs; Simvastatin | 2009 |
Effects of AT1 receptor and beta1 receptor blocking on blood pressure, peripheral hemodynamic and lipid profile in statin-treated hypertensive hypercholesterolemic patients.
Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Anticholesteremic Agents; Antihypertensive Agents; Benzimidazoles; Benzoates; Bisoprolol; Blood Pressure; Cross-Over Studies; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypercholesterolemia; Hypertension; Lipids; Male; Middle Aged; Receptor, Angiotensin, Type 1; Simvastatin; Telmisartan; Treatment Outcome; Young Adult | 2009 |
Specific and pronounced impacts of lisinopril and lisinopril plus simvastatin on erythrocyte antioxidant enzymes.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Atherosclerosis; Blood Pressure; Cholesterol, LDL; Drug Synergism; Energy Metabolism; Erythrocytes; Female; Humans; Hypertension; Lisinopril; Male; Middle Aged; Oxidative Stress; Oxidoreductases; Random Allocation; Simvastatin | 2010 |
Increased cortisol levels are associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Blood Glucose; Brain Ischemia; Combined Modality Therapy; Double-Blind Method; Embolization, Therapeutic; Endothelium, Vascular; Female; Glasgow Coma Scale; Humans; Hydrocortisone; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hypertension; Male; Middle Aged; Neurologic Examination; Prognosis; Simvastatin; Subarachnoid Hemorrhage, Traumatic; Surgical Instruments; von Willebrand Factor | 2010 |
[Plasma endothelin level in hypertensive patients receiving standard anti-hypertensive therapy with or without statins].
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Endothelins; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Simvastatin | 2009 |
Effect of obesity on left ventricular mass and systolic function in patients with asymptomatic aortic stenosis (a Simvastatin Ezetimibe in Aortic Stenosis [SEAS] substudy).
Topics: Aged; Aged, 80 and over; Angiography; Aortic Valve Stenosis; Azetidines; Body Mass Index; Double-Blind Method; Drug Therapy, Combination; Echocardiography, Doppler; Ezetimibe; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Logistic Models; Male; Middle Aged; Multivariate Analysis; Obesity; Probability; Prognosis; Risk Assessment; Severity of Illness Index; Simvastatin; Stroke Volume; Systole; Treatment Outcome | 2010 |
Effects of medical therapies on retinopathy progression in type 2 diabetes.
Topics: Antihypertensive Agents; Cardiovascular Diseases; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Progression; Drug Therapy, Combination; Dyslipidemias; Female; Fenofibrate; Follow-Up Studies; Glycated Hemoglobin; Humans; Hyperglycemia; Hypertension; Hypoglycemic Agents; Hypolipidemic Agents; Male; Middle Aged; Simvastatin | 2010 |
Non-concurrent dosing attenuates the pharmacokinetic interaction between amlodipine and simvastatin.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Area Under Curve; Drug Administration Schedule; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Male; Middle Aged; Simvastatin | 2010 |
Simvastatin reduces sympathetic activity in men with hypertension and hypercholesterolemia.
Topics: Adult; Aldosterone; Anticholesteremic Agents; Blood Pressure; Catecholamines; Comorbidity; Double-Blind Method; Endothelins; Heart Rate; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Neuropeptide Y; Pressoreceptors; Renin; Simvastatin; Sympathetic Nervous System; Treatment Outcome | 2010 |
Impacts of lisinopril and lisinopril plus simvastatin on erythrocyte and plasma arginase, nitrite, and nitrate in hypertensive patients.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginase; Atherosclerosis; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lisinopril; Male; Middle Aged; Nitrates; Nitrites; Simvastatin | 2012 |
Simvastatin enhances the antihypertensive effect of ramipril in hypertensive hypercholesterolemic animals and patients. Possible role of nitric oxide, oxidative stress, and high sensitivity C-reactive protein.
Topics: Adult; Aged; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; C-Reactive Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypertension; In Vitro Techniques; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Rabbits; Ramipril; Rats; Rats, Wistar; Simvastatin; Treatment Outcome; Vasodilation | 2012 |
The effects of simvastatin on left ventricular hypertrophy and left ventricular function in patients with essential hypertension.
Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Blood Pressure; Drug Therapy, Combination; Dyslipidemias; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypertrophy, Left Ventricular; Lipids; Male; Simvastatin; Telmisartan; Treatment Outcome; Ultrasonography; Ventricular Function, Left | 2011 |
Effects of losartan and amlodipine alone or combined with simvastatin in hypertensive patients with nonalcoholic hepatic steatosis.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Body Mass Index; Body Weight; Double-Blind Method; Drug Therapy, Combination; Fatty Liver; Female; Glucose Clamp Technique; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Inflammation Mediators; Insulin Resistance; Lipids; Losartan; Male; Middle Aged; Simvastatin; Ultrasonography | 2012 |
Diastolic function parameters are improved by the addition of simvastatin to enalapril-based treatment in hypertensive individuals.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomarkers; Blood Pressure; Brazil; Chi-Square Distribution; Cholesterol; Diastole; Diuretics; Double-Blind Method; Drug Therapy, Combination; Echocardiography, Doppler; Enalapril; Female; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Prospective Studies; Regression Analysis; Simvastatin; Stroke Volume; Time Factors; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Function, Left | 2012 |
Hypertension in aortic stenosis: implications for left ventricular structure and cardiovascular events.
Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Antihypertensive Agents; Aortic Valve Stenosis; Azetidines; Blood Pressure; Cardiovascular Diseases; Drug Therapy, Combination; Echocardiography; Ezetimibe; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Simvastatin | 2012 |
Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators.
Topics: Administration, Oral; Aged; Analysis of Variance; Antihypertensive Agents; Aspirin; Atenolol; Biomarkers; Blood Pressure; Capsules; Cardiovascular Diseases; Cholesterol, LDL; Creatinine; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; India; Male; Middle Aged; Platelet Aggregation Inhibitors; Polypharmacy; Potassium; Ramipril; Risk Assessment; Risk Factors; Simvastatin; Tablets; Time Factors; Treatment Outcome | 2012 |
Randomized Polypill crossover trial in people aged 50 and over.
Topics: Aged; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypercholesterolemia; Hypertension; Losartan; Male; Middle Aged; Placebos; Simvastatin | 2012 |
Simvastatin reduces sympathetic outflow and augments endothelium-independent dilation in non-hyperlipidaemic primary hypertension.
Topics: Arteries; Blood Pressure; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Male; Middle Aged; Prospective Studies; Simvastatin; Sympathetic Nervous System; Vasodilation | 2013 |
The evening versus morning polypill utilization study: the TEMPUS rationale and design.
Topics: Administration, Oral; Antihypertensive Agents; Aspirin; Biomarkers; Blood Platelets; Blood Pressure; Cardiovascular Diseases; Cholesterol, LDL; Clinical Protocols; Cross-Over Studies; Drug Chronotherapy; Drug Combinations; Dyslipidemias; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lisinopril; Netherlands; Platelet Aggregation Inhibitors; Primary Prevention; Prospective Studies; Research Design; Simvastatin; Tablets; Time Factors; Treatment Outcome | 2014 |
Effect of statin therapy added to ACE-inhibitors on blood pressure control and endothelial functions in normolipidemic hypertensive patients.
Topics: Angiotensin-Converting Enzyme Inhibitors; Arm; Blood Flow Velocity; Blood Pressure; Brachial Artery; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hypertension; Hypolipidemic Agents; Lisinopril; Male; Middle Aged; Prospective Studies; Pulsatile Flow; Simvastatin; Treatment Outcome; Triglycerides; Ultrasonography; Vasodilation | 2003 |
Effects of losartan and simvastatin on monocyte-derived microparticles in hypertensive patients with and without type 2 diabetes mellitus.
Topics: Aged; Angiotensin Receptor Antagonists; Biomarkers; Blood Pressure; Chemokines; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Monocytes; Receptors, Angiotensin; Simvastatin | 2004 |
Simvastatin reduces interleukin-1beta secretion by peripheral blood mononuclear cells in patients with essential hypertension.
Topics: Aged; Angiotensin II; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Hypertension; Inflammation; Interleukin-1; Leukocytes, Mononuclear; Lipids; Male; Middle Aged; Simvastatin; Tetrazoles; Valine; Valsartan | 2004 |
Simvastatin combined with ramipril treatment in hypercholesterolemic patients.
Topics: Angina Pectoris; Biomarkers; C-Reactive Protein; Chemokine CCL2; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Diabetes Complications; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Nitric Oxide; Plasminogen Activator Inhibitor 1; Ramipril; Simvastatin; Triglycerides; Vasodilation | 2004 |
Rosiglitazone improves, while Glibenclamide worsens blood pressure control in treated hypertensive diabetic and dyslipidemic subjects via modulation of insulin resistance and sympathetic activity.
Topics: Administration, Oral; Albuminuria; Blood Glucose; Blood Pressure; Body Mass Index; Brachial Artery; Cholesterol, LDL; Cilazapril; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Cells; Endothelium, Vascular; Evoked Potentials; Female; Glyburide; Glycated Hemoglobin; Heart Rate; Humans; Hyperlipidemias; Hypertension; Insulin; Insulin Resistance; Kidney; Male; Rosiglitazone; Simvastatin; Skin Physiological Phenomena; Sympathetic Nervous System; Thiazolidinediones; Time Factors; Ultrasonography; Vasodilation | 2004 |
Association between different lipid-lowering treatment strategies and blood pressure control in the Brisighella Heart Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticholesteremic Agents; Antihypertensive Agents; Blood Pressure; Cholesterol, LDL; Cholestyramine Resin; Female; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Male; Middle Aged; Prospective Studies; Simvastatin | 2004 |
Long-term effects of statins on arterial pressure and stiffness of hypertensives.
Topics: Anticholesteremic Agents; Arteriosclerosis; Blood Pressure; C-Reactive Protein; Cholesterol; Elasticity; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemias; Hypertension; Indoles; Male; Middle Aged; Pravastatin; Prospective Studies; Pulsatile Flow; Simvastatin; Single-Blind Method | 2005 |
Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy.
Topics: Aged; Aorta, Thoracic; Aortic Diseases; Arteriosclerosis; Cholesterol, LDL; Comorbidity; Coronary Disease; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; Observer Variation; Prospective Studies; Reproducibility of Results; Simvastatin; Smoking; Stroke | 2004 |
Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolemia and hypertension.
Topics: Administration, Oral; Area Under Curve; Blood Pressure; Calcium Channel Blockers; Diltiazem; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Lipids; Liver Function Tests; Male; Middle Aged; Simvastatin; Treatment Outcome | 2004 |
Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients.
Topics: Adiponectin; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure; C-Reactive Protein; Chemokine CCL2; Cross-Over Studies; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Lipids; Losartan; Male; Malondialdehyde; Middle Aged; Simvastatin; Vasodilation | 2004 |
Losartan and simvastatin inhibit platelet activation in hypertensive patients.
Topics: Aged; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Simvastatin | 2004 |
[Effect of simvastatin on cardiac fibrosis in patients with essential hypertension].
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzazepines; Drug Therapy, Combination; Female; Fibrosis; Humans; Hypertension; Male; Middle Aged; Myocardium; Simvastatin | 2005 |
Interaction between amlodipine and simvastatin in patients with hypercholesterolemia and hypertension.
Topics: Administration, Oral; Aged; Amlodipine; Antihypertensive Agents; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Male; Middle Aged; Prospective Studies; Simvastatin | 2005 |
The effects of simvastatin, losartan, and combined therapy on soluble CD40 ligand in hypercholesterolemic, hypertensive patients.
Topics: Antihypertensive Agents; Blood Pressure; C-Reactive Protein; CD40 Ligand; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Lipids; Losartan; Male; Middle Aged; Simvastatin; Solubility; Vasculitis; Vasodilation | 2007 |
The risk of cardiovascular events in Japanese hypertensive patients with hypercholesterolemia: sub-analysis of the Japan Lipid Intervention Trial (J-LIT) Study, a large-scale observational cohort study.
Topics: Adult; Aged; Anticholesteremic Agents; Asian People; Blood Pressure; Cardiovascular Diseases; Cholesterol; Cohort Studies; Coronary Disease; Female; Humans; Hypercholesterolemia; Hypertension; Incidence; Japan; Male; Middle Aged; Risk Assessment; Simvastatin; Stroke | 2005 |
Effects of celiprolol and simvastatin on the calculated risk of coronary heart disease (the Celisimva study).
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Celiprolol; Coronary Disease; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Simvastatin | 2006 |
Effects of valsartan alone versus valsartan/simvastatin combination on ambulatory blood pressure, C-reactive protein, lipoproteins, and monocyte chemoattractant protein-1 in patients with hyperlipidemia and hypertension.
Topics: Antihypertensive Agents; Biomarkers; Blood Pressure Monitoring, Ambulatory; C-Reactive Protein; Chemokine CCL2; Double-Blind Method; Drug Combinations; Drug Synergism; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Simvastatin; Tetrazoles; Valine; Valsartan | 2007 |
Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial.
Topics: Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Diastole; Double-Blind Method; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Pravastatin; Simvastatin; Stroke; Systole; Treatment Outcome | 2008 |
HBPRCA Astra Award. Therapeutic restoration of endothelial function in hypercholesterolaemic subjects: effect of fish oils.
Topics: Acetylcholine; Adult; Australia; Awards and Prizes; Cholesterol; Cholesterol, LDL; Cholestyramine Resin; Drug Therapy, Combination; Endothelium, Vascular; Female; Fish Oils; Forearm; Humans; Hypercholesterolemia; Hypertension; Lovastatin; Male; Middle Aged; Regional Blood Flow; Simvastatin | 1994 |
Short-term safety and efficacy of low-dose simvastatin in elderly patients with hypertensive hypercholesterolemia and fasting hyperinsulinemia.
Topics: Aged; Anticholesteremic Agents; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperinsulinism; Hypertension; Lovastatin; Male; Patient Compliance; Simvastatin | 1997 |
Distinct and combined vascular effects of ACE blockade and HMG-CoA reductase inhibition in hypertensive subjects.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular System; Drug Interactions; Enalapril; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Male; Simvastatin | 1999 |
Use of statins and blood pressure control in treated hypertensive patients with hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Pravastatin; Simvastatin | 2000 |
Additive effects of Simvastatin beyond its effects on LDL cholesterol in hypertensive type 2 diabetic patients.
Topics: Albuminuria; Anticholesteremic Agents; Apolipoproteins; Blood Pressure; Cholesterol, LDL; Cholestyramine Resin; Diabetes Mellitus, Type 2; Female; Glycosaminoglycans; Humans; Hypertension; Male; Middle Aged; Nitrates; Nitrites; Simvastatin | 2000 |
Risk factors for a major coronary event after myocardial infarction in the Scandinavian Simvastatin Survival Study (4S). Impact of predicted risk on the benefit of cholesterol-lowering treatment.
Topics: Anticholesteremic Agents; Cholesterol; Coronary Disease; Diabetes Mellitus; Double-Blind Method; Female; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Myocardial Infarction; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Simvastatin; Smoking; Time Factors | 2001 |
[Simvastatin versus gemfibrozil in the treatment of primary hypercholesterolemia in hypertensive patients treated with hydrochlorothiazide].
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Female; Gemfibrozil; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1990 |
Simvastatin in the treatment of hypercholesterolaemia in patients with essential hypertension.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Dietary Fats, Unsaturated; Female; Humans; Hypercholesterolemia; Hypertension; Lovastatin; Male; Middle Aged; Random Allocation; Simvastatin | 1990 |
78 other study(ies) available for simvastatin and Blood Pressure, High
| Article | Year |
|---|---|
Co-administration of angiotensin II and simvastatin triggers kidney injury upon heme oxygenase-1 deficiency.
Topics: Angiotensin II; Animals; Glutathione; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension; Iron; Kidney; Mice; Mucin-1; Simvastatin | 2023 |
[Effects of changing the appearance of medications in safety and adherence in chronic patients over 65 years of age in primary care. CAMBIMED Study].
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Chronic Disease; Drug Labeling; Drug Packaging; Enalapril; Female; Follow-Up Studies; Humans; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Longitudinal Studies; Male; Medication Adherence; Medication Errors; Primary Health Care; Prospective Studies; Simvastatin | 2020 |
Statin Treatment and Clinical Outcomes of Heart Failure Among Africans: An Inverse Probability Treatment Weighted Analysis.
Topics: Aged; Atorvastatin; Atrial Fibrillation; Black People; Cardiomyopathy, Dilated; Cardiovascular Diseases; Cause of Death; Comorbidity; Coronary Artery Disease; Diabetes Mellitus; Fatty Acids, Monounsaturated; Fluvastatin; Ghana; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Indoles; Kaplan-Meier Estimate; Longitudinal Studies; Middle Aged; Mortality; Multivariate Analysis; Probability; Proportional Hazards Models; Renal Insufficiency, Chronic; Retrospective Studies; Rosuvastatin Calcium; Simvastatin; Treatment Outcome | 2017 |
Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension.
Topics: Angiotensin II; Animals; Cerebrovascular Circulation; Disease Models, Animal; Hypertension; Male; Microcirculation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Simvastatin | 2017 |
Protective effect of the standardized extract of ginkgo biloba (EGb761) against hypertension with hypercholesterolemia-induced renal injury in rats: Insights in the underlying mechanisms.
Topics: Animals; Blood Pressure; Creatinine; Diastole; Ginkgo biloba; Glutathione; Hypercholesterolemia; Hypertension; Kidney; Lipids; Losartan; Male; Malondialdehyde; Nitric Oxide Synthase Type III; Nitrites; Plant Extracts; Protective Agents; Rats, Wistar; Simvastatin; Systole; Urea | 2017 |
Co-Amorphous Simvastatin-Nifedipine with Enhanced Solubility for Possible Use in Combination Therapy of Hypertension and Hypercholesterolemia.
Topics: Anticholesteremic Agents; Antihypertensive Agents; Calorimetry, Differential Scanning; Drug Combinations; Drug Compounding; Drug Liberation; Drug Stability; Hypercholesterolemia; Hypertension; Molecular Structure; Nifedipine; Simvastatin; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2018 |
Clinical features related to statin-associated muscle symptoms.
Topics: Aged; Atorvastatin; Female; Heart Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Logistic Models; Lovastatin; Male; Medical History Taking; Middle Aged; Muscle Weakness; Muscular Diseases; Myalgia; Obesity; Odds Ratio; Pravastatin; Retrospective Studies; Rhabdomyolysis; Risk Factors; Rosuvastatin Calcium; Simvastatin; Smoking; White People | 2019 |
Factors associated with statin selection among privately insured commercial and Medicare patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Atorvastatin; Cardiovascular Diseases; Cohort Studies; Comorbidity; Drug Interactions; Dyslipidemias; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Insurance, Health; Male; Medicare; Middle Aged; Pravastatin; Pyrimidines; Pyrroles; Retrospective Studies; Rosuvastatin Calcium; Sex Factors; Simvastatin; Sulfonamides; United States; Young Adult | 2013 |
Integrative medicine. Cardiovascular health.
Topics: Combined Modality Therapy; Coronary Disease; Dietary Supplements; Female; Fish Oils; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Integrative Medicine; Middle Aged; Mind-Body Therapies; Phytotherapy; Psyllium; Simvastatin | 2013 |
Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Kidney; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; ras Proteins; Rats; Rats, Inbred SHR; Ribosomal Protein S6 Kinases; Signal Transduction; Simvastatin; Solitary Nucleus; Sympathetic Nervous System; Time Factors | 2013 |
[Intraoperative anaphylaxis due to beta-lactams in a hypertensive patient on angiotensin ii receptor antagonists and beta-blockers].
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Anaphylaxis; Angiotensin II Type 1 Receptor Blockers; Bisoprolol; Breast Neoplasms; Carcinoma, Lobular; Drug Therapy, Combination; Female; Humans; Hypertension; Intraoperative Complications; Losartan; Mammaplasty; Mastectomy; Simvastatin | 2015 |
[Myopathy and rhabdomyolysis after treatment with simvastatin, amlodipine, and roxithromycin].
Topics: Aged; Amlodipine; Anti-Bacterial Agents; Antihypertensive Agents; Drug Interactions; Humans; Hypertension; Male; Muscular Diseases; Rhabdomyolysis; Roxithromycin; Simvastatin | 2014 |
Simvastatin prescribing patterns before and after FDA dosing restrictions: a retrospective analysis of a large healthcare claims database.
Topics: Amlodipine; Calcium Channel Blockers; Comorbidity; Drug Interactions; Drug Labeling; Drug Prescriptions; Dyslipidemias; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Incidence; Insurance, Health; Male; Middle Aged; Muscular Diseases; Off-Label Use; Pharmacovigilance; Practice Patterns, Physicians'; Retrospective Studies; Risk Factors; Simvastatin; United States; United States Food and Drug Administration | 2015 |
The effect of simvastatin and pravastatin on arterial blood pressure, baroreflex, vasoconstrictor, and hypertensive effects of angiotensin II in Sprague-Dawley rats.
Topics: Angiotensin II; Animals; Baroreflex; Blood Pressure; Drug Synergism; Heart Rate; Hypertension; Male; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Vasoconstriction | 2014 |
A pharmacokinetic drug-drug interaction model of simvastatin and verapamil in humans.
Topics: Adult; Antihypertensive Agents; Area Under Curve; Calcium Channel Blockers; Cross-Over Studies; Double-Blind Method; Drug Incompatibility; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Models, Biological; Simvastatin; Verapamil; Young Adult | 2014 |
Availability and utilization of cardiovascular fixed-dose combination drugs in the United States.
Topics: Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus; Drug Combinations; Dyslipidemias; Humans; Hypertension; Hypoglycemic Agents; Hypolipidemic Agents; Lisinopril; Metformin; Practice Patterns, Physicians'; Simvastatin; United States; United States Food and Drug Administration | 2015 |
Vascular and metabolic effects of ezetimibe combined with simvastatin in patients with hypercholesterolemia.
Topics: Adiponectin; Aged; Animals; Anticholesteremic Agents; Blood Pressure; C-Reactive Protein; Drug Therapy, Combination; Ezetimibe; Fat Body; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Randomized Controlled Trials as Topic; Rats; Simvastatin; Single-Blind Method | 2015 |
Statin use associated with a reduced risk of pneumonia requiring hospitalization in patients with myocardial infarction: a nested case-control study.
Topics: Aged; Atorvastatin; Case-Control Studies; Comorbidity; Diabetes Mellitus; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heart Failure; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Incidence; Indoles; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Pneumonia; Protective Factors; Retrospective Studies; Risk Factors; Simvastatin; Stroke; Taiwan | 2016 |
[Drug interaction in 63-year-old male sportsman--a case report].
Topics: Amlodipine; Confusion; Dizziness; Drug Interactions; Exercise; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Myalgia; Simvastatin | 2015 |
3-Methylcholanthrene/Aryl-Hydrocarbon Receptor-Mediated Hypertension Through eNOS Inactivation.
Topics: Animals; Cerebrum; Down-Regulation; Endothelial Cells; Hypertension; Methylcholanthrene; Mice; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Protein Binding; Proto-Oncogene Proteins c-akt; Receptors, Aryl Hydrocarbon; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Time Factors | 2017 |
Statin-associated muscle symptoms and SLCO1B1 rs4149056 genotype in patients with familial hypercholesterolemia.
Topics: Age Factors; Body Mass Index; Cholesterol, LDL; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Hypertension; Liver-Specific Organic Anion Transporter 1; Male; Middle Aged; Myalgia; Odds Ratio; Pravastatin; Rosuvastatin Calcium; Simvastatin | 2016 |
Relation of Variability of Low-Density Lipoprotein Cholesterol and Blood Pressure to Events in Patients With Previous Myocardial Infarction from the IDEAL Trial.
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Blood Pressure; Cardiovascular Diseases; Cause of Death; Cholesterol, LDL; Dyslipidemias; Female; Humans; Hypertension; Male; Middle Aged; Mortality; Myocardial Infarction; Proportional Hazards Models; Randomized Controlled Trials as Topic; Secondary Prevention; Simvastatin; Stroke | 2017 |
Cost-effectiveness of the polypill versus risk assessment for prevention of cardiovascular disease.
Topics: Administration, Oral; Adult; Aged; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Computer Simulation; Cost-Benefit Analysis; Drug Combinations; Drug Costs; Dyslipidemias; Female; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Losartan; Male; Middle Aged; Models, Economic; Primary Prevention; Quality-Adjusted Life Years; Risk Assessment; Risk Factors; Simvastatin; Tablets; Time Factors; Treatment Outcome | 2017 |
Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatin.
Topics: Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atenolol; Azetidines; Carcinoma, Non-Small-Cell Lung; Coronary Artery Disease; Drug Interactions; Erlotinib Hydrochloride; Ezetimibe; Female; Humans; Hyperlipidemias; Hypertension; Lung Neoplasms; Neoplasm Recurrence, Local; Protein Kinase Inhibitors; Quinazolines; Rhabdomyolysis; Simvastatin; Tomography, X-Ray Computed | 2008 |
Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in Israel.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cohort Studies; Diabetes Mellitus; Drug Costs; Emigrants and Immigrants; Female; Follow-Up Studies; Health Maintenance Organizations; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Israel; Male; Medication Adherence; Middle Aged; Obesity; Organizations, Nonprofit; Patient Compliance; Retrospective Studies; Simvastatin; Social Class; Time Factors | 2008 |
The top 10 health stories of 2008.
Topics: Awareness; Azetidines; Blood Glucose; Brain Concussion; Delivery of Health Care; Diabetes Mellitus, Type 2; Diagnostic Imaging; Drug Combinations; Drugs, Generic; Ezetimibe, Simvastatin Drug Combination; Genetic Testing; Genomics; Health Care Reform; Humans; Hypertension; Periodicals as Topic; Simvastatin; Stem Cells; Warfare | 2008 |
Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with rapamycin plus tacrolimus in liver transplant patient.
Topics: Acute Kidney Injury; Anticholesteremic Agents; Drug Therapy, Combination; Fatal Outcome; Hepatitis C; Humans; Hypertension; Immunosuppressive Agents; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Mycophenolic Acid; Postoperative Complications; Rhabdomyolysis; Simvastatin; Tacrolimus | 2009 |
Potential savings without compromising the quality of care.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Antihypertensive Agents; Cost Savings; Cross-Sectional Studies; Diabetes Mellitus; Guideline Adherence; Health Expenditures; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Hypoglycemic Agents; Practice Guidelines as Topic; Primary Health Care; Quality of Health Care; Simvastatin; Sweden | 2009 |
Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension.
Topics: Albuminuria; Animals; Antioxidants; Cholesterol; Cyclic N-Oxides; Dietary Fats; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney Failure, Chronic; Male; Obesity; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Risk Factors; Simvastatin; Spin Labels | 2010 |
Lipid and C-reactive protein levels, cardiovascular disease risk factors and simvastatin treatment in Brazilian individuals.
Topics: Adult; Aged; Anthropometry; Blood Glucose; Brazil; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Europe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lipids; Male; Middle Aged; Obesity; Risk Factors; Simvastatin; Smoking; Triglycerides | 2010 |
ACCORD and Risk-Factor Control in Type 2 Diabetes.
Topics: Antihypertensive Agents; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fenofibrate; Humans; Hypertension; Hypolipidemic Agents; Risk Factors; Simvastatin | 2010 |
Asymmetric septal hypertrophy - a marker of hypertension in aortic stenosis (a SEAS substudy).
Topics: Aortic Valve Stenosis; Azetidines; Biomarkers; Cardiomegaly; Cardiomyopathy, Hypertrophic; Ezetimibe; Female; Heart Atria; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Simvastatin | 2010 |
Approach to the patient who is intolerant of statin therapy.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Atorvastatin; Coronary Disease; Diltiazem; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Middle Aged; Pyrroles; Simvastatin | 2010 |
The utility of observational studies in clinical decision making: lessons learned from statin trials.
Topics: Atorvastatin; Cardiovascular Diseases; Comparative Effectiveness Research; Decision Making; Epidemiologic Studies; Evidence-Based Medicine; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Observation; Pyrroles; Simvastatin | 2010 |
Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel.
Topics: Analysis of Variance; Animals; Blotting, Western; Cell Proliferation; Cerebrovascular Circulation; Chloride Channels; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Mevalonic Acid; Myocytes, Smooth Muscle; Polyisoprenyl Phosphates; Rats; rho-Associated Kinases; Simvastatin | 2010 |
Simvastatin prevents large blood pressure variability induced aggravation of cardiac hypertrophy in hypertensive rats by inhibiting RhoA/Ras-ERK pathways.
Topics: Animals; Blood Pressure; Cardiomegaly; Carotid Sinus; Cell Enlargement; Cholesterol; Denervation; Extracellular Signal-Regulated MAP Kinases; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lipoproteins, HDL; Male; Monomeric GTP-Binding Proteins; Myocytes, Cardiac; Rats; Rats, Inbred SHR; rhoA GTP-Binding Protein; Simvastatin; Treatment Outcome; Triglycerides; Ventricular Remodeling | 2011 |
Getting better value from the NHS drug budget.
Topics: Angiotensin II Type 1 Receptor Blockers; Budgets; Drugs, Generic; Health Care Reform; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Losartan; Patents as Topic; Practice Patterns, Physicians'; Prescription Drugs; Simvastatin; State Medicine; United Kingdom | 2010 |
Simvastatin-induced myopathy, the role of interaction with diltiazem and genetic predisposition.
Topics: Aged, 80 and over; Antihypertensive Agents; Biotransformation; Cytochrome P-450 CYP3A; Diltiazem; Drug Interactions; Female; Hong Kong; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Middle Aged; Muscular Diseases; Polymorphism, Genetic; Simvastatin; Treatment Outcome | 2011 |
Hip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects.
Topics: Aged; Atorvastatin; Body Mass Index; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Prospective Studies; Pyrroles; Simvastatin; Waist Circumference; Waist-Hip Ratio | 2011 |
Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats.
Topics: Animals; Apoptosis; Brain; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Estrogens; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Intracranial Aneurysm; Nitric Oxide Synthase Type III; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin | 2011 |
Oral simvastatin reduces the hypertensive response to air-jet stress.
Topics: Administration, Oral; Animals; Compressed Air; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Rats; Rats, Sprague-Dawley; Simvastatin; Stress, Physiological | 2012 |
Simvastatin attenuated cerebrovascular cell proliferation in the development of hypertension through Rho/Rho-kinase pathway.
Topics: Amides; Animals; Basilar Artery; Blood Pressure; Cell Proliferation; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocytes, Smooth Muscle; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin | 2012 |
[Bilateral occipital intraparenchymatous hemorrhage].
Topics: Cerebral Hemorrhage; Functional Laterality; Humans; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Male; Middle Aged; Occipital Lobe; Simvastatin; Tomography, X-Ray Computed | 2003 |
Niacin and the National Cholesterol Education Program Adult Treatment Panel III Guidelines: case studies.
Topics: Aspirin; Atenolol; Blood Chemical Analysis; Coronary Disease; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Niacin; Obesity; Risk Factors; Simvastatin | 2003 |
Statins: new data in secondary prevention and diabetes. Pravastatin and simvastatin are the best-assessed statins.
Topics: Aged; Anticholesteremic Agents; Clinical Trials as Topic; Coronary Disease; Diabetes Mellitus; Drug Evaluation; Heptanoic Acids; Humans; Hypertension; Pravastatin; Pyrroles; Rhabdomyolysis; Simvastatin; Stroke; Treatment Outcome | 2003 |
[Primary prevention of stroke. What helps--what does not help? The guidelines of the German Society of Neurology briefly summarized].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Alcohol Drinking; Anticholesteremic Agents; Anticoagulants; Antihypertensive Agents; Arrhythmias, Cardiac; Aspirin; Atenolol; Atrial Fibrillation; Carotid Artery, Internal; Carotid Stenosis; Chlorthalidone; Clinical Trials as Topic; Diabetes Complications; Diuretics; Doxazosin; Female; Fibrinolytic Agents; Hormone Replacement Therapy; Humans; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Life Style; Losartan; Male; Neurology; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Pravastatin; Primary Prevention; Risk Factors; Simvastatin; Smoking; Societies, Medical; Stroke | 2003 |
Comparing two different therapies.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Brachial Artery; Drug Therapy, Combination; Humans; Hypertension; Hypolipidemic Agents; Lisinopril; Patient Selection; Prospective Studies; Pulsatile Flow; Randomized Controlled Trials as Topic; Simvastatin; Ultrasonography | 2003 |
Rhabdomyolysis induced by a single dose of a statin.
Topics: Dyspnea; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Rhabdomyolysis; Simvastatin; Ventricular Dysfunction, Left | 2004 |
Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension.
Topics: Animals; Aorta; Blood Pressure; Body Weight; Coenzymes; DNA; Enzyme Inhibitors; Fibrosis; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Rats; Rats, Wistar; Simvastatin; Ubiquinone; Ventricular Remodeling | 2004 |
Statins induce the regression of left ventricular mass in patients with angina.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Cardiomegaly; Case-Control Studies; Constriction, Pathologic; Drug Evaluation; Female; Heart Ventricles; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Pravastatin; Retrospective Studies; Simvastatin | 2004 |
Blood pressure control and factors predicting control in a treatment-compliant male veteran population.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Comorbidity; Demography; Humans; Hypertension; Male; Middle Aged; Patient Care Planning; Patient Compliance; Prognosis; Retrospective Studies; Risk Factors; Simvastatin; Treatment Outcome; Veterans | 2004 |
Increased soluble CD40L levels are reduced by long-term simvastatin treatment in peritoneally dialyzed patients.
Topics: Arteriosclerosis; C-Reactive Protein; CD40 Ligand; E-Selectin; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Inflammation; Kidney Failure, Chronic; Male; Middle Aged; P-Selectin; Peritoneal Dialysis, Continuous Ambulatory; Platelet Aggregation; Simvastatin; Solubility; von Willebrand Factor | 2004 |
Statin-associated exacerbation of myasthenia gravis.
Topics: Atorvastatin; Cytokines; Dysarthria; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Lovastatin; Male; Middle Aged; Mitochondria; Models, Neurological; Muscular Diseases; Myasthenia Gravis; Neural Conduction; Pravastatin; Pyridostigmine Bromide; Pyrroles; Simvastatin; Th2 Cells; Ubiquinone | 2004 |
Beneficial effect of simvastatin and pravastatin treatment on adverse cardiac remodelling and glomeruli loss in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney Glomerulus; Male; Myocardium; Myocytes, Cardiac; Pravastatin; Rats; Rats, Inbred SHR; Simvastatin; Triglycerides; Ventricular Remodeling | 2005 |
Rosuvastatin, but not simvastatin, provides end-organ protection in stroke-prone rats by antiinflammatory effects.
Topics: Acute-Phase Proteins; Animals; Cerebral Arteries; Chemokine CCL2; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; P-Selectin; Proteinuria; Pyrimidines; Rats; Rats, Inbred SHR; RNA, Messenger; Rosuvastatin Calcium; Simvastatin; Sodium Chloride, Dietary; Stroke; Sulfonamides; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Vasculitis | 2005 |
Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin.
Topics: Amides; Animals; Aorta, Thoracic; Calcium Chloride; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Indoles; Male; Mevalonic Acid; Muscle Relaxants, Central; Norepinephrine; Phenylephrine; Potassium Chloride; Pyridines; Rats; Rats, Inbred SHR; Simvastatin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
[Effects of simvastatin on the left ventricular hypertrophy in spontaneously hypertensive rats and its relationship with the expression of protein kinase B].
Topics: Animals; Hypertension; Hypertrophy, Left Ventricular; Male; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Simvastatin | 2005 |
Simvastatin and losartan enhance nitric oxide and reduce oxidative stress in salt-induced hypertension.
Topics: Acetylcholine; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Body Weight; Drug Therapy, Combination; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Kidney; Losartan; Male; Mesenteric Arteries; Myocardium; Nitric Oxide; Organ Size; Oxidative Stress; Prostaglandins; Rats; Rats, Inbred Dahl; Simvastatin; Sodium Chloride, Dietary; Superoxides; Thromboxane A2; Treatment Outcome; Vasoconstriction; Vasodilator Agents | 2005 |
Statins for high-risk patients without heart disease or high cholesterol.
Topics: Atorvastatin; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Diabetes Mellitus, Type 2; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Pravastatin; Pyrroles; Simvastatin; Stroke | 2006 |
Effects of glitazones on blood pressure and vascular structure in mesenteric resistance arteries and basilar artery from genetically hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Basilar Artery; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypertrophy, Left Ventricular; Mesenteric Arteries; Pioglitazone; Rats; Rats, Inbred SHR; Rats, Wistar; Rosiglitazone; Simvastatin; Tetrazoles; Thiazolidinediones; Tunica Media; Valine; Valsartan | 2005 |
[Effect of 6-month therapy with simvastatin on lipid transport function of the blood and the state of endothelium in patients with diabetes and hypertension].
Topics: Biomarkers; Blood Pressure; Diabetes Mellitus; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Hypertension; Hypolipidemic Agents; Lipid Peroxidation; Lipids; Male; Middle Aged; Nitric Oxide; Simvastatin; Time Factors; Treatment Outcome; Vasodilation | 2006 |
Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study.
Topics: Adult; Age Factors; Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins B; Black or African American; Cholesterol, HDL; Cholesterol, LDL; Demography; Female; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Peptide Fragments; Phenotype; Sex Factors; Simvastatin; Smoking; Treatment Outcome; Triglycerides; White People | 2006 |
[Simvastatin inhibits hypertension-induced cardiac hypertrophy in rats through activation of heme oxygenase-1/carbon monoxide pathway].
Topics: Angiotensins; Animals; Carbon Monoxide; Cardiomegaly; Cell Enlargement; Heme Oxygenase-1; Hypertension; Male; Myocytes, Cardiac; Rats; Rats, Wistar; Signal Transduction; Simvastatin | 2006 |
Statins and cerebral vasomotor reactivity: implications for a new therapy?
Topics: Adult; Animals; Arginine; Atorvastatin; Brain Ischemia; Cerebrovascular Circulation; Clinical Trials, Phase II as Topic; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Intracranial Aneurysm; Mice; Middle Cerebral Artery; Nitric Oxide; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Simvastatin; Stroke; Subarachnoid Hemorrhage; Ultrasonography, Doppler, Transcranial; Vasodilation; Vasomotor System; Vasospasm, Intracranial | 2006 |
Evaluation of the cost savings and clinical outcomes of switching patients from atorvastatin to simvastatin and losartan to candesartan in a Primary Care setting.
Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Benzimidazoles; Biphenyl Compounds; Cost Savings; Cost-Benefit Analysis; Drug Costs; Drugs, Generic; Family Practice; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Losartan; Male; Middle Aged; Patient Satisfaction; Pyrroles; Simvastatin; Tetrazoles; Treatment Outcome | 2007 |
The effect of diet on simvastatin and losartan enhancement of endothelial function.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Diet; Diet, Sodium-Restricted; Dietary Fats; Endothelium, Vascular; Epoprostenol; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney; Lipids; Losartan; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Simvastatin; Sodium, Dietary; Superoxides; Thromboxane A2 | 2007 |
Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension.
Topics: Animals; Brain; Coenzymes; Disease Models, Animal; Down-Regulation; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Liver; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Simvastatin; Time Factors; Ubiquinone | 2007 |
Simvastatin reverses target organ damage and oxidative stress in Angiotensin II hypertension: comparison with apocynin, tempol, and hydralazine.
Topics: Acetophenones; Albuminuria; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Cardiomegaly; Carotid Arteries; Cyclic N-Oxides; Hydralazine; Hypertension; Hypolipidemic Agents; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Spin Labels; Superoxides; Tunica Media | 2007 |
The cost-effectiveness of the treatment of high risk women with osteoporosis, hypertension and hyperlipidaemia in Sweden.
Topics: Aged; Aged, 80 and over; Alendronate; Antihypertensive Agents; Bone Density Conservation Agents; Cost-Benefit Analysis; Female; Health Care Costs; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Middle Aged; Models, Econometric; Osteoporosis, Postmenopausal; Quality-Adjusted Life Years; Simvastatin; Sweden | 2008 |
Evaluation of the clinical outcomes of switching patients from atorvastatin to simvastatin and losartan to candesartan in a primary care setting: 2 years on.
Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cholesterol; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Hypertension; Losartan; Male; Pyrroles; Retrospective Studies; Simvastatin; Tetrazoles; Therapeutic Equivalency; Treatment Outcome | 2008 |
Simvastatin reverses the hypertension of heterozygous mice lacking cystathionine beta-synthase and apolipoprotein A-I.
Topics: Animals; Antihypertensive Agents; Aorta; Apolipoprotein A-I; Blood Pressure; Blotting, Western; Chromatography, Liquid; Cystathionine beta-Synthase; Endothelium, Vascular; Heterozygote; Hypertension; Lipoproteins; Male; Mice; Nitrates; Nitric Oxide; Nitrites; Simvastatin | 2008 |
Bilateral posterior ischemic optic neuropathy associated with use of sildenafil.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypotension; Male; Optic Nerve; Optic Neuropathy, Ischemic; Phosphodiesterase Inhibitors; Piperazines; Purines; Retinal Artery; Risk Factors; Sildenafil Citrate; Simvastatin; Sulfones; Vision, Low | 2008 |
Cardiovascular risk in hypertension: implications of the Sheffield Table for lipid-lowering strategy.
Topics: Aged; Anticholesteremic Agents; Cholesterol; Coronary Artery Disease; Humans; Hypertension; Prospective Studies; Risk Factors; Simvastatin; Treatment Outcome | 1998 |
The management of hypercholesterolaemia in patients with coronary artery disease referred for coronary angiography.
Topics: Aged; Anticholesteremic Agents; Cholesterol; Cohort Studies; Coronary Angiography; Coronary Disease; Data Interpretation, Statistical; Diabetes Complications; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Pravastatin; Risk Factors; Simvastatin; Smoking; Treatment Outcome | 1998 |
A comparison of the use, effectiveness and safety of bezafibrate, gemfibrozil and simvastatin in normal clinical practice using the New Zealand Intensive Medicines Monitoring Programme (IMMP).
Topics: Bezafibrate; Cohort Studies; Comorbidity; Diabetes Complications; Female; Gemfibrozil; Humans; Hypertension; Lipids; Male; Myocardial Ischemia; New Zealand; Practice Patterns, Physicians'; Product Surveillance, Postmarketing; Random Allocation; Retrospective Studies; Risk Factors; Simvastatin; Surveys and Questionnaires; Treatment Outcome | 1999 |
Effects of chronic treatment with simvastatin on endothelial dysfunction in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Cardiotonic Agents; Endothelium, Vascular; Enzyme Inhibitors; Follow-Up Studies; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Nitric Oxide Synthase; Nitroarginine; Ouabain; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Simvastatin; Vasodilation; Vasodilator Agents | 1999 |
[Simvastatin attenuates cardiovascular effects and oxidative stress induced by angiotensin II].
Topics: Angiotensin II; Animals; Anticholesteremic Agents; Blood Pressure; Cardiomegaly; Hypertension; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin | 2001 |
Simvastatin improves endothelial function in spontaneously hypertensive rats through a superoxide dismutase mediated antioxidant effect.
Topics: Animals; Antioxidants; Aorta; Endothelium, Vascular; Glutathione Peroxidase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Simvastatin; Superoxide Dismutase; Superoxides | 2002 |