Compounds > simvastatin
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simvastatin and Blood Poisoning

simvastatin has been researched along with Blood Poisoning in 50 studies

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (24.00)29.6817
2010's32 (64.00)24.3611
2020's6 (12.00)2.80

Authors

AuthorsStudies
Chen, J; Huang, MJ; Wu, XM; Xu, L; Zhang, YK1
Arnaboldi, F; Bitto, N; Colombo, M; Denti, L; Dondossola, D; Gagliano, N; La Mura, V; Latini, R; Liguori, E; Peyvandi, F; Procacci, P; Ristagno, G; Salerno, F; Sartori, P; Tripodi, A1
Alberici, LC; Catalão, CHR; da Costa, LHA; de Oliveira Souza, A; Dos Santos, JR; Rocha, MJA; Santos-Junior, NN1
Baron, RM; Conlon, J; Guan, J; Levitt, JE; Matthay, MA; McAuley, DF; Moore, AR; O'Kane, CM; Pienkos, SM; Rogers, AJ1
Alberici, LC; Cárnio, EC; Catalão, CHR; da Costa, LHA; Rocha, MJA; Santos-Junior, NN; Sebollela, A; Souza, AO1
Bozza, PT; de Castro Faria Neto, HC; de Jesus Oliveira, FM; de Moraes, IMM; Gonçalves-de-Albuquerque, CF; Reis, PA; Rocha, VN; Silva, AR1
Dancer, RCA; Greenwood, HL; Hazeldine, J; Lord, JM; Nightingale, P; Parekh, D; Patel, JM; Sadhra, C; Sapey, E; Thickett, DR; Walton, GM1
Ateş, G; Aydın, I; Ergüven, M; Özkök, E; Tamer, Ş; Yorulmaz, H1
Wang, Y; Yang, W; Zhang, L; Zhang, R; Zhao, X1
Chang, SS; Hsu, TC; Lee, CC; Lee, M; Lee, MG; Porta, L; Tsai, KC; Yo, CH1
Wang, Y; Yang, W; Zhang, R; Zhao, X1
Haußmann-Vopel, S; Lehmann, C; Pavlovic, D; Wegner, A1
Amidžić, L; Gajanin, R; Jaćević, V; Kuča, K; Nežić, L; Škrbić, R1
Abreu, AG; Braga Filho, JAF; Cysne, DN; Fortes, TS; Guerra, RNM; Maciel, MCG; Nascimento, FRF; Nascimento, JR; Rios, CEP; Serezani, CH; Silva, DLF; Silva, LA; Trovão, LO1
Wang, X; Wang, Y; Yang, W; Zhang, R; Zhao, X1
Gordon, A; McAuley, DF; O'Kane, C; Prevost, AT; Santhakumaran, S; Shankar-Hari, M1
Fang, P; Lin, J; Qin, L; Xie, X1
Bruns, HA; DeWalt, RI; McDowell, SA; Petkovich, DA; Zahrt, AN1
Drazen, JM; Gelijns, AC1
Dancer, RC; Greenwood, H; Khiroya, H; Mahida, R; Parekh, D; Patel, J; Sapey, E; Thickett, DR; Wang, Q1
Fonseca, CD; Santos, Fdo N; Vasco, CF; Vattimo, Mde F; Watanabe, M1
Huang, CJ; Kao, MC; Li, KY; Shih, PC; Tsai, PS; Yang, CH1
Ates, G; Ozkok, E; Serdaroglu-Oflazer, P; Tamer, AS; Yorulmaz, H1
Abid, T; Ahmed, A; Aird, WC; Berghelli, AV; Chase, M; David, S; Donnino, MW; Ghosh, CC; Haller, H; Kielstein, JT; Maski, MR; Milam, KE; Parikh, SM; Rajakumar, A; Santel, A; Schrimpf, C; Thamm, K; Thickett, D; Wang, K1
Hay, JG; Sauthoff, H1
Azevedo, ÍM; Carvalho, MD; Higuchi, T; Javadi, SM; Lima, FP; Macedo, R; Medeiros, AC; Medeiros, Vde F1
Chen, L; He, ZJ; Li, WC; Zheng, YK; Zhou, L; Zhou, MG; Zou, ZJ1
Guo, Z; Huang, X; Qin, B; Shao, H; Wang, C; Zhang, H; Zhu, W1
Durand, A; Gleeson, J; Grimaldi, D; Taccone, FS1
Alberici, LC; Catalão, CHR; da Costa, LHA; Rocha, MJA; Santos-Júnior, NN; Souza, AO1
Azevedo, ÍM; Carvalho, MD; Egito, ES; Medeiros, AC; Medeiros, VF1
Backman, JT; Bauer, M; Bläss, M; Brealey, D; Hargreaves, I; Lindig, S; McAuley, DF; Morel, J; Neergheen, V; Singer, M1
Alvarez de Sotomayor, M; Herrera, MD; Marhuenda, E; Mingorance, C; Vega, S1
Buerke, M; Buerke, U; Carter, JM; Grandel, U; Grimminger, F; Mueller-Werdan, U; Russ, M; Schlitt, A; Schmidt, H; Seeger, W; Sibelius, U; Werdan, K1
Fraunberger, P; Gröne, E; Gröne, HJ; Walli, AK1
Adhikari, NK; Almog, Y; Amichay, D; Douvdevani, A; Eisinger, M; Frenkel, A; Novack, V; Terblanche, M1
Falagas, ME; Kopterides, P1
Jeppsson, B; Laschke, MW; Menger, MD; Schilling, MK; Slotta, JE; Thorlacius, H1
Araújo-Filho, I; Azevedo, IM; Egito, ES; Jácome, DT; Medeiros, AC; Rêgo, AC1
Beffa, DC; Carter, EA; Fagan, SP; Fischman, AJ; Hamrahi, VF; Kaneki, M; Paul, KW; Tompkins, RG; Yu, YM1
Qi, Z; Rahman, M; Thorlacius, H; Zhang, S1
Jeppsson, B; Lepsenyi, M; Luo, L; Rahman, M; Syk, I; Thorlacius, H; Wang, Y; Zhang, S1
Bruns, HA; Burns, EM; Kushdilian, M; McDowell, SA; Smelser, LK; Stankiewicz, TE; Then, JE1
Hanrath, P; Janssens, U; Liehn, EA; Lütticken, R; Merx, MW; Schrader, J; Weber, C1
Amigues, L; Beraud, JJ; Canaud, B; Cristol, JP; Delbosc, S; Durant, R; Klouche, K; Morena, M1
Stamm, J1
Hu, X; Star, RA; Yasuda, H; Yuen, PS; Zhou, H1
Barber, VS; Drage, SM; Young, JD1
Araújo Filho, I; Azevedo, IM; Brandão-Neto, J; Dominici, VA; Egito, ES; Medeiros, AC; Rego, AC; Souza Neto, JL1
Garcia, JG; Jacobson, JR1

Reviews

3 review(s) available for simvastatin and Blood Poisoning

ArticleYear
Failure of statins in ARDS: the quest for the Holy Grail continues.
    Minerva anestesiologica, 2016, Volume: 82, Issue:11

    Topics: Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Failure; Randomized Controlled Trials as Topic; Renal Insufficiency; Respiration, Artificial; Respiratory Distress Syndrome; Rosuvastatin Calcium; Sepsis; Simvastatin; Treatment Failure

2016
Statins for sepsis: a critical and updated review.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2009, Volume: 15, Issue:4

    Topics: Anticholesteremic Agents; Atorvastatin; Bacterial Infections; Heptanoic Acids; Humans; Pyrroles; Sepsis; Simvastatin; Treatment Outcome

2009
Novel therapies for microvascular permeability in sepsis.
    Current drug targets, 2007, Volume: 8, Issue:4

    Topics: Adenosine Triphosphate; Animals; Capillaries; Capillary Permeability; Dogs; Humans; Lysophospholipids; Protein C; Sepsis; Simvastatin; Sphingosine; Venules

2007

Trials

8 trial(s) available for simvastatin and Blood Poisoning

ArticleYear
Pre-treatment and continuous administration of simvastatin during sepsis improve metabolic parameters and prevent CNS injuries in survivor rats.
    Molecular and cellular biochemistry, 2022, Volume: 477, Issue:11

    Topics: Animals; Cytokines; Disease Models, Animal; Gliosis; Rats; Sepsis; Simvastatin; Survivors

2022
Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials.
    Critical care (London, England), 2023, 03-28, Volume: 27, Issue:1

    Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Respiratory Distress Syndrome; Rosuvastatin Calcium; Sepsis; Simvastatin

2023
Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Which Is Improved by Simvastatin.
    American journal of respiratory and critical care medicine, 2017, 11-15, Volume: 196, Issue:10

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Community-Acquired Infections; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immune System Diseases; Leukocyte Disorders; Male; Middle Aged; Respiratory Tract Infections; Sepsis; Simvastatin

2017
Simvastatin to modify neutrophil function in older patients with septic pneumonia (SNOOPI): study protocol for a randomised placebo-controlled trial.
    Trials, 2014, Aug-22, Volume: 15

    Topics: Administration, Oral; Age Factors; Aged; Anti-Inflammatory Agents; Biomarkers; Clinical Protocols; Community-Acquired Infections; England; Extracellular Traps; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Middle Aged; Neutrophils; Pneumonia, Bacterial; Reactive Oxygen Species; Research Design; Sepsis; Simvastatin; Time Factors; Treatment Outcome

2014
Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis.
    Critical care medicine, 2015, Volume: 43, Issue:7

    Topics: Aged; Angiopoietin-2; Animals; Case-Control Studies; Drug Repositioning; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Middle Aged; Sepsis; Simvastatin

2015
[Influence of simvastatin treatment on Toll-like receptor 4 in monocytes of peripheral blood in patients with sepsis and severe sepsis].
    Zhonghua wei zhong bing ji jiu yi xue, 2016, Volume: 28, Issue:2

    Topics: Down-Regulation; Flow Cytometry; Humans; Intensive Care Units; Monocytes; Prospective Studies; Sepsis; Simvastatin; Toll-Like Receptor 4

2016
Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis.
    Clinical science (London, England : 1979), 2017, Apr-25, Volume: 131, Issue:8

    Topics: Animals; Cholesterol, LDL; Combined Modality Therapy; Cytokines; Drug Evaluation, Preclinical; Fluid Therapy; Gene Expression Profiling; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kaplan-Meier Estimate; Liver; Male; Mitochondria; Muscle, Skeletal; Myocardium; Oxygen Consumption; Rats, Wistar; Sepsis; Simvastatin; Tissue Culture Techniques; Ubiquinone

2017
The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial.
    Intensive care medicine, 2009, Volume: 35, Issue:7

    Topics: Aged; Aged, 80 and over; Bacterial Infections; Cytokines; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Male; Middle Aged; Sepsis; Simvastatin

2009

Other Studies

39 other study(ies) available for simvastatin and Blood Poisoning

ArticleYear
Simvastatin inhibits the inflammation and oxidative stress of human neutrophils in sepsis via autophagy induction.
    Molecular medicine reports, 2022, Volume: 25, Issue:1

    Topics: Adult; Aged; Animals; Autophagy; Beclin-1; Cell Survival; Cytokines; Female; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Male; Middle Aged; Neutrophils; Oxidative Stress; Reactive Oxygen Species; Sepsis; Simvastatin; Tumor Necrosis Factor-alpha

2022
Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia.
    Cells, 2022, 03-29, Volume: 11, Issue:7

    Topics: Animals; Disease Models, Animal; Endothelial Cells; Endotoxemia; Fibrin; Hemostatics; Lipopolysaccharides; Liver Diseases; Male; Necrosis; Rats; Rats, Wistar; Sepsis; Simvastatin; Thrombosis; von Willebrand Factor

2022
Simvastatin Prevents Long-Term Cognitive Deficits in Sepsis Survivor Rats by Reducing Neuroinflammation and Neurodegeneration.
    Neurotoxicity research, 2020, Volume: 38, Issue:4

    Topics: Animals; Brain; Cognitive Dysfunction; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Neurodegenerative Diseases; Rats; Rats, Wistar; Sepsis; Simvastatin

2020
Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis.
    Mediators of inflammation, 2020, Volume: 2020

    Topics: Animals; Cytokines; Inflammation; Male; Mice; Nitric Oxide; Peritoneal Lavage; Sepsis; Simvastatin; Stem Cells

2020
The impact of pretreatment with simvastatin on kidney tissue of rats with acute sepsis.
    Physiology international, 2017, Jun-01, Volume: 104, Issue:2

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Kidney; Male; Nephritis; Premedication; Rats; Rats, Wistar; Sepsis; Simvastatin; Treatment Outcome

2017
An experimental study of the protective effect of simvastatin on sepsis-induced myocardial depression in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 94

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardium; Myocytes, Cardiac; NF-kappa B; Rats; Rats, Wistar; Sepsis; Signal Transduction; Simvastatin; Toll-Like Receptor 4; Transcription Factor RelA

2017
A Population-Based Cohort Study on the Drug-Specific Effect of Statins on Sepsis Outcome.
    Chest, 2018, Volume: 153, Issue:4

    Topics: Aged; Anti-Infective Agents; Atorvastatin; Cohort Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Respiratory Insufficiency; Rosuvastatin Calcium; Sepsis; Simvastatin; Taiwan; Treatment Outcome

2018
Experimental Study of the Protective Effect of Simvastatin on Lung Injury in Rats with Sepsis.
    Inflammation, 2018, Volume: 41, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Caspase 3; Cytokines; Cytoprotection; Deoxyguanosine; Disease Models, Animal; Inflammation Mediators; Lipocalin-2; Lung; Male; Malondialdehyde; Oxidative Stress; Pulmonary Edema; Rats, Wistar; Sepsis; Signal Transduction; Simvastatin; Superoxide Dismutase; Toll-Like Receptor 4; Transcription Factor RelA

2018
Impact of lipid modulation on the intestinal microcirculation in experimental sepsis.
    Microvascular research, 2018, Volume: 120

    Topics: Animals; Anti-Inflammatory Agents; Bezafibrate; Blood Flow Velocity; Capillaries; Cytokines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Intestines; Intravital Microscopy; Leukocyte Rolling; Lipid Metabolism; Lipopolysaccharides; Lipoproteins, HDL; Male; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Rats, Inbred Lew; Regional Blood Flow; Sepsis; Simvastatin

2018
Simvastatin Protects Cardiomyocytes Against Endotoxin-induced Apoptosis and Up-regulates Survivin/NF-κB/p65 Expression.
    Scientific reports, 2018, 10-02, Volume: 8, Issue:1

    Topics: Administration, Oral; Animals; Apoptosis; Cardiomyopathies; Caspase 3; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Escherichia coli; Heart; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Wistar; Sepsis; Signal Transduction; Simvastatin; Survivin; Transcription Factor RelA; Up-Regulation

2018
Prophylactic Treatment With Simvastatin Modulates the Immune Response and Increases Animal Survival Following Lethal Sepsis Infection.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; CD4-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Hydrogen Peroxide; Male; Mice; Sepsis; Simvastatin

2018
Effect of Simvastatin on the Intestinal Rho/ROCK Signaling Pathway in Rats With Sepsis.
    The Journal of surgical research, 2018, Volume: 232

    Topics: Animals; Fatty Acid-Binding Proteins; Intestines; Male; Oxidative Stress; Rats; Rats, Wistar; rho-Associated Kinases; Sepsis; Signal Transduction; Simvastatin; Zonula Occludens-1 Protein

2018
Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials.
    Critical care (London, England), 2019, 05-03, Volume: 23, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents; APACHE; Cardiotonic Agents; Critical Illness; Female; Guideline Adherence; Hospital Mortality; Humans; Hydrocortisone; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intensive Care Units; Male; Middle Aged; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sepsis; Simendan; Simvastatin; Treatment Outcome; Vasoconstrictor Agents; Vasopressins

2019
Prophylactic simvastatin treatment modulates the immune response and increases survival of mice following induction of lethal sepsis.
    The Journal of international medical research, 2019, Volume: 47, Issue:8

    Topics: Animals; Anticholesteremic Agents; Female; Immunity, Cellular; Ligation; Male; Mice; Mice, Inbred C57BL; Sepsis; Simvastatin; Survival Rate

2019
Host cell invasion by Staphylococcus aureus stimulates the shedding of microvesicles.
    Biochemical and biophysical research communications, 2013, Mar-22, Volume: 432, Issue:4

    Topics: Cell Line; Cytoplasmic Vesicles; Host-Pathogen Interactions; Humans; Lung; Protein Transport; Sepsis; Simvastatin; Staphylococcal Infections; Staphylococcus aureus; Thromboplastin

2013
Statin strikeout.
    The New England journal of medicine, 2014, Jun-05, Volume: 370, Issue:23

    Topics: Female; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pulmonary Disease, Chronic Obstructive; Pyrimidines; Respiratory Distress Syndrome; Rosuvastatin Calcium; Sepsis; Simvastatin; Sulfonamides

2014
[Antioxidant protection of statins in acute kidney injury induced by sepsis].
    Revista da Escola de Enfermagem da U S P, 2014, Volume: 48, Issue:5

    Topics: Acute Kidney Injury; Animals; Antioxidants; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rats; Rats, Wistar; Sepsis; Simvastatin

2014
Simvastatin attenuates sepsis-induced blood-brain barrier integrity loss.
    The Journal of surgical research, 2015, Volume: 194, Issue:2

    Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain; Brain Diseases; Chemokine CXCL2; Claudin-3; Claudin-5; Drug Evaluation, Preclinical; Edema; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-6; Male; Malondialdehyde; Oxidative Stress; Random Allocation; Rats, Sprague-Dawley; Sepsis; Simvastatin; Survival Rate

2015
Effects of prior treatment with simvastatin on skeletal muscle structure and mitochondrial enzyme activities during early phases of sepsis.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:12

    Topics: Animals; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Male; Mitochondria; Muscle, Skeletal; Rats; Rats, Wistar; Sepsis; Simvastatin

2014
New Drug for Sepsis on the Cheap?
    Critical care medicine, 2015, Volume: 43, Issue:7

    Topics: Angiopoietin-2; Animals; Female; Forkhead Transcription Factors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Sepsis; Simvastatin

2015
Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition.
    Acta cirurgica brasileira, 2015, Volume: 30, Issue:6

    Topics: Animals; Disease Models, Animal; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intraabdominal Infections; Kidney; Liver; Lung; Radionuclide Imaging; Radiopharmaceuticals; Random Allocation; Rats, Wistar; Reproducibility of Results; Sepsis; Simvastatin; Technetium Tc 99m Sestamibi; Time Factors; Treatment Outcome

2015
Effects of simvastatin on the expression of inducible NOS in acute lung injury in septic rats.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:11

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Sepsis; Simvastatin

2015
Brain Oxidative Stress During Experimental Sepsis Is Attenuated by Simvastatin Administration.
    Molecular neurobiology, 2017, Volume: 54, Issue:9

    Topics: Animals; Apoptosis; Brain; Caspase 3; Cecum; Citrate (si)-Synthase; Cytokines; Glial Fibrillary Acidic Protein; Hippocampus; Ligation; Male; Models, Biological; Nitrates; Oxidative Stress; Prefrontal Cortex; Punctures; Rats, Wistar; Sepsis; Simvastatin; Thiobarbituric Acid Reactive Substances

2017
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats.
    Acta cirurgica brasileira, 2016, Volume: 31, Issue:12

    Topics: Animals; Cacao; Cocos; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Liver; Lung; Rats; Rats, Wistar; Resuscitation; Sepsis; Shock, Hemorrhagic; Simvastatin; Sodium Chloride; Water

2016
Effects of HMG-CoA reductase inhibition by simvastatin on vascular dysfunction induced by lipopolysaccharide in rats.
    Pharmacology, 2008, Volume: 82, Issue:2

    Topics: Animals; Aorta, Thoracic; Blood Pressure; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Sepsis; Simvastatin

2008
Apoptosis contributes to septic cardiomyopathy and is improved by simvastatin therapy.
    Shock (Augusta, Ga.), 2008, Volume: 29, Issue:4

    Topics: Animals; Apoptosis; Cardiomyopathies; Exotoxins; Heart; Hemodynamics; In Situ Nick-End Labeling; In Vitro Techniques; Myocardium; Necrosis; Rats; Sepsis; Simvastatin; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53

2008
Simvastatin reduces endotoxin-induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol.
    Shock (Augusta, Ga.), 2009, Volume: 32, Issue:2

    Topics: Animals; Anticholesteremic Agents; Cholesterol, LDL; Disease Models, Animal; Endotoxins; Guinea Pigs; Humans; Hydroxymethylglutaryl CoA Reductases; Liver; Male; NF-kappa B; Sepsis; Simvastatin; Tumor Necrosis Factors

2009
Simvastatin attenuates hepatic sensitization to lipopolysaccharide after partial hepatectomy.
    The Journal of surgical research, 2010, Volume: 162, Issue:2

    Topics: Alanine Transaminase; Animals; DNA Primers; DNA, Complementary; Hepatectomy; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Neutrophils; P-Selectin; Postoperative Complications; Reverse Transcriptase Polymerase Chain Reaction; Sepsis; Simvastatin; Tumor Necrosis Factor-alpha

2010
[Effect of the simvastatin in abdominal sepsis of diabetic rats].
    Revista do Colegio Brasileiro de Cirurgioes, 2010, Volume: 37, Issue:1

    Topics: Abdomen; Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Preoperative Care; Rats; Rats, Wistar; Sepsis; Simvastatin

2010
Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6.
    Burns : journal of the International Society for Burn Injuries, 2011, Volume: 37, Issue:2

    Topics: Animals; Burns; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Interleukin-6; Male; Mice; Sepsis; Simvastatin; Survival Analysis

2011
Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis.
    Journal of leukocyte biology, 2011, Volume: 89, Issue:5

    Topics: Abdomen; Animals; Anticholesteremic Agents; Blotting, Western; CD40 Ligand; Cell Proliferation; Chemokines, CXC; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Pulmonary Edema; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sepsis; Simvastatin

2011
Simvastatin protects against T cell immune dysfunction in abdominal sepsis.
    Shock (Augusta, Ga.), 2012, Volume: 38, Issue:5

    Topics: Animals; Anticholesteremic Agents; Apoptosis; Cytokines; HMGB1 Protein; Inflammation; Male; Mice; Sepsis; Simvastatin; Spleen; T-Lymphocytes, Regulatory

2012
Short term statin treatment improves survival and differentially regulates macrophage-mediated responses to Staphylococcus aureus.
    Current pharmaceutical biotechnology, 2013, Volume: 14, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Female; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Sepsis; Simvastatin; Staphylococcal Infections; Staphylococcus aureus

2013
HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis.
    Circulation, 2004, Jun-01, Volume: 109, Issue:21

    Topics: Animals; Aorta; Bradykinin; Cardiac Output; Cardiotonic Agents; Cecal Diseases; Cell Adhesion; Cells, Cultured; Coronary Circulation; Dobutamine; Drug Evaluation, Preclinical; Endothelium, Vascular; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Perforation; Leukocytes; Ligation; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Sepsis; Simvastatin; Ultrasonography

2004
Superoxide anion overproduction in sepsis: effects of vitamin e and simvastatin.
    Shock (Augusta, Ga.), 2004, Volume: 22, Issue:1

    Topics: APACHE; C-Reactive Protein; Cell Line; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocyte Count; Male; Middle Aged; Models, Biological; Oxidative Stress; Reference Values; Sepsis; Simvastatin; Superoxides; Tetradecanoylphorbol Acetate; Triglycerides; Vitamin E

2004
Simvastatin and survival in sepsis.
    Circulation, 2004, Sep-21, Volume: 110, Issue:12

    Topics: Animals; Bacteremia; Gram-Negative Bacterial Infections; Humans; Lipopolysaccharides; Mice; Premedication; Pyridines; Retrospective Studies; Sepsis; Simvastatin; Staphylococcal Infections

2004
Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects.
    Kidney international, 2006, Volume: 69, Issue:9

    Topics: Acute Kidney Injury; Animals; Antibodies; Blood Vessels; Delayed-Action Preparations; Hypoxia; Kidney Tubules; Lipids; Male; Mice; Mice, Inbred C57BL; Microcirculation; Permeability; Renal Circulation; Sepsis; Simvastatin; Tumor Necrosis Factor-alpha

2006
Statins and sepsis: panacea or Pandora's box?
    The Lancet. Infectious diseases, 2007, Volume: 7, Issue:2

    Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Randomized Controlled Trials as Topic; Sepsis; Simvastatin

2007
Effects of simvastatin in abdominal sepsis in rats.
    Acta cirurgica brasileira, 2006, Volume: 21 Suppl 4

    Topics: Animals; Anti-Inflammatory Agents; Cecum; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes; Lymphocytes; Neutrophils; Random Allocation; Rats; Rats, Wistar; Sepsis; Simvastatin; Tumor Necrosis Factor-alpha

2006