simvastatin and B16 Melanoma

Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Proliferation; Disease Progression; Liposomes; Macrophages; Male; Melanoma; Melanoma, Cutaneous Malignant; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Oxidative Stress; Simvastatin; Skin Neoplasms; Tumor Microenvironment; Xanthones

Topics: Angiogenesis Inhibitors; Animals; Cell Communication; Cell Movement; Cell Proliferation; Coculture Techniques; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Macrophages; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Neovascularization, Pathologic; Simvastatin; Tumor Microenvironment; Xanthones

Topics: Animals; Lymphangiogenesis; Lymphatic Metastasis; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Simvastatin; Skin Neoplasms

Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Female; Fluvastatin; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung Neoplasms; Melanoma, Experimental; Mice, Inbred C57BL; Signal Transduction; Simvastatin; Skin Neoplasms; Tumor Burden

Topics: Angiogenesis Modulating Agents; Animals; Antineoplastic Agents; Capillary Permeability; Carcinoma, Lewis Lung; Cell Hypoxia; Cells, Cultured; Cisplatin; Cyclophosphamide; Drug Synergism; Female; Free Radical Scavengers; Human Umbilical Vein Endothelial Cells; Humans; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Microvessels; Nitric Oxide Synthase Type III; Onium Compounds; Reactive Oxygen Species; Regional Blood Flow; Simvastatin; Tumor Burden; Ultrasonography; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

Topics: 3T3 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholesterol; Disease Progression; DNA-Binding Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Melanoma, Experimental; Mice; Mice, Inbred C57BL; RNA-Binding Proteins; Simvastatin; Skin Neoplasms; Survival; Survival Rate; Wound Healing

Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Melanoma, Experimental; Mice; Necrosis; Oxidation-Reduction; Oxidative Stress; Pravastatin; Simvastatin

Topics: Animals; Blotting, Western; Catalase; Cell Proliferation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Liposomes; Macrophages; Male; Malondialdehyde; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Nitric Oxide; Oxidative Stress; Simvastatin; Tumor Cells, Cultured

Topics: Actins; Animals; cdc42 GTP-Binding Protein; Cytochalasin D; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrogen-Ion Concentration; Matrix Metalloproteinase 9; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neuropeptides; Phospholipase D; Promoter Regions, Genetic; rac1 GTP-Binding Protein; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Simvastatin

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Proliferation; Cholesterol, LDL; Drug Synergism; Female; Immunoenzyme Techniques; Injections, Intraperitoneal; Lipids; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Paclitaxel; Receptors, LDL; Simvastatin; Tumor Cells, Cultured

Topics: Animals; Cell Division; Cell Line, Tumor; Cells, Cultured; Female; Interferon Regulatory Factors; Interleukin-10; Lymphocyte Activation; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Myeloid-Derived Suppressor Cells; Myelopoiesis; Nitric Oxide; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Simvastatin; T-Lymphocyte Subsets; Tumor Microenvironment

Topics: Administration, Oral; Animals; Antineoplastic Agents; Blotting, Western; Cell Adhesion; Cell Movement; Cell Survival; Extracellular Matrix Proteins; Fatty Acids, Monounsaturated; Female; Fluvastatin; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Integrins; Lim Kinases; Lung Neoplasms; Matrix Metalloproteinases; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Myosin Light Chains; Neoplasm Invasiveness; Phosphorylation; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Simvastatin; Time Factors

Topics: Aging; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Doxorubicin; Drug Synergism; Humans; Lovastatin; Melanoma, Experimental; Mice; Simvastatin