simvastatin has been researched along with B-Cell Chronic Lymphocytic Leukemia in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, TA; Hayslip, J; Leggas, M | 1 |
| Boccadoro, M; Buondonno, I; Campia, I; Castella, B; Coscia, M; Drandi, D; Foglietta, M; Griggio, V; Ladetto, M; Massaia, M; Riganti, C; Rigoni, M; Robino, M; Sciancalepore, P; Vitale, C | 1 |
| Chocholska, S; Dmoszynska, A; Halicka, D; Klimek, P; Kowal, M; Podhorecka, M | 1 |
| Chapman-Shimshoni, D; Lishner, M; Radnay, J; Shapiro, H; Yuklea, M | 1 |
1 trial(s) available for simvastatin and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Pharmacokinetics of high-dose simvastatin in refractory and relapsed chronic lymphocytic leukemia patients.
Topics: Administration, Oral; Area Under Curve; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Maximum Tolerated Dose; Pilot Projects; Recurrence; Simvastatin; Tandem Mass Spectrometry | 2013 |
3 other study(ies) available for simvastatin and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Cell Line; Cell Survival; Coculture Techniques; Doxorubicin; Drug Resistance, Multiple; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mutation; Signal Transduction; Simvastatin; Stromal Cells; Tumor Cells, Cultured | 2015 |
Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells.
Topics: ADP-ribosyl Cyclase 1; Anticholesteremic Agents; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Proteins; Cladribine; DNA-Binding Proteins; Enzyme Activation; Histones; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Prognosis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Purines; Simvastatin; Tumor Cells, Cultured; Tumor Suppressor Proteins; Vidarabine; ZAP-70 Protein-Tyrosine Kinase | 2010 |
Simvastatin induces apoptosis of B-CLL cells by activation of mitochondrial caspase 9.
Topics: Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Enzyme Activation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Lymphocytic, Chronic, B-Cell; Simvastatin; Tumor Cells, Cultured | 2003 |