simvastatin has been researched along with Astrocytoma, Grade IV in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 7 (87.50) | 2.80 |
| Authors | Studies |
|---|---|
| Bruinsmann, FA; de Cristo Soares Alves, A; de Fraga Dias, A; Figueiró, F; Lopes Silva, LF; Raffin Pohlmann, A; Sonvico, F; Stanisçuaski Guterres, S; Visioli, F | 1 |
| Guo, T; Li, H; Li, N; Wang, X; Xie, C; Yang, S; Zhou, S | 1 |
| Blanco-Acevedo, C; Castaño, JP; Doval-Rosa, C; Fuentes-Fayos, AC; G-García, ME; Gahete, MD; Jiménez-Vacas, JM; López, M; Luque, RM; Martín-Colom, J; Montero-Hidalgo, AJ; Ortega-Salas, RM; Peralbo-Santaella, E; Pérez-Gómez, JM; Sánchez-Sánchez, R; Solivera, J; Tena-Sempere, M; Toledano-Delgado, Á; Torres, E | 1 |
| Aghaei, M; Akbari, M; Albokashy, M; Alizadeh, J; Butterfield, Y; Cole, LK; Eftekharpour, E; Ghavami, S; Hatch, GM; Hombach-Klonisch, S; Islam, MI; Kardami, E; Klonisch, T; Koleini, N; Marzban, H; Samiei, E; Shojaei, S; Thliveris, J; Vosoughi, AR; Xu, F | 1 |
| Li, W; Li, Y; Wang, Q; Wei, X; Yang, T | 1 |
| Dastghaib, S; Ghavami, S; Mokarram, P; Mostafavi-Pour, Z; Patterson, JB; Samali, A; Sharma, P; Shojaei, S | 1 |
| Bates, SJ; Bianchetti, E; Nguyen, TTT; Roth, KA; Siegelin, MD | 1 |
| Bababeygy, SR; Hou, LC; Polevaya, NV; Prugpichailers, T; Steinman, L; Sun, A; Tse, V; Veeravagu, A; Xiong, A; Youssef, S | 1 |
8 other study(ies) available for simvastatin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Nose-to-brain delivery of simvastatin mediated by chitosan-coated lipid-core nanocapsules allows for the treatment of glioblastoma in vivo.
Topics: Administration, Intranasal; Animals; Brain; Cell Line, Tumor; Chitosan; Glioblastoma; Lipids; Nanocapsules; Rats; Simvastatin | 2022 |
Simvastatin Inhibits Tumor Growth and Migration by Mediating Caspase-1-Dependent Pyroptosis in Glioblastoma Multiforme.
Topics: Caspase 1; Glioblastoma; Humans; Hypolipidemic Agents; MicroRNAs; NLR Family, Pyrin Domain-Containing 3 Protein; Nucleotides; Pyroptosis; RNA, Messenger; Simvastatin | 2022 |
Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Mice; Proto-Oncogene Proteins c-akt; Retrospective Studies; Simvastatin; Transforming Growth Factor beta | 2023 |
Simvastatin increases temozolomide-induced cell death by targeting the fusion of autophagosomes and lysosomes.
Topics: Animals; Autophagosomes; Cell Death; Cell Line, Tumor; Female; Glioblastoma; Humans; Lysosomes; Macrolides; Mice; Simvastatin; Temozolomide; Xenograft Model Antitumor Assays | 2020 |
Inverse screening of Simvastatin kinase targets from glioblastoma druggable kinome.
Topics: Glioblastoma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Models, Molecular; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Kinases; Simvastatin | 2020 |
Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Glioblastoma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Phosphorylation; Signal Transduction; Simvastatin; Temozolomide; Unfolded Protein Response | 2020 |
RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in Glioblastoma Cells.
Topics: Astrocytes; bcl-X Protein; Biomarkers, Tumor; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Down-Regulation; Energy Metabolism; Gene Silencing; Glioblastoma; Humans; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Prognosis; Proto-Oncogene Proteins c-myc; rab GTP-Binding Proteins; Simvastatin | 2021 |
HMG-CoA reductase inhibition causes increased necrosis and apoptosis in an in vivo mouse glioblastoma multiforme model.
Topics: Acyl Coenzyme A; Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Glioblastoma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Mice; Mice, Inbred C57BL; Necrosis; Neoplasms, Experimental; Neovascularization, Physiologic; Simvastatin | 2009 |