simvastatin has been researched along with Asthma, Bronchial in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 16 (69.57) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Alabed, M; Elemam, NM; Hafezi, S; Halwani, R; Kalaji, Z; Mdkhana, B; Saheb Sharif-Askari, F; Saheb Sharif-Askari, N; Salam Bayram, O; Selvakumar, B | 1 |
| Chen, YR; Liu, D; Peng, B; Sun, F; Xiang, XD; Xiao, BW; Yan, MY | 1 |
| Agrawal, A; Ahmad, M; Ahmad, T; Ghosh, B; Khanna, K; Kulshreshtha, A; Singh, S | 1 |
| Basu, S; Bews, HJ; Carlson, JC; Halayko, AJ; Jha, A; Oo, O; Ryu, MH; Schwartz, J; Wong, CS | 1 |
| Spence, JD | 1 |
| Boskabady, MH; Jafari, M; Jahromi, GP; Khamse, S; Mohammadian, M; Nejad, AK; Sadeghipour, HR | 1 |
| Alcala, SE; Anderson, J; Benton, AS; Damsker, J; Freishtat, RJ; Hayes, K; Hoffman, EP; Kureshi, S; Lee, AJ; Nagaraju, K; Reeves, EM; Rose, MC; Wang, Z; Watson, AM; Williams, AM | 1 |
| Lee, SI; Liu, JN; Park, HS; Shin, YS; Suh, DH; Yang, EM | 1 |
| Boskabady, MH; Golchoobian, R; Jahromi, GP; Kashani, IR; Mohammadian, M; Nejad, AK; Omidi, A; Sadeghipour, HR | 1 |
| Bendella, Z; Boyaci, N; Gallert, WJ; Grensemann, B; Jungck, D; Knobloch, J; Koch, A; Körber, S; Yakin, Y; Yanik, SD | 1 |
| Cui, R; Ding, T; Gu, W; Guo, X; Han, F; Li, X; Peng, J; Xu, W | 1 |
| Han, W; Li, J; Sun, L; Tang, H | 1 |
| Franzi, L; Kenyon, NJ; Last, J; Zeki, AA | 1 |
| Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A | 1 |
| Cowan, DC; Cowan, JO; Palmay, R; Taylor, DR; Williamson, A | 1 |
| Barnes, PJ; Ekjiratrakul, W; Kasetsinsombat, K; Maneechotesuwan, K; Wongkajornsilp, A | 1 |
| Bratt, JM; Kenyon, NJ; Last, JA; Rabowsky, M; Zeki, AA | 1 |
| Chakir, J; Ghavami, S; Halayko, AJ; Jacques, E; Laviolette, M; McNeill, KD; Mutawe, MM; Schaafsma, D; Unruh, H | 1 |
| Cao, R; Dong, XW; Jiang, JX; Li, FF; Shen, HJ; Shen, LL; Sun, Y; Xie, QM; Xu, L; Yao, HY | 1 |
| Leung, BP; Liew, FY; McInnes, IB; McKay, A; Thomson, NC | 1 |
| Li, SQ; Liu, CT; Luo, FM; Wang, ZL | 1 |
| Barnes, M; Fleming, D; Lipworth, BJ; Meldrum, KT; Menzies, D; Nair, A | 1 |
| Kim, DY; Lee, YS; Lim, JE; Ro, JY; Ryu, SY | 1 |
3 trial(s) available for simvastatin and Asthma, Bronchial
| Article | Year |
|---|---|
Simvastatin in the treatment of asthma: lack of steroid-sparing effect.
Topics: Adult; Aged; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Epidemiologic Methods; Female; Fluticasone; Glucocorticoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Simvastatin; Young Adult | 2010 |
Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase.
Topics: Adult; Anti-Inflammatory Agents; Asthma; Budesonide; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Enzyme Induction; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macrophages; Male; Middle Aged; Simvastatin; Treatment Outcome | 2010 |
Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma.
Topics: Adult; Anti-Inflammatory Agents; Asthma; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Nitric Oxide; Simvastatin; Th1 Cells; Th2 Cells | 2007 |
20 other study(ies) available for simvastatin and Asthma, Bronchial
| Article | Year |
|---|---|
Simvastatin reduced infiltration of memory subsets of T lymphocytes in the lung tissue during Th2 allergic inflammation.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Simvastatin; Th2 Cells | 2022 |
Simvastatin Reduces NETosis to Attenuate Severe Asthma by Inhibiting PAD4 Expression.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; DNA; Extracellular Traps; Histones; Inflammation; Lipopolysaccharides; Lung; Mice; Neutrophils; Ovalbumin; RNA, Messenger; Simvastatin | 2023 |
Simvastatin mediates inhibition of exosome synthesis, localization and secretion via multicomponent interventions.
Topics: Animals; Asthma; Atherosclerosis; Cell Line; Cholesterol; Disease Models, Animal; Exosomes; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Monocytes; Simvastatin | 2019 |
Prophylactic benefits of systemically delivered simvastatin treatment in a house dust mite challenged murine model of allergic asthma.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Cytokines; Disease Models, Animal; Eosinophils; Female; Lung; Mice, Inbred BALB C; Neutrophils; Pyroglyphidae; Simvastatin | 2018 |
Problems with polypills.
Topics: Adrenergic beta-Antagonists; Asthma; Citrus paradisi; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Polypharmacy; Precision Medicine; Primary Prevention; Rhabdomyolysis; Simvastatin; Stroke | 2018 |
Simvastatin and bone marrow-derived mesenchymal stem cells (BMSCs) affects serum IgE and lung cytokines levels in sensitized mice.
Topics: Animals; Asthma; Bone Marrow; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulin E; Interleukin-13; Lung; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Ovalbumin; Simvastatin; Transforming Growth Factor beta | 2019 |
Mitotic asynchrony induces transforming growth factor-β1 secretion from airway epithelium.
Topics: Aphidicolin; Asthma; Bronchi; Cells, Cultured; Culture Media, Conditioned; Dexamethasone; Epithelial Cells; Epithelium; Fibrosis; Humans; Inflammation; Mitosis; Respiratory Mucosa; Simvastatin; Time Factors; Transforming Growth Factor beta1 | 2014 |
Attenuation of airway inflammation by simvastatin and the implications for asthma treatment: is the jury still out?
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukins; Lung; Mice, Inbred BALB C; Simvastatin | 2014 |
Evaluation of Simvastatin and Bone Marrow-Derived Mesenchymal Stem Cell Combination Therapy on Airway Remodeling in a Mouse Asthma Model.
Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cell Movement; Collagen; Combined Modality Therapy; Disease Models, Animal; Eosinophils; Fibrosis; Goblet Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; Leukocyte Count; Male; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Pneumonia; Simvastatin | 2016 |
Simvastatin requires activation in accessory cells to modulate T-cell responses in asthma and COPD.
Topics: Asthma; Carboxylesterase; Female; Humans; Interferon-gamma; Interleukin-13; Interleukin-5; Macrophages, Alveolar; Male; Middle Aged; Monocytes; Pulmonary Disease, Chronic Obstructive; Simvastatin; Smoking; Th1 Cells; Th2 Cells | 2016 |
Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma.
Topics: Adenine; Airway Remodeling; Animals; Asthma; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cytokines; Disease Models, Animal; Extracellular Matrix; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interferon-gamma; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Myocytes, Smooth Muscle; Ovalbumin; Simvastatin; Up-Regulation | 2017 |
Treatment of obese asthma in a mouse model by simvastatin is associated with improving dyslipidemia and decreasing leptin level.
Topics: Animals; Asthma; Blood Glucose; Body Weight; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dyslipidemias; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leptin; Leukocyte Count; Lipids; Lung; Mice; Mice, Inbred C57BL; Obesity; Simvastatin | 2017 |
Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond.
Topics: Animals; Asthma; Biosynthetic Pathways; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonic Acid; Mice; Mice, Inbred BALB C; Simvastatin | 2009 |
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Epithelial Cells; Epithelium; Lung; Male; Mice; Mice, Inbred BALB C; Mucus; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrosation; Pneumonia; Simvastatin; Stress, Physiological | 2011 |
Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
Topics: Aerosols; Animals; Arginase; Arginine; Asthma; Blotting, Western; Coloring Agents; Disease Models, Animal; Goblet Cells; Hydroxyproline; Hyperplasia; Immunohistochemistry; Inflammation; Lung; Mice; Nitrates; Nitrites; Ovalbumin; Simvastatin; Transforming Growth Factor beta1 | 2010 |
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.
Topics: Adult; Airway Remodeling; Alkyl and Aryl Transferases; Asthma; Bronchi; Case-Control Studies; Cells, Cultured; Dose-Response Relationship, Drug; Farnesyltranstransferase; Fibroblasts; Fibronectins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Sesquiterpenes; Simvastatin; Time Factors; Transforming Growth Factor beta1; Young Adult | 2011 |
Simvastatin delivery via inhalation attenuates airway inflammation in a murine model of asthma.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred BALB C; Ovalbumin; RNA, Messenger; Simvastatin | 2012 |
A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma.
Topics: Administration, Oral; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cytokines; Disease Models, Animal; Eosinophilia; Epitopes; Female; Injections, Intraperitoneal; Lymph Nodes; Mice; Mice, Inbred BALB C; Ovalbumin; Simvastatin; Th2 Cells | 2004 |
[Simvastatin induces eosinophil apoptosis in vitro].
Topics: Adult; Apoptosis; Asthma; Cells, Cultured; Eosinophils; Female; Humans; Male; Simvastatin; Young Adult | 2005 |
Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; CD40 Antigens; CD40 Ligand; Cytokines; Disease Models, Animal; Female; GTP-Binding Proteins; Immunoglobulin E; Leukocyte Count; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Ovalbumin; RNA, Messenger; Simvastatin; Vascular Cell Adhesion Molecule-1 | 2007 |