simvastatin has been researched along with Arthritis, Rheumatoid in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (45.83) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Almond, LM; Gardner, I; Jamei, M; Joshi, A; Kenny, JR; Machavaram, KK; Rostami-Hodjegan, A; Tay, S; Wong, S | 1 |
| Cardoso, PR; Da Rocha, LF; Dantas, AT; Duarte, ÂL; Galdino-Pitta, MR; Gonçalves, SM; Pereira, MC; Pitta, MG; Rêgo, MJ; Santos, FA | 1 |
| Hisdal, J; Holme, I; Ikdahl, E; Kvien, TK; Pedersen, TR; Rollefstad, S; Semb, AG | 1 |
| Abo-Saif, AA; Ahmed, YM; Messiha, BA | 1 |
| Ahlquist, P; Bagdat, D; Blegvad, J; Christensen, R; Christensen, TG; Colic, A; Ellingsen, T; Emmertsen, H; Fredberg, U; Giraldi, A; Graugaard, C; Hansen, IM; Hørslev-Petersen, K; Jensen, HS; Løgstrup, BB; Persson, F; Sheetal, E; Svendsen, L; Svensson, AL; Thygesen, T | 1 |
| Bodrug, I; Daskalakis, N; Fleischmann, R; Kivitz, A; Lee, EB; Miller, B; Paccaly, A; Xu, C | 1 |
| Bykerk, VP; Chinenov, Y; Goodman, SM; Gupta, S; Kirou, KA; Leuenberger, L; Maharaj, RK; Pernis, AB; Rozo, C; Salmon, JE | 1 |
| Kozlov, VA; Shirinskiĭ, IV; Shirinskiĭ, VS; Zheltova, OI | 1 |
| Chen, G; Fan, J; Fu, D; Liang, L; Lin, H; Sun, L; Xiao, Y; Xu, H; Yang, X; Ye, Y | 1 |
| Holme, I; Kvien, TK; Pedersen, TR; Semb, AG | 1 |
| Liu, Y; Shen, L; Wang, S; Xu, Y | 1 |
| Grange, S; Kivitz, AJ; Kuhn, B; Schmitt, C; Zhang, X | 1 |
| Fan, J; Fu, D; Li, L; Lian, F; Liang, L; Lin, H; Pan, Y; Sun, L; Xiao, Y; Xu, H; Yang, X | 1 |
| Chang, CC; Hong, CY; Hou, KL; Hsiao, M; Kok, SH; Lai, EH; Lin, LD; Lin, SK; Wang, JH | 1 |
| Hamasaki, K; Kanda, H; Kanda, Y; Kubo, K; Mimura, T; Tateishi, S; Yamamoto, K; Yonezumi, A | 1 |
| Campbell, C; Crilly, A; Gracie, JA; Leung, BP; Liew, FY; Madhok, R; McCarey, DW; McInnes, IB; Payne, H; Prach, M; Sattar, N | 1 |
| Chenevard, R; Corti, R; Enseleit, F; Forster, A; Frey, D; Gay, RE; Gay, S; Hellermann, JP; Hermann, F; Hermann, M; Hürlimann, D; Lüscher, TF; Michel, BA; Neidhart, M; Noll, G; Riesen, W; Ruschitzka, F; Spieker, LE | 1 |
| Bayindir, P; Bayturan, O; Pirildar, T; Taneli, F; Tikiz, C; Tikiz, H; Tuzun, C; Utuk, O | 1 |
| Akiyama, Y; Hirano, M; Mimura, T; Miyazaki, T; Yokota, K | 1 |
| Danesh, FR; Liang, L; Liu, P; Peng, H; Sun, L; Xu, H; Yang, X; Ye, Y; Yu, X; Zhan, Z | 1 |
| Booth, AD; Brown, J; Hall, FC; Mäki-Petäjä, KM; McEniery, CM; Wallace, SM; Wilkinson, IB | 1 |
| Kanda, H; Kohno, C; Komagata, Y; Mimura, T; Sato, K; Sawada, T; Shimada, K; Yamaguchi, M; Yamamoto, K; Yokota, K | 1 |
| Bielinska, A; Gluszko, P | 1 |
| Akiyama, Y; Asanuma, Y; Mimura, T; Miyazaki, T; Miyoshi, F; Sato, K; Yokota, K; Yoshida, Y | 1 |
1 review(s) available for simvastatin and Arthritis, Rheumatoid
| Article | Year |
|---|---|
[Statins--are they potentially useful in rheumatology?].
Topics: Arthritis, Rheumatoid; Atorvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lupus Erythematosus, Systemic; Osteoporosis; Pyrroles; Rheumatic Diseases; Simvastatin; Treatment Outcome | 2007 |
8 trial(s) available for simvastatin and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Multifactorial intervention to prevent cardiovascular disease in patients with early rheumatoid arthritis: protocol for a multicentre randomised controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cardiovascular Diseases; Denmark; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Lipoproteins, LDL; Male; Middle Aged; Prospective Studies; Research Design; Risk Factors; Severity of Illness Index; Simvastatin; Young Adult | 2016 |
Disease-Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Male; Middle Aged; Receptors, Interleukin-6; Simvastatin | 2017 |
Effects of simvastatin on the function of dendritic cells in patients with rheumatic arthritis.
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cytokines; Dendritic Cells; Female; Humans; Male; Middle Aged; Simvastatin | 2010 |
Disease-drug-drug interaction involving tocilizumab and simvastatin in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Humans; Interleukin-6; Male; Middle Aged; Simvastatin | 2011 |
Simvastatin improves endothelial function in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Middle Aged; Oxidative Stress; Simvastatin | 2005 |
Effects of Angiotensin-converting enzyme inhibition and statin treatment on inflammatory markers and endothelial functions in patients with longterm rheumatoid arthritis.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1; Interleukin-6; Male; Middle Aged; Nitric Oxide; Quinapril; Simvastatin; Tetrahydroisoquinolines; Tumor Necrosis Factor-alpha | 2005 |
Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis.
Topics: Aged; Anticholesteremic Agents; Aorta; Arthritis, Rheumatoid; Azetidines; Blood Flow Velocity; C-Reactive Protein; Cholesterol; Cross-Over Studies; Double-Blind Method; Elasticity; Endothelium, Vascular; Ezetimibe; Female; Humans; Inflammation; Lipoproteins, LDL; Male; Middle Aged; Simvastatin; Stress, Mechanical | 2007 |
Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; CD4 Antigens; CD4-Positive T-Lymphocytes; CD8 Antigens; CD8-Positive T-Lymphocytes; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Middle Aged; Rheumatoid Factor; Simvastatin; Th1 Cells; Th2 Cells; Treatment Outcome | 2007 |
15 other study(ies) available for simvastatin and Arthritis, Rheumatoid
| Article | Year |
|---|---|
A physiologically based pharmacokinetic modeling approach to predict disease-drug interactions: suppression of CYP3A by IL-6.
Topics: Anticholesteremic Agents; Area Under Curve; Arthritis, Rheumatoid; Bone Marrow Transplantation; Computer Simulation; Cyclosporine; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Immunosuppressive Agents; Interleukin-6; Models, Biological; Simvastatin | 2013 |
Simvastatin inhibits cytokines in a dose response in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cytokines; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes, Mononuclear; Male; Middle Aged; Simvastatin | 2014 |
Systemic inflammation in patients with inflammatory joint diseases does not influence statin dose needed to obtain LDL cholesterol goal in cardiovascular prevention.
Topics: Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Atorvastatin; Cardiovascular Diseases; Cholesterol, LDL; Comorbidity; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Middle Aged; Rosuvastatin Calcium; Simvastatin; Spondylitis, Ankylosing | 2015 |
Protective Effects of Simvastatin and Hesperidin against Complete Freund's Adjuvant-Induced Rheumatoid Arthritis in Rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Female; Freund's Adjuvant; Hesperidin; Immunoglobulins; Joints; Rats, Wistar; Simvastatin; Spleen | 2015 |
Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE.
Topics: Adult; Aged; Amides; Arthritis, Rheumatoid; Case-Control Studies; Cells, Cultured; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-17; Interleukins; Lupus Erythematosus, Systemic; Male; Middle Aged; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; T-Lymphocytes; Th17 Cells | 2017 |
[Simvastatin effects on the disease activity and cholesterol content in blood serum lipoprotein subfractions in patients with rheumatoid arthritis].
Topics: Adult; Aged; Anticholesteremic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Cholesterol; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lipoproteins; Male; Middle Aged; Pilot Projects; Simvastatin; Treatment Outcome | 2008 |
HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes, Mononuclear; Male; Middle Aged; NF-kappa B; Peptidoglycan; Prednisone; rhoA GTP-Binding Protein; RNA, Small Interfering; Simvastatin; Staphylococcus aureus; Toll-Like Receptor 2; Transfection | 2011 |
Intensive lipid lowering in patients with rheumatoid arthritis and previous myocardial infarction: an explorative analysis from the incremental decrease in endpoints through aggressive lipid lowering (IDEAL) trial.
Topics: Aged; Anticholesteremic Agents; Arthritis, Rheumatoid; Atorvastatin; Cholesterol; Female; Heptanoic Acids; Humans; Male; Middle Aged; Myocardial Infarction; Pyrroles; Randomized Controlled Trials as Topic; Risk Factors; Simvastatin; Statistics as Topic | 2011 |
Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA.
Topics: Aged; Arthritis, Rheumatoid; Cell Adhesion; Cell Movement; Cytoskeleton; Female; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Prenylation; rhoA GTP-Binding Protein; Simvastatin; Synovial Membrane | 2013 |
Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CCL20; Cysteine-Rich Protein 61; Disease Models, Animal; Fibroblasts; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; Sirtuin 1; Synovial Membrane; Tumor Necrosis Factor-alpha | 2013 |
Antiinflammatory effect of simvastatin in patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Male; Middle Aged; Pain Measurement; Prospective Studies; Range of Motion, Articular; Recovery of Function; Sampling Studies; Severity of Illness Index; Simvastatin; Synovial Membrane; Treatment Outcome | 2002 |
A novel anti-inflammatory role for simvastatin in inflammatory arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; CD28 Antigens; CD3 Complex; Cells, Cultured; Coculture Techniques; Collagen; Disease Models, Animal; Epitopes, T-Lymphocyte; Humans; Immune Sera; Immunosuppressive Agents; Injections, Intraperitoneal; Macrophages; Male; Mice; Mice, Inbred CBA; Simvastatin; Th1 Cells | 2003 |
Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Fibroblasts; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Interleukin-8; Mevalonic Acid; Polyisoprenyl Phosphates; RNA, Messenger; Simvastatin; Synovial Membrane; Tumor Necrosis Factor-alpha | 2006 |
RhoA-mediated, tumor necrosis factor alpha-induced activation of NF-kappaB in rheumatoid synoviocytes: inhibitory effect of simvastatin.
Topics: Aged; Arthritis, Rheumatoid; Cells, Cultured; Female; Genes, Dominant; Genes, Reporter; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Interleukin-6; Middle Aged; NF-kappa B; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Synovial Membrane; Tumor Necrosis Factor-alpha | 2006 |
High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Topics: Apoptosis; Arthritis, Rheumatoid; Caspase 3; Caspase 9; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Flow Cytometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Interleukin-8; Simvastatin; Synovial Membrane | 2008 |