Compounds > simvastatin
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simvastatin and Anoxia-Ischemia, Brain

simvastatin has been researched along with Anoxia-Ischemia, Brain in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (80.00)29.6817
2010's1 (10.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Balduini, W; Carloni, S1
Balduini, W; Buonocore, G; Carloni, S1
Kaminska, B; Kaplán, P; Lehotský, J; Pavlíková, M; Sivonová, M; Tatarková, Z; Urban, P1
Balduini, W; Buonocore, G; Carloni, S; Girelli, S; Longini, M1
Li, A; Li, S; Lv, S; Ma, H; Piao, H; Sun, C; Yu, Z; Zhang, N; Zhang, Y; Zhao, H1
Balduini, W; Carloni, S; Cimino, M; De Simoni, MG; Mazzoni, E; Perego, C; Sironi, L1
Balduini, W; Carloni, S; Cimino, M; De Simoni, MG; Mazzoni, E; Perego, C; Scopa, C1
Huang, L; Jiang, L; Miao, H1
Choi, IY; Kim, HS; Kim, WK; Lee, JC; Lee, YH; Lim, JH; Oh, YK; Park, JS1
Balduini, W; Cimino, M; De Angelis, V; Mazzoni, E1

Other Studies

10 other study(ies) available for simvastatin and Anoxia-Ischemia, Brain

ArticleYear
Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation.
    Experimental neurology, 2020, Volume: 324

    Topics: Adenine; Animals; Animals, Newborn; Autophagy; Brain Damage, Chronic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Ischemic Preconditioning; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Simvastatin; Sirtuin 1

2020
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury.
    Neurobiology of disease, 2008, Volume: 32, Issue:3

    Topics: Adenine; Analysis of Variance; Androstadienes; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cell Count; Cerebral Cortex; Hippocampus; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Necrosis; Neurons; Rats; Rats, Sprague-Dawley; Simvastatin; Sirolimus; Wortmannin

2008
Molecular analysis of endoplasmic reticulum stress response after global forebrain ischemia/reperfusion in rats: effect of neuroprotectant simvastatin.
    Cellular and molecular neurobiology, 2009, Volume: 29, Issue:2

    Topics: Activating Transcription Factor 6; Animals; DNA-Binding Proteins; Endoplasmic Reticulum; Gene Expression Regulation; Heat-Shock Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Male; Molecular Chaperones; Neuroprotective Agents; Oxidative Stress; Protein Folding; Rats; Rats, Wistar; Regulatory Factor X Transcription Factors; Reperfusion Injury; RNA, Messenger; Simvastatin; Time Factors; Transcription Factors; Up-Regulation; X-Box Binding Protein 1

2009
Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation.
    Experimental neurology, 2009, Volume: 220, Issue:1

    Topics: Age Factors; Aging; Animals; Animals, Newborn; Brain; Brain Infarction; Carotid Stenosis; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation

2009
Simvastatin attenuates hypomyelination induced by hypoxia-ischemia in neonatal rats.
    Neurological research, 2010, Volume: 32, Issue:9

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weight; CD11b Antigen; Demyelinating Diseases; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Myelin Basic Protein; Rats; Rats, Sprague-Dawley; Simvastatin

2010
Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does
    Stroke, 2003, Volume: 34, Issue:8

    Topics: Animals; Animals, Newborn; Body Weight; Brain; Brain Chemistry; Cholesterol; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Interleukin-1; Male; Maze Learning; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha

2003
Simvastatin reduces caspase-3 activation and inflammatory markers induced by hypoxia-ischemia in the newborn rat.
    Neurobiology of disease, 2006, Volume: 21, Issue:1

    Topics: Animals; Animals, Newborn; Apoptosis; Biomarkers; Calpain; Caspase 1; Caspase 3; Caspases; Cytochromes c; Enzyme Activation; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Intercellular Adhesion Molecule-1; Interleukin-1; Nerve Degeneration; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Simvastatin

2006
Effects of simvastatin on the expression of intercellular adhesion molecule-1 mRNA in neonatal brain with hypoxic-ischemic damage.
    Journal of nanoscience and nanotechnology, 2005, Volume: 5, Issue:8

    Topics: Animals; Animals, Newborn; Base Sequence; Brain; Cerebral Cortex; Cytidine Diphosphate Choline; DNA, Complementary; Female; Gene Expression; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Intercellular Adhesion Molecule-1; Male; Nanotechnology; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin

2005
Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal.
    Journal of neurochemistry, 2006, Volume: 97, Issue:1

    Topics: Aldehydes; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cytoprotection; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Lipid Peroxidation; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Simvastatin

2006
Simvastatin protects against long-lasting behavioral and morphological consequences of neonatal hypoxic/ischemic brain injury.
    Stroke, 2001, Volume: 32, Issue:9

    Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Choice Behavior; Disease Models, Animal; Hypoxia-Ischemia, Brain; Male; Maze Learning; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Simvastatin

2001