Page last updated: 2024-08-23

simvastatin and Angiospasm, Intracranial

simvastatin has been researched along with Angiospasm, Intracranial in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (68.42)29.6817
2010's6 (31.58)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chicoine, M; Derdeyn, CP; Dhar, R; Diringer, MN; Powers, WJ; Scalfani, M; Zazulia, AR1
Bao, S; Duan, H; Li, L; Zhang, J1
Ayata, C; Badjatia, N; Chou, SH; Nogueira, RG; Ogilvy, CS; Rordorf, GA; Sims, JR; Smith, EE1
Ayer, R; Chen, W; Jadhav, V; Sugawara, T; Tsubokawa, T; Zhang, JH2
Czosnyka, M; Hutchinson, PJ; Kirkpatrick, PJ; Pickard, JD; Richards, HK; Tseng, MY; Turner, CL1
Garces Ambrossi, GL; Huang, J; McGirt, MJ; Tamargo, RJ1
Ayer, R; Jadhav, V; Sugawara, T; Zhang, J1
Bian, JY; Chen, G; Shen, XO; Wang, Z; Zhou, D; Zhu, WW1
Belousova, OB; Éliava, ShSh; Okishev, DN; Sarshaev, MA; Shekhtman, OD; Tseĭtlin, AM1
Chandra, PS; Garg, K; Kale, SS; Kumar, R; Mahapatra, AK; Pandey, RM; Sharma, BS; Sharma, MS; Singh, MM; Sinha, S; Suri, A1
Laskowitz, DT; Lynch, JR; McGirt, MJ; Parra, A; Pearlstein, RD; Pelligrino, DA; Sheng, H; Warner, DS1
Alexander, MJ; Blessing, R; Coon, AL; Floyd, J; Friedman, AH; Graffagnino, C; Laskowitz, DT; Lynch, JR; McGirt, MJ; Wang, H; Warner, DS1
Clatterbuck, R; Laskowitz, DT; Legnani, F; Lynch, JR; McGirt, MJ; Pradilla, G; Tamargo, R; Warner, D; Woodworth, GF1
Clatterbuck, RE; Legnani, FG; McGirt, MJ; Pradilla, G; Recinos, PF; Tamargo, RJ; Thai, QA1
Carod-Artal, FJ1
Agrawal, VK; Bulsara, KR; Coates, JR; Durham, HE; Eifler, DM; Fine, DM; Toft, K; Wagner-Mann, CC1
Ayer, R; Jadhav, V; Sugawara, T; Zhang, JH1
Bleck, TP; Dumont, AS; Gurka, MJ; Kassell, NF; Kramer, AH; Nathan, B1

Reviews

2 review(s) available for simvastatin and Angiospasm, Intracranial

ArticleYear
Simvastatin for the prevention of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a single-institution prospective cohort study.
    Journal of neurosurgery, 2009, Volume: 110, Issue:5

    Topics: Cohort Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Aneurysm; Length of Stay; Male; Middle Aged; Prospective Studies; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2009
Mechanisms of statin treatment in cerebral vasospasm.
    Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 2

    Topics: Animals; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Rats; Review Literature as Topic; Simvastatin; Time Factors; Vasospasm, Intracranial

2011

Trials

5 trial(s) available for simvastatin and Angiospasm, Intracranial

ArticleYear
Effect of High-Dose Simvastatin on Cerebral Blood Flow and Static Autoregulation in Subarachnoid Hemorrhage.
    Neurocritical care, 2016, Volume: 25, Issue:1

    Topics: Aged; Brain Ischemia; Cerebrovascular Circulation; Female; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Positron-Emission Tomography; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2016
A randomized, double-blind, placebo-controlled pilot study of simvastatin in aneurysmal subarachnoid hemorrhage.
    Stroke, 2008, Volume: 39, Issue:10

    Topics: Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pilot Projects; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2008
Role of simvastatin in prevention of vasospasm and improving functional outcome after aneurysmal sub-arachnoid hemorrhage: a prospective, randomized, double-blind, placebo-controlled pilot trial.
    British journal of neurosurgery, 2013, Volume: 27, Issue:2

    Topics: Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pilot Projects; Prospective Studies; Simvastatin; Subarachnoid Hemorrhage; Treatment Outcome; Vasospasm, Intracranial

2013
Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial.
    Stroke, 2005, Volume: 36, Issue:9

    Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Brain; Brain Ischemia; Creatine Kinase; Double-Blind Method; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Middle Aged; Models, Statistical; Pilot Projects; Simvastatin; Subarachnoid Hemorrhage; Time Factors; Treatment Outcome; Vascular Diseases; Vasospasm, Intracranial

2005
Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase.
    Clinical neurosurgery, 2005, Volume: 52

    Topics: Animals; Awards and Prizes; Basilar Artery; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Male; Mice; Middle Aged; Neurons; Nitric Oxide Synthase; Rabbits; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2005

Other Studies

12 other study(ies) available for simvastatin and Angiospasm, Intracranial

ArticleYear
Effect of Simvastatin on Proliferation of Vascular Smooth Muscle Cells During Delayed Cerebral Vasospasm After Subarachnoid Hemorrhage.
    Turkish neurosurgery, 2016, Volume: 26, Issue:4

    Topics: Animals; Basilar Artery; Cell Proliferation; Cerebral Angiography; Disease Models, Animal; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Rabbits; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2016
Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase.
    Journal of neuroscience research, 2008, Volume: 86, Issue:16

    Topics: Androstadienes; Animals; Carotid Stenosis; Cerebral Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Simvastatin; Subarachnoid Hemorrhage; Up-Regulation; Vasospasm, Intracranial; Wortmannin

2008
Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhage.
    Neurosurgery, 2008, Volume: 63, Issue:6

    Topics: Brain Ischemia; Cohort Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Retrospective Studies; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2008
Simvastatin attenuates cerebral vasospasm and improves outcomes by upregulation of PI3K/Akt pathway in a rat model of subarachnoid hemorrhage.
    Acta neurochirurgica. Supplement, 2008, Volume: 102

    Topics: Analysis of Variance; Animals; Carotid Artery, Internal; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; Subarachnoid Hemorrhage; Up-Regulation; Vasospasm, Intracranial

2008
Influence of simvastatin on microthrombosis in the brain after subarachnoid hemorrhage in rats: a preliminary study.
    Annals of clinical and laboratory science, 2010,Winter, Volume: 40, Issue:1

    Topics: Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Intracranial Thrombosis; Male; Rats; Rats, Sprague-Dawley; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2010
[Simvastatin efficacy in vasospasm treatment in patients after aneurysm SAH].
    Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko, 2012, Volume: 76, Issue:5

    Topics: Adolescent; Adult; Aged; Aneurysm, Ruptured; Anticholesteremic Agents; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Length of Stay; Male; Middle Aged; Retrospective Studies; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2012
Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.
    Stroke, 2002, Volume: 33, Issue:12

    Topics: Animals; Brain; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Middle Cerebral Artery; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Simvastatin; Subarachnoid Hemorrhage; Time Factors; Up-Regulation; Vascular Patency; Vasospasm, Intracranial

2002
Systemic administration of simvastatin after the onset of experimental subarachnoid hemorrhage attenuates cerebral vasospasm.
    Neurosurgery, 2006, Volume: 58, Issue:5

    Topics: Animals; Cell Movement; Rabbits; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2006
Statins and cerebral vasomotor reactivity: implications for a new therapy?
    Stroke, 2006, Volume: 37, Issue:10

    Topics: Adult; Animals; Arginine; Atorvastatin; Brain Ischemia; Cerebrovascular Circulation; Clinical Trials, Phase II as Topic; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Intracranial Aneurysm; Mice; Middle Cerebral Artery; Nitric Oxide; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Simvastatin; Stroke; Subarachnoid Hemorrhage; Ultrasonography, Doppler, Transcranial; Vasodilation; Vasomotor System; Vasospasm, Intracranial

2006
Effect of combined simvastatin and cyclosporine compared with simvastatin alone on cerebral vasospasm after subarachnoid hemorrhage in a canine model.
    Neurosurgical focus, 2006, Sep-15, Volume: 21, Issue:3

    Topics: Analysis of Variance; Angiography; Animals; Basilar Artery; Cyclosporine; Disease Models, Animal; Dogs; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Random Allocation; Simvastatin; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial

2006
A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model.
    Journal of neuroscience methods, 2008, Jan-30, Volume: 167, Issue:2

    Topics: Analysis of Variance; Animals; Basilar Artery; Disease Models, Animal; Evaluation Studies as Topic; Hemorrhage; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Simvastatin; Statistics as Topic; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2008
Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhage.
    Neurosurgery, 2008, Volume: 62, Issue:2

    Topics: Brain Ischemia; Cohort Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Retrospective Studies; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2008