simvastatin has been researched along with Alloxan Diabetes in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.47) | 18.2507 |
| 2000's | 32 (39.51) | 29.6817 |
| 2010's | 38 (46.91) | 24.3611 |
| 2020's | 9 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Argüelles, N; Chamorro-Cevallos, G; Cruz, Mdel C; Garduño-Siciliano, L; Jiménez, F; Medina-Franco, JL; Mendieta, A; Sánchez-Sandoval, E; Tamariz, J; Villa-Tanaca, L | 1 |
| Kourounakis, AP; Ladopoulou, E; Matralis, AN | 1 |
| Jia, J; Leng, H; Song, C; Tan, J; Xu, Y; Zhang, C; Zhu, J | 1 |
| Abdel-Bakky, MS; Alqasoumi, A; Altowayan, WM; Amin, E; Darwish, MA | 1 |
| Abolmaali, SS; Azarpira, N; Heidari, R; Janipour, Z; Najafi, H; Özyılmaz, ED; Tamaddon, AM | 1 |
| Buendía, AJ; Camacho-Alonso, F; Martínez-Beneyto, Y; Martínez-Ortiz, C; Mercado-Díaz, AM; Merino, JJ; Navarro, JA; Plazas-Buendía, L; Vilaplana-Vivo, C | 1 |
| Dai, Q; Ding, F; Guo, C; Li, H; Ouyang, Q; Shan, C; Shen, W; Wu, X; Zhang, Y; Zheng, J; Zhou, Z | 1 |
| Hai, B; Leng, H; Liu, C; Song, C; Wang, H; Xu, Y; Zhang, W; Zhu, J | 1 |
| Abd-Elhady, SL; El-Shahat, MA; Morsy, AI; Shams, AM; Youssef, OM | 1 |
| Ahmad, W; Alavi, T; Ng, SF; Rezvanian, M | 1 |
| Chen, F; Fang, SC; Hong, H; Hu, M; Kong, LY; Long, Y; Sun, HB; Tang, SS; Xie, H | 1 |
| Ni, Y; Sun, Z; Wang, Z; Xu, H; Zheng, L | 1 |
| Chen, H; Cui, X; Li, H; Liu, R; Yang, L; Zhao, Q | 1 |
| Cao, J; Fan, L; Hao, WJ; Ke, SZ; Li, JH; Liu, L; Luo, XX; Sun, YF | 1 |
| Fawzy Fahim, V; Ishak Attallah, M; Shafik, AN; Wadie, W | 1 |
| Bak, EJ; Cha, JH; Kim, A; Kim, AR; Kim, JH; Sohn, Y; Yoo, YJ | 1 |
| Li, H; Zhang, HY; Zhang, Y; Zhang, Z | 1 |
| Chevion, M; Drenger, B; Grievink, H; Kuzmina, N | 1 |
| Han, Q; Liu, Q; Lu, M; Tang, F; Wang, H; Zhang, H; Zhang, Y | 1 |
| Chen, HZ; Cui, XL; Li, FL; Liu, X; Wan, X; Wang, X; Wu, YL | 1 |
| Bhakoo, KK; Boominathan, R; Chan, K; Cheng, P; Goggi, JL; Haslop, A; Robins, EG; Soh, V | 1 |
| Chen, X; Liu, S; Liu, Y; Song, Y; Yang, X; Zhou, Y | 1 |
| Dunna, NR; Foye, JL; Joshi, M; Maulik, N; Otani, H; Selvaraju, V; Thirunavukkarasu, M | 1 |
| Alkan, A; Aydın, MŞ; Ezirganlı, Ş; Kazancıoğlu, HO; Mihmanlı, A; Sharifov, R | 1 |
| Hu, S; Huang, X; Ma, X; Pang, S; Wang, L; Wang, S | 1 |
| Casiano, H; Crespo, MJ; Cruz, N; Hernandez, C; Quidgley, J; Rivera, K; Torres, H | 1 |
| Hu, MY; Jia, LL; Li, F; Liu, C; Liu, L; Liu, XD; Wang, DW; Wu, J; Xu, D; Zhang, J; Zhang, M; Zhong, ZY | 1 |
| Chen, XY; Lan, D; Li, T; Liu, LM; Tian, KL; Wu, Y; Yang, GM; Zhu, Y | 1 |
| Bekmukhambetov, Y; Dworacka, M; Dworacki, G; Iskakova, S; Zharmakhanova, G | 1 |
| ElBatsh, MM | 1 |
| Bradamante, V; Kelava, M; Konjevoda, P; Lovrić, J; Macan, M; Štambuk, N; Vrkić, N; Vukšić, A; Žunec, S | 1 |
| Chen, CY; Chen, JW; Chen, JY; Huang, PH; Lin, SJ; Shih, CC | 1 |
| Israsena, N; Patumraj, S; Sukpat, S | 1 |
| Namazi, H | 1 |
| Arulmozhi, DK; Bodhankar, SL; Kurian, R; Veeranjaneyulu, A | 1 |
| Barbosa, DS; Delfino, VD; Elias, JA; Fabris, BA; Matsuo, T | 1 |
| Rydgren, T; Sandler, S | 1 |
| Adameová, A; Harcárová, A; Kucharská, J; Kuzelová, M; Paulíková, I; Sumbalová, Z; Svec, P | 1 |
| Demirel, E; Ergül, E; Köksoy, C; Yalcin, B; Yalcin, S | 1 |
| Adameova, A; Bartekova, M; Carnicka, S; Harcarova, A; Kuzelova, M; Matejikova, J; Pancza, D; Ravingerova, T; Styk, J; Svec, P | 1 |
| Gao, Q; Jia, ZH; Li, LS; Liu, ZH; Qin, WS; Zeng, CH; Zheng, JM | 1 |
| Chang, W; Hong, BK; Hwang, KC; Kim, M; Kwon, HM; Lee, BK; Lee, YH; Min, PK; Park, SJ; Rim, SJ; Yoon, SJ; Yoon, YW | 1 |
| Chen, K; Chen, Y; Li, XC; Wang, YX; Yang, GW; Yao, XM; Ye, SD; Zai, Z | 1 |
| Balwanz, CR; Grimm, PR; Padanilam, BJ; Sansom, SC; Settles, DC; Wei, P | 1 |
| Baraka, AM; Gawad, HA; Guemei, A | 1 |
| Semenova, EV | 1 |
| Kowluru, RA | 1 |
| Araújo-Filho, I; Azevedo, IM; Egito, ES; Jácome, DT; Medeiros, AC; Rêgo, AC | 1 |
| Chen, H; Gu, Q; Ke, B; Li, P; Li, Q; Su, L; Wang, H; Xu, X; Zheng, B; Zheng, Z | 1 |
| Hur, DY; Kim, HW; Kim, JL; Lee, HK; Lee, SG; Ryu, GW; Yang, JW; Yun, IH | 1 |
| Lin, FL; Lin, KQ; Shen, HC; Zhu, B | 1 |
| Aasato, M; Hayashi, SS; Kamei, J; Ohsawa, M | 1 |
| Cho, SY; Kim, SW; Park, K | 1 |
| Oroma Owira, PM; Xulu, S | 1 |
| Hu, YB; Liu, YM; Sun, ZY; Yan, H; Zhang, JK | 1 |
| Yan, H; Zhang, W | 1 |
| Asai, J; Hagura, A; Hirakawa, S; Kajiya, K; Katoh, N; Kinoshita, S; Kishimoto, S; Maruyama, K; Sakabe, J; Takenaka, H; Tokura, Y | 1 |
| Aoki, T; Imaeda, A; Kaneko, T; Kondo, Y; Nagase, H; Nakamura, N; Yoshikawa, T | 1 |
| Cao, Z; Cooper, ME; Hu, L; Liu, J; Qin, J; Sun, L; Zhang, Z | 1 |
| Hirose, F; Honda, Y; Katsuta, H; Kiryu, J; Miyahara, S; Miyamoto, K; Nishijima, K; Tamura, H; Tsujikawa, A; Yamashiro, K | 1 |
| Aktan, F; Can, B; Ceylan, A; Güven, C; Karasu, C; Ozansoy, G | 1 |
| Aktan, F; Ceylan, A; Karasu, C; Ozansoy, G | 1 |
| Hu, Y; Lin, F; Shen, H; Zhou, J; Zhu, B | 1 |
| Batejko, O; Feman, SS; Haas, MJ; Hovsepyan, M; Mooradian, AD | 1 |
| Chen, ZX; Lei, MX; Zhang, J; Zhu, LF | 1 |
| Banes-Berceli, AK; Brands, M; Caldwell, RW; Eaton, DC; Fulton, D; Ma, G; Marrero, MB; Shaw, S; Stern, DM | 1 |
| Caldwell, RB; Caldwell, RW; El-Remessy, AB; Ma, G; Matragoon, S; Tawfik, HE | 1 |
| Adameová, A; Faberová, V; Kuzelová, M; Svec, P | 1 |
| Cakmak, A; Demirpençe, E; Deniz Dinçer, U; Köksoy, A; Köksoy, C; Okcu-Heper, A; Oziş, E; Yazgan, U | 1 |
| Chang, LT; Chua, S; Sun, CK; Wang, CY; Wu, CJ; Yip, HK; Youssef, AA | 1 |
| Cakmak, A; Dalkara, T; Dinçer, D; Köksoy, C; Yazgan, U; Yemişçi, M | 1 |
| Chang, LT; Chang, NK; Chiang, CH; Lee, FY; Sheu, JJ; Sun, CK; Wu, CJ; Yip, HK; Youssef, AA | 1 |
| Rydgren, T; Sandler, S; Vaarala, O | 1 |
| Chang, PJ; Cheng, H; Huang, WJ; Lin, CL; Tung, CW; Wang, JY; Yang, JT | 1 |
| Cakmak, A; Cakmak, S; Demiriz, M; Gönül, M; Gül, U | 1 |
| Altavilla, D; Bitto, A; Bonaiuto, M; Calò, M; Caputi, AP; Fiumara, T; Galeano, M; Lo Cascio, P; Marini, H; Migliorato, A; Minutoli, L; Polito, F; Squadrito, F | 1 |
| Al-Shabrawey, M; Bartoli, M; Caldwell, RB; Caldwell, RW; El-Remessy, AB; Lemtalsi, T; Ma, G; Matragoon, S | 1 |
| Kamata, K; Kobayashi, T; Matsumoto, T; Takenouchi, Y | 1 |
| Chen, SJ; Chiu, JJ; Hou, CJ; Shiao, MS; Su, CH; Tsai, CH; Wu, YJ; Yeh, HI | 1 |
| Kazumi, T; Maeda, E; Matsushita, M; Morita, M; Murata, Y; Nagata, K; Naka, Y; Yoshino, G | 1 |
| Dhir, S; Gopaul, N; Palmer, AM; Poston, L; Thomas, CR; Tribe, RM | 1 |
81 other study(ies) available for simvastatin and Alloxan Diabetes
| Article | Year |
|---|---|
Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Binding Sites; Computer Simulation; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Design; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred ICR; Schizosaccharomyces | 2010 |
New multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine derivatives with antioxidant, antihyperlipidemic, and antidiabetic action.
Topics: Animals; Antioxidants; Atherosclerosis; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Farnesyl-Diphosphate Farnesyltransferase; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Lipoproteins, LDL; Male; Mice; Oxidative Stress; Probucol; Rats | 2013 |
Single Intraosseous Simvastatin Application Induces Endothelial Progenitor Cell Mobilization and Therapeutic Angiogenesis in a Diabetic Hindlimb Ischemia Rat Model.
Topics: Animals; Chronic Limb-Threatening Ischemia; Collateral Circulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endothelial Progenitor Cells; Hindlimb; Humans; Infusions, Intraosseous; Male; Neovascularization, Physiologic; Rats; Simvastatin; Streptozocin | 2021 |
Simvastatin mitigates streptozotocin-induced type 1 diabetes in mice through downregulation of ADAM10 and ADAM17.
Topics: ADAM10 Protein; ADAM17 Protein; Amyloid Precursor Protein Secretases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Down-Regulation; Gene Expression Regulation, Enzymologic; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Simvastatin | 2022 |
Simvastatin-Releasing Nanofibrous Peptide Hydrogels for Accelerated Healing of Diabetic Wounds.
Topics: Animals; Diabetes Mellitus, Experimental; Humans; Hydrogels; Inflammation; Mice; Nanofibers; Peptides; Simvastatin; Spectroscopy, Fourier Transform Infrared | 2023 |
Bone union formation in the rat mandibular symphysis using hydroxyapatite with or without simvastatin: effects on healthy, diabetic, and osteoporotic rats.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Diabetes Mellitus, Experimental; Durapatite; Female; Mandible; Osteogenesis; Osteoporosis; Ovariectomy; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin; Vascular Endothelial Growth Factor A; X-Ray Microtomography | 2020 |
Simvastatin alleviated diabetes mellitus-induced erectile dysfunction in rats by enhancing AMPK pathway-induced autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Diabetes Mellitus, Experimental; Erectile Dysfunction; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Simvastatin | 2020 |
Single Intraosseous Injection of Simvastatin Promotes Endothelial Progenitor Cell Mobilization, Neovascularization, and Wound Healing in Diabetic Rats.
Topics: Adiponectin; Angiogenesis Inducing Agents; Animals; Chemokine CXCL12; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Combinations; Endothelial Progenitor Cells; Hydrogels; Injections; Male; Neovascularization, Physiologic; Poloxamer; Rats, Sprague-Dawley; Simvastatin; Skin; Wound Healing | 2020 |
The neuroprotective effect of simvastatin on the cerebellum of experimentally-induced diabetic rats through klotho upregulation: An immunohistochemical study.
Topics: Animals; Blood Glucose; Cerebellum; Diabetes Mellitus, Experimental; Glucuronidase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Klotho Proteins; Male; Neuroprotective Agents; Oxidative Stress; Rats; Simvastatin; Up-Regulation | 2020 |
In-vivo evaluation of Alginate-Pectin hydrogel film loaded with Simvastatin for diabetic wound healing in Streptozotocin-induced diabetic rats.
Topics: Alginates; Animals; Biological Dressings; Collagen; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Drug Repositioning; Hydrogels; Hydroxyproline; Male; Materials Testing; Neovascularization, Physiologic; Pectins; Random Allocation; Rats; Rats, Wistar; Re-Epithelialization; Simvastatin; Skin; Vascular Endothelial Growth Factor A; Wound Healing | 2021 |
Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Blood Glucose; Brain; Cytokines; Diabetes Mellitus, Experimental; Disease Models, Animal; Hypolipidemic Agents; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Neurotoxicity Syndromes; Peptide Fragments; Signal Transduction; Simvastatin | 2017 |
GATA4 protects against hyperglycemia‑induced endothelial dysfunction by regulating NOX4 transcription.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Enzyme Induction; GATA4 Transcription Factor; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Male; Mice, Inbred C57BL; NADPH Oxidase 4; Nitric Oxide; Simvastatin | 2018 |
Protective Effect and Potential Mechanism of Simvastatin on Myocardial Injury Induced by Diabetes with Hypoglycemia.
Topics: Animals; Calcium; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Male; MicroRNAs; NF-kappa B; Rats; Rats, Sprague-Dawley; Simvastatin | 2018 |
[The experimental study of simvastatin on improving aspirin resistance in diabetic rats].
Topics: Animals; Aspirin; Diabetes Mellitus, Experimental; Endothelium, Vascular; Epoprostenol; Male; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Simvastatin; Thromboxane B2 | 2016 |
Role of simvastatin and insulin in memory protection in a rat model of diabetes mellitus and dementia.
Topics: Amyloid beta-Peptides; Animals; Blood Glucose; Cholesterol; Dementia; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hippocampus; Insulin; Maze Learning; Memory; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin | 2019 |
Simvastatin attenuates tibial bone loss in rats with type 1 diabetes and periodontitis.
Topics: Alveolar Bone Loss; Animals; Blood Glucose; Body Weight; Bone Morphogenetic Proteins; Bone Resorption; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fasting; Genetic Markers; Lipoproteins, LDL; Male; Osteoclasts; Periodontitis; Rats, Inbred F344; Simvastatin; Tibia; Triglycerides | 2018 |
Inactivation of the Ras/MAPK/PPARγ signaling axis alleviates diabetic mellitus-induced erectile dysfunction through suppression of corpus cavernosal endothelial cell apoptosis by inhibiting HMGCS2 expression.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Screening Assays, Antitumor; Endothelial Cells; Erectile Dysfunction; Hydroxymethylglutaryl-CoA Synthase; Male; MAP Kinase Signaling System; Penis; PPAR gamma; ras Proteins; Rats, Sprague-Dawley; RNA, Small Interfering; Simvastatin | 2019 |
Sevoflurane postconditioning is not mediated by ferritin accumulation and cannot be rescued by simvastatin in isolated streptozotocin-induced diabetic rat hearts.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Ferritins; Gene Expression Regulation; Heart; Iron; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Nitric Oxide; Rats; Sevoflurane; Simvastatin; Streptozocin | 2019 |
Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-κB (NF-κB).
Topics: Animals; Calpain; Cardiomegaly; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Inflammation; Intercellular Adhesion Molecule-1; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Simvastatin; Streptozocin; Vascular Cell Adhesion Molecule-1 | 2019 |
[Simvastatin prevented myocardium of diabetes rats from apoptosis through inhibition of oxidative stress].
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin | 2018 |
Imaging the Proangiogenic Effects of Cardiovascular Drugs in a Diabetic Model of Limb Ischemia.
Topics: Animals; Cardiovascular Agents; Diabetes Mellitus, Experimental; Hindlimb; Immunohistochemistry; Ischemia; Magnetic Resonance Imaging; Male; Metformin; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Oligopeptides; Simvastatin | 2019 |
Effect of simvastatin on fracture healing of type 2 diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fracture Healing; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Rats; Simvastatin | 2021 |
Simvastatin treatment inhibits hypoxia inducible factor 1-alpha-(HIF-1alpha)-prolyl-4-hydroxylase 3 (PHD-3) and increases angiogenesis after myocardial infarction in streptozotocin-induced diabetic rat.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Myocardial Infarction; Neovascularization, Physiologic; Prolyl-Hydroxylase Inhibitors; Rats; Simvastatin; Streptozocin | 2013 |
The effect of local simvastatin application on critical size defects in the diabetic rats.
Topics: Administration, Topical; Animals; Bone Regeneration; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin; Skull; Tomography, X-Ray Computed; Wound Healing | 2014 |
Effect of simvastatin on the expression of farnesoid X receptor in diabetic animal models of altered glucose homeostasis.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Homeostasis; Insulin Resistance; Liver X Receptors; Male; Orphan Nuclear Receptors; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin; Sterol Regulatory Element Binding Protein 1 | 2014 |
Daily administration of atorvastatin and simvastatin for one week improves cardiac function in type 1 diabetic rats.
Topics: Animals; Atorvastatin; Blood Glucose; Cardiac Output; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Administration Schedule; Heart; Heart Rate; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin; Ventricular Function, Left | 2014 |
Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cytochrome P-450 CYP3A; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hepatocytes; Liver; Male; Microsomes, Liver; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Simvastatin | 2014 |
Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Connexins; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Drug Therapy, Combination; Female; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Male; Metformin; MicroRNAs; Muscle, Smooth, Vascular; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Renal Artery; rho-Associated Kinases; Simvastatin; Vasculitis | 2015 |
[Simvastatin's effect on insulin resistance in rats with diabetes mellitus].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Rats; Simvastatin | 2015 |
Antidepressant-like effect of simvastatin in diabetic rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Corticosterone; Depression; Diabetes Mellitus, Experimental; Dopamine; Hippocampus; Hypothalamo-Hypophyseal System; Male; Motor Activity; Pituitary-Adrenal System; Rats, Wistar; Serotonin; Simvastatin; Swimming | 2015 |
Effects of simvastatin on malondialdehyde level and esterase activity in plasma and tissue of normolipidemic rats.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Carotid Artery, Common; Cytokines; Diabetes Mellitus, Experimental; Glutamic Acid; Hippocampus; Male; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Pioglitazone; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Simvastatin; Thiazolidinediones | 2015 |
Simvastatin pretreatment enhances ischemia-induced neovascularization and blood flow recovery in streptozotocin-treated mice.
Topics: Animals; Blood Flow Velocity; Collateral Circulation; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Endothelial Progenitor Cells; Ezetimibe; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Male; Mice; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Phosphorylation; Recovery of Function; Regional Blood Flow; Simvastatin; Streptozocin; Time Factors; Vascular Endothelial Growth Factor A; Vasodilation | 2016 |
Pleiotropic Effects of Simvastatin on Wound Healing in Diabetic Mice.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Physiologic; Simvastatin; Wound Healing | 2016 |
Regarding "A novel molecular mechanism to account for the action of simvastatin against limb ischemia".
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Ischemia; Lymphocyte Function-Associated Antigen-1; Muscle, Skeletal; Neutrophil Infiltration; Neutrophils; Simvastatin | 2008 |
Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mouse model of diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Fenofibrate; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Male; Metformin; Mice; Peroxisome Proliferator-Activated Receptors; Rosiglitazone; Simvastatin; Streptozocin; Sulfonylurea Compounds; Thiazolidinediones; Triglycerides | 2008 |
[Effects of ramipril and simvastatin on the oxidative stress of diabetic rats].
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Oxidative Stress; Ramipril; Random Allocation; Rats; Simvastatin; Statistics, Nonparametric | 2008 |
The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocyte Function-Associated Antigen-1; Male; Mice; Mice, Inbred Strains; Simvastatin; Streptozocin | 2009 |
The effect of simvastatin on coenzyme Q and antioxidant/oxidant balance in diabetic-hypercholesterolaemic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Organ Specificity; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Simvastatin; Ubiquinone | 2008 |
Vascular reactivity in the experimental, simvastatin-treated diabetes with endothelial dysfunction.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; In Vitro Techniques; Lipids; Male; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Simvastatin; Thapsigargin; Vasoconstriction | 2008 |
Simvastatin alleviates myocardial contractile dysfunction and lethal ischemic injury in rat heart independent of cholesterol-lowering effects.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Cholesterol; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Recovery of Function; Simvastatin; Ventricular Pressure | 2009 |
Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy.
Topics: Albuminuria; Animals; Anthraquinones; Anticholesteremic Agents; Cholesterol; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drugs, Chinese Herbal; Dyslipidemias; Extracellular Matrix; Fibronectins; Kidney; Mice; Mice, Inbred C57BL; Mice, Knockout; Phytotherapy; Rheum; Rhizome; Simvastatin; Transforming Growth Factor beta1 | 2010 |
Potential role of HMG CoA reductase inhibitor on oxidative stress induced by advanced glycation endproducts in vascular smooth muscle cells of diabetic vasculopathy.
Topics: Animals; Aorta; Cell Proliferation; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocytes, Smooth Muscle; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Simvastatin; Transcription Factor RelA | 2009 |
Simvastatin protects diabetic rats against kidney injury through the suppression of renal matrix metalloproteinase-9 expression.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation, Enzymologic; Glomerular Basement Membrane; Glycated Hemoglobin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Lipids; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Microscopy, Electron; Organ Size; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin | 2010 |
Simvastatin reverses podocyte injury but not mesangial expansion in early stage type 2 diabetes mellitus.
Topics: Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glomerular Mesangium; Immunohistochemistry; Kidney Function Tests; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Organ Size; Podocytes; Probability; Random Allocation; Risk Factors; Severity of Illness Index; Simvastatin | 2009 |
Role of modulation of vascular endothelial growth factor and tumor necrosis factor-alpha in gastric ulcer healing in diabetic rats.
Topics: Acetic Acid; Animals; Anticholesteremic Agents; Diabetes Mellitus, Experimental; Free Radical Scavengers; Insulin; Male; Pentoxifylline; Rats; Rats, Wistar; Simvastatin; Stomach Ulcer; Streptozocin; Treatment Outcome; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Wound Healing | 2010 |
[Possibilities of pharmacological hepatopathy and correction of fat metabolism violations in diabetes mellitus type 1].
Topics: Animals; Anticholesteremic Agents; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Female; Humans; Lipid Metabolism; Liver; Male; Pyridines; Rats; Simvastatin | 2009 |
Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-Ras.
Topics: Animals; Apoptosis; Cattle; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Enzyme Activation; Genes, ras; Matrix Metalloproteinase 9; Rats; Rats, Wistar; Retina; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Simvastatin; Tissue Inhibitor of Metalloproteinase-1; Transfection | 2010 |
[Effect of the simvastatin in abdominal sepsis of diabetic rats].
Topics: Abdomen; Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Preoperative Care; Rats; Rats, Wistar; Sepsis; Simvastatin | 2010 |
Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha.
Topics: Actins; Animals; Apoptosis; Capillaries; Capillary Permeability; Cattle; Cell Division; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Heat-Shock Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Membrane Potentials; Mitochondrial Membranes; Peroxisome Proliferator-Activated Receptors; Rats; Reactive Oxygen Species; Retina; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin; Vascular Endothelial Growth Factor A | 2010 |
Simvastatin suppresses expression of angiogenic factors in the retinas of rats with streptozotocin-induced diabetes.
Topics: Administration, Oral; Angiogenic Proteins; Angiopoietin-1; Animals; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Fluorescent Antibody Technique, Indirect; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2011 |
[Effects of simvastatin on expression of CTGF and α-SMA in renal tubulointerstitium of rats with diabetic nephropathy].
Topics: Actins; Animals; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Kidney; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin | 2010 |
RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice.
Topics: Amides; Animals; Complement C3; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type III; Pain Threshold; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Spinal Cord; Streptozocin; Time Factors | 2011 |
Erectile response to type 5 phosphodiesterase inhibitor could be preserved with the addition of simvastatin to conventional insulin treatment in rat model of diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erectile Dysfunction; Insulin; Male; Nitric Oxide Synthase Type III; Penile Erection; Phosphodiesterase 5 Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Sulfonamides | 2011 |
Naringin ameliorates atherogenic dyslipidemia but not hyperglycemia in rats with type 1 diabetes.
Topics: Animals; Atherosclerosis; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dyslipidemias; Flavanones; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Rats; Rats, Wistar; Simvastatin; Streptozocin | 2012 |
[Effects of simvastatin on expression of connective tissue growth factor in vitreous and retina of diabetic rats].
Topics: Animals; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; Rats; Rats, Wistar; Retina; Simvastatin; Vitreous Body | 2012 |
Simvastatin increases circulating endothelial progenitor cells and reduces the formation and progression of diabetic retinopathy in rats.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Blood Glucose; Blood-Retinal Barrier; Body Weight; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Progression; Endothelium, Vascular; Flow Cytometry; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Retinal Vessels; RNA, Messenger; Simvastatin; Stem Cells; Vascular Endothelial Growth Factor A | 2012 |
Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis.
Topics: Administration, Topical; Animals; Apoptosis; Capillaries; Cell Movement; Cell Proliferation; Diabetes Mellitus, Experimental; Endothelial Cells; Granulation Tissue; Humans; Lymphangiogenesis; Macrophages; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Phenotype; Simvastatin; Vascular Endothelial Growth Factor C; Wound Healing | 2012 |
Antioxidative effects of fluvastatin and its metabolites against DNA damage in streptozotocin-treated mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Blood Glucose; Blood Urea Nitrogen; Creatinine; Deoxyguanosine; Diabetes Mellitus, Experimental; DNA; DNA Damage; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Kidney; Liver; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Pravastatin; Simvastatin; Weight Gain | 2002 |
Effects of the combination of an angiotensin II antagonist with an HMG-CoA reductase inhibitor in experimental diabetes.
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy, Combination; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Losartan; Male; Rats; Rats, Wistar; Simvastatin; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2003 |
Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes.
Topics: Animals; Capillary Permeability; CD18 Antigens; Cell Adhesion; Cell Communication; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Leukocytes; Ligands; Male; Nitric Oxide Synthase; Rats; Rats, Long-Evans; Retina; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin; Streptozocin; Vascular Endothelial Growth Factor A | 2004 |
Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of diabetic rat myocardium.
Topics: Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Heart; Heart Ventricles; Lipid Peroxidation; Lipids; Male; Myocardium; Oxidants; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Simvastatin; Streptozocin | 2003 |
Simvastatin treatment restores vasoconstriction and the inhibitory effect of LPC on endothelial relaxation via affecting oxidizing metabolism in diabetic rats.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; Hypolipidemic Agents; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Simvastatin; Streptozocin; Triglycerides; Vasodilation | 2004 |
Effects of simvastatin on oxidative stress in streptozotocin-induced diabetic rats: a role for glomeruli protection.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Catalase; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glutathione Transferase; Hypolipidemic Agents; Kidney Glomerulus; Lipid Peroxidation; Male; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Simvastatin; Superoxide Dismutase; Triglycerides | 2005 |
Statins ameliorate endothelial barrier permeability changes in the cerebral tissue of streptozotocin-induced diabetic rats.
Topics: Animals; Blood-Brain Barrier; Blood-Retinal Barrier; Brain; Capillary Permeability; Coronary Circulation; Dextrans; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Male; Myocardium; Pyrimidines; Rats; Rats, Inbred F344; Retina; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2005 |
[Effects of simvastatin on TGF-beta system of diabetic rat kidneys].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Down-Regulation; Female; Kidney; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; RNA, Messenger; Simvastatin; Transforming Growth Factor beta | 2005 |
Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells.
Topics: Angiotensin II; Animals; Anticholesteremic Agents; Blood Glucose; Cells, Cultured; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Janus Kinase 2; Male; Mesangial Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Signal Transduction; Simvastatin; STAT1 Transcription Factor; STAT3 Transcription Factor; Terpenes | 2006 |
Simvastatin improves diabetes-induced coronary endothelial dysfunction.
Topics: Animals; Arginine; Coronary Vessels; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Streptozocin; Superoxides; Tyrosine; Vasodilation | 2006 |
Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Cholesterol; Cholesterol, Dietary; Clofibrate; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Sterol O-Acyltransferase | 2006 |
Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model.
Topics: Animals; Diabetes Mellitus, Experimental; Edema; Glutathione; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Male; Malondialdehyde; Muscle, Skeletal; Necrosis; Peroxidase; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Severity of Illness Index; Simvastatin; Time Factors; Tourniquets | 2007 |
Downregulation of peroxisme proliferator activated receptor gamma co-activator 1alpha in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Down-Regulation; Losartan; Male; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; RNA, Messenger; Simvastatin; Stroke Volume; Transcription Factors; Ventricular Function, Left | 2006 |
Statin pre-treatment protects brain against focal cerebral ischemia in diabetic mice.
Topics: Animals; Brain; Brain Ischemia; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Mice; Motor Activity; Neurologic Examination; Simvastatin | 2007 |
Impact of diabetes on cardiomyocyte apoptosis and connexin43 gap junction integrity: role of pharmacological modulation.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Connexin 43; Diabetes Mellitus, Experimental; Gap Junctions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Losartan; Male; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Simvastatin | 2007 |
Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Glucose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred NOD; Secondary Prevention; Simvastatin; Streptozocin | 2007 |
Simvastatin reverses high glucose-induced apoptosis of mesangial cells via modulation of Wnt signaling pathway.
Topics: Animals; Apoptosis; beta Catenin; Caspase 3; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Activation; Glucose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mesangial Cells; Models, Biological; Rats; Signal Transduction; Simvastatin; Wnt Proteins | 2008 |
Statin therapy and diabetic skin.
Topics: Animals; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Simvastatin; Skin | 2008 |
Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes.
Topics: Animals; Anticholesteremic Agents; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Immunohistochemistry; Mice; Nitric Oxide; Platelet Endothelial Cell Adhesion Molecule-1; RNA, Messenger; Simvastatin; Skin; Vascular Endothelial Growth Factor A; Wound Healing | 2008 |
Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy.
Topics: Animals; Blood-Retinal Barrier; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dose-Response Relationship, Drug; Endothelial Cells; Glucose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Retinal Vessels; Simvastatin; STAT3 Transcription Factor; Up-Regulation; Vascular Endothelial Growth Factor A | 2008 |
Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice.
Topics: Adrenomedullin; Animals; Aorta; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clonidine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Male; Mice; Mice, Inbred ICR; Nitrates; Nitrites; Nitroprusside; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Simvastatin; Vasodilation; Vasodilator Agents | 2008 |
Diabetes reduces aortic endothelial gap junctions in ApoE-deficient mice: simvastatin exacerbates the reduction.
Topics: Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Blotting, Western; Connexins; Diabetes Mellitus, Experimental; Endothelium, Vascular; Gap Junction alpha-4 Protein; Gap Junction alpha-5 Protein; Gap Junctions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Simvastatin | 2008 |
Effect of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor on triglyceride kinetics in chronically streptozotocin-diabetic rats.
Topics: Animals; Cholesterol; Chronic Disease; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipids; Lovastatin; Male; Rats; Rats, Wistar; Reference Values; Simvastatin; Triglycerides | 1993 |
Endothelial dysfunction in streptozotocin-diabetic rats is not reversed by dietary probucol or simvastatin supplementation.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diet; Dinoprost; Eating; Endothelium, Vascular; F2-Isoprostanes; Hypolipidemic Agents; Lipid Peroxidation; Lipids; Male; Mesenteric Arteries; Muscle Relaxation; Oxidative Stress; Probucol; Rats; Rats, Sprague-Dawley; Simvastatin; Tissue Distribution | 1998 |