simvastatin has been researched along with Airflow Obstruction, Chronic in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 25 (78.13) | 24.3611 |
| 2020's | 5 (15.63) | 2.80 |
| Authors | Studies |
|---|---|
| DU, K; Lan, B; Leng, B; Liang, B; Yu, M; Zhang, Y; Zhao, N | 1 |
| Jiang, N; Liu, J; Liu, T; Luo, W | 1 |
| Fugger, J; Gmeiner, M; Herkner, H; Hüttinger, F; Janistyn, W; Pichler, G; Pichler, M; Sajdik, C; Schenk, P; Schmeikal, S; Schügerl, S; Spiel, AO | 1 |
| Criner, G; Del Carpio-Cano, F; Janapati, S; Lu, X; Rao, AK; Voelker, H; Zhao, H | 1 |
| Camac, ER; Criner, GJ; Voelker, H | 1 |
| Chciałowski, A; Kalicka, A; Korsak, J; Patyk, I; Rybacki, C; Rzeszotarska, A | 1 |
| Chang, R; Cheng, N; Lu, Y; Teng, Y; Xu, X; Yao, J | 1 |
| Bebawy, M; Buttini, F; Colombo, P; Haghi, M; Marin, L; Ong, HX; Traini, D; Young, P | 1 |
| Persson, C | 1 |
| Zeki, AA | 1 |
| Drazen, JM; Gelijns, AC | 1 |
| Aaron, SD; Albert, RK; Bailey, WC; Casaburi, R; Connett, JE; Cooper, JA; Criner, GJ; Curtis, JL; Dransfield, MT; Han, MK; Lazarus, SC; Make, B; Marchetti, N; Martinez, FJ; Niewoehner, DE; Scanlon, PD; Scharf, SM; Sciurba, FC; Sin, DD; Voelker, H; Washko, GR; Woodruff, PG | 1 |
| Connett, JE; Criner, GJ; Voelker, H | 1 |
| Egom, EE | 1 |
| Suissa, S | 1 |
| Colombo, P; Morgan, L; Ong, HX; Traini, D; Tulbah, AS; Young, PM | 1 |
| Bolton, CE; Cockcroft, JR; Coward, WR; Harrison, TW; John, ME; Johnson, SR; Knox, AJ; McKeever, TM; Shale, DJ; Thornton, JG | 1 |
| Jiang, X; Li, Z; Sun, W; Wang, L; Wang, Y; Zhang, L | 1 |
| Adcock, IM; Barnes, PJ; Maneechotesuwan, K; Wongkajornsilp, A | 1 |
| Deng, X; Li, C; Ren, W; Wang, S; Xiong, L; Zhou, Q; Zhu, C | 2 |
| Bendella, Z; Boyaci, N; Gallert, WJ; Grensemann, B; Jungck, D; Knobloch, J; Koch, A; Körber, S; Yakin, Y; Yanik, SD | 1 |
| Barnes, PJ; Kasetsinsombat, K; Maneechotesuwan, K; Wongkajornsilp, A | 1 |
| Gorkiewicz-Kot, I; Kaczmarek, P; Rzeszutko, M; Skucha, W; Sladek, K; Stepien, E; Tracz, W; Undas, A | 1 |
| Dziedzina, S; Iwaniec, T; Kaczmarek, P; Rzeszutko, M; Skucha, W; Szczeklik, A; Sładek, K | 1 |
| DeFilippis, A; Eberlein, M; Girgis, RE; Iacono, A; Jones, S; Lechtzin, N; Reed, RM | 1 |
| Bebawy, M; Colombo, P; Marin, L; Traini, D; Young, PM | 1 |
| Chan, WC; Hopkins, R; Jackson, G; Lawes, CM; Marshall, R; Thornley, S; Young, R | 1 |
| Pearson, M | 1 |
| Andersson, M; Bjermer, L; Brandelius, A; Calvén, J; Mahmutovic Persson, I; Persson, CG; Uller, L | 1 |
| Bratt, JM; Davis, BB; Filosto, S; Goldkorn, T; Kenyon, NJ; Pinkerton, KE; Schelegle, ES; Walby, WF; Wang, L; Zeki, AA | 1 |
| Bitter-Suermann, S; Kanniess, F; Magnussen, H; Watz, H | 1 |
3 review(s) available for simvastatin and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
Effectiveness of long-term using statins in COPD - a network meta-analysis.
Topics: Atorvastatin; Drug Administration Schedule; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Network Meta-Analysis; Pulmonary Disease, Chronic Obstructive; Simvastatin; Time Factors; Treatment Outcome | 2019 |
Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages, Alveolar; Mevalonic Acid; Pulmonary Disease, Chronic Obstructive; Simvastatin | 2011 |
[Pharmacological treatment of COPD and future of anti-inflammatory therapy].
Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Dyspnea; Expectorants; Forced Expiratory Volume; Forecasting; Humans; Inflammation; Infliximab; Lung; Macrolides; Nitriles; Phosphodiesterase Inhibitors; Pilot Projects; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Research; Respiratory Function Tests; Simvastatin; Smoking Cessation; Tetracycline; Theophylline; Tumor Necrosis Factor-alpha | 2006 |
8 trial(s) available for simvastatin and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
Can simvastatin reduce COPD exacerbations? A randomised double-blind controlled study.
Topics: Disease Progression; Double-Blind Method; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pulmonary Disease, Chronic Obstructive; Quality of Life; Simvastatin | 2021 |
Effects of simvastatin on tissue factor pathway of blood coagulation in STATCOPE (Simvastatin in the prevention of COPD exacerbations) trial.
Topics: Blood Coagulation; Factor VIIa; Female; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Simvastatin; Thromboplastin | 2021 |
Simvastatin for the prevention of exacerbations in moderate-to-severe COPD.
Topics: Adult; Aged; Female; Forced Expiratory Volume; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Middle Aged; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Quality of Life; Severity of Illness Index; Simvastatin; Treatment Failure; Vital Capacity | 2014 |
Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Biomarkers; Cardiovascular Agents; Cholesterol; Double-Blind Method; England; Female; Forced Expiratory Volume; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Lung; Male; Middle Aged; Pneumonia; Pulmonary Disease, Chronic Obstructive; Pulse Wave Analysis; Simvastatin; Spirometry; Time Factors; Treatment Outcome; Vascular Stiffness; Vital Capacity | 2015 |
Simvastatin Suppresses Airway IL-17 and Upregulates IL-10 in Patients With Stable COPD.
Topics: Aged; Aged, 80 and over; Chromatography, Liquid; Cross-Over Studies; Double-Blind Method; Female; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-10; Interleukin-17; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Reverse Transcriptase Polymerase Chain Reaction; RNA; Simvastatin; Sputum | 2015 |
Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism.
Topics: 5'-Nucleotidase; Adenosine Deaminase; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Cells, Cultured; Cigarette Smoking; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Down-Regulation; Female; Forced Expiratory Volume; GPI-Linked Proteins; Humans; Interleukin-13; Lung; Macrophages; Male; Middle Aged; Osteopontin; Pulmonary Disease, Chronic Obstructive; Signal Transduction; Simvastatin; Smoke; Sputum; STAT6 Transcription Factor; Transcription, Genetic; Up-Regulation | 2016 |
Fibrin clot properties are altered in patients with chronic obstructive pulmonary disease. Beneficial effects of simvastatin treatment.
Topics: Aged; Blood Coagulation; Case-Control Studies; Female; Fibrin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Microscopy, Electron, Scanning; Middle Aged; Pulmonary Disease, Chronic Obstructive; Simvastatin; Thrombosis | 2009 |
The influence of simvastatin on selected inflammatory markers in patients with chronic obstructive pulmonary disease.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers; C-Reactive Protein; Cytokines; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Simvastatin | 2010 |
21 other study(ies) available for simvastatin and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
Simvastatin represses inflammation and cell apoptosis in COPD rats via rho/rho kinase signaling pathway.
Topics: Animals; Apoptosis; Inflammation; Pulmonary Disease, Chronic Obstructive; Rats; rho-Associated Kinases; Signal Transduction; Simvastatin | 2023 |
Clinical effect of simvastatin combined with exercise training in the treatment of stationary chronic obstructive pulmonary disease complicated with metabolic syndrome.
Topics: Aged; Exercise; Female; Humans; Lung; Male; Metabolic Syndrome; Middle Aged; Pulmonary Disease, Chronic Obstructive; Simvastatin | 2020 |
Impact of COPD exacerbations leading to hospitalization on general and disease-specific quality of life.
Topics: Aged; Azithromycin; Disease Progression; Female; Follow-Up Studies; Health Surveys; Hospitalization; Humans; Male; Middle Aged; Patient Acuity; Prognosis; Pulmonary Disease, Chronic Obstructive; Quality of Life; Simvastatin; Spirometry | 2021 |
Simvastatin Therapy and Bronchoalveolar Lavage Fluid Biomarkers in Chronic Obstructive Pulmonary Disease.
Topics: Anti-Inflammatory Agents; Biomarkers; Bronchoalveolar Lavage Fluid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Pulmonary Disease, Chronic Obstructive; Pulmonary Surfactant-Associated Protein D; Simvastatin; Treatment Outcome | 2019 |
Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: implications in the treatment of chronic obstructive airway pathologies.
Topics: Cell Line; Cell Survival; Drug Administration Schedule; Drug Delivery Systems; Epithelial Cells; Humans; Hydroxy Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mucus; Pulmonary Disease, Chronic Obstructive; Simvastatin; Surface Properties; Temperature; Time Factors | 2013 |
Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy.
Topics: Animals; Epithelium; Male; Pulmonary Disease, Chronic Obstructive; Simvastatin; Smoke | 2014 |
Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy.
Topics: Animals; Epithelium; Male; Pulmonary Disease, Chronic Obstructive; Simvastatin; Smoke | 2014 |
Statin strikeout.
Topics: Female; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pulmonary Disease, Chronic Obstructive; Pyrimidines; Respiratory Distress Syndrome; Rosuvastatin Calcium; Sepsis; Simvastatin; Sulfonamides | 2014 |
Simvastatin in moderate-to-severe COPD.
Topics: Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pulmonary Disease, Chronic Obstructive; Simvastatin | 2014 |
Simvastatin in moderate-to-severe COPD.
Topics: Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pulmonary Disease, Chronic Obstructive; Simvastatin | 2014 |
Simvastatin in moderate-to-severe COPD.
Topics: Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pulmonary Disease, Chronic Obstructive; Simvastatin | 2014 |
Dry powder formulation of simvastatin.
Topics: Administration, Inhalation; Aerosols; Cell Line; Chemistry, Pharmaceutical; Cystic Fibrosis; Dry Powder Inhalers; Humans; Particle Size; Powders; Pulmonary Disease, Chronic Obstructive; Respiratory Mucosa; Simvastatin | 2015 |
Simvastatin mitigates functional and structural impairment of lung and right ventricle in a rat model of cigarette smoke-induced COPD.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lung; Male; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; RNA-Binding Proteins; Simvastatin; Smoking | 2014 |
[Effects of simvastatin on airway inflammation and airway mucus hypersecretion in rats with chronic obstructive pulmonary disease].
Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Enzyme-Linked Immunosorbent Assay; Inflammation; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Lung; Male; Mucin 5AC; Mucus; NF-kappa B; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Simvastatin; Smoke | 2015 |
[Effect of aminophylline and simvastatin on airway inflammation and mucus hypersecretion in rats with chronic obstructive pulmonary disease].
Topics: Aminophylline; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Cytokines; Inflammation; Lipopolysaccharides; Lung; Male; Mucin 5AC; Mucus; Pulmonary Disease, Chronic Obstructive; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin; Smoke; Smoking; Toll-Like Receptor 4 | 2016 |
Simvastatin requires activation in accessory cells to modulate T-cell responses in asthma and COPD.
Topics: Asthma; Carboxylesterase; Female; Humans; Interferon-gamma; Interleukin-13; Interleukin-5; Macrophages, Alveolar; Male; Middle Aged; Monocytes; Pulmonary Disease, Chronic Obstructive; Simvastatin; Smoking; Th1 Cells; Th2 Cells | 2016 |
Statin therapy is associated with decreased pulmonary vascular pressures in severe COPD.
Topics: Aged; Atorvastatin; Cross-Sectional Studies; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Pulmonary Wedge Pressure; Pyrroles; Regression Analysis; Simvastatin | 2011 |
Statin use in COPD patients is associated with a reduction in mortality: a national cohort study.
Topics: Aged; Atorvastatin; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Medical Record Linkage; Middle Aged; New Zealand; Pulmonary Disease, Chronic Obstructive; Pyrroles; Simvastatin; Treatment Outcome | 2012 |
Statins for COPD: a challenge to conventional beliefs?
Topics: Atorvastatin; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pulmonary Disease, Chronic Obstructive; Pyrroles; Simvastatin | 2012 |
Selective inhibition by simvastatin of IRF3 phosphorylation and TSLP production in dsRNA-challenged bronchial epithelial cells from COPD donors.
Topics: Adult; Aged; Anti-Inflammatory Agents; Bronchi; Cells, Cultured; Cytokines; Dexamethasone; Epithelial Cells; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon Regulatory Factor-3; Male; Middle Aged; NF-kappa B; Phosphorylation; Pulmonary Disease, Chronic Obstructive; RNA, Double-Stranded; Simvastatin | 2013 |
Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy.
Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cholesterol; Epithelium; Inflammation; Leukocytes; Macrophages; Male; Monomeric GTP-Binding Proteins; Neutrophils; Nicotiana; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Inbred SHR; Respiratory Function Tests; rho GTP-Binding Proteins; Simvastatin; Smoke; Treatment Outcome | 2013 |