simvastatin has been researched along with Aging in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allore, H; Gemikonakli, G; Hilmer, SN; Howlett, SE; Little, CB; Mach, J; Tran, T; Wu, H | 1 |
| Chen, S; Li, H; Liu, M; Tang, J; Wang, M; Xi, Y | 1 |
| Blatt, T; Cirilli, I; Knott, A; Marcheggiani, F; Orlando, P; Silvestri, S; Tiano, L; Vogelsang, A; Weise, JM | 1 |
| Dhakal, S; Fraser, JM; Gardiner, K; Macreadie, I; Subhan, M | 1 |
| Becker, ML; de Keyser, CE; Hofman, A; Klungel, OH; Maitland-van der Zee, AH; Peters, BJ; Stricker, BH; Uitterlinden, AG; Verstuyft, C; Visser, LE | 1 |
| Bilianou, H; Goumas, G; Katsiki, N; Kolovou, G; Mikhailidis, DP; Pavlidis, A | 1 |
| Astort, F; Ferraro, SA; Tasat, DR; Yakisich, JS | 1 |
| Dai, K; Liu, M; Tang, T; Wang, K; Zhu, Z | 1 |
| Brouillette, J; Fernandes, P; Hamel, E; Nicolakakis, N; Ongali, B; Quirion, R; Tong, XK | 1 |
| Balduini, W; Buonocore, G; Carloni, S; Girelli, S; Longini, M | 1 |
| Boegehold, MA; Frisbee, JC; Goodwill, AG; Samora, JB | 1 |
| Astle, CM; Baur, JA; Boyd, AR; de Cabo, R; Fernandez, E; Flurkey, K; Harrison, DE; Javors, MA; Miller, RA; Nadon, NL; Nelson, JF; Orihuela, CJ; Pletcher, S; Sharp, ZD; Sinclair, D; Starnes, JW; Strong, R; Wilkinson, JE | 1 |
| Guo, DH; Hu, J; Luan, ZP; Shi, ZG; Wang, R; Yin, H; Yu, YS | 1 |
| Hamel, E; Lecrux, C; Rosa-Neto, P; Tong, XK | 1 |
| Ablao, KP; Bodmer, R; Dhahbi, JM; Li, R; Mote, P; Ocorr, K; Spindler, SR; Wang, Y; Williams, RT; Yamakawa, A | 1 |
| Helmy, MM | 1 |
| Balduini, W; Carloni, S; Cimino, M; Gelosa, P; Guerrini, U; Sironi, L; Tremoli, E | 1 |
| Andriantsitohaina, R; de Sotomayor, MA; Herrrera, MD; Jimenez, L; Marhuenda, E; Marín, R; Pérez-Guerrero, C | 1 |
| Babić, Z; Bradamante, V; Katanec, D; Muacević-Katanec, D; Poljicanin, T; Reiner, Z; Simeon-Rudolf, V | 1 |
| Bär, PR; Bredman, JJ; Cohen, LH; De Vries, AC; Vermeer, MA | 1 |
| Berg, K; Cook, TJ; Faergeman, O; Kjekshus, J; Miettinen, TA; Musliner, TA; Olsson, AG; Pedersen, T; Pyörälä, K | 1 |
| Feleszko, W; Jakobisiak, M; Zagozdzon, R | 1 |
| Gaw, A | 1 |
| Kawada, T | 1 |
| Amin, RD; Cheng, H; Dobrinska, MR; Quan, H; Rogers, JD; Stein, EA; Sweany, AE; Tate, AC | 1 |
4 review(s) available for simvastatin and Aging
| Article | Year |
|---|---|
The SLCO1B1 c.521T>C polymorphism is associated with dose decrease or switching during statin therapy in the Rotterdam Study.
Topics: Aged; Aging; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cytosine; Databases, Factual; Dose-Response Relationship, Drug; Female; Genetic Association Studies; Heptanoic Acids; Humans; Hypercholesterolemia; Liver-Specific Organic Anion Transporter 1; Male; Middle Aged; Organic Anion Transporters; Polymorphism, Single Nucleotide; Prospective Studies; Pyrroles; Risk Factors; Sex Characteristics; Simvastatin; Thymine | 2014 |
Ageing mechanisms and associated lipid changes.
Topics: Aging; Animals; Humans; Hypercholesterolemia; Lipid Metabolism; Lipids; Simvastatin | 2014 |
Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia.
Topics: Aging; Animals; Animals, Newborn; Brain Ischemia; Disease Models, Animal; Enzyme Activation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Nitric Oxide Synthase Type III; Simvastatin; Stroke | 2005 |
Healthy ageing: addressing acute coronary syndrome?
Topics: Acute Disease; Adult; Age Factors; Aged; Aging; Australia; Coronary Disease; Endothelium, Vascular; Evidence-Based Medicine; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Middle Aged; New Zealand; Pravastatin; Risk Factors; Sex Factors; Simvastatin; Syndrome; United States | 2001 |
1 trial(s) available for simvastatin and Aging
| Article | Year |
|---|---|
Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S)
Topics: Adult; Aged; Aging; Angina Pectoris; Anticholesteremic Agents; Cohort Studies; Female; Hospitalization; Humans; Lipids; Male; Middle Aged; Mortality; Myocardial Infarction; Simvastatin; Survival Analysis | 1997 |
20 other study(ies) available for simvastatin and Aging
| Article | Year |
|---|---|
Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex.
Topics: Age Factors; Aging; Animals; Behavior, Animal; Cholinergic Antagonists; Circadian Rhythm; Exploratory Behavior; Female; Hypnotics and Sedatives; Locomotion; Male; Metoprolol; Mice; Polypharmacy; Sex Factors; Simvastatin | 2022 |
Effect of simvastatin on osteogenesis of the extremity bones in aging rats.
Topics: Aging; Animals; Bone Density; Lower Extremity; Osteocalcin; Osteogenesis; Osteoporosis; Rats; Rats, Sprague-Dawley; Simvastatin | 2023 |
Modulation of Coenzyme Q
Topics: Aging; Cell Survival; Cells, Cultured; Fibroblasts; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitochondria; Oxidative Stress; Simvastatin; Ubiquinone | 2019 |
Simvastatin Efficiently Reduces Levels of Alzheimer's Amyloid Beta in Yeast.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Cellular Senescence; Ergosterol; Gene Expression; Gene Order; Genes, Reporter; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Plasmids; Proteolysis; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Simvastatin; Yeasts | 2019 |
Particulate matter cytotoxicity in cultured SH-SY5Y cells is modulated by simvastatin: Toxicological assessment for oxidative damage.
Topics: Aging; Anticholesteremic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Coal Ash; Dose-Response Relationship, Drug; Environmental Pollutants; Humans; Neuroblastoma; NF-E2-Related Factor 2; Oxidation-Reduction; Reactive Oxygen Species; Simvastatin; Superoxides | 2016 |
The effect of simvastatin on the differentiation of marrow stromal cells from aging rats.
Topics: Adipocytes; Aging; Alkaline Phosphatase; Animals; Azo Compounds; Bone Development; Bone Marrow Cells; Cell Differentiation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Osteoblasts; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin; Stromal Cells | 2009 |
Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Encephalitis; Humans; Learning Disabilities; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroimmunomodulation; Neurons; Neuroprotective Agents; Oxidative Stress; Plaque, Amyloid; Protease Nexins; Receptors, Cell Surface; Simvastatin; Space Perception | 2009 |
Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Brain; Brain Infarction; Carotid Stenosis; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation | 2009 |
Growth-dependent changes in the contribution of carbon monoxide to arteriolar function.
Topics: Acetylcholine; Age Factors; Aging; Aminolevulinic Acid; Animals; Animals, Newborn; Arterioles; Carbon Dioxide; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Heme Oxygenase (Decyclizing); In Vitro Techniques; Male; Mesoporphyrins; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptides; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Simvastatin; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2010 |
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Topics: Aging; Animals; Female; Genetic Heterogeneity; Longevity; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Resveratrol; Simvastatin; Sirolimus; Stilbenes | 2011 |
Protection against osteoporosis by statins is linked to a reduction of oxidative stress and restoration of nitric oxide formation in aged and ovariectomized rats.
Topics: Aging; Animals; Cell Line; Female; Humans; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Osteoblasts; Osteoporosis; Ovariectomy; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin | 2012 |
Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits.
Topics: Aging; Alzheimer Disease; Animals; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Simvastatin | 2012 |
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.
Topics: Aging; Animals; Behavior, Animal; Benzamides; Cardiovascular Diseases; Drosophila melanogaster; Feeding Behavior; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Longevity; Male; Methionine; Mice; Simvastatin; Ubiquinone | 2012 |
Potential hepato-protective effect of α-tocopherol or simvastatin in aged rats.
Topics: Age Factors; Aging; alpha-Tocopherol; Animals; Antioxidants; Catalase; Lipids; Liver; Liver Diseases; Male; Nitrates; Nitrites; Rats; Rats, Wistar; Simvastatin; Thiobarbituric Acid Reactive Substances | 2012 |
Improvement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathways.
Topics: Acetylcholine; Aging; Animals; Aorta; Calcimycin; Cholesterol; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Simvastatin; Thromboxane B2; Triglycerides; Vasodilation; Vasodilator Agents | 2005 |
Clinical study on the effect of simvastatin on paraoxonase activity.
Topics: Adult; Aged; Aging; Anticholesteremic Agents; Aryldialkylphosphatase; Body Mass Index; Carboxylic Ester Hydrolases; Female; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Male; Middle Aged; Sex Characteristics; Simvastatin | 2007 |
Cholesterol content of the rat lens is lowered by administration of simvastatin, but not by pravastatin.
Topics: Aging; Animals; Anticholesteremic Agents; Cholesterol; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lens, Crystalline; Lovastatin; Microsomes, Liver; Organ Culture Techniques; Pravastatin; Rats; Rats, Wistar; Simvastatin; Time Factors | 1993 |
Re: Greying of America will foster new strategies in oncology.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Doxorubicin; Drug Synergism; Humans; Lovastatin; Melanoma, Experimental; Mice; Simvastatin | 1998 |
Information on cholesterol program.
Topics: Aged; Aging; Cholesterol; Cholesterol, LDL; Female; Humans; Hypercholesterolemia; Japan; Male; Reference Values; Risk Factors; Simvastatin | 2002 |
Influence of age and gender on the plasma profiles of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitory activity following multiple doses of lovastatin and simvastatin.
Topics: Adult; Aged; Aging; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Sex Characteristics; Simvastatin | 1992 |