simvastatin has been researched along with Age-Related Osteoporosis in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (4.26) | 18.2507 |
| 2000's | 12 (25.53) | 29.6817 |
| 2010's | 20 (42.55) | 24.3611 |
| 2020's | 13 (27.66) | 2.80 |
| Authors | Studies |
|---|---|
| Gou, Y; Hu, Y; Li, H; Lian, Q; Tian, F; Zhang, L | 1 |
| Abd El Reheem, MH; Ahmed, SA; Elbahy, DA | 1 |
| Chen, S; Li, H; Liu, M; Tang, J; Wang, M; Xi, Y | 1 |
| Chen, CH; Fu, YC; Kang, L; Lee, CY; Lin, CW; Lin, SY; Wang, CK | 1 |
| Fechete, R; Micu, AM; Orban, E; Pap, Z; Sipos, RS | 1 |
| Chauhan, S; Dora, CP; Grewal, AK; Kaur, M; Nagpal, M; Singh, TG | 1 |
| Cui, X; Deng, X; Gao, Y; Hu, F; Jia, F; Lu, J; Pan, Z; Wang, X; Wu, Y; Xu, C; Yang, X; Zhang, X; Zhang, Z | 1 |
| Buendía, AJ; Camacho-Alonso, F; Martínez-Beneyto, Y; Martínez-Ortiz, C; Mercado-Díaz, AM; Merino, JJ; Navarro, JA; Plazas-Buendía, L; Vilaplana-Vivo, C | 1 |
| Feng, C; Li, DY; Liao, W; Lu, AQ; Tang, TY; Wang, ZR; Xiao, L; Yu, JC | 1 |
| Jiang, Y; Li, X; Liu, R; Wang, D; Xu, H; Zhao, B | 1 |
| Tao, ZS; Xu, HG; Yang, M; Zhou, WS | 1 |
| Jia, J; Leng, H; Song, C; Wang, H; Wu, C; Xu, Y; Zhang, C; Zhang, Q; Zhu, J | 1 |
| Hu, F; Lv, J; Song, Y; Tao, S; Wang, C; Yu, F; Yuan, H; Zhao, R; Zhou, W | 1 |
| Liu, J; Sun, Y; Xie, H; Xu, Z; Zhang, X; Zhao, Y | 1 |
| Gonçalves, RV; Maldonado, IRSC; Novaes, RD; Oliveira, MGA; Oliveira, TT; Pinto, AS; Sequetto, PL | 1 |
| Kaleağasıoğlu, F; Olcay, E; Onur, R | 1 |
| Deng, A; Huang, H; Huang, J; Liu, C; Tan, X; Xie, Y; Zou, P | 1 |
| Bürki, A; Eckelt, U; Ferguson, SJ; Kautz, A; Kneissel, M; Korn, P; Kramer, I; Range, U; Schlottig, F; Schnabelrauch, M; Stadlinger, B; Tödtmann, N | 1 |
| Haneji, T; Nakashima, Y | 1 |
| Dai, L; Hu, M; Shen, Z; Wang, Y; Wu, H; Xu, M; Xue, L; Yuan, D; Zhao, H | 1 |
| Dos Santos Kotake, BG; Ervolino, E; Gonçalves Gonzaga, M; Ingraci de Lucia, C; Issa, JP; Macedo, AP; Mizusaki Iyomasa, D; Tocchini de Figueiredo, FA | 1 |
| Cui, YY; Du, GH; Fu, X; Guo, Q; Leng, HJ; Liu, C; Liu, ZJ; Ma, T; Song, CL; Sun, CG; Tan, J; Wang, H; Xu, YS; Yin, X; Zhang, XH | 1 |
| Chai, G; Hu, FQ; Liu, J; Tao, S; Wang, H; Wang, J; Yuan, H | 1 |
| Cui, W; Huang, ZL; Lv, YX; Sun, T; Tao, ZS; Tu, KK; Yang, L; Zhou, Q; Zhou, WS | 1 |
| Moshiri, A; Oryan, A; Sharifi, AM | 1 |
| Gu, H; Wu, Y; Xu, Z; Yang, Y; Zhao, X | 1 |
| Gonzaga, MG; Issa, JP; Macedo, AP; Monteiro, LO; Paulini, MR; Ramos, J; Shimano, AC; Shimano, RC; Tocchini de Figueiredo, FA; Yanagihara, GR | 1 |
| Abuelezz, SA; Atalla, SS; El Aziz, LFA; Gorge, SS; Mohamed, MT | 1 |
| Chen, J; Du, Z; Xiao, Y; Yan, F | 1 |
| Brandt, NJ; Stefanacci, RG | 1 |
| Chen, J; Doan, N; Du, Z; Ivanovski, S; Xiao, Y; Yan, F | 1 |
| Guo, DH; Hu, J; Luan, ZP; Shi, ZG; Wang, R; Yin, H; Yu, YS | 1 |
| Hamada, H; Ohshima, H; Otsuka, M | 1 |
| Iafisco, M; Ito, T; Otsuka, M; Prat, M; Rimondini, L; Saito, M; Senna, M; Uchino, T | 1 |
| Erdemli, B; Erdemli, E; Serin-Kiliçoglu, S | 1 |
| Gonyeau, MJ | 1 |
| Carmina, E; Castello, F; Di Fede, G; Mansueto, P; Rini, GB; Rizzo, M | 1 |
| Jadhav, SB; Jain, GK | 1 |
| Galus, K | 1 |
| Rini, GB; Rizzo, M | 1 |
| Lv, RK; Wang, JW; Xu, SW; Yang, DS | 1 |
| Erdemli, E; Kiliçcoglu, SS; Serin-Kilicoglu, S | 1 |
| Crockett, JC; Hughes, A; Idris, AI; Rogers, MJ | 1 |
| Bielinska, A; Gluszko, P | 1 |
| Boyce, B; Chan, J; Chen, D; Garrett, R; Gutierrez, G; Harris, S; Mundy, G; Rossini, G; Zhao, M | 1 |
| Vogel, G | 1 |
| Abe, K; Asami, S; Kodama, T; Konishi, K; Oikawa, S; Sugiyama, M | 1 |
7 review(s) available for simvastatin and Age-Related Osteoporosis
| Article | Year |
|---|---|
Role of Simvastatin on fracture healing and osteoporosis: a systematic review on in vivo investigations.
Topics: Animals; Cell Differentiation; Fracture Healing; Fractures, Bone; Humans; Osteoclasts; Osteogenesis; Osteoporosis; Simvastatin | 2016 |
Statins and osteoporosis: a clinical review.
Topics: Aged; Bone and Bones; Bone Density; Clinical Trials as Topic; Female; Fractures, Bone; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Middle Aged; Osteogenesis; Osteoporosis; Simvastatin; Treatment Outcome; United States | 2005 |
Statins and osteoporosis: myth or reality?
Topics: Anticholesteremic Agents; Atorvastatin; Bone Development; Female; Fractures, Bone; Heptanoic Acids; Humans; Osteoporosis; Pyrroles; Simvastatin | 2004 |
Statins and osteoporosis: new role for old drugs.
Topics: Animals; Atorvastatin; Bone and Bones; Clinical Trials as Topic; Drug Delivery Systems; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Fractures, Bone; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Lovastatin; Osteogenesis; Osteoporosis; Pharmacokinetics; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Quinolines; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2006 |
[Prevention and treatment of osteoporosis].
Topics: Absorptiometry, Photon; Anticholesteremic Agents; Bone Density; Bone Density Conservation Agents; Calcitonin; Calcium, Dietary; Diphosphonates; Female; Fractures, Bone; Health Behavior; Health Knowledge, Attitudes, Practice; Humans; Male; Osteoporosis; Osteoporosis, Postmenopausal; Parathyroid Hormone; Selective Estrogen Receptor Modulators; Simvastatin; Sodium Fluoride; Strontium; Vitamin D | 2005 |
Statins, fracture risk, and bone remodeling: What is true?
Topics: Bone Remodeling; Female; Fractures, Bone; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Longitudinal Studies; Male; Myocardial Ischemia; Osteoporosis; Pravastatin; Randomized Controlled Trials as Topic; Risk Factors; Simvastatin | 2006 |
[Statins--are they potentially useful in rheumatology?].
Topics: Arthritis, Rheumatoid; Atorvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lupus Erythematosus, Systemic; Osteoporosis; Pyrroles; Rheumatic Diseases; Simvastatin; Treatment Outcome | 2007 |
40 other study(ies) available for simvastatin and Age-Related Osteoporosis
| Article | Year |
|---|---|
The combined anti-osteoporotic effects of simvastatin and exercise in ovariectomized mice fed a high-fat diet.
Topics: Animals; Diet, High-Fat; Estrogens; Female; Humans; Mice; Mice, Inbred C57BL; Obesity; Osteoporosis; Ovariectomy; Simvastatin; X-Ray Microtomography | 2022 |
l-Carnitine ameliorates the osteoporotic changes and protects against simvastatin induced myotoxicity and hepatotoxicity in glucocorticoid-induced osteoporosis in rats.
Topics: Animals; Carnitine; Chemical and Drug Induced Liver Injury; Glucocorticoids; Myotoxicity; Osteoporosis; Rats; Rats, Wistar; Simvastatin | 2022 |
Effect of simvastatin on osteogenesis of the extremity bones in aging rats.
Topics: Aging; Animals; Bone Density; Lower Extremity; Osteocalcin; Osteogenesis; Osteoporosis; Rats; Rats, Sprague-Dawley; Simvastatin | 2023 |
Bone-Targeting Nanoparticles of a Dendritic (Aspartic acid)
Topics: Animals; Aspartic Acid; Biopolymers; Bone and Bones; Gold; Lipids; Minerals; Nanoparticles; Osteoporosis; Polyesters; Polyethylene Glycols; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Simvastatin | 2022 |
Callus formation in albino Wistar rats after femur fracture assessed by visible spectroscopy.
Topics: Animals; Bony Callus; Eosine Yellowish-(YS); Female; Femoral Fractures; Femur; Fenofibrate; Fracture Healing; Hematoxylin; Humans; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Simvastatin; Spectrum Analysis | 2022 |
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis.
Topics: Animals; Delayed-Action Preparations; Drug Carriers; Hydroxyapatites; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactic Acid; Nanoparticles; Osteoporosis; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Simvastatin | 2023 |
Periostin-targeted SDSSD peptide decorated calcium phosphate nanocomposites incorporation with simvastatin for osteoporosis treatment.
Topics: Animals; Calcium Phosphates; Nanocomposites; Osteoporosis; Peptides; Simvastatin | 2023 |
Bone union formation in the rat mandibular symphysis using hydroxyapatite with or without simvastatin: effects on healthy, diabetic, and osteoporotic rats.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Diabetes Mellitus, Experimental; Durapatite; Female; Mandible; Osteogenesis; Osteoporosis; Ovariectomy; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin; Vascular Endothelial Growth Factor A; X-Ray Microtomography | 2020 |
Simvastatin promotes osteogenic differentiation of mesenchymal stem cells in rat model of osteoporosis through BMP-2/Smads signaling pathway.
Topics: Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Hypolipidemic Agents; Mesenchymal Stem Cells; Osteogenesis; Osteoporosis; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; Smad Proteins | 2020 |
Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits.
Topics: Animals; Bone-Implant Interface; Coated Materials, Biocompatible; Female; Hydroxyapatites; Osseointegration; Osteogenesis; Osteoporosis; Oxidation-Reduction; Prostheses and Implants; Rabbits; Simvastatin; Strontium; Tibia | 2020 |
Simvastatin can enhance the osseointegration of titanium rods in ovariectomized rats maintenance treatment with valproic acid.
Topics: 3T3 Cells; Animals; Anticonvulsants; Female; Gene Expression Regulation; Mice; Osseointegration; Osteogenesis; Osteoporosis; Ovariectomy; Prostheses and Implants; Prosthesis Design; Rats; Rats, Sprague-Dawley; Simvastatin; Titanium; Valproic Acid; X-Ray Microtomography | 2020 |
Osteogenic effects in a rat osteoporosis model and femur defect model by simvastatin microcrystals.
Topics: Animals; Bone Density; Crystallization; Disease Models, Animal; Drug Compounding; Female; Femur; Osteogenesis; Osteoporosis; Ovariectomy; Particle Size; Poloxamer; Rats; Rats, Sprague-Dawley; Simvastatin; X-Ray Microtomography | 2021 |
Water/pH dual responsive in situ calcium supplement collaborates simvastatin for osteoblast promotion mediated osteoporosis therapy via oral medication.
Topics: Calcium; Humans; Hydrogen-Ion Concentration; Osteoblasts; Osteoporosis; Simvastatin; Water | 2021 |
The effect of simvastatin on periprosthetic bone mineral density in the hypercholesterolaemic patients after total hip arthroplasty.
Topics: Absorptiometry, Photon; Adult; Aged; Anticholesteremic Agents; Arthroplasty, Replacement, Hip; Bone Density; Female; Femoral Neck Fractures; Follow-Up Studies; Humans; Hypercholesterolemia; Male; Middle Aged; Osteoporosis; Postoperative Period; Prospective Studies; Simvastatin | 2018 |
Low Doses of Simvastatin Potentiate the Effect of Sodium Alendronate in Inhibiting Bone Resorption and Restore Microstructural and Mechanical Bone Properties in Glucocorticoid-Induced Osteoporosis.
Topics: Alendronate; Alkaline Phosphatase; Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Bone Resorption; Calcium; Dexamethasone; Drug Synergism; Osteoporosis; Phosphorus; Rats; Rats, Wistar; Simvastatin; Urea | 2017 |
Statins as potential agents for the prevention and treatment of osteoporosis.
Topics: Animals; Atorvastatin; Bone Density; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Osteoporosis; Rats; Simvastatin | 2018 |
Bone-targeted delivery of simvastatin-loaded PEG-PLGA micelles conjugated with tetracycline for osteoporosis treatment.
Topics: Animals; Bone and Bones; Disease Models, Animal; Drug Carriers; Drug Compounding; Human Umbilical Vein Endothelial Cells; Humans; Micelles; Osteoporosis; Particle Size; Polyesters; Polyethylene Glycols; Rats; Simvastatin; Tetracycline | 2018 |
Osseointegration of biochemically modified implants in an osteoporosis rodent model.
Topics: Animals; Biomechanical Phenomena; Diphosphonates; Disease Models, Animal; Female; Fluorescent Dyes; Imidazoles; Implants, Experimental; Osseointegration; Osteoporosis; Rats; Rats, Wistar; Simvastatin; X-Ray Microtomography; Zoledronic Acid | 2013 |
Stimulation of osteoclast formation by RANKL requires interferon regulatory factor-4 and is inhibited by simvastatin in a mouse model of bone loss.
Topics: Animals; Bone Density; Bone Density Conservation Agents; Cell Differentiation; Cell Line; Drug Evaluation, Preclinical; Epigenesis, Genetic; Female; Gene Expression; Histones; Humans; Interferon Regulatory Factors; Methylation; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Osteoclasts; Osteoporosis; Protein Processing, Post-Translational; Protein Transport; RANK Ligand; Signal Transduction; Simvastatin | 2013 |
The functional mechanism of simvastatin in experimental osteoporosis.
Topics: Animals; Bone Density; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Osteoblasts; Osteoporosis; Simvastatin | 2016 |
The effect of simvastatin treatment on bone repair of femoral fracture in animal model.
Topics: Animals; Bone and Bones; Disease Models, Animal; Female; Femoral Fractures; Fracture Healing; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunohistochemistry; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Osteoporosis; Rats; Rats, Wistar; Simvastatin; Stainless Steel | 2015 |
A single CT-guided percutaneous intraosseous injection of thermosensitive simvastatin/poloxamer 407 hydrogel enhances vertebral bone formation in ovariectomized minipigs.
Topics: Absorptiometry, Photon; Animals; Bone Density; Bone Morphogenetic Protein 2; Chemistry, Physical; Drug Combinations; Drug Delivery Systems; Drug Evaluation, Preclinical; Female; Hydrogel, Polyethylene Glycol Dimethacrylate; Injections, Spinal; Lumbar Vertebrae; Microscopy, Electron, Scanning; Osteogenesis; Osteoporosis; Ovariectomy; Poloxamer; Radiography, Interventional; Rheology; Simvastatin; Swine; Swine, Miniature; Tomography, X-Ray Computed; Vascular Endothelial Growth Factor A | 2016 |
Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system.
Topics: 3T3 Cells; Animals; Bone and Bones; Cell Differentiation; Chromatography, High Pressure Liquid; Drug Delivery Systems; Female; Fluorescein; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Nanoparticles; Osteogenesis; Osteoporosis; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Simvastatin; Solvents; Surface Properties; Tetracycline | 2015 |
The effects of combined human parathyroid hormone (1-34) and simvastatin treatment on osseous integration of hydroxyapatite-coated titanium implants in the femur of ovariectomized rats.
Topics: Animals; Arthroplasty, Replacement, Hip; Bone Density Conservation Agents; Bone Regeneration; Coated Materials, Biocompatible; Disease Models, Animal; Drug Therapy, Combination; Durapatite; Female; Femur; Implants, Experimental; Osseointegration; Osteoporosis; Ovariectomy; Parathyroid Hormone; Rats; Rats, Sprague-Dawley; Simvastatin; Titanium | 2015 |
[Therapeutic effects and mechanisms of androgen and simvastatin on osteoporosis in castrated rats].
Topics: Androgens; Animals; Bone and Bones; Bone Density; Male; Osteocalcin; Osteogenesis; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Simvastatin | 2015 |
Effect of treatment with simvastatin on bone microarchitecture of the femoral head in an osteoporosis animal model.
Topics: Animals; Disease Models, Animal; Femur Head; Osteoporosis; Ovariectomy; Photomicrography; Rats; Rats, Wistar; Simvastatin | 2016 |
The anti-osteoporotic and anti-atherogenic effects of alendronate and simvastatin in ovariectomized rats fed high fat diet: A comparative study of combination therapy versus monotherapy.
Topics: Alendronate; Alkaline Phosphatase; Animals; Atherosclerosis; Body Weight; Bone and Bones; Bone Density; Combined Modality Therapy; Diet, High-Fat; Female; Osteocalcin; Osteoporosis; Ovariectomy; Rats; Simvastatin | 2017 |
Effects of Simvastatin on bone healing around titanium implants in osteoporotic rats.
Topics: Animals; Bone Density; Bone Density Conservation Agents; Bone Screws; Dental Implants; Dental Materials; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Osseointegration; Osteogenesis; Osteoporosis; Ovariectomy; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin; Tibia; Time Factors; Titanium | 2009 |
Discontinuation of unnecessary medications in older adults.
Topics: Aged; Aged, 80 and over; Alendronate; Anti-Ulcer Agents; Antihypertensive Agents; Assisted Living Facilities; Bone Density Conservation Agents; Case Management; Diabetes Mellitus; Drug Therapy; Evidence-Based Medicine; Guidelines as Topic; Hepatitis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Lisinopril; Longevity; Male; Omeprazole; Osteoporosis; Palliative Care; Pharmacists; Precision Medicine; Simvastatin | 2011 |
Serum bone formation marker correlation with improved osseointegration in osteoporotic rats treated with simvastatin.
Topics: Alkaline Phosphatase; Animals; Biomarkers; Dental Implants; Female; Implants, Experimental; Osseointegration; Osteocalcin; Osteogenesis; Osteoporosis; Ovariectomy; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin; Tibia | 2013 |
Protection against osteoporosis by statins is linked to a reduction of oxidative stress and restoration of nitric oxide formation in aged and ovariectomized rats.
Topics: Aging; Animals; Cell Line; Female; Humans; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Osteoblasts; Osteoporosis; Ovariectomy; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin | 2012 |
Dissolution medium responsive simvastatin release from biodegradable apatite cements and the therapeutic effect in osteoporosis rats.
Topics: Analysis of Variance; Animals; Apatites; Body Fluids; Bone Cements; Bone Density Conservation Agents; Drug Delivery Systems; Female; Models, Biological; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Simvastatin; Tomography, X-Ray Computed | 2012 |
Preparation of injectable auto-forming alginate gel containing simvastatin with amorphous calcium phosphate as a controlled release medium and their therapeutic effect in osteoporosis model rat.
Topics: Alginates; Animals; Buffers; Calcium Phosphates; Catalysis; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Female; Gels; Hypolipidemic Agents; Injections; Osteoporosis; Polymerization; Rats; Rats, Sprague-Dawley; Simvastatin | 2012 |
A new approach to the treatment of osteoporosis.
Topics: Animals; Bone Development; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Osteoporosis; Rats; Simvastatin | 2005 |
Locally applied simvastatin promotes fracture healing in ovariectomized rat.
Topics: Alkaline Phosphatase; Animals; Biomechanical Phenomena; Bony Callus; Cholesterol; Drug Evaluation, Preclinical; Female; Fracture Healing; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Subcutaneous; Osteoporosis; Ovariectomy; Radiography; Rats; Rats, Sprague-Dawley; Simvastatin; Tibia; Tibial Fractures | 2007 |
New addition to the statin's effect.
Topics: Animals; Bone Density; Cell Differentiation; Fracture Healing; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Osteoporosis; Rats; Rats, Wistar; Simvastatin; Stem Cells | 2007 |
A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo.
Topics: Anabolic Agents; Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Cells, Cultured; Disease Models, Animal; Female; Hydrophobic and Hydrophilic Interactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred BALB C; Osteoclasts; Osteoporosis; Ovariectomy; Pravastatin; Protein Prenylation; Pyridines; Rabbits; rap1 GTP-Binding Proteins; Signal Transduction; Simvastatin; Water | 2007 |
Stimulation of bone formation in vitro and in rodents by statins.
Topics: Animals; Bone Density; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Line; Female; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mice; Mice, Inbred ICR; Organ Culture Techniques; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; Promoter Regions, Genetic; Rats; Recombinant Proteins; Simvastatin; Skull; Transfection; Transforming Growth Factor beta | 1999 |
Cholesterol-lowering drugs may boost bones.
Topics: Animals; Anticholesteremic Agents; Bone Density; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Clinical Trials as Topic; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Osteogenesis; Osteoporosis; Rats; Simvastatin; Transforming Growth Factor beta | 1999 |
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells.
Topics: Anti-Bacterial Agents; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Bone Neoplasms; Cloning, Molecular; Disulfides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Indole Alkaloids; Lovastatin; Mevalonic Acid; Osteoporosis; Osteosarcoma; Pravastatin; Promoter Regions, Genetic; RNA, Messenger; Simvastatin; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |