Page last updated: 2024-08-23

simvastatin and Age-Related Memory Disorders

simvastatin has been researched along with Age-Related Memory Disorders in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (38.89)29.6817
2010's9 (50.00)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Nikbakhtzadeh, M; Roghani, M; Sanaeierad, A; Zahedi, E; Zamani, E1
Hojati, V; Jafari, M; Khaksari, M; Vaezi, G1
Chen, F; Fang, SC; Hong, H; Hu, M; Kong, LY; Long, Y; Sun, HB; Tang, SS; Xie, H1
Binks, S; Cardoso, MJ; Chan, D; Chataway, J; Frost, C; Nicholas, JM; Nicholas, R; Ourselin, S; Wilkie, D1
Chopp, M; Darwish, H; Mahmood, A; Schallert, T; Therrien, B1
Schetz, D; Sein Anand, J1
de Silva, V; Hanwella, R; Suraweera, C1
Brouillette, J; Fernandes, P; Hamel, E; Nicolakakis, N; Ongali, B; Quirion, R; Tong, XK1
Burgos, JS; Pineda, A; Ramirez, C; Tercero, I1
Simon, HB1
Hamel, E; Lecrux, C; Rosa-Neto, P; Tong, XK1
Isiguzoro, I; Okeahialam, BN1
Arvik, BM; Doraiswamy, PM; Mitton, MW; Wagstaff, LR1
Harrell, TK; Jones, DW; King, DS; Lindley, BJ; Wilburn, AJ; Wofford, MR1
Cao, D; Fukuchi, K; Kim, H; Lester, R; Li, L1
Chen, J; Chopp, M; Goussev, A; Jiang, H; Li, Y; Lu, C; Lu, D; Mahmood, A; Qu, C; Schallert, T1
Kurinami, H; Morishita, R; Ogihara, T; Sato, N; Shimamura, M; Shinohara, M; Takeda, S; Takeuchi, D1
Orsi, A; Sherman, O; Woldeselassie, Z1

Reviews

1 review(s) available for simvastatin and Age-Related Memory Disorders

ArticleYear
Statin-associated memory loss: analysis of 60 case reports and review of the literature.
    Pharmacotherapy, 2003, Volume: 23, Issue:7

    Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Memory Disorders; Pravastatin; Randomized Controlled Trials as Topic; Simvastatin

2003

Trials

2 trial(s) available for simvastatin and Age-Related Memory Disorders

ArticleYear
Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial.
    The Lancet. Neurology, 2017, Volume: 16, Issue:8

    Topics: Adult; Cognitive Dysfunction; Double-Blind Method; Executive Function; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Memory Disorders; Middle Aged; Multiple Sclerosis, Chronic Progressive; Outcome Assessment, Health Care; Quality of Life; Simvastatin

2017
Simvastatin and environmental enrichment effect on recognition and temporal order memory after mild-to-moderate traumatic brain injury.
    Brain injury, 2014, Volume: 28, Issue:2

    Topics: Analysis of Variance; Animals; Brain Injuries; Environment, Controlled; Humans; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Rats; Rats, Wistar; Recognition, Psychology; Simvastatin; Synaptic Transmission

2014

Other Studies

15 other study(ies) available for simvastatin and Age-Related Memory Disorders

ArticleYear
Simvastatin improves learning and memory impairment via gut-brain axis regulation in an ovariectomized/D-galactose Alzheimer's rat model.
    Behavioural brain research, 2023, 09-13, Volume: 453

    Topics: Alzheimer Disease; Animals; Brain-Gut Axis; Disease Models, Animal; Female; Galactose; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Memory Disorders; Rats; Simvastatin

2023
Simvastatin attenuates spatial memory impairment via inhibiting microgliosis and apoptotic cell death against ethanol induced neurotoxicity in the developing rat hippocampus.
    Brain research, 2021, 05-01, Volume: 1758

    Topics: Alcohol-Induced Disorders, Nervous System; Animals; Animals, Newborn; Apoptosis; Central Nervous System Depressants; Ethanol; Gliosis; Hippocampus; Male; Memory Disorders; Neuroprotective Agents; Rats; Rats, Wistar; Simvastatin; Spatial Memory

2021
Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice.
    Neuroscience, 2017, 07-04, Volume: 355

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Blood Glucose; Brain; Cytokines; Diabetes Mellitus, Experimental; Disease Models, Animal; Hypolipidemic Agents; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Neurotoxicity Syndromes; Peptide Fragments; Signal Transduction; Simvastatin

2017
[Neurological disturbances in patient who ingested high doses of simvastatin].
    Przeglad lekarski, 2014, Volume: 71, Issue:9

    Topics: Atherosclerosis; Cognition Disorders; Drug Overdose; Dyslipidemias; Electromagnetic Fields; Humans; Male; Memory Disorders; Middle Aged; Occupational Diseases; Simvastatin; Sleep Wake Disorders

2014
Simvastatin-induced cognitive dysfunction: two case reports.
    Journal of medical case reports, 2016, Apr-05, Volume: 10

    Topics: Adult; Cognitive Dysfunction; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Memory Disorders; Middle Aged; Simvastatin

2016
Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice.
    Neurobiology of disease, 2009, Volume: 35, Issue:3

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Encephalitis; Humans; Learning Disabilities; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroimmunomodulation; Neurons; Neuroprotective Agents; Oxidative Stress; Plaque, Amyloid; Protease Nexins; Receptors, Cell Surface; Simvastatin; Space Perception

2009
Simvastatin is the statin that most efficiently protects against kainate-induced excitotoxicity and memory impairment.
    Journal of Alzheimer's disease : JAD, 2011, Volume: 24, Issue:1

    Topics: Animals; Excitatory Amino Acid Agonists; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kainic Acid; Memory Disorders; Mice; Mice, Transgenic; Neuroprotective Agents; Random Allocation; Simvastatin; Treatment Outcome

2011
On call. My doctor just started me on Zocor to lower my cholesterol. I have had just one side effect, forgetfulness. It's not as bad as it sounds, since my memory remains excellent, except that I often forget to take my pill in the evening. So I'd like to
    Harvard men's health watch, 2011, Volume: 16, Issue:3

    Topics: Anticholesteremic Agents; Drug Administration Schedule; Health Knowledge, Attitudes, Practice; Humans; Male; Medication Adherence; Memory Disorders; Simvastatin

2011
Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Apr-04, Volume: 32, Issue:14

    Topics: Aging; Alzheimer Disease; Animals; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Simvastatin

2012
Statin related memory dysfunction in a Nigerian woman: a case report.
    Current drug safety, 2012, Volume: 7, Issue:1

    Topics: Activities of Daily Living; Adult; Dyslipidemias; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Memory Disorders; Nigeria; Simvastatin

2012
Cognitive impairment associated with atorvastatin and simvastatin.
    Pharmacotherapy, 2003, Volume: 23, Issue:12

    Topics: Aged; Atorvastatin; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Memory Disorders; Pyrroles; Simvastatin

2003
Simvastatin enhances learning and memory independent of amyloid load in mice.
    Annals of neurology, 2006, Volume: 60, Issue:6

    Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Brain; Cholesterol; Cytoprotection; Disease Models, Animal; Female; Learning; Learning Disabilities; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Nitric Oxide Synthase Type III; Plaque, Amyloid; Proto-Oncogene Proteins c-akt; Signal Transduction; Simvastatin; Treatment Outcome

2006
Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury.
    Journal of neurotrauma, 2007, Volume: 24, Issue:7

    Topics: Animals; Atorvastatin; Brain Injuries; Cell Proliferation; Dentate Gyrus; Dose-Response Relationship, Drug; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Maze Learning; Memory Disorders; Neovascularization, Physiologic; Nerve Degeneration; Nerve Regeneration; Neuronal Plasticity; Neurons; Neuroprotective Agents; Pyrroles; Rats; Rats, Wistar; Recovery of Function; Simvastatin; Stem Cells; Treatment Outcome

2007
Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model.
    International journal of molecular medicine, 2008, Volume: 21, Issue:5

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Memory Disorders; Mice; Oxidative Stress; Simvastatin

2008
Simvastatin-associated memory loss.
    Pharmacotherapy, 2001, Volume: 21, Issue:6

    Topics: Anticholesteremic Agents; Humans; Hypercholesterolemia; Male; Memory Disorders; Middle Aged; Pravastatin; Recovery of Function; Simvastatin

2001