Page last updated: 2024-08-23

simvastatin and Adverse Drug Event

simvastatin has been researched along with Adverse Drug Event in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (3.85)	18.2507
2000's	4 (15.38)	29.6817
2010's	18 (69.23)	24.3611
2020's	3 (11.54)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, B; Chen, SP; Cheng, RY; Lin, Y; Tsui, L; Xu, S; Ye, P	1
Li, XY; Mao, YM; Zhong, W	1
Ball, S; Carroll, CB; Creanor, S; Eyre, V; Foggo, A; Stevens, KN; Vickery, J; Webb, D; Webber, M; Whone, A; Wyse, R; Zajicek, J	1
Álvarez, D; Cartier, M; Marino, M; Míguez, C; Muñoz, AE; Pollarsky, F; Romero, G; Salgado, P; Vázquez, H	1
Bontkes, HJ; de Gruijl, TD; Huijts, CM; Reijm, M; Schneiders, FL; van der Vliet, HJ; Verheul, HMW	1
Garcia, B; Halvorsen, KH; Samdal, H; Svendsen, K; Vorren, S	1
Spence, JD	1
Brookhart, MA; Jonsson Funk, M; Kshirsagar, AV; Layton, JB; Pate, V; Simpson, RJ; Stürmer, T	1
Gurwitz, D; Janssens, ACJW; Maitland-van der Zee, AH; Tonk, ECM	1
Armitage, J; Baigent, C; Blackwell, L; Blumenthal, R; Collins, R; Danesh, J; DeMets, D; Emberson, J; Evans, S; Law, M; MacMahon, S; Martin, S; Neal, B; Peto, R; Poulter, N; Preiss, D; Reith, C; Ridker, P; Roberts, I; Rodgers, A; Sandercock, P; Schulz, K; Sever, P; Simes, J; Smeeth, L; Smith, GD; Wald, N; Yusuf, S	1
Scholl, JH; van Puijenbroek, EP	1
Chyou, TY; Nishtala, PS	1
Nakamura, Y	1
Bays, HE; Doyle, RT; Maki, KC; McKenney, J; Meadowcroft, A; Schroyer, R; Snipes, R; Stein, E	1
Daly, AK	2
Choi, MJ; Hong, SS; Hong, SW; Jung, KH; Kim, JM; Kwon, HN; Park, S; Wen, H; Yang, HJ	1
Becker, ML; Elens, LL; Hofman, A; Stricker, BH; Uitterlinden, AG; van Schaik, RH; Visser, LE	1
Guthrie, RM	1

Reviews

4 review(s) available for simvastatin and Adverse Drug Event

Article	Year
Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet (London, England), 2016, 11-19, Volume: 388, Issue:10059 Topics: Anticholesteremic Agents; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Drug-Related Side Effects and Adverse Reactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Infarction; Risk Assessment; Safety; Simvastatin; Stroke	2016
Genome-wide association studies in pharmacogenomics. Nature reviews. Genetics, 2010, Volume: 11, Issue:4 Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2C9; Drug-Related Side Effects and Adverse Reactions; Floxacillin; Genome-Wide Association Study; Humans; Interferon-alpha; Mixed Function Oxygenases; Muscular Diseases; Pharmacogenetics; Platelet Aggregation Inhibitors; Simvastatin; Vitamin K Epoxide Reductases	2010
Using genome-wide association studies to identify genes important in serious adverse drug reactions. Annual review of pharmacology and toxicology, 2012, Volume: 52 Topics: Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2C8; Drug-Related Side Effects and Adverse Reactions; Exanthema; Genetic Predisposition to Disease; Genome-Wide Association Study; Genome, Human; Genotype; HLA-A Antigens; Humans; Hypersensitivity; Liver; Pharmacogenetics; Polymorphism, Genetic; Risk Factors; Simvastatin	2012
How safe is aggressive statin therapy? Progress in cardiovascular nursing, 2006,Summer, Volume: 21, Issue:3 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Muscular Diseases; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides	2006

Trials

3 trial(s) available for simvastatin and Adverse Drug Event

Article	Year
Simvastatin as a neuroprotective treatment for Parkinson's disease (PD STAT): protocol for a double-blind, randomised, placebo-controlled futility study. BMJ open, 2019, 10-07, Volume: 9, Issue:10 Topics: Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Interviews as Topic; Male; Middle Aged; Neurologic Examination; Neuroprotective Agents; Outcome Assessment, Health Care; Parkinson Disease; Randomized Controlled Trials as Topic; Simvastatin	2019
Safety of Chronic Simvastatin Treatment in Patients with Decompensated Cirrhosis: Many Adverse Events but No Liver Injury. Digestive diseases and sciences, 2021, Volume: 66, Issue:9 Topics: Argentina; Cardiovascular Diseases; Disease Progression; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Gastrointestinal Diseases; Headache; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Cirrhosis; Male; Middle Aged; Myalgia; Outcome and Process Assessment, Health Care; Risk Assessment; Severity of Illness Index; Simvastatin	2021
Long-term up to 24-month efficacy and safety of concomitant prescription omega-3-acid ethyl esters and simvastatin in hypertriglyceridemic patients. Current medical research and opinion, 2010, Volume: 26, Issue:4 Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Fatty Acids, Omega-3; Female; Humans; Hypertriglyceridemia; Male; Middle Aged; Prospective Studies; Simvastatin	2010

Other Studies

19 other study(ies) available for simvastatin and Adverse Drug Event

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Adverse drug reactions of statin therapy in China from 1989 to 2019: a national database analysis. European journal of hospital pharmacy : science and practice, 2023, Volume: 30, Issue:e1 Topics: Drug-Related Side Effects and Adverse Reactions; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Rosuvastatin Calcium; Simvastatin	2023
[Statin-related drug-induced liver injury]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2023, Jun-20, Volume: 31, Issue:6 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Simvastatin	2023
The effects of systemic treatment with aminobisphosphonates and statins on circulating Vγ9Vδ2-T cells in patients with advanced cancer. Immunobiology, 2018, Volume: 223, Issue:2 Topics: Acute-Phase Reaction; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Drug-Related Side Effects and Adverse Reactions; Female; Granzymes; HLA-DR Antigens; Humans; Immunophenotyping; Lymphocyte Activation; Male; Middle Aged; Perforin; Pilot Projects; Prostatic Neoplasms; Receptors, Antigen, T-Cell, gamma-delta; Simvastatin; T-Lymphocytes	2018
Adverse drug reaction reporting: how can drug consumption information add to analyses using spontaneous reports? European journal of clinical pharmacology, 2018, Volume: 74, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Atorvastatin; Central Nervous System Stimulants; Databases, Factual; Drug Utilization Review; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Methylphenidate; Norway; Pharmaceutical Services; Pharmacovigilance; Risk Factors; Sex Factors; Simvastatin	2018
Problems with polypills. International journal of stroke : official journal of the International Stroke Society, 2018, Volume: 13, Issue:6 Topics: Adrenergic beta-Antagonists; Asthma; Citrus paradisi; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Polypharmacy; Precision Medicine; Primary Prevention; Rhabdomyolysis; Simvastatin; Stroke	2018
Acute kidney injury in statin initiators. Pharmacoepidemiology and drug safety, 2013, Volume: 22, Issue:10 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insurance Claim Review; Male; Medicare; Middle Aged; Simvastatin; United States	2013
Assessment of pharmacogenetic tests: presenting measures of clinical validity and potential population impact in association studies. The pharmacogenomics journal, 2017, Volume: 17, Issue:4 Topics: Dideoxynucleosides; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Genetic Testing; Genetic Variation; HLA-B Antigens; Humans; Pharmacogenetics; Simvastatin	2017
The value of time-to-onset in statistical signal detection of adverse drug reactions: a comparison with disproportionality analysis in spontaneous reports from the Netherlands. Pharmacoepidemiology and drug safety, 2016, Volume: 25, Issue:12 Topics: Adverse Drug Reaction Reporting Systems; Data Interpretation, Statistical; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Netherlands; Nitrofurantoin; Odds Ratio; Papillomavirus Vaccines; Pharmacovigilance; Pilot Projects; Sensitivity and Specificity; Simvastatin; Time Factors	2016
Exploring New Zealand prescription data using sequence symmetry analyses for predicting adverse drug reactions. Journal of clinical pharmacy and therapeutics, 2017, Volume: 42, Issue:2 Topics: Aged; Amiodarone; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Humans; New Zealand; Pharmacoepidemiology; Simvastatin	2017
Pharmacogenomics and drug toxicity. The New England journal of medicine, 2008, Aug-21, Volume: 359, Issue:8 Topics: Drug-Related Side Effects and Adverse Reactions; Genetic Markers; Genetic Predisposition to Disease; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver-Specific Organic Anion Transporter 1; Muscular Diseases; Organic Anion Transporters; Pharmacogenetics; Polymorphism, Single Nucleotide; Rhabdomyolysis; Simvastatin	2008
An effective assessment of simvastatin-induced toxicity with NMR-based metabonomics approach. PloS one, 2011, Feb-22, Volume: 6, Issue:2 Topics: Animals; Biomarkers, Pharmacological; Blood Chemical Analysis; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Female; Hypolipidemic Agents; Liver; Metabolome; Metabolomics; Nuclear Magnetic Resonance, Biomolecular; Rats; Rats, Wistar; Simvastatin; Treatment Outcome; Urinalysis	2011
Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy. The pharmacogenomics journal, 2013, Volume: 13, Issue:3 Topics: Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Association Studies; Haplotypes; Heptanoic Acids; Humans; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Proportional Hazards Models; Pyrroles; Simvastatin	2013
[2,700 reported adverse effects of drugs in 1991. A large spectrum of new antidepressive agents]. Lakartidningen, 1992, Jul-22, Volume: 89, Issue:30-31 Topics: Adult; Antidepressive Agents; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Indoles; Lovastatin; Male; Simvastatin; Sulfonamides; Sumatriptan; Sweden	1992