Page last updated: 2024-08-23

simvastatin and Acute Respiratory Distress Syndrome

simvastatin has been researched along with Acute Respiratory Distress Syndrome in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (12.50)29.6817
2010's10 (62.50)24.3611
2020's4 (25.00)2.80

Authors

AuthorsStudies
Boyle, AJ; Bradbury, I; Conlon, J; Ferris, P; McAuley, DF; O'Kane, CM; Rogers, AJ; Shankar-Hari, M1
Blackwood, B; Clarke, M; Lee, B; McAuley, DF; McDowell, C; Verghis, RM1
Baron, RM; Conlon, J; Guan, J; Levitt, JE; Matthay, MA; McAuley, DF; Moore, AR; O'Kane, CM; Pienkos, SM; Rogers, AJ1
Coleman, MD; Izotov, BN; Kteniadakis, S; Papadakis, GZ; Spandidos, DA; Stancioiu, F; Tsatsakis, A1
Chen, M; Chen, Q; Cheng, L; Geng, Y; Jiang, H; Lu, J; Wang, X1
Agus, A; Hulme, C; Jackson, C; Laffey, JG; McAuley, DF; McDowell, C; O'Kane, CM; Verghis, RM1
Fan, E; Lawler, PR1
Calfee, CS; Delucchi, KL; Hackett, J; Laffey, JG; Matthay, MA; McAuley, DF; McDowell, C; O'Kane, CM; Shankar-Hari, M; Sinha, P1
Agus, A; Campbell, C; Kennedy, G; McAuley, D; O'Kane, C; Perkins, GD; Phair, G; Shyamsundar, M1
Gordon, A; McAuley, DF; O'Kane, C; Prevost, AT; Santhakumaran, S; Shankar-Hari, M1
Drazen, JM; Gelijns, AC1
Hopkins, PA; Johnston, AJ; Johnston, P; Laffey, JG; McAuley, DF; McDowell, C; McNally, C; Mullan, B; O'Kane, CM; Perkins, GD; Trinder, TJ1
Durand, A; Gleeson, J; Grimaldi, D; Taccone, FS1
Fessler, MB1
An, J; Chen, YJ; Guo, LL; Shen, YC; Wang, CN; Wang, T; Wen, FQ; Xu, D; Yang, T; Zhang, XH; Zhao, L; Zuo, QN1
Aldemir, D; Arslan, G; Candan, S; Ozen, O; Pirat, A; Yücel, M; Zeyneloglu, P1

Reviews

3 review(s) available for simvastatin and Acute Respiratory Distress Syndrome

ArticleYear
A dissection of SARS‑CoV2 with clinical implications (Review).
    International journal of molecular medicine, 2020, Volume: 46, Issue:2

    Topics: Amiodarone; Animals; COVID-19; Curcumin; Humans; Pioglitazone; Respiratory Distress Syndrome; SARS-CoV-2; Simvastatin

2020
[Statin in the treatment of ALI/ARDS: a systematic review and Meta-analysis based on international databases].
    Zhonghua wei zhong bing ji jiu yi xue, 2017, Volume: 29, Issue:1

    Topics: Acute Lung Injury; Cohort Studies; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intensive Care Units; Length of Stay; Respiration, Artificial; Respiratory Distress Syndrome; Simvastatin

2017
Failure of statins in ARDS: the quest for the Holy Grail continues.
    Minerva anestesiologica, 2016, Volume: 82, Issue:11

    Topics: Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Failure; Randomized Controlled Trials as Topic; Renal Insufficiency; Respiration, Artificial; Respiratory Distress Syndrome; Rosuvastatin Calcium; Sepsis; Simvastatin; Treatment Failure

2016

Trials

6 trial(s) available for simvastatin and Acute Respiratory Distress Syndrome

ArticleYear
Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial.
    Critical care (London, England), 2022, 06-07, Volume: 26, Issue:1

    Topics: Carrier Proteins; Cytokines; Humans; Inflammasomes; Interleukin-18; Respiratory Distress Syndrome; Simvastatin

2022
Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials.
    Critical care (London, England), 2023, 03-28, Volume: 27, Issue:1

    Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Respiratory Distress Syndrome; Rosuvastatin Calcium; Sepsis; Simvastatin

2023
Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial.
    Critical care (London, England), 2017, 05-17, Volume: 21, Issue:1

    Topics: Adult; Aged; Cost-Benefit Analysis; Double-Blind Method; Female; Humans; Male; Middle Aged; Quality-Adjusted Life Years; Respiratory Distress Syndrome; Simvastatin; State Medicine; Time

2017
Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.
    The Lancet. Respiratory medicine, 2018, Volume: 6, Issue:9

    Topics: Adult; Aged; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Positive-Pressure Respiration; Respiratory Distress Syndrome; Simvastatin; Time Factors

2018
Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial.
    Trials, 2018, Dec-18, Volume: 19, Issue:1

    Topics: Double-Blind Method; Elective Surgical Procedures; Esophagectomy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Multicenter Studies as Topic; Myocardial Infarction; One-Lung Ventilation; Pneumonectomy; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Risk Factors; Simvastatin; Time Factors; Treatment Outcome; United Kingdom

2018
Simvastatin in the acute respiratory distress syndrome.
    The New England journal of medicine, 2014, Oct-30, Volume: 371, Issue:18

    Topics: Adult; Aged; Combined Modality Therapy; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intensive Care Units; Kaplan-Meier Estimate; Male; Middle Aged; Respiration, Artificial; Respiratory Distress Syndrome; Simvastatin; Tidal Volume; Treatment Failure

2014

Other Studies

7 other study(ies) available for simvastatin and Acute Respiratory Distress Syndrome

ArticleYear
Re-analysis of ventilator-free days (VFD) in acute respiratory distress syndrome (ARDS) studies.
    Trials, 2023, Mar-13, Volume: 24, Issue:1

    Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Respiration, Artificial; Respiratory Distress Syndrome; Simvastatin

2023
Heterogeneity and phenotypic stratification in acute respiratory distress syndrome.
    The Lancet. Respiratory medicine, 2018, Volume: 6, Issue:9

    Topics: Dyspnea; Humans; Intensive Care Units, Pediatric; Respiratory Distress Syndrome; Simvastatin

2018
Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials.
    Critical care (London, England), 2019, 05-03, Volume: 23, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents; APACHE; Cardiotonic Agents; Critical Illness; Female; Guideline Adherence; Hospital Mortality; Humans; Hydrocortisone; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intensive Care Units; Male; Middle Aged; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sepsis; Simendan; Simvastatin; Treatment Outcome; Vasoconstrictor Agents; Vasopressins

2019
Statin strikeout.
    The New England journal of medicine, 2014, Jun-05, Volume: 370, Issue:23

    Topics: Female; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pulmonary Disease, Chronic Obstructive; Pyrimidines; Respiratory Distress Syndrome; Rosuvastatin Calcium; Sepsis; Simvastatin; Sulfonamides

2014
Simvastatin as a potential therapeutic for acute respiratory distress syndrome.
    American journal of respiratory and critical care medicine, 2009, Nov-15, Volume: 180, Issue:10

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Lovastatin; Lung; Mevalonic Acid; Mice; Neutrophils; Respiratory Distress Syndrome; Simvastatin

2009
Ox-LDL-induced TGF-β1 production in human alveolar epithelial cells: involvement of the Ras/ERK/PLTP pathway.
    Journal of cellular physiology, 2012, Volume: 227, Issue:9

    Topics: Cell Line, Tumor; Epithelial Cells; Gene Expression Regulation; Genes, ras; Humans; Hypolipidemic Agents; Lipoproteins, LDL; MAP Kinase Kinase Kinase 3; MAP Kinase Signaling System; Mevalonic Acid; Phospholipid Transfer Proteins; Phosphorylation; Pulmonary Alveoli; Respiratory Distress Syndrome; RNA, Small Interfering; Simvastatin; Smad3 Protein; Transforming Growth Factor beta1

2012
Pretreatment with simvastatin reduces lung injury related to intestinal ischemia-reperfusion in rats.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:1

    Topics: Animals; Intestinal Mucosa; Intestines; Lung; Lung Injury; Male; Premedication; Rats; Rats, Wistar; Reperfusion Injury; Respiratory Distress Syndrome; Simvastatin

2006