simvastatin has been researched along with Acute Confusional Senile Dementia in 62 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 27 (43.55) | 29.6817 |
| 2010's | 30 (48.39) | 24.3611 |
| 2020's | 5 (8.06) | 2.80 |
| Authors | Studies |
|---|---|
| Hamel, E; Royea, J; Tong, XK | 1 |
| Degrush, E; Drachman, D; Gounis, MJ; Henninger, N; Lindsay, C; Shazeeb, MS; Vardar, Z | 1 |
| Dang, L; Gao, F; Qu, Q; Wang, J; Wei, S | 1 |
| Nikbakhtzadeh, M; Roghani, M; Sanaeierad, A; Zahedi, E; Zamani, E | 1 |
| Azadi, A; Azadi, S; Farjadian, F; Mohammadi Samani, S; Mozafari, N | 1 |
| Huang, W; Li, Z; Zhao, L; Zhao, W | 1 |
| Cherrier, M; Fagan, AM; Li, G; Mayer, CL; Millard, SP; Morelli, D; Peskind, ER; Petrie, EC; Raskind, MA; Raskind, WH | 1 |
| Alexiou, C; Cicha, I; Friedrich, RP; Janko, C; Lyer, S; Pöttler, M | 1 |
| Ji, J; Liu, W; Zhang, X; Zhao, Y | 1 |
| Gao, J; Li, Y; Liu, Q; Liu, X; Sun, J; Wang, J | 1 |
| Dhakal, S; Fraser, JM; Gardiner, K; Macreadie, I; Subhan, M | 1 |
| Abrahamson, EE; Dekosky, ST; Foley, LM; Hitchens, TK; Ho, C; Ikonomovic, MD; Kochanek, PM | 1 |
| McLaurin, J; Stefanovic, B; Thomason, LA | 1 |
| Hamel, E; Papadopoulos, P; Tong, XK | 1 |
| Chen, L; Chen, WX; Lu, ZH; Qu, WJ; Zeng, YY; Zhi, WH | 1 |
| Caslake, M; Cooper, SA; Evans, J; Hassiotis, A; Jahoda, A; McConnachie, A; Morrison, J; Ring, H; Starr, J; Stiles, C; Sullivan, F | 1 |
| Bullock, R; Craig, D; Malouf, R; McGuinness, B; Passmore, P | 1 |
| Aisen, PS; Donohue, MC; Edland, SD; Galasko, D; Moghadam, SH; Petersen, RC; Rissman, RA; Roe, AD; Sano, M; Sun, CK; Thomas, RG | 1 |
| Chen, L; Chen, T; Li, G; Sha, S; Wang, C; Zhou, L | 1 |
| Corbett, GT; Gonzalez, FJ; Jana, M; Kundu, M; Luan, CH; Mishra, RK; Pahan, K; Rangaswamy, SB; Roy, A | 1 |
| Ahn, JY; Chang, JY; Han, MK; Jeong, JH; Kim, M; Kim, S; Lapchak, PA; Yum, KS | 1 |
| Brown, CL; Dias, HK; Griffiths, HR; Lip, GY; Polidori, MC | 1 |
| Bullock, R; Craig, D; McGuinness, B; Passmore, P | 2 |
| Hamel, E; Ongali, B; Royea, J; Tong, XK | 1 |
| Alena, T; Brcakova, E; Cibicek, N; Cibickova, L; Daniel, J; Eva, B; Helena, Z; Hyspler, R; Jun, D; Micuda, S; Norbert, C; Palicka, V; Radomir, H; Stanislav, M; Ticha, A; Vladimir, P; Zivna, H | 1 |
| Albers, JJ; Dong, W; Vuletic, S | 1 |
| Eckert, GP; Hooff, GP; Igbavboa, U; Müller, WE; Strandjord, DM; Volmer, DA; Wood, WG | 1 |
| Baker, SP; Caselli, R; Evans, BA; Evans, JE; Hinerfeld, D; Kane, K; Moonis, M; Pollen, DA; Rogaeva, E; St George-Hyslop, P; Swearer, J | 1 |
| Brouillette, J; Fernandes, P; Hamel, E; Nicolakakis, N; Ongali, B; Quirion, R; Tong, XK | 1 |
| Abrahamson, EE; DeKosky, ST; Dixon, CE; Ikonomovic, MD | 1 |
| Alquezar, C; Bartolomé, F; Bermejo-Pareja, F; Collado, A; Esteras, N; Martín-Requero, A; Muñoz, U | 1 |
| Bullock, R; Craig, D; Malouf, R; McGuinness, B; O'Hare, J; Passmore, P | 1 |
| Asai, M; Ishiura, S; Iwata, N; Iwatsubo, T; Maruyama, K; Saido, TC; Tomita, T | 1 |
| Longenberger, J; Shah, ZA | 1 |
| Borre, Y; Douma, TN; Hendriksen, H; Olivier, B; Oosting, RS | 1 |
| Biasibetti, R; Bobermin, L; Gonçalves, CA; Quincozes-Santos, A; Rodrigues, L; Tramontina, AC; Tramontina, F; Wartchow, KM | 1 |
| Aisen, PS; Bell, KL; Galasko, D; Galvin, JE; Sano, M; Thomas, RG; van Dyck, CH | 1 |
| Cao, D; Fukuchi, K; Kou, J; Li, L; Lim, JE; Pattanayak, A; Song, M; Yang, J | 1 |
| Hamel, E; Lecrux, C; Rosa-Neto, P; Tong, XK | 1 |
| Gottfried, JA; Pressman, P | 1 |
| Tobe, E | 1 |
| Beyreuther, K; Dichgans, J; Hartmann, T; Lütjohann, D; Schulz, JB; Schwärzler, F; Simons, M; von Bergmann, K; Wormstall, H | 1 |
| Tony, JC | 1 |
| Lipton, AM; Lutjohann, D; Moore, C; Svetlik, D; Vega, GL; Von Bergmann, K; Weiner, MF | 1 |
| Blennow, K; Davidsson, P; Edman, A; Gustafsson, K; Olsson, A; Sjögren, M; Syversen, S; Wallin, A | 1 |
| Baskin, F; Fang, X; Hynan, LS; Moore, CB; Rosenberg, RN; Vega, GL; Weiner, M | 1 |
| Baudry, M; Bi, X; Brucher, F; Fu, L; Liu, J; Lynch, G; Yao, Y | 1 |
| Carter, TL; Ehrlich, ME; Gandy, S; Pedrini, S; Petanceska, S; Prendergast, G | 1 |
| Blennow, K; Hoglund, K; Lutjohann, D; Sjogren, M; Syversen, S; Thelen, KM; Vanderstichele, H; Vanmechelen, E; von Bergmann, K; Wallin, A | 1 |
| Blennow, K; Höglund, K; Lewczuk, P; Syversen, S; Wallin, A; Wiltfang, J | 1 |
| Albers, JJ; Galasko, D; Hazzard, WR; Lee, M; Lee, VM; Leverenz, JB; Li, G; Montine, TJ; Peskind, ER; Petrie, EC; Riekse, RG; Schellenberg, GD; Seubert, P; Vavrek, D; Vuletic, S | 1 |
| Ghribi, O | 1 |
| Cao, D; Fukuchi, K; Kim, H; Lester, R; Li, L | 1 |
| Bartolomé, F; Bermejo, F; Martín-Requero, A; Muñoz, U; Sala, SG | 1 |
| James, BD; Karlawish, J; Kim, SY; Knopman, D; Marson, D; van Dyck, CH | 1 |
| Asthana, S; Atwood, CS; Blazel, HM; Carlsson, CM; Gleason, CE; Hermann, BP; Hess, TM; Johnson, SC; Koscik, RL; McBride, PE; Moreland, KA; Puglielli, L; Sager, MA; Schreiber, NT; Stein, JH | 1 |
| Kurinami, H; Morishita, R; Ogihara, T; Sato, N; Shimamura, M; Shinohara, M; Takeda, S; Takeuchi, D | 1 |
| Bergmann, C; Bertsch, T; Beyreuther, K; Fassbender, K; Hartmann, T; Hennerici, M; Keller, P; Kuhl, S; Lutjohann, D; Runz, H; Simons, M; Stroick, M; von Bergmann, K | 1 |
| Lesser, GT; Libow, LS | 1 |
| Beisiegel, U; Locatelli, S; Lütjohann, D; Otto, C; Schmidt, HH; von Bergmann, K | 1 |
| Carlson, LA | 1 |
7 review(s) available for simvastatin and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Cerebrovascular contributions to Alzheimer's disease pathophysiology and potential therapeutic interventions in mouse models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Hemorrhage; Cerebrum; Disease Models, Animal; Inositol; Mice; Simvastatin | 2013 |
Statins for the treatment of dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Atorvastatin; Dementia; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin | 2014 |
Statins for the prevention of dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Anticholesteremic Agents; Cognition; Dementia; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Pravastatin; Randomized Controlled Trials as Topic; Simvastatin | 2016 |
Neurovascular and Cognitive failure in Alzheimer's Disease: Benefits of Cardiovascular Therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Humans; Losartan; Simvastatin | 2016 |
Statins for the prevention of dementia.
Topics: Alzheimer Disease; Anticholesteremic Agents; Cognition; Dementia; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Randomized Controlled Trials as Topic; Simvastatin | 2009 |
Statins for the treatment of dementia.
Topics: Alzheimer Disease; Atorvastatin; Dementia; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin | 2010 |
Simvastatin and other HMG-CoA reductase inhibitors on brain cholesterol levels in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Cholesterol; Clinical Trials, Phase II as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Simvastatin | 2011 |
16 trial(s) available for simvastatin and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Effects of Simvastatin on Plasma Amyloid-β Transport in Patients with Hyperlipidemia: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Middle Aged; Peptide Fragments; Simvastatin; Triglycerides | 2022 |
Simvastatin ameliorate memory deficits and inflammation in clinical and mouse model of Alzheimer's disease via modulating the expression of miR-106b.
Topics: Aged; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Behavior, Animal; Cell Line, Tumor; Computational Biology; Double-Blind Method; Female; Gene Expression Regulation; Humans; Inflammation Mediators; Male; Maze Learning; Mice, Transgenic; MicroRNAs; Neural Stem Cells; Neurons; Nootropic Agents; RNA; Simvastatin | 2017 |
Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cholesterol, LDL; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Outcome Assessment, Health Care; Peptide Fragments; Simvastatin; tau Proteins | 2017 |
Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial.
Topics: Age of Onset; Alzheimer Disease; Cognition Disorders; Down Syndrome; Feasibility Studies; Humans; Hypolipidemic Agents; Middle Aged; Neuropsychological Tests; Pilot Projects; Primary Prevention; Qualitative Research; Research Design; Simvastatin | 2014 |
Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Biomarkers; Blood Chemical Analysis; Cognitive Dysfunction; Disease Progression; Donepezil; Female; Heterozygote; Humans; Indans; Longitudinal Studies; Male; Nootropic Agents; Peptide Fragments; Piperidines; Severity of Illness Index; Simvastatin; Vitamin E | 2015 |
LDL-lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells: mitigation by statin intervention.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Capillary Permeability; Cells, Cultured; Endothelial Cells; England; Germany; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Inflammation Mediators; Lipid Peroxidation; Lipoproteins, LDL; Male; Microvessels; Middle Aged; Protein Carbonylation; Simvastatin; Time Factors; Treatment Outcome | 2015 |
A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease.
Topics: Aged; Alzheimer Disease; Apolipoproteins E; Cholesterol; Cholesterol, LDL; Cholinesterase Inhibitors; Cognition; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Liver Function Tests; Male; Neuropsychological Tests; Nootropic Agents; Simvastatin; Treatment Outcome | 2011 |
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Anticholesteremic Agents; Cholesterol; Double-Blind Method; Female; Humans; Male; Mental Status Schedule; Middle Aged; Peptide Fragments; Placebos; Simvastatin | 2002 |
Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Brain; Cholesterol 24-Hydroxylase; Female; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Middle Aged; Niacin; Pravastatin; Simvastatin; Steroid Hydroxylases; Treatment Outcome | 2003 |
Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Male; Simvastatin | 2003 |
Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Blood Platelets; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Niacin; Pravastatin; Protein Processing, Post-Translational; Simvastatin; Single-Blind Method | 2003 |
Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Molecular Weight; Peptide Fragments; Peptides; Simvastatin; Treatment Outcome | 2005 |
Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Brain; Cholesterol; Cholesterol, LDL; F2-Isoprostanes; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Neuroprotective Agents; Peptide Fragments; Pravastatin; Simvastatin; tau Proteins; Triglycerides | 2006 |
The views of Alzheimer disease patients and their study partners on proxy consent for clinical trial enrollment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Attitude; Caregivers; Cross-Sectional Studies; Ethics, Research; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mental Status Schedule; Middle Aged; Patient Participation; Research Subjects; Simvastatin; Third-Party Consent | 2008 |
Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Anticholesteremic Agents; Apolipoprotein E4; Cognition Disorders; Double-Blind Method; Female; Genetic Predisposition to Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Male; Middle Aged; Neuropsychological Tests; Risk Factors; Severity of Illness Index; Simvastatin | 2008 |
Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain.
Topics: Administration, Oral; Adult; Aged; Alzheimer Disease; Anticholesteremic Agents; Brain; Cholesterol; Female; Humans; Hydroxycholesterols; Hypercholesterolemia; Male; Middle Aged; Prospective Studies; Simvastatin | 2002 |
39 other study(ies) available for simvastatin and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; beta Catenin; Disease Models, Animal; Hippocampus; Ki-67 Antigen; Mice; Neurogenesis; Neurons; Simvastatin; Wnt Signaling Pathway | 2022 |
Cumulative effect of simvastatin, L-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer's disease.
Topics: Alzheimer Disease; Arginine; Biopterins; Cerebrovascular Circulation; Cognition; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neuropsychological Tests; Nitric Oxide Synthase Type III; Proof of Concept Study; Simvastatin | 2022 |
Simvastatin improves learning and memory impairment via gut-brain axis regulation in an ovariectomized/D-galactose Alzheimer's rat model.
Topics: Alzheimer Disease; Animals; Brain-Gut Axis; Disease Models, Animal; Female; Galactose; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Memory Disorders; Rats; Simvastatin | 2023 |
Simvastatin-chitosan-citicoline conjugates nanoparticles as the co-delivery system in Alzheimer susceptible patients.
Topics: Alzheimer Disease; Chitosan; Cytidine Diphosphate Choline; Disease Susceptibility; Drug Carriers; Humans; Nanoparticles; Simvastatin | 2020 |
Treat or track: nanoagents in the service of health.
Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Cell Tracking; Drug Delivery Systems; Embryonic Stem Cells; Humans; Multiple Sclerosis; Nanomedicine; Nanoparticles; Optical Imaging; Plaque, Atherosclerotic; Protein Corona; Simvastatin | 2017 |
Simvastatin ameliorates cognitive impairments via inhibition of oxidative stress‑induced apoptosis of hippocampal cells through the ERK/AKT signaling pathway in a rat model of senile dementia.
Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Apoptosis; Cells, Cultured; Cognitive Dysfunction; Hippocampus; Male; MAP Kinase Signaling System; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin | 2018 |
Mitochondrial protective mechanism of simvastatin protects against amyloid β peptide-induced injury in SH-SY5Y cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anticholesteremic Agents; Apoptosis; Cell Line; Cell Survival; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neuroprotective Agents; Peptide Fragments; Simvastatin | 2018 |
Simvastatin Efficiently Reduces Levels of Alzheimer's Amyloid Beta in Yeast.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Cellular Senescence; Ergosterol; Gene Expression; Gene Order; Genes, Reporter; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Plasmids; Proteolysis; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Simvastatin; Yeasts | 2019 |
Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Brain; Brain Injuries; Cerebrovascular Circulation; Gene Knock-In Techniques; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Risk Factors; Simvastatin | 2013 |
Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Early Growth Response Protein 1; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; Mutation; Nitric Oxide; Simvastatin; Transforming Growth Factor beta1 | 2014 |
Simvastatin exerts antiamnesic effect in Aβ25-35 -injected mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Animals, Newborn; Anticholesteremic Agents; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; MAP Kinase Signaling System; Maze Learning; Mice; Mice, Inbred ICR; Oncogene Protein v-akt; Patch-Clamp Techniques; Peptide Fragments; Phosphorylation; Pyramidal Cells; Simvastatin | 2014 |
Simvastatin prevents β-amyloid(25-35)-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Mice, Inbred ICR; Neurogenesis; Neuroprotective Agents; Peptide Fragments; Phosphatidylinositol 3-Kinases; Polyisoprenyl Phosphates; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Simvastatin | 2015 |
HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.
Topics: Alzheimer Disease; Animals; Brain; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Memory; Mice; Mice, Mutant Strains; Nerve Growth Factors; Neurons; PPAR alpha; Simvastatin; Up-Regulation | 2015 |
Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer's disease cybrid cells.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA, Mitochondrial; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoassay; Mitochondria; Neurons; Risk Factors; Simvastatin | 2015 |
The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Atorvastatin; Brain; Brain Chemistry; Cholesterol; Cholesterol, Dietary; Diet; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Male; Pyrroles; Rats; Rats, Wistar; Simvastatin | 2009 |
Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells.
Topics: Alzheimer Disease; Apolipoproteins E; Astrocytes; ATP-Binding Cassette Transporters; Blotting, Western; Cells, Cultured; Electrophoresis; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neurons; Phospholipid Transfer Proteins; Polymerase Chain Reaction; Pravastatin; Simvastatin; tau Proteins | 2009 |
Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients.
Topics: Acyl Coenzyme A; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Cholesterol; Farnesyltranstransferase; Frontal Lobe; Geranyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Polyisoprenyl Phosphates; Sesquiterpenes; Simvastatin | 2009 |
Long-term statin therapy and CSF cholesterol levels: implications for Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Apolipoproteins E; Atorvastatin; Cholesterol; Female; Heptanoic Acids; Heterozygote; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Mutation; Pilot Projects; Presenilin-1; Pyrroles; Simvastatin | 2009 |
Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Encephalitis; Humans; Learning Disabilities; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroimmunomodulation; Neurons; Neuroprotective Agents; Oxidative Stress; Plaque, Amyloid; Protease Nexins; Receptors, Cell Surface; Simvastatin; Space Perception | 2009 |
Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain Injuries; Disease Models, Animal; Hippocampus; Humans; Maze Learning; Mice; Neuroprotective Agents; Postural Balance; Risk Factors; Simvastatin; Tissue Distribution | 2009 |
Simvastatin overcomes the resistance to serum withdrawal-induced apoptosis of lymphocytes from Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Animals; Apoptosis; Cell Line; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Male; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Serum; Signal Transduction; Simvastatin | 2010 |
Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Mice; Neurons; Receptors, Notch; Simvastatin | 2010 |
Simvastatin improves learning and memory in control but not in olfactory bulbectomized rats.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Simvastatin | 2011 |
The neuroprotective effect of two statins: simvastatin and pravastatin on a streptozotocin-induced model of Alzheimer's disease in rats.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Pravastatin; Rats; Rats, Wistar; Simvastatin; Streptozocin | 2011 |
Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Animals; Cerebral Amyloid Angiopathy; Disease Models, Animal; Female; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Simvastatin | 2012 |
Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits.
Topics: Aging; Alzheimer Disease; Animals; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Simvastatin | 2012 |
Journal Club: a randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease.
Topics: Alzheimer Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Simvastatin | 2012 |
Pseudodementia caused by severe depression.
Topics: Aged; Alzheimer Disease; Antidepressive Agents; Dementia; Depressive Disorder, Major; Diagnosis, Differential; Factitious Disorders; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Simvastatin | 2012 |
Alzheimer's disease and angiogenesis.
Topics: Alzheimer Disease; Angiogenesis Inhibitors; Cerebral Cortex; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neovascularization, Pathologic; Simvastatin | 2003 |
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia.
Topics: Alzheimer Disease; Animals; CD11b Antigen; Cell Proliferation; Cell Shape; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Microglia; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Simvastatin; Terpenes; Tumor Necrosis Factor-alpha | 2004 |
Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Atorvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Neuroblastoma; Phosphorylation; Protein Serine-Threonine Kinases; Pyrroles; rho-Associated Kinases; Simvastatin; Tumor Cells, Cultured | 2005 |
The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Anticholesteremic Agents; Biomarkers; Brain Chemistry; Cholesterol; Cognition; Cognition Disorders; Female; Humans; Lipids; Male; Phosphorylation; Simvastatin; Sterols; tau Proteins | 2005 |
Preservation of the blood brain barrier integrity may underlie neuroprotective effects of statins in Alzheimer's disease.
Topics: Alzheimer Disease; Blood-Brain Barrier; Brain; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Neuroprotective Agents; Pravastatin; Randomized Controlled Trials as Topic; Simvastatin | 2006 |
Simvastatin enhances learning and memory independent of amyloid load in mice.
Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Brain; Cholesterol; Cytoprotection; Disease Models, Animal; Female; Learning; Learning Disabilities; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Nitric Oxide Synthase Type III; Plaque, Amyloid; Proto-Oncogene Proteins c-akt; Signal Transduction; Simvastatin; Treatment Outcome | 2006 |
HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects.
Topics: Aged; Alzheimer Disease; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Simvastatin | 2008 |
Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Memory Disorders; Mice; Oxidative Stress; Simvastatin | 2008 |
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Cholesterol; Genetic Predisposition to Disease; Guinea Pigs; In Vitro Techniques; Mutation; Peptide Fragments; Protein Isoforms; Reference Standards; Simvastatin | 2001 |
Statin-Alzheimer disease association not yet proven.
Topics: Alzheimer Disease; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Polypharmacy; Prevalence; Simvastatin | 2001 |
[Reduced incidence of dementia in patients treated with antilipemic agents].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anticholesteremic Agents; Humans; Incidence; Simvastatin | 2002 |