simvastatin has been researched along with Abdominal Aortic Aneurysm in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 12 (54.55) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Ge, X; Lu, Y; Meng, L; Meng, X; Sui, W; Wang, X; Zhang, Y; Zhong, M | 1 |
| Ciavarella, C; Faggioli, G; Fenelli, C; Gallitto, E; Gargiulo, M; Indelicato, G; Mascoli, C; Pasquinelli, G; Pini, R; Vacirca, A | 1 |
| Grochot-Przęczek, A; Hajduk, K; Józkowicz, A; Klóska, D; Kopacz, A; Neumayer, C; Piechota-Polanczyk, A; Werner, E | 1 |
| Bolliger, M; Domenig, C; Habrowska-Górczyńska, DE; Huk, I; Kowalska, K; Neumayer, C; Piastowska-Ciesielska, AW; Piechota-Polanczyk, A | 1 |
| Demyanets, S; Domenig, CM; Huk, I; Klinger, M; Mittlboeck, M; Nanobachvili, J; Neumayer, C; Nykonenko, O; Piechota-Polanczyk, A; Wojta, J | 1 |
| Demyanets, S; Domenig, CM; Hofmann, M; Huk, I; Klinger, M; Mittlboeck, M; Nanobachvili, J; Neumayer, C; Piechota-Polanczyk, A; Wojta, J | 1 |
| Aoki, H; Furutani, A; Hamano, K; Kudo, J; Morikage, N; Nagasawa, A; Onoda, M; Yoshimura, K | 1 |
| Paraskevas, KI | 1 |
| Kitas, GD; Melas, N; Saratzis, A; Saratzis, N | 1 |
| Beasley, D; Galper, JB; Moulton, KS; Naggar, JC; Park, HJ; Welzig, CM; Zhang, Y | 1 |
| de Vries, JP; Hoefer, IE; Hurks, R; Kerver, M; Moll, FL; Pasterkamp, G; Schoneveld, A; Tangelder, MJ; Vink, A | 1 |
| Cullen, B; Golledge, J; Moran, C; Rush, C | 1 |
| Choke, E; Cockerill, GW; Dawson, JA; Loftus, IM; Thompson, MM | 1 |
| Vega de Céniga, M | 2 |
| Anagnostopoulos, CE; Angouras, DC; Chamogeorgakis, TP; Mastoraki, ST; Papalois, A; Rokkas, CK; Tiniakos, D; Toumpoulis, IK | 1 |
| Demyanets, S; Domenig, C; Goraca, A; Huk, I; Klinger, M; Mittlboeck, M; Nanobachvili, J; Neumayer, C; Piechota-Polanczyk, A; Wojta, J | 1 |
| Buckley, C; Ennis, TL; Goeddel, LA; Hawkins, CJ; Mao, D; Shames, ML; Steinmetz, EF; Thompson, RW; Vanvickle-Chavez, SJ | 1 |
| Carey, DJ; Elmore, JR; Franklin, DP; Galt, SW; Golden, A; Kalyanasundaram, A; Manazer, JR; Zakhary, EM | 1 |
| Aronow, WS; Babu, S; Kakar, P; Sandhu, R; Sukhija, R | 1 |
| Bax, JJ; Boersma, E; Dunkelgrün, M; Feringa, HH; Koning, J; Poldermans, D; Schouten, O; van Laanen, JH; van Urk, H; Vidakovic, R | 1 |
| Evans, J; Loftus, IM; Powell, JT; Schwalbe, E; Thompson, MM | 1 |
1 review(s) available for simvastatin and Abdominal Aortic Aneurysm
| Article | Year |
|---|---|
Can statins suppress the development of abdominal aortic aneurysms? A review of the current evidence.
Topics: Animals; Aortic Aneurysm, Abdominal; Atorvastatin; Blood Vessels; Cardiovascular Agents; Disease Progression; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Matrix Metalloproteinases; Models, Animal; Pyrroles; Risk Assessment; Simvastatin | 2010 |
2 trial(s) available for simvastatin and Abdominal Aortic Aneurysm
| Article | Year |
|---|---|
A randomised placebo-controlled double-blind trial to evaluate lipid-lowering pharmacotherapy on proteolysis and inflammation in abdominal aortic aneurysms.
Topics: Aged; Anticholesteremic Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Azetidines; Biopsy; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Ezetimibe; Female; Humans; Interleukins; Lipids; Male; Matrix Metalloproteinases; Pilot Projects; Simvastatin; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tumor Necrosis Factor-alpha | 2011 |
Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue.
Topics: Aged; Aorta; Aortic Aneurysm, Abdominal; Elective Surgical Procedures; Female; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Preoperative Care; Protease Inhibitors; Simvastatin; Time Factors; Treatment Outcome; Vascular Surgical Procedures | 2007 |
19 other study(ies) available for simvastatin and Abdominal Aortic Aneurysm
| Article | Year |
|---|---|
Statin therapy protects against abdominal aortic aneurysms by inducing the accumulation of regulatory T cells in ApoE
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Dysbiosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Knockout; Simvastatin; T-Lymphocytes, Regulatory | 2022 |
Different Drugs Effect on Mesenchymal Stem Cells Isolated From Abdominal Aortic Aneurysm.
Topics: Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cell Separation; Cell Survival; Cells, Cultured; Doxycycline; Female; Humans; Male; Matrix Metalloproteinase 9; Mesenchymal Stem Cells; Middle Aged; Pioglitazone; PPAR gamma; Signal Transduction; Simvastatin | 2020 |
Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Blood Pressure; Collagen; Elastin; Humans; Inflammation; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Signal Transduction; Simvastatin; Transcription, Genetic; Vascular Cell Adhesion Molecule-1 | 2020 |
Lower levels of Caveolin-1 and higher levels of endothelial nitric oxide synthase are observed in abdominal aortic aneurysm patients treated with simvastatin.
Topics: Aged; Aortic Aneurysm, Abdominal; Case-Control Studies; Caveolin 1; Cytokines; Female; Humans; Interleukin-17; Interleukin-6; Male; Middle Aged; Nitric Oxide Synthase Type III; Simvastatin; Toll-Like Receptor 4 | 2018 |
Decreased tissue levels of cyclophilin A, a cyclosporine a target and phospho-ERK1/2 in simvastatin patients with abdominal aortic aneurysm.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Basigin; Blotting, Western; Case-Control Studies; Cyclophilin A; Down-Regulation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Linear Models; Male; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin | 2013 |
The Influence of Simvastatin on NGAL, Matrix Metalloproteinases and Their Tissue Inhibitors in Human Intraluminal Thrombus and Abdominal Aortic Aneurysm Tissue.
Topics: Acute-Phase Proteins; Aged; Aortic Aneurysm, Abdominal; Female; Humans; Lipocalin-2; Lipocalins; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Proto-Oncogene Proteins; RNA, Messenger; Simvastatin; Thrombosis; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2015 |
Inhibitory effect of statins on inflammation-related pathways in human abdominal aortic aneurysm tissue.
Topics: Aged; Aged, 80 and over; Aminoquinolines; Anthracenes; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Chemokine CCL8; Chemokine CXCL5; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Male; Matrix Metalloproteinase 9; Middle Aged; NF-kappa B; Pyrimidines; rac1 GTP-Binding Protein; Signal Transduction; Simvastatin; Tumor Necrosis Factor-alpha | 2015 |
Statins suppress the development of aneurysms: fact or fiction?
Topics: Animals; Aortic Aneurysm, Abdominal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Aneurysm; Simvastatin; Vasculitis | 2008 |
Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Benzamides; Blood Pressure; Blotting, Western; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; MAP Kinase Kinase Kinase 3; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Random Allocation; Reference Values; Renin-Angiotensin System; Simvastatin | 2009 |
Different effects of commonly prescribed statins on abdominal aortic aneurysm wall biology.
Topics: Aged; Aorta; Aortic Aneurysm, Abdominal; Atorvastatin; Biomarkers; Cathepsin A; Cathepsin B; Chi-Square Distribution; Cohort Studies; Disease Progression; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Interleukins; Lymphotoxin-alpha; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Netherlands; Pravastatin; Pyrroles; Risk Assessment; Risk Factors; Simvastatin; Tumor Necrosis Factor-alpha; Vascular Surgical Procedures | 2010 |
Efficacy of simvastatin in reducing aortic dilatation in mouse models of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Apolipoproteins E; Lipids; Male; Mice; Mice, Transgenic; Plaque, Atherosclerotic; Receptors, Lipoprotein; Simvastatin | 2010 |
Comments regarding 'A randomised placebo-controlled double-blind trial to evaluate lipid-lowering pharmacotherapy on proteolysis and inflammation in abdominal aortic aneurysms'.
Topics: Anticholesteremic Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Azetidines; Biopsy; Drug Therapy, Combination; Ezetimibe; Humans; Interleukin-6; Matrix Metalloproteinase 9; Randomized Controlled Trials as Topic; Simvastatin | 2011 |
Treatment with simvastatin inhibits the formation of abdominal aortic aneurysms in rabbits.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rabbits; Simvastatin; Time Factors; Tissue Inhibitor of Metalloproteinase-1 | 2012 |
Commentary on 'simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-κB'.
Topics: Antioxidants; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Female; Free Radicals; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; NF-kappa B; Oxidative Stress; Simvastatin | 2012 |
Simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-κB.
Topics: Aged; Aged, 80 and over; Aldehydes; Antioxidants; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Austria; Case-Control Studies; Catalase; Female; Free Radicals; Humans; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Male; Middle Aged; NF-kappa B; Oxidative Stress; Signal Transduction; Simvastatin; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2012 |
Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice.
Topics: Animals; Aortic Aneurysm, Abdominal; Elastin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Models, Animal; Myocytes, Smooth Muscle; Simvastatin; Tissue Inhibitor of Metalloproteinases; Tunica Media | 2005 |
Simvastatin suppresses experimental aortic aneurysm expansion.
Topics: Animals; Aortic Aneurysm, Abdominal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Random Allocation; Rats; Rats, Wistar; Simvastatin | 2006 |
Mortality and size of abdominal aortic aneurysm at long-term follow-up of patients not treated surgically and treated with and without statins.
Topics: Aged; Aortic Aneurysm, Abdominal; Atorvastatin; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pyrroles; Simvastatin | 2006 |
Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth.
Topics: Aged; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Atorvastatin; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Netherlands; Population Surveillance; Pyrroles; Retrospective Studies; Simvastatin; Time Factors; Ultrasonography | 2006 |