simethicone and Migraine-Disorders

simethicone has been researched along with Migraine-Disorders* in 2 studies

Reviews

1 review(s) available for simethicone and Migraine-Disorders

ArticleYear
The Link Between Infantile Colic and Migraine.
    Current pain and headache reports, 2016, Volume: 20, Issue:5

    Infantile colic is a self-limiting disorder of excessive infant crying or fussiness that peaks at 6 weeks of age and typically improves by 3 months of age. The etiology of infantile colic has yet to be definitively elucidated, but there is increasing research to support its relationship to migraine. The aims of this review are to present recent research investigating the connection between infantile colic and migraine. The importance of identifying this connection is useful in reducing invasive and potentially harmful investigations and to identify age appropriate pharmacologic interventions that would be safe in this population.

    Topics: Colic; Dicyclomine; Diet Therapy; Humans; Migraine Disorders; Proton Pump Inhibitors; Simethicone

2016

Other Studies

1 other study(ies) available for simethicone and Migraine-Disorders

ArticleYear
Testing non-inferiority of a new treatment in three-arm clinical trials with binary endpoints.
    BMC medical research methodology, 2014, Dec-18, Volume: 14

    A two-arm non-inferiority trial without a placebo is usually adopted to demonstrate that an experimental treatment is not worse than a reference treatment by a small pre-specified non-inferiority margin due to ethical concerns. Selection of the non-inferiority margin and establishment of assay sensitivity are two major issues in the design, analysis and interpretation for two-arm non-inferiority trials. Alternatively, a three-arm non-inferiority clinical trial including a placebo is usually conducted to assess the assay sensitivity and internal validity of a trial. Recently, some large-sample approaches have been developed to assess the non-inferiority of a new treatment based on the three-arm trial design. However, these methods behave badly with small sample sizes in the three arms. This manuscript aims to develop some reliable small-sample methods to test three-arm non-inferiority.. Saddlepoint approximation, exact and approximate unconditional, and bootstrap-resampling methods are developed to calculate p-values of the Wald-type, score and likelihood ratio tests. Simulation studies are conducted to evaluate their performance in terms of type I error rate and power.. Our empirical results show that the saddlepoint approximation method generally behaves better than the asymptotic method based on the Wald-type test statistic. For small sample sizes, approximate unconditional and bootstrap-resampling methods based on the score test statistic perform better in the sense that their corresponding type I error rates are generally closer to the prespecified nominal level than those of other test procedures.. Both approximate unconditional and bootstrap-resampling test procedures based on the score test statistic are generally recommended for three-arm non-inferiority trials with binary outcomes.

    Topics: Cisapride; Clinical Trials as Topic; Computer Simulation; Data Interpretation, Statistical; Humans; Migraine Disorders; Research Design; Simethicone; Treatment Outcome

2014