simethicone has been researched along with Helicobacter-Infections* in 4 studies
3 trial(s) available for simethicone and Helicobacter-Infections
Article | Year |
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A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia.
To compare the efficacy of simethicone with placebo and the prokinetic cisapride in patients with functional dyspepsia.. One hundred and eighty-five patients with functional dyspepsia were randomized and treated in a double-dummy technique with simethicone (105 mg t.d.s.), cisapride (10 mg t.d.s.) or placebo (t.d.s.). The primary outcome measure was the O'Brien global measure of the patients' rating of 10 upper gastrointestinal symptoms (graded as absent = 0, moderate = 1, severe = 2 or very severe = 3). Outcome measures were assessed at baseline and after 2, 4 and 8 weeks of treatment (intention-to-treat).. At 2, 4 and 8 weeks, treatment with simethicone and cisapride yielded significantly (all P values < 0.0001) better improvement of symptoms compared to placebo. Simethicone was significantly better than cisapride after 2 weeks (P = 0.0007), but the differences were not statistically significant after 4 and 8 weeks. Patients treated with simethicone judged the efficacy of their treatment as very good in 46% of cases, compared to 15% and 16% receiving cisapride and placebo, respectively.. Simethicone and cisapride were significantly better than placebo for symptom control in patients with functional dyspepsia after 2, 4 and 8 weeks of treatment. Simethicone was also superior to the prokinetic cisapride in the first 2 weeks of treatment. Topics: Adult; Aged; Cisapride; Double-Blind Method; Dyspepsia; Female; Gastrointestinal Agents; Health Status Indicators; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Patient Compliance; Patient Satisfaction; Simethicone; Treatment Outcome | 2002 |
[A trial of the use of Maldroxal in treating patients with duodenal peptic ulcer].
The foreign-made drug preparation maldroxal the formulation of which includes aluminium hydroxide, magnesia hydroxide and dimeticon, is an effective medicine making for the instant relief of pain and dyspeptic syndromes; it is capable of exerting an antiinflammatory effect. It has also been ascertained that maldroxal fails to influence much the elimination of H. p., which fact necessitates an additional prescription of antibacterial drugs. Topics: Adult; Aluminum Hydroxide; Antacids; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Duodenal Ulcer; Duodenitis; Female; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Magnesium Hydroxide; Male; Middle Aged; Simethicone | 1998 |
[Antibacterial treatment of gastric ulcers associated with Helicobacter pylori without acid suppression].
Topics: Aluminum Hydroxide; Antacids; Anti-Bacterial Agents; Anti-Ulcer Agents; Bismuth; Drug Combinations; Drug Therapy, Combination; Gastric Acidity Determination; Helicobacter Infections; Helicobacter pylori; Humans; Magnesium Hydroxide; Metronidazole; Omeprazole; Simethicone; Stomach Ulcer; Tetracycline | 1995 |
1 other study(ies) available for simethicone and Helicobacter-Infections
Article | Year |
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Effect of simethicone on the accuracy of the rapid urease test.
Simethicone, which is a principal ingredient in the defoaming agent used during gastroscopy, can inhibit the growth of Helicobacter pylori (MIC, 64-128 mg/l). This prospective study was designed to evaluate the in vivo and in vitro effects of simethicone on the accuracy of the rapid urease test (RUT).. In the in vivo study, three sets of gastric biopsies (two from the antrum, and one from the corpus) were taken from 75 patients. The first set was examined histologically, and the second set was used for the RUT (pre-simethicone RUT). Then, 25 ml simethicone (1200 mg/l) was introduced into the stomach for a contact time of 1 min. A third set of gastric biopsies was taken for the RUT (post-simethicone RUT). In the in vitro clinical study, 41 patients were recruited. The first set of gastric biopsies was used for the RUT (pre-incubation RUT). The second set was incubated in 1 ml of simethicone for 5 min before being used for the RUT (post-incubation RUT). In the spectrophotometric study, urease activity before and after incubation in simethicone for 5 min was quantified in 12 patients by measuring the absorbance at 560 nm.. Reading at 15 min, the concordance rate between the pre-simethicone and post-simethicone RUT was 98%. In the in vitro clinical study, the concordance rate between the pre-incubation and post-incubation RUT was 97%. The spectophotometric study showed a significant reduction of 43% in urease activity after incubation in simethicone.. The application of a defoaming agent containing simethicone does not affect the accuracy of the RUT. However, simethicone modestly suppresses urea hydrolysis. Topics: Diagnostic Techniques, Digestive System; Helicobacter Infections; Helicobacter pylori; Humans; Prospective Studies; Sensitivity and Specificity; Simethicone; Stomach; Urease | 1998 |