simethicone and Gastritis

The foreign-made drug preparation maldroxal the formulation of which includes aluminium hydroxide, magnesia hydroxide and dimeticon, is an effective medicine making for the instant relief of pain and dyspeptic syndromes; it is capable of exerting an antiinflammatory effect. It has also been ascertained that maldroxal fails to influence much the elimination of H. p., which fact necessitates an additional prescription of antibacterial drugs.

Topics: Adult; Aluminum Hydroxide; Antacids; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Duodenal Ulcer; Duodenitis; Female; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Magnesium Hydroxide; Male; Middle Aged; Simethicone

A double-blind, randomized trial was undertaken to compare the clinical, endoscopic and histological response to 6-weeks' treatment with hydrotalcite/dimethicone suspension or magnesium hydroxide/aluminum hydroxide suspension in 36 patients with symptomatic gastritis. Significantly more patients (P less than 0.05) showed symptomatic improvement in the antacid-treated group than in the hydrotalcite/dimethicone-treated group and more had a reduction in histological inflammatory scores (P less than 0.01), although there was little correlation between histology and symptoms. There was no evidence from this study that the bile acid binding and anti-foaming properties of hydrotalcite/dimethicone suspension were of any benefit in the treatment of patients with symptomatic gastritis.

Topics: Adult; Aluminum Hydroxide; Antacids; Carbonates; Double-Blind Method; Drug Combinations; Female; Gastritis; Humans; Magnesium; Magnesium Hydroxide; Male; Silicones; Simethicone

Twenty seven children who had been diagnosed as having idiopathic chest pain were investigated to find out if the pain was of gastrointestinal origin. The symptoms had lasted from two weeks to eight months. In 21 of the 27 children (78%) the chest pain had a gastrointestinal cause: 16 had oesophagitis, four had gastritis, and one had diffuse oesophageal spasm. All patients responded to medical treatment of their gastrointestinal symptoms, resulting in disappearance of the chest pain.

Topics: Adolescent; Adult; Chest Pain; Child; Dicyclomine; Endoscopy; Esophageal Spasm, Diffuse; Esophagitis; Female; Gastritis; Humans; Male; Manometry; Pressure; Ranitidine; Simethicone

In an open safety-in-use study, the subjective effectiveness and taste acceptability of a new high-potency antacid product were compared to previous treatment in 109 patients presenting with upper gastro-intestinal disorders of functional origin. Severity of the dominant symptoms prior to treatment was compared with that of symptoms present during treatment. Sixty-seven per cent to 73% of upper gastro-intestinal tract symptoms were completely relieved. Eighty-three per cent versus 48% of patients seen in a private practice setting, as compared with the speciality practice, reported good to excellent results, with 92% versus 56% describing good to excellent taste acceptability. When compared with previous antacid therapy, 70% of the patients preferred the new high-potency formulation to the regular-strength products, for both effectiveness and taste. The incidence of product-related side-effects was low, with only 6.7% experiencing the diarrhoea or loose stools commonly associated with conventional products containing magnesium hydroxide.

Topics: Adolescent; Adult; Aged; Aluminum Hydroxide; Antacids; Colonic Diseases, Functional; Constipation; Diarrhea; Drug Combinations; Drug Evaluation; Dyspepsia; Esophagitis, Peptic; Female; Gastritis; Humans; Magnesium; Magnesium Hydroxide; Male; Middle Aged; Silicones; Simethicone