simethicone and Biliary-Tract-Diseases

Endoscopic retrograde cholangiopancreaticography (ERCP) is performed for diagnostic and therapeutic purposes in patients with pancreaticobiliary diseases. We investigated the role of simethicone and concomitant otilonium bromide during ERCP.. This prospective randomized study included 120 patients who underwent ERCP (study and control group=60 patients each). The study group received otilonium bromide and simethicone. The control group received no medication.. The quantity of duodenal foam and bubbles in the study group was significantly lesser than that in the control group. The duodenal motility score was 2.1±0.7 and 4.3±0.9 in the study and the control groups, respectively. Endoscopist satisfaction was good in 82%, moderate in 15%, and poor in 3% of ERCPs in the study group and good in 15%, moderate in 65%, and poor in 25% of ERCPs in the control group. The study group showed a shorter ERCP duration than the control group.. Simethicone and otilonium bromide administered concomitantly reduce duodenal motility and foam/bubble formation, which facilitates papilla of Vater catheterization to reduce procedure time.

Topics: Adult; Aged; Antifoaming Agents; Biliary Tract Diseases; Cholangiopancreatography, Endoscopic Retrograde; Duodenum; Female; Follow-Up Studies; Gastrointestinal Motility; Humans; Male; Middle Aged; Operative Time; Pancreatic Diseases; Preoperative Care; Prospective Studies; Quality Improvement; Quaternary Ammonium Compounds; Simethicone; Treatment Outcome

In a randomized double-blind comparative study involving a total of 50 patients divided into two equal groups, the effects of Enzym-Paractol and placebo on the ultrasonographic representation of internal organs in two planes--pancreatic and paraaortic--were compared. The visualizability was estimated as percentage figures, and revealed an improvement of about 15% for Enzym-Paractol as compared with placebo. With respect to undesired side effects, there was no difference between the two substances.

Topics: Adult; Aged; Aluminum Hydroxide; Biliary Tract Diseases; Clinical Trials as Topic; Dimethylpolysiloxanes; Double-Blind Method; Drug Combinations; Enzymes; Female; Gastrointestinal Diseases; Heart Diseases; Humans; Kidney Diseases; Liver Diseases; Lung Diseases; Magnesium Oxide; Male; Middle Aged; Premedication; Silicones; Simethicone; Ultrasonography

Topics: Adult; Aluminum Hydroxide; Biliary Tract Diseases; Digestion; Drug Combinations; Female; Humans; Kidney Diseases; Magnesium Oxide; Male; Middle Aged; Radiography; Silicone Elastomers; Simethicone