simendan has been researched along with Injury, Myocardial Reperfusion in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 13 (38.24) | 29.6817 |
| 2010's | 18 (52.94) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Bunte, S; Heinen, A; Hollmann, MW; Huhn, R; Mathes, A; Raupach, A; Sixt, SU; Stroethoff, M; Torregroza, C; van de Snepscheut, M | 1 |
| Adams, V; Barthel, P; Linke, A; Poitz, DM; Schauer, A; Weinbrenner, C | 1 |
| Feige, K; Heinen, A; Hollmann, MW; Huhn, R; Raupach, A; Ruske, R; Stroethoff, M; Torregroza, C; Yueksel, B | 1 |
| Alkan, M; Arslan, M; Erkent, FD; Kılıç, Y; Kucuk, A; Mardin, B; Oktar, GL; Özer, A; Sezen, ŞC; Tosun, M; Ünal, Y | 1 |
| Behmenburg, F; Bongartz, A; Bunte, S; Heinen, A; Hollmann, MW; Huhn, R; Minol, JP; Raupach, A; Sixt, SU; Stroethoff, M | 1 |
| Wu, J; Wu, X; Yan, X; Zhang, Y | 1 |
| Alkan, M; Arslan, M; Bilge, M; Çelik, A; Erdem, Ö; Kavutçu, M; Kip, G; Kiraz, HA; Özer, A; Şıvgın, V | 1 |
| Alkan, M; Arslan, M; Comu, FM; Kip, G; Kiraz, HA; Ozer, A; Sivgin, V | 1 |
| Arslan, M; Demir Amac, N; Elmas, C; Erer, D; Goktas, G; Iriz, E; Oktar, GL; Tatar, T; Zor, MH | 1 |
| Aleksic, I; Alhussini, K; Kanofsky, P; Leistner, M; Leyh, RG; Schimmer, C; Sommer, S; Sommer, SP | 1 |
| Axelsson, B; Gupta, A; Häggmark, S; Haney, M; Johansson, G; Svenmarker, S; Tydén, H; Wouters, P | 1 |
| Gams, E; Klocke, RC; Korbmacher, B; Meyer, K; Schipke, JD | 2 |
| Choi, YH; Cowan, DB; Del Nido, PJ; Hetzer, R; Stamm, C; Wahlers, TC | 1 |
| Algotsson, L; Liao, Q; Linnér, R; Metzsch, C; Steen, S | 1 |
| Ebner, B; Hönisch, A; Strasser, RH; Theuring, N; Wagner, C; Weinbrenner, C | 1 |
| Gok, S; Nese, N; Ozturk, T | 1 |
| Beiras-Fernandez, A; Mutlak, H; Scheiermann, P; Weis, F | 1 |
| Caimmi, PP; Grossini, E; Mary, DA; Micalizzi, E; Molinari, C; Uberti, F; Vacca, G; Valente, G | 1 |
| Cho, S; Hara, T; Higashijima, U; Maekawa, T; Matsumoto, S; Sumikawa, K; Tosaka, S | 1 |
| Bigam, DL; Cheung, PY; Churchill, T; Joynt, C; Manouchehri, N; Vento, M | 1 |
| Cho, S; Hara, T; Maekawa, T; Shibata, I; Sumikawa, K; Ureshino, H; Yoshitomi, O | 1 |
| Bozkurt, AK; Köksal, C; Köseoğlu, S; Süzer, O | 1 |
| Camara, AK; Chen, Q; Pagel, PS; Rhodes, SS; Riess, ML; Ropella, KM; Stowe, DF | 1 |
| De Santis, V; Morelli, A; Nofroni, I; Pietropaoli, P; Puddu, PE; Santulli, M; Singer, M; Tritapepe, L; Vitale, D | 1 |
| Papp, JG; Pollesello, P; Varró, AF; Végh, AS | 1 |
| De Santis, V; Kumar, A; Kumar, S | 1 |
| Eriksson, HI; Hämmäinen, PJ; Petäjä, LM; Salmenperä, MT; Sipponen, JT; Suojaranta-Ylinen, RT | 1 |
| Algotsson, L; Liao, Q; Metzsch, C; Steen, S | 1 |
| Leprán, I; Papp, JG; Pollesello, P; Vajda, S; Varró, A | 1 |
| Papp, Z; Pollesello, P | 1 |
| Altunkan, Z; Apa, D; Balli, E; Bilgin, E; Birbicer, H; Doruk, N; Oral, U; Ozeren, M; Tamer, L; Yapici, D | 1 |
| Abreu-Gonzalez, P; Dominguez-Rodriguez, A; Garcia-Gonzalez, MJ | 1 |
| Du Toit, EF; McCarthy, J; Muller, CA; Opie, LH | 1 |
3 review(s) available for simendan and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
The protective effects of levosimendan on ischemia/reperfusion injury and apoptosis.
Topics: Animals; Apoptosis; Cardiovascular Agents; Evidence-Based Medicine; Humans; Hydrazones; Myocardial Reperfusion Injury; Myocardium; Patents as Topic; Potassium Channels; Pyridazines; Simendan; Treatment Outcome | 2011 |
The cardioprotective effects of levosimendan: preclinical and clinical evidence.
Topics: Animals; Cardiotonic Agents; Drug Evaluation, Preclinical; Humans; Hydrazones; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Reperfusion Injury; Potassium Channels; Pyridazines; Randomized Controlled Trials as Topic; Simendan | 2007 |
New pharmacologic options in the treatment of acute coronary syndromes and myocardial ischemia-reperfusion injury: potential role of levosimendan.
Topics: Acute Coronary Syndrome; Cardiotonic Agents; Evidence-Based Medicine; Humans; Hydrazones; Myocardial Reperfusion Injury; Pyridazines; Simendan; Treatment Outcome; Vasodilator Agents | 2007 |
2 trial(s) available for simendan and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Enhancement of myocardial function and reduction of injury with levosimendan after percutaneous coronary intervention for acute myocardial infarction: a pilot study.
Topics: Biomarkers; Cardiotonic Agents; Emergency Treatment; Female; Hemodynamics; Humans; Hydrazones; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardial Stunning; Percutaneous Coronary Intervention; Pilot Projects; Pyridazines; Simendan; Treatment Outcome | 2014 |
Preconditioning effects of levosimendan in coronary artery bypass grafting--a pilot study.
Topics: Aged; Angina Pectoris; Biomarkers; Cardiotonic Agents; Coronary Artery Bypass; Double-Blind Method; Female; Hemodynamics; Humans; Hydrazones; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Reperfusion Injury; Pilot Projects; Preoperative Care; Pyridazines; Simendan; Troponin I | 2006 |
29 other study(ies) available for simendan and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Impact of Ca
Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ischemic Preconditioning, Myocardial; Isolated Heart Preparation; Large-Conductance Calcium-Activated Potassium Channels; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats, Wistar; Simendan; Small-Conductance Calcium-Activated Potassium Channels | 2019 |
Pharmacological Pre- and Postconditioning With Levosimendan Protect H9c2 Cardiomyoblasts From Anoxia/Reoxygenation-induced Cell Death via PI3K/Akt Signaling.
Topics: Animals; Apoptosis; Autophagy; Cardiovascular Agents; Cell Hypoxia; Cell Line; Mitochondria, Heart; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; Necrosis; Phosphatidylinositol 3-Kinase; Potassium Channels; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Simendan | 2021 |
Combination of Cyclosporine A and Levosimendan Induces Cardioprotection under Acute Hyperglycemia.
Topics: Animals; Cardiotonic Agents; Cyclosporine; Disease Models, Animal; Heart; Hyperglycemia; Male; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Simendan | 2021 |
Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats.
Topics: Animals; bcl-2-Associated X Protein; Benzoquinones; Hydrazones; Immunohistochemistry; Injections, Intraperitoneal; Lung Injury; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Proto-Oncogene Proteins c-bcl-2; Pyridazines; Rats; Rats, Wistar; Simendan | 2018 |
Preconditioning by Levosimendan is Mediated by Activation of Mitochondrial Ca
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Indoles; Isolated Heart Preparation; Large-Conductance Calcium-Activated Potassium Channels; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Potassium Channel Blockers; Rats, Wistar; Simendan; Ventricular Function, Left | 2018 |
The effect of levosimendan on lung damage after myocardial ischemia reperfusion in rats in which experimental diabetes was induced.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Hydrazones; Lung Injury; Male; Myocardial Reperfusion Injury; Pyridazines; Random Allocation; Rats, Wistar; Simendan; Vasodilator Agents | 2015 |
Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury.
Topics: Animals; Cardiotonic Agents; Diabetes Mellitus, Experimental; Disease Models, Animal; Erythrocyte Deformability; Hydrazones; Male; Myocardial Reperfusion Injury; Pyridazines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Simendan; Streptozocin | 2015 |
The histopathological effects of levosimendan on liver injury induced by myocardial ischemia and reperfusion.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Hydrazones; Liver; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyridazines; Rats; Rats, Wistar; Simendan; Vasodilator Agents | 2015 |
Impact of levosimendan and ischaemia-reperfusion injury on myocardial subsarcolemmal mitochondrial respiratory chain, mitochondrial membrane potential, Ca2+ cycling and ATP synthesis.
Topics: Adenosine Triphosphate; Animals; Biomarkers; Calcium; Cardiotonic Agents; Electron Transport; Hydrazones; Male; Membrane Potential, Mitochondrial; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Pyridazines; Random Allocation; Rats, Wistar; Sarcolemma; Simendan | 2016 |
Effects of Combined Milrinone and Levosimendan Treatment on Systolic and Diastolic Function During Postischemic Myocardial Dysfunction in a Porcine Model.
Topics: Animals; Cardiotonic Agents; Diastole; Disease Models, Animal; Drug Therapy, Combination; Hydrazones; Milrinone; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Pyridazines; Recovery of Function; Simendan; Sus scrofa; Systole; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure | 2016 |
Ca2+ sensitizer superior to catecholamine during myocardial stunning?
Topics: Animals; Calcium; Cardiotonic Agents; Coronary Circulation; Diastole; Drug Evaluation, Preclinical; Epinephrine; Hemodynamics; Hydrazones; Male; Myocardial Reperfusion Injury; Myocardial Stunning; Oxygen Consumption; Pyridazines; Rabbits; Simendan; Systole; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Inotropic, vasodilating and preconditioning actions of levosimendan in the heart.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart; Hemodynamics; Hydrazones; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Oxygen Consumption; Potassium Channels; Pyridazines; Rabbits; Simendan; Vasodilator Agents | 2008 |
Calcium sensitisation impairs diastolic relaxation in post-ischaemic myocardium: implications for the use of Ca(2+) sensitising inotropes after cardiac surgery.
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Cardiotonic Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cytosol; Diacetyl; Diastole; Dopamine; Enzyme Inhibitors; Hydrazones; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardial Stunning; Organ Culture Techniques; Organic Chemicals; Pyridazines; Rabbits; Simendan; Ventricular Function, Left | 2010 |
Levosimendan cardioprotection in acutely beta-1 adrenergic receptor blocked open chest pigs.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Clinical Protocols; Female; Glucose; Glycerol; Hemodynamics; Hydrazones; Lactic Acid; Male; Metoprolol; Microdialysis; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyridazines; Pyruvic Acid; Simendan; Swine; Thoracic Surgical Procedures; Treatment Outcome | 2010 |
Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition.
Topics: Animals; Cardiotonic Agents; Enoximone; Hemodynamics; Hydrazones; Immunoblotting; KATP Channels; Male; Myocardial Reperfusion Injury; Myocardium; Phosphatidylinositol 3-Kinases; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Pyridazines; Rats; Rats, Wistar; Signal Transduction; Simendan | 2010 |
Levosimendan attenuates reperfusion injury in an isolated perfused rat heart model.
Topics: Animals; Apoptosis; Disease Models, Animal; Hydrazones; Male; Myocardial Reperfusion Injury; Organ Culture Techniques; Pyridazines; Rats; Rats, Wistar; Simendan | 2010 |
Intracoronary levosimendan prevents myocardial ischemic damages and activates survival signaling through ATP-sensitive potassium channel and nitric oxide.
Topics: Animals; Blotting, Western; Cardiotonic Agents; Hydrazones; Infusions, Intralesional; KATP Channels; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Pyridazines; Signal Transduction; Simendan; Survival Analysis; Swine | 2011 |
Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts.
Topics: Animals; Blood Glucose; Disease Models, Animal; Hemodynamics; Hydrazones; Hyperglycemia; Male; Milrinone; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Pyridazines; Rats; Rats, Wistar; Simendan; Time Factors | 2012 |
Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Dopamine; Drug Therapy, Combination; Hemodynamics; Hydrazones; Hypoxia; Mesenteric Arteries; Milrinone; Models, Animal; Myocardial Reperfusion; Myocardial Reperfusion Injury; Oxidative Stress; Pyridazines; Simendan; Swine; Vasodilator Agents | 2012 |
Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Hemodynamics; Hydrazones; Male; Milrinone; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardial Stunning; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridazines; Simendan; Swine; Time Factors | 2013 |
Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas' hospital cardioplegic solutions used for myocardial preservation in isolated guinea pig hearts.
Topics: Amrinone; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardiotonic Agents; Enoximone; Female; Guinea Pigs; Heart; Heart Arrest, Induced; Hydrazones; In Vitro Techniques; Magnesium; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Organ Preservation; Phosphodiesterase Inhibitors; Potassium Chloride; Pyridazines; Simendan; Sodium Chloride | 2002 |
Ischemia-reperfusion injury changes the dynamics of Ca2+-contraction coupling due to inotropic drugs in isolated hearts.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Digoxin; Dobutamine; Dopamine; Dopamine Agonists; Feedback, Physiological; Guinea Pigs; Heart; Hydrazones; In Vitro Techniques; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Pyridazines; Signal Transduction; Simendan; Ventricular Function, Left | 2006 |
Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Vessels; Dogs; Electrophysiology; Female; Heart Ventricles; Hemodynamics; Hydrazones; Male; Milrinone; Myocardial Reperfusion Injury; Pyridazines; Simendan; Ventricular Function | 2006 |
The preconditioning effects of levosimendan.
Topics: Cardiotonic Agents; Coronary Artery Bypass; Humans; Hydrazones; Ischemic Preconditioning, Myocardial; Myocardial Reperfusion Injury; Preoperative Care; Pyridazines; Simendan | 2006 |
Levosimendan reversing low output syndrome after heart transplantation.
Topics: Cardiotonic Agents; Heart Transplantation; Humans; Hydrazones; Male; Middle Aged; Myocardial Reperfusion Injury; Pyridazines; Recovery of Function; Shock, Cardiogenic; Simendan; Time Factors; Treatment Outcome | 2006 |
Levosimendan cardioprotection reduces the metabolic response during temporary regional coronary occlusion in an open chest pig model.
Topics: Animals; Cardiac Output; Cardiotonic Agents; Coronary Circulation; Glucose; Hydrazones; Infusions, Intravenous; Lactic Acid; Microdialysis; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Pyridazines; Pyruvic Acid; Simendan; Sus scrofa | 2007 |
Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model.
Topics: Animals; Diastole; Hydrazones; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Pyridazines; Rabbits; Simendan; Ventricular Function, Left | 2006 |
Effects of levosimendan on myocardial ischaemia-reperfusion injury.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Hydrazones; Male; Malondialdehyde; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Peroxidase; Pyridazines; Rats; Rats, Wistar; Simendan; Sodium-Potassium-Exchanging ATPase | 2008 |
Levosimendan: effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Agonists; Calcium Channel Blockers; Cyclic AMP; Cyclic GMP; Dobutamine; Glyburide; Guinea Pigs; Heart; Hydrazones; In Vitro Techniques; L-Lactate Dehydrogenase; Lactic Acid; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nucleotides, Cyclic; Phosphocreatine; Pyridazines; Simendan; Stereoisomerism | 1999 |