Page last updated: 2024-08-24

simendan and Disease Models, Animal

simendan has been researched along with Disease Models, Animal in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.52)	18.2507
2000's	21 (31.82)	29.6817
2010's	36 (54.55)	24.3611
2020's	8 (12.12)	2.80

Authors

Authors	Studies
Abdildinova, A; Aziz, H; Boesen, N; Jeong, H; Kang, DM; Kim, KH; Kim, YK; Lee, GH; Lee, HE; Lee, J; Lee, JS; Lim, S; Lim, SM; Lukianenko, N; Pae, AN; Ryu, H; Shin, S; Song, JY; Sung, Y; Yu, BY	1
Bunte, S; Heinen, A; Hollmann, MW; Huhn, R; Mathes, A; Raupach, A; Sixt, SU; Stroethoff, M; Torregroza, C; van de Snepscheut, M	1
Djärv, T; Eriksson, H; Fyrdahl, A; Jonsson Fagerlund, M; Lundberg, J; Lundin, M; Nordberg, P; Pernow, J; Rysz, S; Ugander, M; Wieslander, B	1
Mamalyga, LM; Mamalyga, ML	1
Chang, WT; Chen, WJ; Huang, CH; Tsai, MS; Wang, CH	1
Abuirmeileh, AN; Alzoubi, KH; Rababa'h, AM	1
Axelsson, B; Grafver, I; Jansson, K; Kiszakiewicz, L; Nilsson, KF; Oikonomakis, I; Seilitz, J	1
Jia, T; Liu, G; Lu, X; Luo, C; Shang, Z; Wang, S; Wang, Z; Yang, Q; Zhu, C	1
Feige, K; Heinen, A; Hollmann, MW; Huhn, R; Raupach, A; Ruske, R; Stroethoff, M; Torregroza, C; Yueksel, B	1
Babik, B; Balogh, AL; Fodor, GH; Ivankovitsne-Kiss, O; Petak, F; Sudy, R	1
Atasoy, P; Ateş, G; Bakar, B; Büyükkoçak, Ü; Kısa, Ü; Yaman, F	1
El-Kherbetawy, MK; Makary, S; Tawfik, MK	1
Behmenburg, F; Bongartz, A; Bunte, S; Heinen, A; Hollmann, MW; Huhn, R; Minol, JP; Raupach, A; Sixt, SU; Stroethoff, M	1
Isbary, S; Johannsen, S; Roewer, N; Schuster, F; Türkmeneli, I	1
Askin, S; Ekinci Akdemir, FN; Eser, G; Gozeler, MS; Sahin, A; Yildirim, S	1
Andersson, KB; Christensen, G; Golz, S; Hillestad, V; Knorr, A; Kramer, F	1
Bauer, I; Beck, C; Picker, O; Vollmer, C; Weiß, S	1
Coleman, L; Horton, SB; Konstantinov, IE; Namachivayam, P; Penny, DJ; Rees, S; Shekerdemian, LS; Shields, AE; Smolich, JJ	1
Li, Z; Liu, Y; Ma, S; Wang, X; Xu, W	1
Chen, SJ; Huang, HC; Ka, SM; Li, KY; Liaw, WJ; Tsao, CM; Wu, CC	1
Ge, S; Guo, Z; Liu, H; Shi, Y; Zhang, C	1
Alkan, M; Arslan, M; Comu, FM; Kip, G; Kiraz, HA; Ozer, A; Sivgin, V	1
Arslan, M; Demir Amac, N; Elmas, C; Erer, D; Goktas, G; Iriz, E; Oktar, GL; Tatar, T; Zor, MH	1
Chalkias, A; Dontas, I; Kosmidou, ML; Lappas, T; Lekka, N; Lelovas, P; Papadimitriou, L; Perrea, D; Varvarousi, G; Xanthos, T	1
Abedelzaher, LA; Hattori, K; Hattori, Y; Imaizumi, T; Matsuda, N; Ohashi, W; Sakamoto, T; Sakata, K; Takashina, M; Wang, Q; Yokoo, H	1
Andersen, A; Andersen, S; Hillgaard, TK; Nielsen, JM; Nielsen-Kudsk, JE; Ringgaard, S; Vildbrad, MD	1
Duvall, E; Haavisto, M; Kentala, R; Knuuti, J; Levijoki, J; Nyman, L; Pietilä, M; Roivainen, A; Saraste, A; Saukko, P; Saunavaara, V; Savunen, T; Stark, C; Strandberg, M; Tarkia, M; Teräs, M; Tolvanen, T; Vähäsilta, T	1
Axelsson, B; Gupta, A; Häggmark, S; Haney, M; Johansson, G; Svenmarker, S; Tydén, H; Wouters, P	1
Aleyasin, AR; Amini-Khoei, H; Amiri, S; Dehpour, AR; Ghasemi, K; Gooshe, M; Mojahedi, P; Tabaeizadeh, M; Vafaei, A; Yousefi, F	1
Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Kohnke, A; Pott, C	1
Ertmer, C; Morelli, A; Westphal, M	2
Blomquist, S; Cunha-Goncalves, D; Dahm, PL; Grins, E; Perez-de-Sa, V; Thörne, J	1
Blomquist, S; Cunha-Goncalves, D; Larsson, A; Perez-de-Sa, V; Thörne, J	1
Finckenberg, P; Forsten, H; Kaheinen, P; Kytö, V; Leskinen, H; Levijoki, J; Louhelainen, M; Merasto, S; Mervaala, E; Tikkanen, I; Vahtola, E	1
Bassiakou, E; Dontas, I; Goulas, S; Koudouna, E; Kouskouni, E; Papadimitriou, L; Perrea, D; Rokas, G; Xanthos, T	1
Graudins, A	1
Gok, S; Nese, N; Ozturk, T	1
Hermansen, SE; How, OJ; Jakobsen, Ø; Müller, S; Myrmel, T; Røsner, A; Stenberg, TA	1
Kiviniemi, V; Kurola, J; Leppikangas, H; Lindgren, L; Magga, J; Ruokonen, E; Rutanen, J	1
Biala, A; Finckenberg, P; Kaheinen, P; Levijoki, J; Louhelainen, M; Luft, FC; Martonen, E; Merasto, S; Mervaala, E; Muller, DN	1
Coburn, M; Hein, M; Loetscher, PD; Roehl, AB; Rossaint, J; Rossaint, R; Weis, J	1
Cheng, CP; Cheng, HJ; Little, WC; Masutani, S; Tachibana, H	1
Babelova, A; Brandes, RP; Buerkl, J; Hofstetter, C; Kirschning, T; Mieth, A; Neofitidou, S; Revermann, M; Schermuly, RT; Schloss, M; Schröder, K	1
Bigam, D; Cheung, PY; Esch, J; Joynt, C; Lee, TF; Li, YQ; Manouchehri, N; Vento, M	1
Aro, S; Høydal, M; Kirkeby-Garstad, I; Kolseth, SM; Nordgaard, H; Nordhaug, D; Rognmo, Ø; Wahba, A	1
Cho, S; Hara, T; Higashijima, U; Maekawa, T; Matsumoto, S; Sumikawa, K; Tosaka, S	1
Kylhammar, D; Rådegran, G; Wiklund, A	1
Albayrak, A; Aydin, A; Bayir, Y; Cadirci, E; Ferah, I; Halici, Z; Karakus, E; Odaci, E; Unal, D	1
Cho, S; Hara, T; Maekawa, T; Shibata, I; Sumikawa, K; Ureshino, H; Yoshitomi, O	1
Bent, F; Plaschke, K	1
Frishman, WH	1
Cammarata, G; Cao, L; Huang, L; Sun, S; Tang, W; Weil, MH	1
Barán, M; Canales, HS; Dubin, A; Edul, VS; Estenssoro, E; Maskin, B; Murias, G; Pozo, MO; Sottile, JP	1
Brizard, CP; Horton, SB; Mynard, JP; Nørgaard, MA; Penny, DJ; Shekerdemian, LS; Stocker, CF	1
Missant, C; Rex, S; Segers, P; Wouters, PF	1
Barraud, D; Damy, T; Faivre, V; Gayat, E; Heymes, C; Mebazaa, A; Payen, D; Shah, AM; Welschbillig, S	1
Haikala, H; Kankaanranta, H; Moilanen, E; Nissinen, E; Ruotsalainen, M; Tumelius, R; Zhang, X	1
Bassiakou, E; Goulas, S; Koudouna, E; Lelovas, P; Papadimitriou, D; Papadimitriou, L; Tsirikos, N; Xanthos, T	1
Altunkan, Z; Apa, D; Balli, E; Bilgin, E; Birbicer, H; Doruk, N; Oral, U; Ozeren, M; Tamer, L; Yapici, D	1
Graudins, A; Najafi, J; Rur-SC, MP	1
Aksun, M; Bahriye Lafci, B; Gurbuz, A; Ortac, R; Ozbek, C; Tulukoglu, E; Yakut, N; Yasa, H	1
Emrecan, B; Ergunes, K; Gurbuz, A; Karahan, N; Ortac, R; Ozbek, C; Yakut, N; Yasa, H	1
Bickenbach, J; Bleilevens, C; Fries, M; Ince, C; Mik, EG; Rex, S; Rossaint, R	1
Boost, KA; Czerwonka, H; Dolfen, A; Hoegl, S; Hofstetter, C; Scheiermann, P; Zwissler, B	1
Papp, JG; Udvary, E; Végh, A	1

Trials

1 trial(s) available for simendan and Disease Models, Animal

Article	Year
Levosimendan attenuates pulmonary vascular remodeling. Intensive care medicine, 2011, Volume: 37, Issue:8 Topics: Airway Remodeling; Animals; Cardiotonic Agents; Disease Models, Animal; Germany; Glyburide; Hydrazones; Hypertension, Pulmonary; Hypoglycemic Agents; Myocardial Contraction; Nicorandil; Potassium Channels; Pulmonary Circulation; Pyridazines; Rats; Rats, Sprague-Dawley; Simendan; Vasodilator Agents	2011

Article

Year

Levosimendan attenuates pulmonary vascular remodeling.

Intensive care medicine, 2011, Volume: 37, Issue:8

Topics: Airway Remodeling; Animals; Cardiotonic Agents; Disease Models, Animal; Germany; Glyburide; Hydrazones; Hypertension, Pulmonary; Hypoglycemic Agents; Myocardial Contraction; Nicorandil; Potassium Channels; Pulmonary Circulation; Pyridazines; Rats; Rats, Sprague-Dawley; Simendan; Vasodilator Agents

2011

Other Studies

65 other study(ies) available for simendan and Disease Models, Animal

Article	Year
Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in Tau Experimental & molecular medicine, 2023, Volume: 55, Issue:3 Topics: Alzheimer Disease; Animals; Disease Models, Animal; Mice; Mice, Transgenic; Neurons; Simendan; tau Proteins; Tauopathies	2023
Impact of Ca Cardiovascular drugs and therapy, 2019, Volume: 33, Issue:5 Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ischemic Preconditioning, Myocardial; Isolated Heart Preparation; Large-Conductance Calcium-Activated Potassium Channels; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats, Wistar; Simendan; Small-Conductance Calcium-Activated Potassium Channels	2019
The effect of levosimendan on survival and cardiac performance in an ischemic cardiac arrest model - A blinded randomized placebo-controlled study in swine. Resuscitation, 2020, Volume: 150 Topics: Animals; Cardiopulmonary Resuscitation; Cardiotonic Agents; Disease Models, Animal; Hemodynamics; Hydrazones; Pyridazines; Simendan; Swine	2020
Experimental Study of Heart Functionality during Treatment of Chronic Heart Failure in Rats of Different Age Groups with Levosimendan (Experimental Study). Bulletin of experimental biology and medicine, 2020, Volume: 169, Issue:1 Topics: Animals; Chronic Disease; Disease Models, Animal; Doxorubicin; Heart; Heart Failure; Heart Function Tests; Male; Myocardium; Rats; Rats, Wistar; Simendan	2020
Synergistic Effects of Moderate Therapeutic Hypothermia and Levosimendan on Cardiac Function and Survival After Asphyxia-Induced Cardiac Arrest in Rats. Journal of the American Heart Association, 2020, 06-16, Volume: 9, Issue:12 Topics: Animals; Asphyxia; Biomarkers; Cardiac Output; Cardiotonic Agents; Combined Modality Therapy; Disease Models, Animal; Heart Arrest; Hypothermia, Induced; Interleukin-1beta; Interleukin-6; Male; Nitrates; Nitrites; Rats, Wistar; Recovery of Function; Return of Spontaneous Circulation; Simendan; Time Factors; Ventricular Function, Left	2020
The Effect of Levosimendan on Two Distinct Rodent Models of Parkinson's Disease. Current Alzheimer research, 2020, Volume: 17, Issue:11 Topics: Animals; Apomorphine; Cardiotonic Agents; Disease Models, Animal; Dopamine; Dopamine Agents; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Simendan; Substantia Nigra; Sympatholytics	2020
A Randomized Porcine Study in Low Cardiac Output of Vasoactive and Inotropic Drug Effects on the Gastrointestinal Tract. Shock (Augusta, Ga.), 2021, 08-01, Volume: 56, Issue:2 Topics: Animals; Cardiac Output, Low; Disease Models, Animal; Female; Gastrointestinal Tract; Male; Milrinone; Norepinephrine; Random Allocation; Simendan; Splanchnic Circulation; Swine; Vasodilator Agents; Vasopressins	2021
Levosimendan Ameliorates Post-resuscitation Acute Intestinal Microcirculation Dysfunction Partly Independent of its Effects on Systemic Circulation: A Pilot Study on Cardiac Arrest in a Rat Model. Shock (Augusta, Ga.), 2021, 10-01, Volume: 56, Issue:4 Topics: Animals; Cardiopulmonary Resuscitation; Disease Models, Animal; Heart Arrest; Intestines; Male; Microcirculation; Pilot Projects; Rats; Rats, Sprague-Dawley; Simendan; Vasodilator Agents	2021
Combination of Cyclosporine A and Levosimendan Induces Cardioprotection under Acute Hyperglycemia. International journal of molecular sciences, 2021, Apr-26, Volume: 22, Issue:9 Topics: Animals; Cardiotonic Agents; Cyclosporine; Disease Models, Animal; Heart; Hyperglycemia; Male; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Simendan	2021
Levosimendan prevents bronchoconstriction and adverse respiratory tissue mechanical changes in rabbits. American journal of physiology. Lung cellular and molecular physiology, 2017, Nov-01, Volume: 313, Issue:5 Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Cardiac Output; Disease Models, Animal; Glyburide; Hydrazones; KATP Channels; Lung; Male; Methacholine Chloride; Pyridazines; Rabbits; Simendan	2017
Evaluation of the systemic antiinflammatory effects of levosimendan in an experimental blunt thoracic trauma model. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2017, Volume: 23, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Hydrazones; Inflammation; Interleukin-1beta; Pyridazines; Random Allocation; Rats; Rats, Wistar; Simendan; Thoracic Injuries; Wounds, Nonpenetrating	2017
Cardioprotective and Anti-Aggregatory Effects of Levosimendan on Isoproterenol-Induced Myocardial Injury in High-Fat-Fed Rats Involves Modulation of PI3K/Akt/mTOR Signaling Pathway and Inhibition of Apoptosis: Comparison to Cilostazol. Journal of cardiovascular pharmacology and therapeutics, 2018, Volume: 23, Issue:5 Topics: Animals; Apoptosis; Cilostazol; Diet, High-Fat; Disease Models, Animal; Heart Rate; Inflammation Mediators; Isoproterenol; Lipids; Myocardial Infarction; Myocytes, Cardiac; Phosphatidylinositol 3-Kinase; Platelet Aggregation; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Simendan; TOR Serine-Threonine Kinases	2018
Preconditioning by Levosimendan is Mediated by Activation of Mitochondrial Ca Cardiovascular drugs and therapy, 2018, Volume: 32, Issue:5 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Indoles; Isolated Heart Preparation; Large-Conductance Calcium-Activated Potassium Channels; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Potassium Channel Blockers; Rats, Wistar; Simendan; Ventricular Function, Left	2018
In vitro effects of levosimendan on muscle of malignant hyperthermia susceptible and non-susceptible swine. BMC anesthesiology, 2018, 12-03, Volume: 18, Issue:1 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Phosphodiesterase 3 Inhibitors; Simendan; Swine	2018
Levosimendan ameliorates cisplatin-induced ototoxicity: Rat model. International journal of pediatric otorhinolaryngology, 2019, Volume: 122 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cisplatin; Cochlea; Deoxyguanosine; Disease Models, Animal; Female; Glutathione Peroxidase; Hearing; Hearing Loss; Malondialdehyde; Otoacoustic Emissions, Spontaneous; Oxidative Stress; Phosphodiesterase 3 Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Signal-To-Noise Ratio; Simendan; Superoxide Dismutase	2019
Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene. Journal of applied physiology (Bethesda, Md. : 1985), 2013, Volume: 115, Issue:10 Topics: Animals; Calcium Signaling; Cardiotonic Agents; Diastole; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Heart Failure; Hydrazones; Hypertrophy, Left Ventricular; Mice; Mice, Knockout; Myocytes, Cardiac; Pyridazines; Recovery of Function; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Simendan; Stroke Volume; Systole; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure	2013
Hypothermia improves oral and gastric mucosal oxygenation during hypoxic challenges. British journal of anaesthesia, 2014, Volume: 113, Issue:3 Topics: Animals; Cardiac Output; Cardiotonic Agents; Cross-Over Studies; Disease Models, Animal; Dogs; Female; Gastric Mucosa; Glyburide; Hydrazones; Hypoglycemic Agents; Hypothermia, Induced; Hypoxia; Laser-Doppler Flowmetry; Microcirculation; Mouth Mucosa; Oxygen; Pyridazines; Simendan	2014
Impact of levosimendan on brain injury patterns in a lamb model of infant cardiopulmonary bypass. Pediatric research, 2014, Volume: 76, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Blood Gas Analysis; Brain; Brain Injuries; Cardiac Output; Cardiopulmonary Bypass; Carotid Arteries; Disease Models, Animal; Dopamine; Hemodynamics; Hydrazones; Immunohistochemistry; Magnetic Resonance Imaging; Neuroglia; Oxidative Stress; Pyridazines; Sheep; Simendan	2014
Effects and mechanism analysis of combined infusion by levosimendan and vasopressin on acute lung injury in rats septic shock. Cell biochemistry and biophysics, 2014, Volume: 70, Issue:3 Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Cardiovascular Agents; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Female; HMGB1 Protein; Hydrazones; Lung; Nitrogen Oxides; Norepinephrine; Pyridazines; Rats; Shock, Septic; Simendan; Vasopressins	2014
Levosimendan attenuates multiple organ injury and improves survival in peritonitis-induced septic shock: studies in a rat model. Critical care (London, England), 2014, Nov-29, Volume: 18, Issue:6 Topics: Animals; Disease Models, Animal; Hydrazones; Infusions, Intravenous; Male; Multiple Organ Failure; Oxidative Stress; Peritonitis; Pyridazines; Random Allocation; Rats; Rats, Wistar; Shock, Septic; Simendan; Survival Rate	2014
Influence of levosimendan postconditioning on apoptosis of rat lung cells in a model of ischemia-reperfusion injury. PloS one, 2015, Volume: 10, Issue:1 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiotonic Agents; Caspase 3; Decanoic Acids; Disease Models, Animal; Hydrazones; Hydroxy Acids; Lung; Lung Diseases; Male; Pyridazines; Rats; Reperfusion Injury; Simendan	2015
Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury. Bratislavske lekarske listy, 2015, Volume: 116, Issue:1 Topics: Animals; Cardiotonic Agents; Diabetes Mellitus, Experimental; Disease Models, Animal; Erythrocyte Deformability; Hydrazones; Male; Myocardial Reperfusion Injury; Pyridazines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Simendan; Streptozocin	2015
The histopathological effects of levosimendan on liver injury induced by myocardial ischemia and reperfusion. Bratislavske lekarske listy, 2015, Volume: 116, Issue:4 Topics: Acute Lung Injury; Animals; Disease Models, Animal; Hydrazones; Liver; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyridazines; Rats; Rats, Wistar; Simendan; Vasodilator Agents	2015
Levosimendan Improves Neurological Outcome in a Swine Model of Asphyxial Cardiac Arrest. Heart, lung & circulation, 2015, Volume: 24, Issue:9 Topics: Animals; Asphyxia; Disease Models, Animal; Heart Arrest; Hemodynamics; Hydrazones; Pyridazines; Simendan; Swine	2015
Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages. Critical care medicine, 2015, Volume: 43, Issue:11 Topics: Animals; Anti-Inflammatory Agents; Biopsy, Needle; Blotting, Western; Cecum; Cells, Cultured; Cytokines; Disease Models, Animal; Echocardiography; Enzyme-Linked Immunosorbent Assay; Hydrazones; Immunohistochemistry; Injections, Intravenous; Ligation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Pyridazines; Random Allocation; Real-Time Polymerase Chain Reaction; Reference Values; Sepsis; Simendan; Statistics, Nonparametric; Survival Rate	2015
Levosimendan Prevents Pressure-Overload-induced Right Ventricular Failure. Journal of cardiovascular pharmacology, 2016, Volume: 67, Issue:4 Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Echocardiography; Heart Failure; Hydrazones; Hypertrophy, Right Ventricular; Magnetic Resonance Imaging; Male; Myocardial Contraction; Pyridazines; Rats; Rats, Wistar; Simendan; Ventricular Dysfunction, Right; Ventricular Function, Right	2016
Effect of levosimendan therapy on myocardial infarct size and left ventricular function after acute coronary occlusion. Heart (British Cardiac Society), 2016, Volume: 102, Issue:6 Topics: Acute Disease; Animals; Cardiotonic Agents; Coronary Occlusion; Diastole; Disease Models, Animal; Follow-Up Studies; Hydrazones; Male; Myocardial Contraction; Myocardial Infarction; Myocardium; Pyridazines; Simendan; Stroke Volume; Swine; Systole; Ventricular Function, Left; Ventricular Remodeling	2016
Effects of Combined Milrinone and Levosimendan Treatment on Systolic and Diastolic Function During Postischemic Myocardial Dysfunction in a Porcine Model. Journal of cardiovascular pharmacology and therapeutics, 2016, Volume: 21, Issue:5 Topics: Animals; Cardiotonic Agents; Diastole; Disease Models, Animal; Drug Therapy, Combination; Hydrazones; Milrinone; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Pyridazines; Recovery of Function; Simendan; Sus scrofa; Systole; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure	2016
Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for K Life sciences, 2017, Jan-01, Volume: 168 Topics: Animals; Anticonvulsants; Disease Models, Animal; Enzyme Activation; Hydrazones; KATP Channels; Male; Mice; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Pyridazines; Seizures; Signal Transduction; Simendan	2017
Experimental evidence for a severe proarrhythmic potential of levosimendan. International journal of cardiology, 2017, Feb-01, Volume: 228 Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart Conduction System; Hydrazones; Infusions, Intravenous; Pyridazines; Rabbits; Severity of Illness Index; Simendan; Treatment Outcome; Ventricular Fibrillation	2017
Levo is in the air: take a deep breath! Critical care medicine, 2008, Volume: 36, Issue:6 Topics: Administration, Inhalation; Adult; Animals; Cardiotonic Agents; Disease Models, Animal; Female; Hemodynamics; Humans; Hydrazones; Multiple Organ Failure; Postoperative Complications; Pyridazines; Rats; Respiratory Distress Syndrome; Risk Factors; Shock, Septic; Simendan	2008
Calcium sensitizing in sepsis: is levosimendan on the right path? Critical care medicine, 2008, Volume: 36, Issue:6 Topics: Animals; Calcium; Cardiotonic Agents; Disease Models, Animal; Endothelium, Vascular; Hemodynamics; Hydrazones; Microcirculation; Mouth Mucosa; Norepinephrine; Oxygen; Phosphodiesterase Inhibitors; Pyridazines; Rats; Regional Blood Flow; Shock, Septic; Simendan	2008
Inotropic support during experimental endotoxemic shock: part I. The effects of levosimendan on splanchnic perfusion. Anesthesia and analgesia, 2009, Volume: 109, Issue:5 Topics: Animals; Blood Pressure; Blood Volume; Cardiac Output; Cardiotonic Agents; Combined Modality Therapy; Disease Models, Animal; Fluid Therapy; Heart Rate; Hemodynamics; Hydrazones; Hypotension; Lactic Acid; Lipopolysaccharides; Liver Circulation; Oxygen; Pyridazines; Regional Blood Flow; Shock, Septic; Simendan; Splanchnic Circulation; Swine; Time Factors; Vascular Resistance	2009
Inotropic support during experimental endotoxemic shock: part II. A comparison of levosimendan with dobutamine. Anesthesia and analgesia, 2009, Volume: 109, Issue:5 Topics: Animals; Blood Pressure; Blood Volume; Cardiac Output; Cardiotonic Agents; Combined Modality Therapy; Disease Models, Animal; Dobutamine; Drug Therapy, Combination; Fluid Therapy; Heart Rate; Hemodynamics; Hydrazones; Hypotension; Lactic Acid; Lipopolysaccharides; Liver Circulation; Norepinephrine; Oxygen; Pyridazines; Regional Blood Flow; Shock, Septic; Simendan; Splanchnic Circulation; Swine; Time Factors; Vascular Resistance	2009
Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats. Journal of hypertension, 2009, Volume: 27, Issue:10 Topics: Administration, Oral; Animals; Apoptosis; Blood Pressure; Cardiomegaly; Cardiotonic Agents; Cyclin-Dependent Kinase Inhibitor p16; Diabetes Complications; Diabetes Mellitus, Type 2; Disease Models, Animal; Heart Failure; Homeodomain Proteins; Hydrazones; Male; Myocardial Infarction; Pyridazines; Rats; Rats, Mutant Strains; Rats, Wistar; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Simendan; STAT1 Transcription Factor; Ventricular Remodeling	2009
Combination pharmacotherapy in the treatment of experimental cardiac arrest. The American journal of emergency medicine, 2009, Volume: 27, Issue:6 Topics: Adrenergic beta-Agonists; Animals; Atenolol; Cardiotonic Agents; Disease Models, Animal; Drug Therapy, Combination; Epinephrine; Heart Arrest; Hydrazones; Lactic Acid; Phosphopyruvate Hydratase; Pyridazines; S100 Proteins; Simendan; Swine; Troponin I	2009
Letter regarding levosimendan in a rat model of severe verapamil poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2009, Volume: 5, Issue:3 Topics: Animals; Antidotes; Cardiotonic Agents; Cardiovascular Agents; Disease Models, Animal; Drug Overdose; Hemodynamics; Hydrazones; Phosphodiesterase Inhibitors; Pyridazines; Rats; Severity of Illness Index; Simendan; Vasodilator Agents; Verapamil	2009
Levosimendan attenuates reperfusion injury in an isolated perfused rat heart model. Journal of cardiothoracic and vascular anesthesia, 2010, Volume: 24, Issue:4 Topics: Animals; Apoptosis; Disease Models, Animal; Hydrazones; Male; Myocardial Reperfusion Injury; Organ Culture Techniques; Pyridazines; Rats; Rats, Wistar; Simendan	2010
Oxygen-wasting effect of inotropy: is there a need for a new evaluation? An experimental large-animal study using dobutamine and levosimendan. Circulation. Heart failure, 2010, Volume: 3, Issue:2 Topics: Analysis of Variance; Animals; Cardiotonic Agents; Disease Models, Animal; Dobutamine; Hydrazones; Male; Myocardial Contraction; Myocardial Stunning; Oxygen Consumption; Pyridazines; Simendan; Swine	2010
Effect of levosimendan in experimental verapamil-induced myocardial depression. Scandinavian journal of trauma, resuscitation and emergency medicine, 2010, Mar-11, Volume: 18 Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disease Models, Animal; Heart Arrest; Hydrazones; Pyridazines; Simendan; Swine; Verapamil	2010
Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:10 Topics: Angiotensin II; Angiotensinogen; Animals; bcl-2-Associated X Protein; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Heart; Heart Failure; Heart Rate; Humans; Hydrazones; Hypertension; Major Histocompatibility Complex; Male; Pyridazines; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Simendan	2010
Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury. BMC neurology, 2010, Oct-21, Volume: 10 Topics: Animals; Brain Injuries; Disease Models, Animal; Hippocampus; Hydrazones; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Organ Culture Techniques; Pyridazines; Simendan	2010
Levosimendan restores the positive force-frequency relation in heart failure. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:2 Topics: Analysis of Variance; Animals; Cardiac Pacing, Artificial; Cardiotonic Agents; Disease Models, Animal; Dogs; Excitation Contraction Coupling; Heart Failure; Heart Rate; Hydrazones; Male; Myocardial Contraction; Pyridazines; Simendan; Stroke Volume; Tachycardia; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure	2011
Differential hemodynamic effects of levosimendan in a porcine model of neonatal hypoxia-reoxygenation. Neonatology, 2012, Volume: 101, Issue:3 Topics: Animals; Animals, Newborn; Cardiac Output; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Fetal Hypoxia; Hydrazones; Oxygen; Pyridazines; Simendan; Swine	2012
A dose-response study of levosimendan in a porcine model of acute ischaemic heart failure. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2012, Volume: 41, Issue:6 Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Heart Failure; Hemodynamics; Hydrazones; Mitochondria, Heart; Myocardial Contraction; Oxygen Consumption; Pyridazines; Simendan; Sus scrofa; Ventricular Function, Left	2012
Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts. Cardiovascular diabetology, 2012, Jan-12, Volume: 11 Topics: Animals; Blood Glucose; Disease Models, Animal; Hemodynamics; Hydrazones; Hyperglycemia; Male; Milrinone; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Pyridazines; Rats; Rats, Wistar; Simendan; Time Factors	2012
Levosimendan attenuates hypoxia-induced pulmonary hypertension in a porcine model. Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:5 Topics: Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Disease Models, Animal; Female; Heart Rate; Hydrazones; Hypertension, Pulmonary; Hypoxia; Oxygen Consumption; Pyridazines; Simendan; Swine; Time Factors; Vascular Resistance	2012
Beneficial pharmacological effects of levosimendan on antioxidant status of acute inflammation induced in paw of rat: involvement in inflammatory mediators. Basic & clinical pharmacology & toxicology, 2013, Volume: 112, Issue:3 Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Disease Models, Animal; Edema; Hydrazones; Inflammation Mediators; Lower Extremity; Male; Pyridazines; Rats; Rats, Wistar; Simendan	2013
Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine. Scandinavian cardiovascular journal. Supplement, 2013, Volume: 47, Issue:1 Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Hemodynamics; Hydrazones; Male; Milrinone; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardial Stunning; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridazines; Simendan; Swine; Time Factors	2013
Levosimendan's effect on platelet function in a rat sepsis model. Platelets, 2013, Volume: 24, Issue:3 Topics: Animals; Blood Platelets; Disease Models, Animal; Hydrazones; Lipopolysaccharides; Male; Platelet Aggregation; Pyridazines; Rats; Sepsis; Simendan	2013
Advances in positive inotropic therapy: levosimendan. Critical care medicine, 2003, Volume: 31, Issue:9 Topics: Animals; Cardiotonic Agents; Clinical Trials as Topic; Disease Models, Animal; Heart Failure; Hemodynamics; Humans; Hydrazones; Myocardial Contraction; Prognosis; Pyridazines; Simendan; Treatment Outcome	2003
Levosimendan improves postresuscitation outcomes in a rat model of CPR. The Journal of laboratory and clinical medicine, 2005, Volume: 146, Issue:5 Topics: Adrenergic beta-Agonists; Animals; Cardiac Output; Cardiopulmonary Resuscitation; Cardiotonic Agents; Disease Models, Animal; Dobutamine; Heart Arrest; Heart Rate; Hydrazones; Male; Pyridazines; Random Allocation; Rats; Rats, Sprague-Dawley; Simendan; Single-Blind Method; Survival Rate; Ventricular Fibrillation; Ventricular Function, Left	2005
Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study. Resuscitation, 2006, Volume: 69, Issue:2 Topics: Acidosis; Animals; Disease Models, Animal; Endotoxemia; Escherichia coli Infections; Hemodynamics; Hydrazones; Intestinal Mucosa; Lactic Acid; Oxygen; Pyridazines; Sheep; Simendan; Vasodilator Agents	2006
Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass. Critical care medicine, 2007, Volume: 35, Issue:1 Topics: Age Factors; Animals; Cardiac Output; Cardiac Output, Low; Cardiopulmonary Bypass; Cardiotonic Agents; Diastole; Disease Models, Animal; Drug Evaluation, Preclinical; Heart Rate; Humans; Hydrazones; Infant; Milrinone; Oxygen Consumption; Pulmonary Gas Exchange; Pyridazines; Risk Factors; Simendan; Swine; Time Factors; Vascular Resistance; Ventricular Function, Left	2007
Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction. Critical care medicine, 2007, Volume: 35, Issue:3 Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Hydrazones; Hypertension, Pulmonary; Myocardial Contraction; Pulmonary Artery; Pyridazines; Simendan; Stroke Volume; Swine; Vascular Resistance; Vasodilator Agents; Ventricular Dysfunction, Right; Ventricular Function, Right	2007
Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone. Critical care medicine, 2007, Volume: 35, Issue:5 Topics: Animals; Cardiotonic Agents; Diastole; Disease Models, Animal; Dobutamine; Heart Failure; Hydrazones; Lipopolysaccharides; Milrinone; Pyridazines; Rabbits; Sepsis; Simendan; Systole; Ventricular Function, Left	2007
Antieosinophilic activity of simendans. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:1 Topics: Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Caspases; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA Fragmentation; Enzyme Inhibitors; Eosinophils; fas Receptor; Humans; Hydrazones; Interleukin-5; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred BALB C; Ovalbumin; Potassium Channels; Pulmonary Eosinophilia; Pyridazines; Simendan	2007
Levosimendan improves the initial outcome of cardiopulmonary resuscitation in a swine model of cardiac arrest. Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:8 Topics: Adrenergic alpha-Agonists; Animals; Cardiopulmonary Resuscitation; Cardiotonic Agents; Disease Models, Animal; Drug Therapy, Combination; Epinephrine; Female; Heart Arrest; Hydrazones; Male; Pyridazines; Random Allocation; Simendan; Swine; Treatment Outcome; Ventricular Fibrillation	2007
Effects of levosimendan on myocardial ischaemia-reperfusion injury. European journal of anaesthesiology, 2008, Volume: 25, Issue:1 Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Hydrazones; Male; Malondialdehyde; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Peroxidase; Pyridazines; Rats; Rats, Wistar; Simendan; Sodium-Potassium-Exchanging ATPase	2008
Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity. Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:1 Topics: Animals; Antidotes; Blood Pressure; Calcium Chloride; Cardiac Output; Disease Models, Animal; Heart Failure; Heart Rate; Hydrazones; KATP Channels; Male; Poisoning; Pyridazines; Rats; Rats, Wistar; Simendan; Survival Rate; Vasodilator Agents; Verapamil	2008
The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study. Interactive cardiovascular and thoracic surgery, 2008, Volume: 7, Issue:2 Topics: Animals; Atrophy; Disease Models, Animal; Female; Hydrazones; Iloprost; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Malondialdehyde; Necrosis; Protective Agents; Pyridazines; Rabbits; Reperfusion Injury; Simendan	2008
Protective effects of levosimendan and iloprost on lung injury induced by limb ischemia-reperfusion: a rabbit model. The Journal of surgical research, 2008, Jun-01, Volume: 147, Issue:1 Topics: Animals; Disease Models, Animal; Extremities; Female; Hydrazones; Iloprost; Lung; Male; Malondialdehyde; Pyridazines; Rabbits; Reperfusion Injury; Simendan	2008
Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock. Critical care medicine, 2008, Volume: 36, Issue:6 Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Fluid Therapy; Hemodynamics; Hydrazones; Lactic Acid; Male; Microcirculation; Mouth Mucosa; Norepinephrine; Oxygen; Pyridazines; Rats; Rats, Sprague-Dawley; Shock, Septic; Simendan; Vasodilator Agents	2008
Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injury. Critical care medicine, 2008, Volume: 36, Issue:6 Topics: Acid-Base Equilibrium; Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Carbon Dioxide; Cardiotonic Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrazones; Inflammation Mediators; Injections, Intravenous; Interleukin-1beta; Lung; Macrophage Inflammatory Proteins; Macrophages, Alveolar; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Oxygen; Pneumonia, Ventilator-Associated; Pyridazines; Rats; Rats, Wistar; Respiration, Artificial; Simendan; Survival Rate; Vasodilator Agents	2008
Cardiovascular effects of the calcium sensitizer, levosimendan, in heart failure induced by rapid pacing in the presence of aortic constriction. British journal of pharmacology, 1995, Volume: 114, Issue:3 Topics: Analysis of Variance; Animals; Aorta; Cardiac Pacing, Artificial; Cardiotonic Agents; Disease Models, Animal; Dogs; Electrodes, Implanted; Female; Heart Failure; Hemodynamics; Hydrazones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Pyridazines; Simendan; Ventricular Function, Left	1995