Compounds > silybin
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silybin and Liver Steatosis

silybin has been researched along with Liver Steatosis in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (31.58)29.6817
2010's11 (57.89)24.3611
2020's2 (10.53)2.80

Authors

AuthorsStudies
Chen, C; Gao, J; Han, X; Jiang, J; Liu, Y; Qian, J; Tang, X; Wen, B; Zhao, X1
Chen, EQ; Lv, DD; Tang, H; Tao, YC; Wang, ML; Wang, YJ; Zhang, DM1
Ou, Q; Wang, S; Weng, Y; Wu, X; Zhang, F; Zhao, Y; Zhou, J1
Carratù, MR; de Bari, O; Diogo, CV; Ferri, D; Grattagliano, I; Liquori, A; Mastrodonato, M; Oliveira, PJ; Persichella, M; Portincasa, P; Wang, DQ1
Bouderba, S; Detaille, D; Koceïr, EA; Sanchez-Martin, C; Villanueva, GR1
Cao, M; Hai, J; Pei, S; Wang, J; Zhang, Q; Zhang, Y1
Abenavoli, L; Bellentani, S1
Baldini, F; Grasselli, E; Grattagliano, I; Portincasa, P; Vecchione, G; Vergani, L; Voci, A; Wang, DQ1
Fehér, J; Lengyel, G1
Altomare, E; Bellanti, F; Giudetti, AM; Gnoni, GV; Petrella, A; Rollo, T; Romano, AD; Serviddio, G; Tamborra, R; Vendemiale, G1
Minhu, C; Yao, J; Zhi, M1
Bucchieri, F; Bugianesi, E; Galvano, F; Li Volti, G; Mangiameli, A; Marino Gammazza, A; Marino, A; Parola, M; Paternostro, C; Salamone, F; Tibullo, D1
Andreone, P; Brisc, C; Brisc, MC; Bugianesi, E; Chiaramonte, M; Cursaro, C; Danila, M; de Sio, I; Del Vecchio Blanco, C; Federico, A; Floreani, A; Freni, MA; Grieco, A; Groppo, M; Lazzari, R; Lobello, S; Loguercio, C; Lorefice, E; Margotti, M; Miele, L; Milani, S; Okolicsanyi, L; Palasciano, G; Portincasa, P; Saltarelli, P; Smedile, A; Somalvico, F; Sorrentino, P; Spadaro, A; Sporea, I; Tuccillo, C; Vecchione, R1
Barbagallo, I; Cappello, F; Galvano, F; Li Volti, G; Mangiameli, A; Salamone, F1
Costa, A; Galletti, S; Steidler, S; Tameni, M; Tava, A; Tedesco, D; Varisco, G1
D'Auria, M; de Sio, I; Di Leva, A; Federico, A; Loguercio, C; Niosi, M; Trappoliere, M; Tuccillo, C1
Capristo, E; Forgione, A; Gabrieli, ML; Gallo, A; Gasbarrini, G; Grieco, A; Miele, L; Vero, V1
de Sio, I; Del Vecchio Blanco, C; Di Leva, A; Federico, A; Loguercio, C; Trappoliere, M; Tuccillo, C1
Capasso, R; D'Auria, MV; de Sio, I; Del Vecchio Blanco, C; Di Leva, A; Federico, A; Loguercio, C; Niosi, M; Trappoliere, M; Tuccillo, C1

Reviews

2 review(s) available for silybin and Liver Steatosis

ArticleYear
[Silymarin in the treatment of chronic liver diseases: past and future].
    Orvosi hetilap, 2008, Dec-21, Volume: 149, Issue:51

    Topics: Antioxidants; Carcinoma, Hepatocellular; Chronic Disease; Colorectal Neoplasms; Fatty Liver; Fatty Liver, Alcoholic; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Oxidative Stress; Silybin; Silymarin; Survival Analysis; Treatment Outcome

2008
[Oxidative stress in metabolic syndrome and nonalcoholic steatohepatitis. Is it possible a role for vitamins in clinical practice?].
    Recenti progressi in medicina, 2006, Volume: 97, Issue:1

    Topics: Adult; Animals; Antioxidants; Cells, Cultured; Clinical Trials as Topic; Endothelial Cells; Fatty Liver; Female; Folic Acid; Hepatitis; Homocysteine; Humans; Insulin Resistance; Male; Metabolic Syndrome; Oxidative Stress; Rats; Risk Factors; Silybin; Silymarin; Time Factors; Vitamin B 12; Vitamin D; Vitamins

2006

Trials

3 trial(s) available for silybin and Liver Steatosis

ArticleYear
Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial.
    Free radical biology & medicine, 2012, May-01, Volume: 52, Issue:9

    Topics: Body Mass Index; Fatty Liver; Humans; Phosphatidylcholines; Romania; Silybin; Silymarin; Vitamin E

2012
[Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study].
    Minerva gastroenterologica e dietologica, 2005, Volume: 51, Issue:2

    Topics: Adult; Aged; Biomarkers; Drug Combinations; Fatty Liver; Female; Hepatitis C, Chronic; Humans; Insulin Resistance; Liver Cirrhosis; Male; Metabolic Syndrome; Middle Aged; Phospholipids; Pilot Projects; Silybin; Silymarin; Vitamin E

2005
A new silybin-vitamin E-phospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: preliminary observations.
    Gut, 2006, Volume: 55, Issue:6

    Topics: Drug Combinations; Fatty Liver; Humans; Insulin Resistance; Phospholipids; Silybin; Silymarin; Vitamin E

2006

Other Studies

14 other study(ies) available for silybin and Liver Steatosis

ArticleYear
Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry: A metabolomic and mechanistic approach.
    Biomedical chromatography : BMC, 2022, Volume: 36, Issue:11

    Topics: Animals; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Cholesterol; Chromatography, Liquid; Emodin; Fatty Liver; Glycerophospholipids; Liver; Mass Spectrometry; Rats; RNA, Messenger; Silybin; Vitamins

2022
Effect of silibinin capsules combined with lifestyle modification on hepatic steatosis in patients with chronic hepatitis B.
    Scientific reports, 2021, 01-12, Volume: 11, Issue:1

    Topics: Adult; Capsules; Fatty Liver; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Life Style; Male; Middle Aged; Protective Agents; Retrospective Studies; ROC Curve; Severity of Illness Index; Silybin

2021
Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway.
    Digestive diseases and sciences, 2018, Volume: 63, Issue:12

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Disease Models, Animal; Fatty Liver; Gene Expression; Lipid Metabolism; Liver Cirrhosis; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Silybin; Treatment Outcome

2018
A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes.
    World journal of gastroenterology, 2013, May-28, Volume: 19, Issue:20

    Topics: Animals; Biomarkers; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Glutathione; Glutathione Peroxidase; Keratin-18; Liver; Male; Malondialdehyde; Mitochondria, Liver; Mitochondrial Proteins; Nitroso Compounds; Oxidative Phosphorylation; Oxidative Stress; Phospholipids; Rats; Rats, Wistar; Silybin; Silymarin; Sulfhydryl Compounds; Thiobarbituric Acid Reactive Substances; Thioredoxins; Time Factors; Tyrosine; Vitamin E

2013
Beneficial effects of silibinin against the progression of metabolic syndrome, increased oxidative stress, and liver steatosis in Psammomys obesus, a relevant animal model of human obesity and diabetes.
    Journal of diabetes, 2014, Volume: 6, Issue:2

    Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Fatty Liver; Gerbillinae; Glutathione; Glutathione Peroxidase; Humans; Insulin; Lipids; Liver; Metabolic Syndrome; Obesity; Oxidative Stress; Silybin; Silymarin; Superoxide Dismutase

2014
Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathway.
    International immunopharmacology, 2013, Volume: 17, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Line; Cell Line, Tumor; Diet, High-Fat; Fatty Liver; Glucose; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Non-alcoholic Fatty Liver Disease; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Silybin; Silymarin

2013
Milk thistle to treat non-alcoholic fatty liver disease: dream or reality?
    Expert review of gastroenterology & hepatology, 2013, Volume: 7, Issue:8

    Topics: Animals; Fatty Liver; Humans; Liver; Non-alcoholic Fatty Liver Disease; Phytotherapy; Plant Extracts; Plants, Medicinal; Silybin; Silybum marianum; Silymarin; Treatment Outcome

2013
Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells.
    World journal of gastroenterology, 2016, Jul-14, Volume: 22, Issue:26

    Topics: Animals; Antioxidants; Blotting, Western; Carnitine O-Palmitoyltransferase; Catalase; Cell Line, Tumor; Cells, Cultured; Fatty Liver; Fluorometry; Hepatocytes; Lipid Droplets; Lipid Metabolism; Lipid Peroxidation; Microscopy, Fluorescence; NF-kappa B; Oleic Acid; Oxidative Stress; Palmitates; Peroxisome Proliferator-Activated Receptors; Rats; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Silybin; Silymarin; Spectrophotometry; Sterol Regulatory Element Binding Protein 1; Triglycerides; Vitamin E

2016
A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:3

    Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Fatty Liver; Glutathione; Hydrogen Peroxide; Lipid Peroxidation; Liver; Male; Membrane Lipids; Membrane Potential, Mitochondrial; Mitochondria, Liver; Oxidation-Reduction; Oxidative Stress; Phospholipids; Rats; Rats, Wistar; Silybin; Silymarin

2010
Effect of silybin on high-fat-induced fatty liver in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2011, Volume: 44, Issue:7

    Topics: Animals; Antioxidants; Dietary Fats; Disease Models, Animal; Drug Evaluation, Preclinical; Fatty Liver; Homeostasis; Hypoglycemic Agents; Insulin Resistance; Lipid Peroxidation; Lipids; Liver; Male; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Rosiglitazone; Silybin; Silymarin; Thiazolidinediones

2011
Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2012, Volume: 44, Issue:4

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline Deficiency; Cytokines; Diet; Fatty Liver; Gene Expression; Glutathione; Insulin Resistance; Isoprostanes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Methionine; Mice; Myocardium; Nitrates; Nitrites; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphorylation; Silybin; Silymarin; Statistics, Nonparametric

2012
Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.
    Translational research : the journal of laboratory and clinical medicine, 2012, Volume: 159, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Choline Deficiency; Disease Models, Animal; Fatty Liver; Homeostasis; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Obese; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Silybin; Silymarin; Translational Research, Biomedical

2012
Effects of silymarin, a natural hepatoprotector, in periparturient dairy cows.
    Journal of dairy science, 2004, Volume: 87, Issue:7

    Topics: 3-Hydroxybutyric Acid; Animals; Body Composition; Cattle; Cattle Diseases; Colostrum; Drug Residues; Fatty Acids, Nonesterified; Fatty Liver; Female; gamma-Glutamyltransferase; Health Status; Lactation; Lipids; Liver Diseases; Milk; Parturition; Pregnancy; Protective Agents; Silybin; Silymarin

2004
The effect of a silybin-vitamin e-phospholipid complex on nonalcoholic fatty liver disease: a pilot study.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:9

    Topics: Adult; Aged; Antioxidants; Cytokines; Disease Progression; Drug Therapy, Combination; Fatty Liver; Female; Follow-Up Studies; Humans; Male; Middle Aged; Phospholipids; Pilot Projects; Silybin; Silybum marianum; Silymarin; Time Factors; Transaminases; Treatment Outcome; Ultrasonography; Vitamin E

2007