silybin has been researched along with Liver Diseases in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 14 (48.28) | 24.3611 |
| 2020's | 5 (17.24) | 2.80 |
| Authors | Studies |
|---|---|
| Atanasov, AG; Bauer, R; Dirsch, VM; Heiss, EH; Kunert, O; Malainer, C; Noha, SM; Oberlies, NH; Pferschy-Wenzig, EM; Schuster, D; Wagner, H | 1 |
| Chin, YW; Kim, J; Kim, SH; Kim, YB; Kim, YC; Lim, SW; Shin, DY; Suh, YG | 1 |
| Kollaras, V; Konstandi, O; Kostomistsopoulos, N; Lambropoulou, M; Pikoulis, E; Simopoulos, C; Tsaroucha, A; Valsami, G | 1 |
| Bai, L; Chen, Y; Duan, Z; Kong, M; Tang, S; Xu, M; Zhang, X; Zheng, S | 1 |
| Gou, J; He, H; Li, X; Liang, X; Lu, C; Tang, X; Yin, T; Zhang, X; Zhang, Y | 1 |
| Xie, Y; Yuan, J; Zhang, D; Zhang, J | 1 |
| Anagnostopoulos, K; Betsou, A; Georgakopoulou, AE; Konstandi, O; Kostomitsopoulos, N; Lambropoulou, M; Simopoulos, CE; Tsalikidis, C; Tsaroucha, AK; Valsami, G | 1 |
| Ardois, M; Cieślak, A; Gogulski, M; Grabska, J; Kołodziejski, PA; Libera, K; Pomorska-Mól, M; Strompfová, V; Szumacher-Strabel, M | 1 |
| Islam, A; Mishra, A; Siddiqui, MA; Siddiquie, S | 1 |
| Bosch-Barrera, J; Menendez, JA; Queralt, B | 1 |
| Oltean, M | 1 |
| Abenavoli, L; Capasso, R; Cicala, C; Izzo, AA; Milić, N; Santini, A | 1 |
| Bui, QD; Chi, SC; Ho, XH; Nguyen, HA; Nguyen, TD; Pham, DV; Tran, CS; Tung, NT | 1 |
| Gilja, OH; Hausken, T; Lied, GA | 1 |
| Wang, Q; Wang, Y; Zhang, D; Zhang, L | 1 |
| Dallio, M; Federico, A; Loguercio, C | 1 |
| Fehér, J; Lengyel, G | 1 |
| Baba, HA; Benko, T; Best, J; de Groot, H; Fandrey, J; Frede, S; Gu, Y; Rauen, U; Schlaak, JF | 1 |
| Abenavoli, L; Capasso, F; Capasso, R; Milic, N | 1 |
| Kolarović, J; Mikov, M; Rašković, A; Stilinović, N; Vasović, V; Vukmirović, S | 1 |
| Kostek, H; Lewandowska-Stanek, H; Majewska, M; Szponar, J; Tchórz, M | 1 |
| Bang, R; Kiemer, AK; Prockl, J; Schümann, J; Tiegs, G; Vollmar, AM | 1 |
| El-Bahay, C; Hanelt, S; Kahl, R; Lewerenz, V; Nastevska, C; Röhrdanz, E | 1 |
| Costa, A; Galletti, S; Steidler, S; Tameni, M; Tava, A; Tedesco, D; Varisco, G | 1 |
| Head, K; Kidd, P | 1 |
| Comelli, MC; Mengs, U; Prosdocimi, M; Schneider, C | 1 |
| Boztok, K; Dedeoglu, E; Karcioglu, O; Soner, BC; Tuncok, Y; Unverir, P | 1 |
| Chamulitrat, W; Erben, G; Huber, A; Lehmann, WD; Stremmel, W; Thongphasuk, P; Tuma, S | 1 |
| Campos, R; Garrido, A; Guerra, R; Valenzuela, A | 1 |
11 review(s) available for silybin and Liver Diseases
| Article | Year |
|---|---|
Metabolism, Transport and Drug-Drug Interactions of Silymarin.
Topics: Animals; Antioxidants; ATP Binding Cassette Transporter, Subfamily G, Member 2; Flavonolignans; Humans; Liver Diseases; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phytotherapy; Rats; Silybin; Silybum marianum; Silymarin | 2019 |
Recapitulation of Evidence of Phytochemical, Pharmacokinetic and Biomedical Application of Silybin.
Topics: Antioxidants; Humans; Liver Diseases; Phytochemicals; Silybin; Silybum marianum; Silymarin | 2021 |
Targeting STAT3 with silibinin to improve cancer therapeutics.
Topics: Antineoplastic Agents; Antioxidants; Drug Resistance, Neoplasm; Humans; Liver Diseases; Neoplasms; Radiation Tolerance; Silybin; Silymarin; STAT3 Transcription Factor | 2017 |
Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Dietary Supplements; Fruit; Humans; Liver Diseases; Phytochemicals; Randomized Controlled Trials as Topic; Silybin; Silybum marianum; Silymarin | 2018 |
Recent advances in the nanotechnology-based drug delivery of Silybin.
Topics: Antioxidants; Crystallization; Evidence-Based Medicine; Humans; Liver Diseases; Macromolecular Substances; Materials Testing; Molecular Conformation; Nanocapsules; Neoplasms; Silybin; Silymarin; Surface Properties; Suspensions; Treatment Outcome | 2014 |
Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Antiviral Agents; Chronic Disease; Humans; Liver Diseases; Silybin; Silymarin | 2017 |
[Silymarin in the treatment of chronic liver diseases: past and future].
Topics: Antioxidants; Carcinoma, Hepatocellular; Chronic Disease; Colorectal Neoplasms; Fatty Liver; Fatty Liver, Alcoholic; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Oxidative Stress; Silybin; Silymarin; Survival Analysis; Treatment Outcome | 2008 |
Milk thistle in liver diseases: past, present, future.
Topics: Animals; Antioxidants; Clinical Trials as Topic; Humans; Lipid Peroxidation; Liver Diseases; Molecular Structure; Phytotherapy; Silybin; Silybum marianum; Silymarin | 2010 |
[Silibinin and its hepatoprotective action from the perspective of a toxicologist].
Topics: Amanita; Amanitins; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Lipid Peroxidation; Liver Diseases; Liver Regeneration; Mushroom Poisoning; Peroxidases; Prostaglandins; Protective Agents; Silybin; Silymarin; Superoxide Dismutase | 2012 |
A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
Topics: Animals; Biological Availability; Drug Combinations; Humans; Liver; Liver Diseases; Phosphatidylcholines; Phytotherapy; Rats; Silybin; Silybum marianum; Silymarin | 2005 |
Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy.
Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Carcinoma; Cytoprotection; Humans; Liver; Liver Diseases; Male; Oxidative Stress; Prostatic Neoplasms; Protein Kinase Inhibitors; Receptors, Growth Factor; Silybin; Silymarin; Transcription Factors; Tumor Necrosis Factor-alpha | 2007 |
18 other study(ies) available for silybin and Liver Diseases
| Article | Year |
|---|---|
Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma.
Topics: Adipocytes; Benzamides; Dose-Response Relationship, Drug; Liver Diseases; Molecular Structure; PPAR gamma; Pyridines; Receptors, Cytoplasmic and Nuclear; Seeds; Silybum marianum; Silymarin; Stereoisomerism | 2014 |
Hepatoprotective pyrrole derivatives of Lycium chinense fruits.
Topics: Animals; Carbon Tetrachloride; Dose-Response Relationship, Drug; Drug Antagonism; Fruit; Hepatocytes; Liver Diseases; Lycium; Magnetic Resonance Spectroscopy; Plants, Medicinal; Protective Agents; Pyrroles; Rats; Structure-Activity Relationship | 2003 |
Effect of silibinin on the expression of MMP2, MMP3, MMP9 and TIMP2 in kidney and lung after hepatic ischemia/reperfusion injury in an experimental rat model.
Topics: Animals; Ischemia; Kidney; Liver Diseases; Lung; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Rats; Rats, Wistar; Reperfusion Injury; Silybin; Tissue Inhibitor of Metalloproteinase-2 | 2021 |
The novel hepatoprotective mechanisms of silibinin-phospholipid complex against d-GalN/LPS-induced acute liver injury.
Topics: Animals; Lipopolysaccharides; Liver Diseases; Mice; MicroRNAs; Silybin | 2023 |
Liver Targeting Albumin-Coated Silybin-Phospholipid Particles Prepared by Nab™ Technology for Improving Treatment Effect of Acute Liver Damage in Intravenous Administration.
Topics: Administration, Intravenous; Albumins; Animals; Drug Delivery Systems; Humans; Liver Diseases; Mice; Nanoparticles; Particle Size; Phospholipids; Rats; Rats, Sprague-Dawley; Silybin; Solubility; Spectroscopy, Fourier Transform Infrared; Tissue Distribution | 2019 |
The hepatoprotective effect of silibinin after hepatic ischemia/reperfusion in a rat model is confirmed by immunohistochemistry and qRT-PCR.
Topics: Animals; Anti-Inflammatory Agents; Chemokine CCL2; Freeze Drying; Inflammation; Ischemia; Liver; Liver Diseases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Phytotherapy; Plant Extracts; Protective Agents; Random Allocation; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Silybin; Silymarin; Tissue Inhibitor of Metalloproteinase-2; Tumor Necrosis Factor-alpha | 2021 |
Effects of silybin supplementation on nutrient digestibility, hematological parameters, liver function indices, and liver-specific mi-RNA concentration in dogs.
Topics: Animal Feed; Animals; Biomarkers; Diet; Dietary Supplements; Digestion; Dog Diseases; Dogs; Female; Liver Diseases; Male; MicroRNAs; Silybin | 2021 |
Silybin Against Liver Ischemia-Reperfusion Injury: Something Old, Something New….
Topics: Animals; HMGB1 Protein; Liver; Liver Diseases; Rats; Reperfusion Injury; Silybin | 2018 |
Formulation and biopharmaceutical evaluation of supersaturatable self-nanoemulsifying drug delivery systems containing silymarin.
Topics: Animals; Biological Availability; Carbon Tetrachloride; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Drug Liberation; Emulsions; Liver Diseases; Male; Mice; Nanoparticles; Poloxamer; Protective Agents; Rabbits; Silybin; Silymarin; Solubility | 2019 |
[Does silibinin have a place in the treatment of liver diseases?].
Topics: Adult; Antioxidants; Female; Humans; Liver; Liver Diseases; Protective Agents; Silybin; Silymarin | 2014 |
Glycine pretreatment ameliorates liver injury after partial hepatectomy in the rat.
Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Aspartate Aminotransferases; Drug Evaluation, Preclinical; Drug Synergism; Glycine; Hepatectomy; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Diseases; Liver Transplantation; Male; Postoperative Complications; Preanesthetic Medication; Prothrombin Time; Random Allocation; Rats; Rats, Wistar; Silybin; Silymarin; Tissue and Organ Harvesting | 2010 |
The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats.
Topics: Animals; Antioxidants; Cardiotonic Agents; Cardiotoxins; Doxorubicin; Heart; Heart Diseases; Liver; Liver Diseases; Male; Myocardium; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Reactive Oxygen Species; Silybin; Silybum marianum; Silymarin | 2011 |
Silibinin protects mice from T cell-dependent liver injury.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Cytoprotection; Enzyme Induction; Galactosamine; Leukocytes; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Recombinant Proteins; RNA, Messenger; Silybin; Silymarin; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2003 |
Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity.
Topics: Acetaminophen; Acetylcysteine; alpha-Tocopherol; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Northern; Cell Death; Chemical and Drug Induced Liver Injury; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Formazans; Hepatocytes; Lipid Peroxides; Liver Diseases; Male; Neutral Red; Rats; Rats, Wistar; RNA; Silybin; Silymarin; Tetrazolium Salts | 2003 |
Effects of silymarin, a natural hepatoprotector, in periparturient dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Body Composition; Cattle; Cattle Diseases; Colostrum; Drug Residues; Fatty Acids, Nonesterified; Fatty Liver; Female; gamma-Glutamyltransferase; Health Status; Lactation; Lipids; Liver Diseases; Milk; Parturition; Pregnancy; Protective Agents; Silybin; Silymarin | 2004 |
Renal and hepatic injury with elevated cardiac enzymes in Amanita phalloides poisoning: a case report.
Topics: Amanita; Amylases; Anti-Bacterial Agents; Antidotes; Charcoal; Clinical Enzyme Tests; Creatine Kinase, MB Form; Diagnosis, Differential; Electrocardiography; Fluid Therapy; Humans; Kidney Failure, Chronic; Kidney Function Tests; Liver Diseases; Liver Function Tests; Male; Middle Aged; Mushroom Poisoning; Myocardial Infarction; Myoglobin; Penicillin G; Renal Dialysis; Silybin; Silymarin; Tachycardia, Sinus; Troponin I; Up-Regulation | 2007 |
Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Movement; Cell Survival; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Humans; Hydrogen Peroxide; Keratinocytes; Liver Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Molecular Structure; Reactive Oxygen Species; Silybin; Silymarin | 2008 |
Acetaminophen hepatotoxicity in rats is attenuated by silybin dihemisuccinate.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Glutathione; Liver Diseases; Male; Rats; Rats, Inbred Strains; Silybin; Silymarin | 1988 |