silybin has been researched along with Liver Cirrhosis in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, JJ; Geng, CA; Huang, XY; Li, TZ; Shen, C; Sun, JJ; Wang, JP; Xue, D | 1 |
| Fang, C; Gong, T; Li, Y; Luo, S; Yang, Y; Zhang, R; Zhang, Z; Zhao, T | 1 |
| Chen, D; Feng, J; Gong, T; Guo, C; He, Q; Li, J; Song, X; Tan, T; Tan, Y; Yang, Q | 1 |
| Dong, Y; Luo, J; Ma, L; Zeng, Y; Zhang, Z | 1 |
| Cui, PF; Fan, QQ; He, YJ; Jiang, HL; Oh, YK; Pang, T; Qiao, JB; Wang, L; Xing, L; Zhang, C; Zhu, JC | 1 |
| Ou, Q; Wang, S; Weng, Y; Wu, X; Zhang, F; Zhao, Y; Zhou, J | 1 |
| Bellanti, F; Giudetti, AM; Serviddio, G; Siculella, L; Stanca, E; Vendemiale, G | 1 |
| Ali, SO; Darwish, HA; Ismail, NA | 1 |
| Anagnostopoulos, A; Böni, J; Braun, DL; Durisch, N; Eberhard, N; Fehr, J; Ledergerber, B; Metzner, KJ; Rauch, A; Weber, R | 1 |
| Canini, L; Conway, JM; Cotler, SJ; Crespo, G; D'Amato, M; Dahari, H; DebRoy, S; Ferenci, P; Forns, X; Mariño, Z; Navasa, M; Perelson, AS | 1 |
| Anagnostopoulos, A; Aouri, M; Böni, J; Braun, DL; Decosterd, L; Durisch, N; Eberhard, N; Fehr, J; Ledergerber, B; Metzner, KJ; Müllhaupt, B; Rauch, A; Weber, R | 1 |
| Fehér, J; Lengyel, G | 1 |
| Bertolani, C; Caligiuri, A; di Manzano, C; Failli, P; Loguercio, C; Marra, F; Novo, E; Pinzani, M; Schmid, M; Trappoliere, M; Vizzutti, F | 1 |
| Berg, T; Biermer, M | 1 |
| D'Auria, M; de Sio, I; Di Leva, A; Federico, A; Loguercio, C; Niosi, M; Trappoliere, M; Tuccillo, C | 1 |
| Chi, CW; Hung, SC; Lin, CH; Lin, LC; Tsai, TH; Wu, JW | 1 |
1 review(s) available for silybin and Liver Cirrhosis
| Article | Year |
|---|---|
[Silymarin in the treatment of chronic liver diseases: past and future].
Topics: Antioxidants; Carcinoma, Hepatocellular; Chronic Disease; Colorectal Neoplasms; Fatty Liver; Fatty Liver, Alcoholic; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Oxidative Stress; Silybin; Silymarin; Survival Analysis; Treatment Outcome | 2008 |
2 trial(s) available for silybin and Liver Cirrhosis
| Article | Year |
|---|---|
A Lead-In with Silibinin Prior to Triple-Therapy Translates into Favorable Treatment Outcomes in Difficult-To-Treat HIV/Hepatitis C Coinfected Patients.
Topics: Adult; Antiretroviral Therapy, Highly Active; Antiviral Agents; Coinfection; Drug Administration Schedule; Female; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Injections, Intravenous; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Patient Safety; Polyethylene Glycols; Prospective Studies; Protease Inhibitors; Recombinant Proteins; Ribavirin; RNA, Viral; Silybin; Silymarin; Treatment Outcome; Viral Load | 2015 |
[Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study].
Topics: Adult; Aged; Biomarkers; Drug Combinations; Fatty Liver; Female; Hepatitis C, Chronic; Humans; Insulin Resistance; Liver Cirrhosis; Male; Metabolic Syndrome; Middle Aged; Phospholipids; Pilot Projects; Silybin; Silymarin; Vitamin E | 2005 |
13 other study(ies) available for silybin and Liver Cirrhosis
| Article | Year |
|---|---|
Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2.
Topics: Cell Line; Cytotoxins; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship | 2021 |
Albumin-Based Silibinin Nanocrystals Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy.
Topics: Albumins; Animals; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Nanoparticles; Silybin | 2023 |
Combined Amphiphilic Silybin Meglumine Nanosuspension Effective Against Hepatic Fibrosis in Mice Model.
Topics: Animals; Biological Availability; Collagen Type I; Disease Models, Animal; Liver Cirrhosis; Meglumine; Mice; Silybin | 2023 |
Co-encapsulation of collagenase type I and silibinin in chondroitin sulfate coated multilayered nanoparticles for targeted treatment of liver fibrosis.
Topics: Animals; Capsules; Cell Line; Chondroitin Sulfates; Collagenases; Disease Models, Animal; Hepatic Stellate Cells; Humans; Hyaluronan Receptors; Liver; Liver Cirrhosis; Mice; Nanoparticles; Silybin | 2021 |
Vitamin A-decorated biocompatible micelles for chemogene therapy of liver fibrosis.
Topics: Animals; Biocompatible Materials; Cell Line; Cell Survival; Collagen Type I; Drug Carriers; Gene Transfer Techniques; Genetic Therapy; Hemolysis; Humans; Liver Cirrhosis; Male; Mice, Inbred C57BL; Micelles; Polymers; Rabbits; Rats; RNA, Small Interfering; Silybin; Vitamin A; Vitamins | 2018 |
Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Disease Models, Animal; Fatty Liver; Gene Expression; Lipid Metabolism; Liver Cirrhosis; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Silybin; Treatment Outcome | 2018 |
Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: potential antiinflammatory effect of silybin.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Antioxidants; Blotting, Western; Chromatography, Thin Layer; Down-Regulation; Gene Expression Regulation; Inflammation; Liver Cirrhosis; Male; Microsomes, Liver; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Silybin; Silymarin | 2013 |
Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Curcumin; Gene Expression Regulation; HSP47 Heat-Shock Proteins; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Oxidative Stress; Rats; Rats, Wistar; Silybin; Silymarin; Thioacetamide; Thioctic Acid; Transforming Growth Factor beta1 | 2014 |
Efficacy of lead-in silibinin and subsequent triple therapy in difficult-to-treat HIV/hepatitis C virus-coinfected patients.
Topics: Adult; Anti-Retroviral Agents; Antiviral Agents; Coinfection; Drug Therapy, Combination; Female; Hepatitis C; HIV Infections; Humans; Injections, Intravenous; Liver Cirrhosis; Male; Middle Aged; Pilot Projects; Protease Inhibitors; RNA, Viral; Silybin; Silymarin | 2014 |
Severity of liver disease affects HCV kinetics in patients treated with intravenous silibinin monotherapy.
Topics: Adult; Age Factors; Aged; Antioxidants; Biological Availability; Cell Death; Computer Simulation; Female; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Injections, Intravenous; Liver Cirrhosis; Male; Middle Aged; Models, Statistical; Severity of Illness Index; Silybin; Silymarin; Viral Load | 2015 |
Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Becaplermin; Calcium; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Collagen Type I; DNA; Hepatic Stellate Cells; Humans; Hydrogen-Ion Concentration; I-kappa B Proteins; Interleukin-1beta; Interleukin-8; Liver Cirrhosis; Matrix Metalloproteinase 2; Models, Biological; NF-KappaB Inhibitor alpha; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Reactive Oxygen Species; Signal Transduction; Silybin; Silymarin | 2009 |
Rapid suppression of hepatitis C viremia induced by intravenous silibinin plus ribavirin.
Topics: Aged; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Infusions, Intravenous; Interferon alpha-2; Interferon-alpha; Liver Cirrhosis; Polyethylene Glycols; Recombinant Proteins; Ribavirin; RNA, Viral; Silybin; Silymarin; Treatment Outcome; Viral Load | 2009 |
Hepatobiliary excretion of silibinin in normal and liver cirrhotic rats.
Topics: Animals; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Biliary Tract; Chromatography, High Pressure Liquid; Cyclosporine; Drug Interactions; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; Silybin; Silymarin | 2008 |