silybin has been researched along with Invasiveness, Neoplasm in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 20 (74.07) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Imai, M; Takahashi, N; Takeda, K | 1 |
| Abazari, O; Abbasi, M; Ebrahimi, M; Eskandari, Y; Faisal Faiz, A; Gravand, A; Khosh Ravesh, R; Lorian, K; Maleki, N; Panji, M; Shafiee Mehr, M; Sharbati, A; Yavari, N | 1 |
| Jo, AI; Kim, MM | 1 |
| Bae, SW; Jang, KJ; Jo, ES; Kang, DY; Lee, JM; Rugamba, A; Sp, N | 1 |
| Byun, HJ; Darvin, P; Joung, YH; Kang, DY; Kim, SJ; Park, JH; Sp, N; Yang, YM | 1 |
| Cheng, Y; Guan, Z; Jiang, Y; Li, Q; Sun, Y; Xu, Y; Zhao, W | 1 |
| Balarino, N; Belgorosky, D; Eiján, AM; Langle, Y; Prack Mc Cormick, B; Sandes, E; Vanzulli, S | 1 |
| Chang, L; Chen, Y; Guo, P; He, D; Jia, J; Jin, B; Li, F; Ma, Z; Sun, Y; Tang, X; Wang, K; Wang, X; Yang, C; Zeng, J | 1 |
| Agarwal, C; Agarwal, R; Chan, D; Mateen, S; Raina, K | 1 |
| Chen, L; Li, Y; Shen, J; Xu, P; Yin, Q; Yu, H; Zhang, Z | 1 |
| Agarwal, C; Agarwal, R; Deep, G; Jain, AK; Kumar, R | 1 |
| Kale, RK; Prajapati, V; Singh, RP | 1 |
| Chang, YC; Hu, FW; Jan, CI; Lai, YC; Peng, CY; Yu, CC | 1 |
| Chakrabarti, M; Ray, SK | 1 |
| Alimoghaddam, K; Ghaffari, SH; Ghasemi, R; Ghavamzadeh, A; Javadikooshesh, S; Miranda, M; Momeny, M; Valenti, G; Yaghmaie, M; Zarrinrad, G; Zekri, A | 1 |
| Chan, KT; Chan, KW; Cheung, AL; Guan, XY; Law, S; Lee, NP; Li, B; Li, J; Qin, YR; Tsao, SW; Xu, WW | 1 |
| Fan, JH; He, DL; Li, L; Wang, XY; Wu, KJ; Zeng, J; Zhang, D; Zhang, LL; Zhu, GD | 1 |
| Barroso-Aranda, J; Contreras, F; McCarty, MF | 1 |
| Agarwal, C; Agarwal, R; Deep, G; Gangar, SC | 1 |
| Chang, HR; Chen, PN; Chu, SC; Hsieh, YS; Hung, TW; Lian, JD; Sun, YS; Wu, SW; Yang, SF | 1 |
| Alimoghaddam, K; Dizaji, MZ; Ghaffari, SH; Ghavamzadeh, A; Malehmir, M | 1 |
| Chang, LS; Chen, YL; Gao, Y; He, D; Li, L; Liang, L; Wang, XY; Wang, ZQ; Zeng, J | 1 |
| Chen, YH; Chiu, JH; Chua, SK; Lin, CM; Ma, HP; Ong, JR; Shyu, KG; Wang, BW | 1 |
| Han, J; Jung, SP; Kim, JH; Kim, JS; Kim, S; Lee, JE; Nam, SJ; Oh, SJ | 1 |
| Chen, PN; Chiou, HL; Chu, SC; Hsieh, YS; Yang, SF | 1 |
| Chen, PN; Chiang, CL; Chiou, HL; Chu, SC; Hsieh, YS; Yang, SF | 1 |
| Chen, PN; Chu, SC; Hsieh, YS; Liu, YC; Lu, KH; Yang, SF | 1 |
27 other study(ies) available for silybin and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
Topics: Aminophenols; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Fibrosarcoma; Humans; Molecular Structure; Neoplasm Invasiveness | 2013 |
Silibinin exerts anti-cancer activity on human ovarian cancer cells by increasing apoptosis and inhibiting epithelial-mesenchymal transition (EMT).
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Invasiveness; Ovarian Neoplasms; Silybin; Xenograft Model Antitumor Assays | 2022 |
Silibinin Inhibits Cell Invasion through the Inhibition of MMPs,
Topics: Cell Line, Tumor; Cell Movement; Fibrosarcoma; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Neoplasm Invasiveness; Silybin | 2023 |
Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells.
Topics: Apoptosis; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; ErbB Receptors; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms; Models, Biological; Neoplasm Invasiveness; Neoplastic Stem Cells; Neovascularization, Physiologic; Promoter Regions, Genetic; Protein Binding; Silybin; Spheroids, Cellular; STAT5 Transcription Factor | 2021 |
Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Janus Kinase 2; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Phosphorylation; Signal Transduction; Silybin; Silymarin; STAT3 Transcription Factor; Triple Negative Breast Neoplasms | 2017 |
Silibinin suppresses bladder cancer cell malignancy and chemoresistance in an NF-κB signal-dependent and signal-independent manner.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Cisplatin; Disease Progression; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Neoplasm Invasiveness; NF-kappa B; Signal Transduction; Silybin; Silymarin; Urinary Bladder Neoplasms | 2017 |
Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Gamma Rays; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Radiation-Sensitizing Agents; Silybin; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2018 |
Silibinin attenuates TGF‑β1‑induced migration and invasion via EMT suppression and is associated with COX‑2 downregulation in bladder transitional cell carcinoma.
Topics: Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Silybin; Transforming Growth Factor beta1; Urinary Bladder Neoplasms | 2018 |
Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells.
Topics: Antioxidants; Azacitidine; Blotting, Western; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Decitabine; Drug Synergism; Enzyme Inhibitors; Epigenesis, Genetic; Gene Silencing; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Silybin; Silymarin; Transcription Factors; Up-Regulation; Zinc Finger E-box-Binding Homeobox 1 | 2013 |
Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Carriers; Drug Synergism; Female; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Nude; Nanoparticles; Neoplasm Invasiveness; Particle Size; Phosphatidylcholines; Polyethylene Glycols; Silybin; Silymarin; Snail Family Transcription Factors; Solubility; Technology, Pharmaceutical; Time Factors; Tissue Distribution; Transcription Factors; Vitamin E; Wound Healing; Xenograft Model Antitumor Assays | 2013 |
Silibinin inhibits fibronectin induced motility, invasiveness and survival in human prostate carcinoma PC3 cells via targeting integrin signaling.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Delivery Systems; Extracellular Matrix; Fibronectins; Humans; Integrins; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Prostatic Neoplasms; Signal Transduction; Silybin; Silymarin; Xenograft Model Antitumor Assays | 2014 |
Silibinin combination with arsenic strongly inhibits survival and invasiveness of human prostate carcinoma cells.
Topics: Apoptosis; Arsenic; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Cyclins; Humans; Male; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Oxidative Stress; Prostatic Neoplasms; Reactive Oxygen Species; Silybin; Silymarin; Vimentin | 2015 |
Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas.
Topics: AC133 Antigen; ADAM Proteins; ADAM10 Protein; Aldehyde Dehydrogenase 1 Family; Amyloid Precursor Protein Secretases; Animals; Antigens, CD; Carcinoma, Squamous Cell; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Glycoproteins; Head and Neck Neoplasms; Humans; Hyaluronan Receptors; Incidence; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Stem Cells; Peptides; Phenotype; Polycomb Repressive Complex 1; Prognosis; Retinal Dehydrogenase; Silybin; Silymarin | 2015 |
Synergistic anti-tumor actions of luteolin and silibinin prevented cell migration and invasion and induced apoptosis in glioblastoma SNB19 cells and glioblastoma stem cells.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Glioblastoma; Humans; Luteolin; Neoplasm Invasiveness; Neoplastic Stem Cells; Silybin; Silymarin | 2015 |
Effects of silibinin on growth and invasive properties of human ovarian carcinoma cells through suppression of heregulin/HER3 pathway.
Topics: Antioxidants; Blotting, Western; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA, Neoplasm; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Neuregulin-1; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Silybin; Silymarin; Survivin | 2016 |
Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Signal Transduction; Silybin; Silymarin; Xenograft Model Antitumor Assays | 2016 |
Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression.
Topics: Antioxidants; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Male; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Prostatic Neoplasms; Silybin; Silymarin; Vimentin | 2009 |
Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy.
Topics: Angiogenesis Inhibitors; Anthracyclines; Cardiac Glycosides; Cell Hypoxia; DNA Topoisomerases, Type I; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Intracellular Signaling Peptides and Proteins; Neoplasm Invasiveness; Neoplasms; NF-kappa B; Protein Serine-Threonine Kinases; Salicylic Acid; Silybin; Silymarin; TOR Serine-Threonine Kinases | 2010 |
Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells.
Topics: Antioxidants; Cadherins; Cell Line, Tumor; Cell Movement; Cell Survival; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Male; Microscopy, Confocal; Neoplasm Invasiveness; Prostatic Neoplasms; Silybin; Silymarin; src-Family Kinases; Wound Healing | 2011 |
Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Renal Cell; Cell Line; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; HEK293 Cells; Humans; Kidney Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred ICR; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Paclitaxel; Silybin; Silymarin; Urokinase-Type Plasminogen Activator; Xenograft Model Antitumor Assays | 2011 |
Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line.
Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Cell Line, Tumor; Drug Synergism; Glioblastoma; Humans; Neoplasm Invasiveness; Oxides; Silybin; Silymarin | 2012 |
Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR/MMP-9 signaling pathway.
Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Screening Assays, Antitumor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Kidney Neoplasms; Lymphatic Metastasis; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Phosphorylation; Protein Processing, Post-Translational; Signal Transduction; Silybin; Silymarin | 2012 |
Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro.
Topics: Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Humans; Interleukin-6; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Promoter Regions, Genetic; Protein Kinase Inhibitors; Silybin; Silymarin; Transcription Factor AP-1 | 2012 |
Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Nitriles; Phosphorylation; Silybin; Silymarin; Tetradecanoylphorbol Acetate; Thyroid Neoplasms | 2013 |
Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.
Topics: Antineoplastic Agents; Blotting, Western; Cell Adhesion; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Plasminogen Activators; Reverse Transcriptase Polymerase Chain Reaction; Silybin; Silybum marianum; Silymarin; Time Factors; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2004 |
Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Protease Inhibitors; Silybin; Silymarin; Tongue Neoplasms; Urokinase-Type Plasminogen Activator | 2006 |
Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2.
Topics: Bone Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Shape; Cell Survival; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; Humans; Male; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Osteosarcoma; Proto-Oncogene Proteins c-jun; Signal Transduction; Silybin; Silymarin; Transcription Factor AP-1; Urokinase-Type Plasminogen Activator | 2007 |