Compounds > silybin
Page last updated: 2024-08-23

silybin and Insulin Sensitivity

silybin has been researched along with Insulin Sensitivity in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (33.33)29.6817
2010's9 (60.00)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Cossiga, V; Dallio, M; Di Sarno, R; Federico, A; Gravina, AG; Lama, S; Loguercio, C; Masarone, M; Morisco, F; Persico, M; Stiuso, P; Tuccillo, C1
Chen, S; Li, Y; Liu, Q; Ren, L; Song, G; Wang, Y; Yang, L; Zhang, H1
Addesi, D; Cassano, V; Maio, R; Perticone, F; Perticone, M; Sciacqua, A; Sesti, G; Tripepi, G1
Chen, Y; Liu, Y; Yu, Q1
Gao, X; Hu, P; Li, C; Yang, X; Yao, J; Zhi, M1
Cao, M; Hai, J; Pei, S; Wang, J; Zhang, Q; Zhang, Y1
Ding, Y; Jiang, WJ; Li, HB; Mo, ZJ; Yang, YR1
Minhu, C; Yao, J; Zhi, M1
Galvano, F; Li Volti, G; Mangiameli, A; Salamone, F; Salomone, S; Siarkos, I; Sorrenti, V; Urso, V1
Bucchieri, F; Bugianesi, E; Galvano, F; Li Volti, G; Mangiameli, A; Marino Gammazza, A; Marino, A; Parola, M; Paternostro, C; Salamone, F; Tibullo, D1
Beccarello, A; Crepaldi, G; De Monte, A; Donadon, V; Lirussi, F; Velussi, M; Zanette, G1
McCarty, MF1
D'Auria, M; de Sio, I; Di Leva, A; Federico, A; Loguercio, C; Niosi, M; Trappoliere, M; Tuccillo, C1
Capristo, E; Forgione, A; Gabrieli, ML; Gallo, A; Gasbarrini, G; Grieco, A; Miele, L; Vero, V1
de Sio, I; Del Vecchio Blanco, C; Di Leva, A; Federico, A; Loguercio, C; Trappoliere, M; Tuccillo, C1

Reviews

1 review(s) available for silybin and Insulin Sensitivity

ArticleYear
[Oxidative stress in metabolic syndrome and nonalcoholic steatohepatitis. Is it possible a role for vitamins in clinical practice?].
    Recenti progressi in medicina, 2006, Volume: 97, Issue:1

    Topics: Adult; Animals; Antioxidants; Cells, Cultured; Clinical Trials as Topic; Endothelial Cells; Fatty Liver; Female; Folic Acid; Hepatitis; Homocysteine; Humans; Insulin Resistance; Male; Metabolic Syndrome; Oxidative Stress; Rats; Risk Factors; Silybin; Silymarin; Time Factors; Vitamin B 12; Vitamin D; Vitamins

2006

Trials

4 trial(s) available for silybin and Insulin Sensitivity

ArticleYear
Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients.
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Adult; Aged; Biomarkers; Body Weight; Cytokines; Drug Therapy, Combination; Endothelial Cells; Female; Humans; Insulin Resistance; Liver; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Silybin; Vitamin D; Vitamin E

2019
Silybin-beta-cyclodextrin in the treatment of patients with diabetes mellitus and alcoholic liver disease. Efficacy study of a new preparation of an anti-oxidant agent.
    Diabetes, nutrition & metabolism, 2002, Volume: 15, Issue:4

    Topics: Antioxidants; beta-Cyclodextrins; Blood Glucose; C-Peptide; Cholesterol, HDL; Cyclodextrins; Diabetes Mellitus, Type 2; Double-Blind Method; Female; gamma-Glutamyltransferase; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Liver Diseases, Alcoholic; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Placebos; Silybin; Silymarin; Triglycerides

2002
[Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study].
    Minerva gastroenterologica e dietologica, 2005, Volume: 51, Issue:2

    Topics: Adult; Aged; Biomarkers; Drug Combinations; Fatty Liver; Female; Hepatitis C, Chronic; Humans; Insulin Resistance; Liver Cirrhosis; Male; Metabolic Syndrome; Middle Aged; Phospholipids; Pilot Projects; Silybin; Silymarin; Vitamin E

2005
A new silybin-vitamin E-phospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: preliminary observations.
    Gut, 2006, Volume: 55, Issue:6

    Topics: Drug Combinations; Fatty Liver; Humans; Insulin Resistance; Phospholipids; Silybin; Silymarin; Vitamin E

2006

Other Studies

10 other study(ies) available for silybin and Insulin Sensitivity

ArticleYear
Silibinin improves nonalcoholic fatty liver by regulating the expression of miR‑122: An
    Molecular medicine reports, 2021, Volume: 23, Issue:5

    Topics: Acetyl-CoA Carboxylase; Animals; Fatty Acid Synthases; Gene Expression Regulation; Hep G2 Cells; Humans; Insulin Resistance; Lipid Metabolism; Liver; Mice; MicroRNAs; Non-alcoholic Fatty Liver Disease; Palmitic Acid; Silybin; Triglycerides

2021
Metabolic and vascular effects of silybin in hypertensive patients with high 1-h post-load plasma glucose.
    Internal and emergency medicine, 2019, Volume: 14, Issue:1

    Topics: Adult; Blood Glucose; Drug Combinations; Female; Glucose Tolerance Test; Humans; Hypertension; Insulin Resistance; Longitudinal Studies; Male; Middle Aged; Phospholipids; Pilot Projects; Protective Agents; Silybin; Treatment Outcome; Vitamin E

2019
Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 108

    Topics: CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Down-Regulation; Glucose; Hep G2 Cells; Humans; Inflammation; Insulin Resistance; Lipid Metabolism; MAP Kinase Signaling System; Nitric Oxide; Oleic Acid; Oxidative Stress; Signal Transduction; Silybin; Triglycerides; Up-Regulation

2018
Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:3

    Topics: Animals; Antioxidants; Glucose Tolerance Test; Homeostasis; Insulin Resistance; Lipid Metabolism; Liver; Male; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; Silybin; Silymarin; Time Factors

2013
Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathway.
    International immunopharmacology, 2013, Volume: 17, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Line; Cell Line, Tumor; Diet, High-Fat; Fatty Liver; Glucose; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Non-alcoholic Fatty Liver Disease; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Silybin; Silymarin

2013
Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:5

    Topics: Animals; Antioxidants; Cell Line; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Muscle Fibers, Skeletal; Myoblasts; Myoblasts, Skeletal; Oncogene Protein v-akt; Palmitic Acid; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Signal Transduction; Silybin; Silymarin

2015
Effect of silybin on high-fat-induced fatty liver in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2011, Volume: 44, Issue:7

    Topics: Animals; Antioxidants; Dietary Fats; Disease Models, Animal; Drug Evaluation, Preclinical; Fatty Liver; Homeostasis; Hypoglycemic Agents; Insulin Resistance; Lipid Peroxidation; Lipids; Liver; Male; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Rosiglitazone; Silybin; Silymarin; Thiazolidinediones

2011
Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice.
    Cardiovascular diabetology, 2011, Jul-14, Volume: 10

    Topics: Acetylcholine; Animals; Antioxidants; Aorta; Arginine; Diabetes Mellitus; Disease Models, Animal; Endothelium, Vascular; Insulin Resistance; Liver; Male; Mice; Mice, Obese; Nitroprusside; Obesity; Phenylephrine; Silybin; Silymarin; Vasoconstrictor Agents; Vasodilator Agents

2011
Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2012, Volume: 44, Issue:4

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline Deficiency; Cytokines; Diet; Fatty Liver; Gene Expression; Glutathione; Insulin Resistance; Isoprostanes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Methionine; Mice; Myocardium; Nitrates; Nitrites; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphorylation; Silybin; Silymarin; Statistics, Nonparametric

2012
Potential utility of natural polyphenols for reversing fat-induced insulin resistance.
    Medical hypotheses, 2005, Volume: 64, Issue:3

    Topics: Adipocytes; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Flavonoids; Humans; I-kappa B Kinase; Insulin Resistance; Models, Biological; Phenols; Polyphenols; Probenecid; Protein Serine-Threonine Kinases; Resveratrol; Silybin; Silymarin; Stilbenes

2005