silybin has been researched along with Inflammation in 37 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (5.41) | 29.6817 |
2010's | 22 (59.46) | 24.3611 |
2020's | 13 (35.14) | 2.80 |
Authors | Studies |
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Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J | 1 |
Dhaked, RK; Nagar, DP; Saxena, N | 1 |
Bagheri, N; Jafarzadeh, J; Karimi, A; Karimi, M; Musazadeh, V; Niazkar, HR; Sanaie, S; Vajdi, M | 1 |
Chen, X; Jiang, T; Li, Y; Lu, Y; Xu, J | 1 |
Chang, HY; Cheng, CD; Cheng, WC; Chih, SM; Dyke, TV; Huang, RY; Shieh, YS; Sung, CE; Weng, PW | 1 |
Cao, L; Ding, C; Hao, H; He, T; Shuai, Y; Wang, Y; Wu, J; Xie, Z; Xu, W; Zhang, C; Zhang, S | 1 |
Chen, Y; Forouzanfar, T; Han, Y; Huang, S; Jaspers, RT; Ji, Y; Li, X; Mao, Y; Shi, L; Sun, X; Wu, G; Zeng, J; Zhang, X; Zhou, R | 1 |
Che, L; Fang, Z; Feng, B; Hua, L; Jiang, X; Li, J; Lin, Y; Liu, Y; Ren, Z; Sun, M; Wang, J; Xu, S; Zhuo, Y | 1 |
Cho, YK; Jung, TY; Kim, HJ; Kim, JC; Kim, JS; Ko, JW; Lee, IC; Lee, SJ; Lim, JO; Nam, HH; Seo, YS; Shin, IS; Shin, NR | 1 |
Chen, J; Li, C; Li, DL; Liu, WF; Liu, X; Ma, YR; Wu, PP; Xie, LN; Xu, XT; Zhang, K; Zheng, X; Zhou, RP | 1 |
Ali Karami, M; Pooranian, M; Rezai, A; Sharif Makhmalzadeh, B | 1 |
Anagnostopoulos, K; Betsou, A; Georgakopoulou, AE; Konstandi, O; Kostomitsopoulos, N; Lambropoulou, M; Simopoulos, CE; Tsalikidis, C; Tsaroucha, AK; Valsami, G | 1 |
Chen, J; Chen, Z; Yang, XD; Yang, YY; Ye, L | 1 |
Ali, SA; Godugu, C; Saifi, MA; Talla, V | 1 |
Han, J; Liao, W; Pan, W; Shi, W; Song, J; Sun, Y | 1 |
Fernandes, V; Kalia, K; Sharma, D; Tiwari, V | 1 |
Kang, BS; Kwon, OS; Lee, DE; Lee, DS; Lee, HS; Lee, SJ; Nam, MJ; Park, JW | 1 |
Chen, Y; Liu, Y; Yu, Q | 1 |
Fernandes, CJDC; Peracoli, MTS; Veiga, MR; Zambuzzi, WF | 1 |
Ikejima, T; Jiang, S; Liu, W; Onodera, S; Tashiro, S; Wang, Q; Xie, X; Ye, Y; Zang, G; Zeng, H | 1 |
Bellanti, F; Giudetti, AM; Serviddio, G; Siculella, L; Stanca, E; Vendemiale, G | 1 |
Ali, F; Hamiza, OO; Hasan, SK; Khan, AQ; Khan, R; Lateef, A; Rehman, MU; Sultana, S; Tahir, M | 1 |
Barker, G; Lappas, M; Lim, R; Morwood, CJ | 1 |
Choi, MS; Jeon, MT; Jung, UJ; Kim, SR | 1 |
Khaleghi, N; Minaiyan, M; Varshosaz, J | 1 |
Dickerson, E; Kassie, F; Khammanivong, A; Qian, X; Song, JM; Teferi, F; Upadhyaya, P | 1 |
Kassie, F; Luo, X; Molla, K; O Sullivan, G; Qian, X; Song, JM; Teferi, F; Upadhyaya, P | 1 |
Bezbaruah, BK; Dwivedi, S; Gogoi, R; Gurjar, SS; Jangra, A; Kasbe, P; Kwatra, M; Lahkar, M; Mishra, M; Pandey, SN; Sarma, N; Sulakhiya, K; Venu, AK | 1 |
Du, Z; Li, Y; Liu, W; Zhang, K; Zheng, X | 1 |
Ahn, KS; Kim, JH; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR | 1 |
Agarwal, C; Agarwal, R; Deep, G; Dhar, D; Guillermo-Lagae, R; Jain, AK; Orlicky, DJ; Rigby, CM; Roy, S | 1 |
Cui, L; Hattori, S; Hayashi, T; Ikejima, T; Lei, D; Onodera, S; Song, X; Tashiro, SI; Ushiki-Kaku, Y; Xia, M; Yao, G; Zhang, P; Zhou, B | 1 |
Bannwart, CF; Medeiros, LT; Nakaira-Takahagi, E; Peraçoli, JC; Peraçoli, MT; Romão, M; Silva, MG; Souza, CO; Weel, IC | 1 |
Agarwal, C; Agarwal, R; Inturi, S; Jain, AK; Tewari-Singh, N; White, CW | 1 |
Muthumani, M; Prabu, SM | 1 |
Agarwal, R; Chittezhath, M; Deep, G; Dwyer-Nield, LD; Kaur, M; Malkinson, AM; Singh, RP | 1 |
Agarwal, C; Agarwal, R; Dhanalakshmi, S; Gu, M; Singh, RP | 1 |
1 review(s) available for silybin and Inflammation
Article | Year |
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The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms.
Topics: Antioxidants; COVID-19 Drug Treatment; Humans; Inflammation; Polyphenols; RNA; SARS-CoV-2; Silybin; Silymarin | 2022 |
36 other study(ies) available for silybin and Inflammation
Article | Year |
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Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature | 2010 |
Silibinin ameliorates abrin induced hepatotoxicity by attenuating oxidative stress, inflammation and inhibiting Fas pathway.
Topics: Abrin; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Interactions; fas Receptor; Inflammation; Mice; Oxidative Stress; Signal Transduction; Silybin | 2022 |
Network Pharmacology Analysis and Experimental Validation to Explore the Anti-inflammatory Mechanism of Asiatic Acid on Alcoholic Steatohepatitis.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Cholesterol; Eosine Yellowish-(YS); Ethanol; Fatty Liver, Alcoholic; Hematoxylin; Inflammation; Interleukin-1beta; Interleukin-6; Lipids; Liver; Mice; Network Pharmacology; NF-kappa B; Silybin; Tumor Necrosis Factor-alpha | 2022 |
Silibinin alleviates inflammation-induced bone loss by modulating biological interaction between human gingival fibroblasts and monocytes.
Topics: Cell Differentiation; Cytokines; Fibroblasts; Humans; Inflammation; Lipopolysaccharides; Monocytes; Osteoclasts; Periodontitis; RANK Ligand; Silybin | 2023 |
Polyunsaturated fatty acids drive neutrophil extracellular trap formation in nonalcoholic steatohepatitis.
Topics: Animals; Disease Models, Animal; Extracellular Traps; Fatty Acids, Unsaturated; Inflammation; Mice; Neutrophils; Non-alcoholic Fatty Liver Disease; Silybin | 2023 |
Silibinin Attenuates Experimental Periodontitis by Downregulation of Inflammation and Oxidative Stress.
Topics: Animals; Anti-Inflammatory Agents; Down-Regulation; Humans; Inflammation; Lipopolysaccharides; NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Periodontitis; Rats; Silybin | 2023 |
Silibinin Alleviates Lipopolysaccharide Induced Inflammation in Porcine Mammary Epithelial Cells via mTOR/NF-κB Signaling Pathway.
Topics: Animals; Epithelial Cells; Female; Inflammation; Lactation; Lipopolysaccharides; Mammals; NF-kappa B; NF-KappaB Inhibitor alpha; Signal Transduction; Silybin; Swine; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2023 |
Silibinin Attenuates Silica Dioxide Nanoparticles-Induced Inflammation by Suppressing TXNIP/MAPKs/AP-1 Signaling.
Topics: Animals; Antineoplastic Agents, Phytogenic; Humans; Inflammation; Mice; Mitogen-Activated Protein Kinases; Nanoparticles; Signal Transduction; Silicon Dioxide; Silybin | 2020 |
Synergistic anti-inflammatory effects of silibinin and thymol combination on LPS-induced RAW264.7 cells by inhibition of NF-κB and MAPK activation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Drug Synergism; Inflammation; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; RAW 264.7 Cells; Reactive Oxygen Species; Silybin; Thymol; Tumor Necrosis Factor-alpha | 2020 |
Preparation and optimization of silibinin-loaded chitosan-fucoidan hydrogel: an
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chitosan; Delayed-Action Preparations; Female; Hydrogels; Hydrogen Peroxide; Inflammation; Mice; Mice, Hairless; Polysaccharides; Silybin; Skin; Ultraviolet Rays | 2021 |
The hepatoprotective effect of silibinin after hepatic ischemia/reperfusion in a rat model is confirmed by immunohistochemistry and qRT-PCR.
Topics: Animals; Anti-Inflammatory Agents; Chemokine CCL2; Freeze Drying; Inflammation; Ischemia; Liver; Liver Diseases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Phytotherapy; Plant Extracts; Protective Agents; Random Allocation; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Silybin; Silymarin; Tissue Inhibitor of Metalloproteinase-2; Tumor Necrosis Factor-alpha | 2021 |
Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Survival; Choline Deficiency; Cytokines; Esculin; Fatty Acids, Nonesterified; Fibrosis; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Models, Animal; NF-kappa B; Non-alcoholic Fatty Liver Disease; RNA, Small Interfering; Signal Transduction; Silybin; Sirtuin 1 | 2021 |
Silibinin alleviates silica-induced pulmonary fibrosis: Potential role in modulating inflammation and epithelial-mesenchymal transition.
Topics: Animals; Bleomycin; Epithelial-Mesenchymal Transition; Inflammation; Mice; Pulmonary Fibrosis; Silicon Dioxide; Silybin | 2021 |
Aspergillus fumigatus-induced early inflammatory response in pulmonary microvascular endothelial cells: Role of p38 MAPK and inhibition by silibinin.
Topics: Antioxidants; Aspergillus fumigatus; Cells, Cultured; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Invasive Pulmonary Aspergillosis; Lung; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Silybin; Silymarin | 2017 |
Neuroprotective effects of silibinin: an in silico and in vitro study.
Topics: Astrocytes; Cell Line, Tumor; Computer Simulation; Glial Fibrillary Acidic Protein; Humans; In Vitro Techniques; Inflammation; Lipid Peroxidation; Models, Molecular; Neuroprotective Agents; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Silybin | 2018 |
Silibinin Ameliorates
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; beta-N-Acetylhexosaminidases; Choline Deficiency; Humans; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Peroxiredoxins; Proteomics; RAW 264.7 Cells; Silybin; Silymarin | 2018 |
Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells.
Topics: CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Down-Regulation; Glucose; Hep G2 Cells; Humans; Inflammation; Insulin Resistance; Lipid Metabolism; MAP Kinase Signaling System; Nitric Oxide; Oleic Acid; Oxidative Stress; Signal Transduction; Silybin; Triglycerides; Up-Regulation | 2018 |
Modulatory effects of silibinin in cell behavior during osteogenic phenotype.
Topics: Animals; Bone Remodeling; Cell Adhesion; Cell Differentiation; Cell Line; Cell Proliferation; Extracellular Matrix; Humans; Inflammation; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Osteoblasts; Osteogenesis; Osteoporosis; Phenotype; Signal Transduction; Silybin | 2019 |
p53-mediated autophagy adjustment is involved in the protection of silibinin against murine dermal inflammation and epidermal apoptosis induced by UVB irradiation.
Topics: Animals; Apoptosis; Autophagy; Epidermis; Epithelial Cells; Inflammation; Male; Mice; Molecular Structure; Silybin; Silymarin; Skin Neoplasms; Tumor Suppressor Protein p53 | 2013 |
Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: potential antiinflammatory effect of silybin.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Antioxidants; Blotting, Western; Chromatography, Thin Layer; Down-Regulation; Gene Expression Regulation; Inflammation; Liver Cirrhosis; Male; Microsomes, Liver; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Silybin; Silymarin | 2013 |
Silibinin inhibits tumor promotional triggers and tumorigenesis against chemically induced two-stage skin carcinogenesis in Swiss albino mice: possible role of oxidative stress and inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carcinogenesis; Catalase; Cell Transformation, Neoplastic; Chemoprevention; Cyclooxygenase 2; Down-Regulation; Female; Glucosephosphate Dehydrogenase; Inflammation; Interleukin-1beta; Interleukin-6; Lipid Peroxidation; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Silybin; Silymarin; Skin; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2014 |
Effect of silibinin in reducing inflammatory pathways in in vitro and in vivo models of infection-induced preterm birth.
Topics: Animals; Cyclooxygenase 2; Extraembryonic Membranes; Female; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Interleukin-8; Lipopolysaccharides; Mice; Myometrium; Pregnancy; Premature Birth; Silybin; Silymarin | 2014 |
Silibinin attenuates MPP⁺-induced neurotoxicity in the substantia nigra in vivo.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Female; Inflammation; Interleukin-1beta; Microglia; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide Synthase Type II; Parkinson Disease; Rats; Rats, Sprague-Dawley; Silybin; Silymarin; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2014 |
Eudragit nanoparticles loaded with silybin: a detailed study of preparation, freeze-drying condition and in vitro/in vivo evaluation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Dexamethasone; Drug Carriers; Freeze Drying; Inflammation; Interleukin-6; Male; Nanoparticles; Peroxidase; Polymethacrylic Acids; Rats, Wistar; Silybin; Silybum marianum; Silymarin; Tumor Necrosis Factor-alpha | 2015 |
RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Female; Gene Expression Regulation, Neoplastic; Indoles; Inflammation; Lipopolysaccharides; Lung; Lung Neoplasms; Mice; Mice, Inbred A; RNA; Sequence Analysis, RNA; Silybin; Silymarin | 2015 |
Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators.
Topics: Animals; Anticarcinogenic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Cyclin D1; Cyclin-Dependent Kinases; Cyclooxygenase 2; Drug Combinations; Female; Humans; I-kappa B Proteins; Indoles; Inflammation; Interleukin-6; Lipopolysaccharides; Lung; Lung Neoplasms; Mice; Mice, Inbred A; NF-KappaB Inhibitor alpha; Nitrosamines; Proto-Oncogene Proteins c-akt; Random Allocation; Retinoblastoma Protein; Silybin; Silymarin; Smoke; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2015 |
Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus.
Topics: Aluminum; Animals; Antioxidants; Behavior, Animal; Brain-Derived Neurotrophic Factor; Catalase; Cognition Disorders; Cytokines; Glutathione; Hesperidin; Hippocampus; Inflammation; Interleukin-1beta; Lipid Peroxidation; Male; Maze Learning; Mice; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nitrogen; Oxidative Stress; Silybin; Silymarin; Tumor Necrosis Factor-alpha | 2015 |
Potent inhibitory effect of silibinin from milk thistle on skin inflammation stimuli by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Dermatitis; Dose-Response Relationship, Drug; Female; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Mice, Inbred BALB C; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Silybin; Silybum marianum; Silymarin; Skin; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2015 |
Silibinin Inhibits Neutrophilic Inflammation and Mucus Secretion Induced by Cigarette Smoke via Suppression of ERK-SP1 Pathway.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Inflammation; Male; Mice; Mice, Inbred C57BL; Mucus; Neutrophils; Phosphorylation; Plants, Medicinal; Reactive Oxygen Species; Signal Transduction; Silybin; Silymarin | 2016 |
Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammation and skin carcinogenesis.
Topics: Animals; Antioxidants; Cell Transformation, Neoplastic; DNA Damage; Female; Inflammation; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Knockout; Silybin; Silymarin; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2017 |
Silibinin ameliorates Aβ
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Autophagy; Dose-Response Relationship, Drug; Inflammation; Male; Memory Disorders; Oxidative Stress; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; Silybin; Silymarin | 2017 |
Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by L-NAME in rats.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunologic Factors; Inflammation; Liver; NG-Nitroarginine Methyl Ester; Pre-Eclampsia; Pregnancy; Protective Agents; Rats; Rats, Wistar; Silybin; Silymarin | 2012 |
Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antidotes; Apoptosis; Cells, Cultured; Chemical Warfare Agents; Cyclooxygenase 2; Deoxyguanosine; DNA Damage; Female; Gene Expression Regulation; Humans; Inflammation; Matrix Metalloproteinase 9; Mice; Mice, Hairless; Mustard Gas; Nitric Oxide Synthase Type II; Oxidative Stress; Signal Transduction; Silybin; Silymarin; Skin | 2012 |
Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats.
Topics: Adenosine Triphosphatases; Animals; Antioxidants; Apoptosis; Arsenic; Biomarkers; Caspase 3; Drinking Behavior; Feeding Behavior; Inflammation; Kidney; Kidney Diseases; Membranes; NADPH Oxidases; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Organ Size; Oxidative Stress; Protein Binding; Rats; Real-Time Polymerase Chain Reaction; Silybin; Silymarin; Tumor Necrosis Factor-alpha; Weight Gain | 2012 |
Effect of silibinin on the growth and progression of primary lung tumors in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Proliferation; Cyclin D1; Cyclooxygenase 2; Disease Models, Animal; Fibroblast Growth Factor 2; Immunohistochemistry; Inflammation; Lung Neoplasms; Mice; Microcirculation; Neovascularization, Pathologic; Nitric Oxide Synthase Type II; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Silybin; Silymarin; Urethane; Vascular Endothelial Growth Factor A | 2006 |
Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice.
Topics: Animals; Antioxidants; Cell Growth Processes; Cell Nucleus; Cell Transformation, Neoplastic; Cyclooxygenase 2; Female; Inflammation; Mice; Mice, Hairless; Neovascularization, Pathologic; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; Silybin; Silymarin; Skin; Skin Neoplasms; STAT3 Transcription Factor; Ultraviolet Rays | 2007 |