Page last updated: 2024-08-23

silybin and Depression

silybin has been researched along with Depression in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Chen, W; Fujisaki, H; Hattori, S; Hayashi, T; Ikejima, T; Liu, W; Liu, X; Mizuno, K; Wang, C1
Heidari-Soureshjani, S; Rostamian, S; Sherwin, CMT1
Cui, L; Hattori, S; Hayashi, T; Ikejima, T; Liu, B; Liu, W; Song, X; Tashiro, SI; Ushiki-Kaku, Y; Xu, F; Zhou, B1
Li, YJ; Niu, WM; Wei, XM; Wu, YM; Yang, LD; Yang, Q; Zhang, K; Zhao, MG; Zheng, KY1
Bertino, G; Caraci, F; Chisari, G; Drago, F; Greco, C; Malaguarnera, G; Malaguarnera, M; Motta, M; Nunnari, G; Vacante, M; Vecchio, M1

Reviews

1 review(s) available for silybin and Depression

ArticleYear
The Therapeutic Effect of Silymarin and Silibinin on Depression and Anxiety Disorders and Possible Mechanism in the Brain: A Systematic Review.
    Central nervous system agents in medicinal chemistry, 2023, Volume: 23, Issue:2

    Topics: Antioxidants; Anxiety Disorders; Depression; Glutathione; Hippocampus; Humans; Silybin; Silymarin

2023

Trials

1 trial(s) available for silybin and Depression

ArticleYear
Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety and increases work ability.
    BMC psychiatry, 2016, Nov-15, Volume: 16, Issue:1

    Topics: Adult; Antioxidants; Antiviral Agents; Anxiety; Depression; Double-Blind Method; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Psychiatric Status Rating Scales; Ribavirin; Silybin; Silymarin; Treatment Outcome; Work Performance

2016

Other Studies

3 other study(ies) available for silybin and Depression

ArticleYear
Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation.
    Physiology & behavior, 2021, 11-01, Volume: 241

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anxiety; Depression; Disease Models, Animal; Humans; Interferon Regulatory Factor-3; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Quality of Life; Silybin

2021
Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus.
    Physiology & behavior, 2017, Oct-01, Volume: 179

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Autophagy; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Indans; Male; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Psychotropic Drugs; Rats, Sprague-Dawley; Receptor, trkB; Signal Transduction; Silybin; Silymarin; Up-Regulation

2017
Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway.
    Behavioural brain research, 2018, 08-01, Volume: 348

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; Disease Models, Animal; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Silybin; Silymarin; Stress, Psychological

2018