Page last updated: 2024-08-23

silybin and Chemical and Drug Induced Liver Injury

silybin has been researched along with Chemical and Drug Induced Liver Injury in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.38)	18.7374
1990's	3 (7.14)	18.2507
2000's	9 (21.43)	29.6817
2010's	19 (45.24)	24.3611
2020's	10 (23.81)	2.80

Authors

Authors	Studies
Jung, JH; Kang, SS; Kim, YC; Lee, CO	1
Choi, YH; Huh, H; Kim, J; Kim, SY; Kim, YC; Lee, HS	1
Adnyana, IK; Banskota, AH; Kadota, S; Tezuka, Y; Tran, KQ; Xiong, Q	1
Matsuda, H; Morikawa, T; Ninomiya, K; Xu, F; Yoshikawa, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Imura, K; Matsuda, H; Morikawa, T; Muraoka, O; Ninomiya, K; Pan, Y; Yoshikawa, M; Yuan, D	1
Fujisaki, H; Hattori, S; Hayashi, T; Ikejima, T; Liu, PC; Liu, WW; Mizuno, K; Song, XY	1
Ding, Y; Ge, Y; Sun, Z; Tong, Z; Wang, W; Xu, Q; Zhang, S; Zhou, H; Zhou, L	1
Dhaked, RK; Nagar, DP; Saxena, N	1
Liu, X; Lu, Y; Qiu, S; Wang, M; Xing, H; Xu, R; You, M; Zhang, J; Zhang, L; Zhang, P; Zhu, J	1
Chen, C; Gao, J; Han, X; Jiang, J; Liu, Y; Qian, J; Tang, X; Wen, B; Zhao, X	1
Feng, Y; Han, X; Jiang, G; Kang, W; Li, X; Mao, Y; Raza, HK; Tan, Q; Wang, L; Zhang, B; Zhao, C	1
Alavizadeh, SH; Doagooyan, M; Gheybi, F; Hoseinian, A; Houshangi, K; Jaafari, MR; Khoddamipour, Z; Khooei, A; Papi, A; Sahebkar, A	1
Dhawan, V; Fahr, A; Lokras, A; Nagarsenker, M; Saraf, M; Sutariya, B; Thamm, J; Warawdekar, U	1
Biary, R; De Olano, J; Gosselin, S; Hoffman, RS; Su, MK; Villeneuve, E; Wang, JJ	1
Goh, ZH; Ho, HK; Tee, JK	1
Feng, SL; Li, YZ; Liu, CX; Liu, L; Liu, ZQ; Xie, Y; Yuan, ZW; Zhou, H	1
Arici, MA; Atabey, N; Durmus, N; Ergur, BU; Kalkan, S; Sahin, A; Tuncok, Y; Yakut Aksu, I; Yilmaz, Y	1
Bi, X; Liu, Z; Qu, B; Xie, Y; Yuan, Z; Zhou, H	1
Hao, HP; Wang, GJ; Wang, H; Wang, ZX; Xie, Y	1
Ali, SO; Darwish, HA; Ismail, NA	1
Deshpande, P; Jain, P; Kumar, N; Kutty, NG; Mathew, G; Rai, A; Raj, PV; Rao, CM; Reddy, ND; Udupa, N	1
Aksozek, A; Beydilli, H; Celik, OI; Cetin, ES; Cigerci, IH; Sozen, H; Topal, Y; Yilmaz, N	1
Bhavani, G; Ezhilarasan, D; Jesudas, B; Karthikeyan, S; Raghu, R	1
Fix, OK; Hameed, B; Karvellas, CJ; Lee, WM; Leung, AA; McGuire, BM; Schilsky, ML; Stravitz, RT; Tillman, H	1
Ezhilarasan, D; Karthikeyan, S	1
Hashem, RM; Hassan, MG; Hassanin, KM; Mahmoud, MO; Rashed, LA	1
Chen, H; Lin, F; Liu, DC; Tang, X; Wang, D; Xu, WW; Yang, ZH	1
Karthikeyan, S; Raghu, R	1
Matsuda, H; Morikawa, T; Nakamura, S; Ninomiya, K; Okazaki, Y; Yoshikawa, M	1
Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A	1
Meng, Q; Ruan, X; Shen, C	1
Muthumani, M; Prabu, SM	1
Kostek, H; Lewandowska-Stanek, H; Majewska, M; Szponar, J; Tchórz, M	1
Baek, JY; Byun, EH; Cho, BO; Jeong, IY; Jin, CH; Park, KH; Ryu, HW; So, Y	1
Agarwal, R; Katare, OP; Maheshwari, H; Patil, C	1
Bang, R; Kiemer, AK; Prockl, J; Schümann, J; Tiegs, G; Vollmar, AM	1
El-Bahay, C; Hanelt, S; Kahl, R; Lewerenz, V; Nastevska, C; Röhrdanz, E	1
Betten, DP; Clark, RF; Favata, M; Hernandez, M; Richardson, WH; Riffenburgh, RH; Tanen, DA; Tong, TC	1
Chamulitrat, W; Erben, G; Huber, A; Lehmann, WD; Stremmel, W; Thongphasuk, P; Tuma, S	1
Conti, M; Pace, R; Pifferi, G	1
Campos, R; Garrido, A; Guerra, R; Valenzuela, A	1

Reviews

1 review(s) available for silybin and Chemical and Drug Induced Liver Injury

Article	Year
[Silibinin and its hepatoprotective action from the perspective of a toxicologist]. Przeglad lekarski, 2012, Volume: 69, Issue:8 Topics: Amanita; Amanitins; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Lipid Peroxidation; Liver Diseases; Liver Regeneration; Mushroom Poisoning; Peroxidases; Prostaglandins; Protective Agents; Silybin; Silymarin; Superoxide Dismutase	2012

Other Studies

41 other study(ies) available for silybin and Chemical and Drug Induced Liver Injury

Article	Year
New bioactive cerebrosides from Arisaema amurense. Journal of natural products, 1996, Volume: 59, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cerebrosides; Chemical and Drug Induced Liver Injury; Drug Screening Assays, Antitumor; Humans; Korea; L-Iditol 2-Dehydrogenase; Liver; Magnetic Resonance Spectroscopy; Plant Roots; Plants, Medicinal; Rats; Tumor Cells, Cultured	1996
New antihepatotoxic cerebroside from Lycium chinense fruits. Journal of natural products, 1997, Volume: 60, Issue:3 Topics: Animals; Cells, Cultured; Cerebrosides; Chemical and Drug Induced Liver Injury; Hydrolysis; Liver; Magnetic Resonance Spectroscopy; Plants, Medicinal; Rats; Spectrometry, Mass, Fast Atom Bombardment	1997
Quadranosides I-V, new triterpene glucosides from the seeds of Combretum quadrangulare. Journal of natural products, 2000, Volume: 63, Issue:4 Topics: Africa; Animals; Antineoplastic Agents, Phytogenic; Asia; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, Thin Layer; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Plants, Medicinal; Saponins; Seeds; Spectrophotometry, Ultraviolet; Tumor Necrosis Factor-alpha	2000
Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica. Bioorganic & medicinal chemistry letters, 2003, Mar-24, Volume: 13, Issue:6 Topics: Animals; Brassicaceae; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Egypt; Flavonoids; Hepatocytes; Mice; Molecular Conformation; Plants, Medicinal	2003
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. Bioorganic & medicinal chemistry, 2010, Mar-01, Volume: 18, Issue:5 Topics: Animals; Caffeic Acids; Chemical and Drug Induced Liver Injury; Cistanche; Coumaric Acids; Glucosides; Hepatocytes; Lipopolysaccharides; Mice; Plant Stems; Trisaccharides	2010
Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission. Toxicology in vitro : an international journal published in association with BIBRA, 2022, Volume: 80 Topics: Acetaldehyde; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Chemical and Drug Induced Liver Injury; Ethanol; Humans; Liver; Mitochondrial Dynamics; Mitochondrial Proteins; Protective Agents; Silybin	2022
Preclinical validation of silibinin/albumin nanoparticles as an applicable system against acute liver injury. Acta biomaterialia, 2022, 07-01, Volume: 146 Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Mice; Nanoparticles; Serum Albumin, Bovine; Silybin	2022
Silibinin ameliorates abrin induced hepatotoxicity by attenuating oxidative stress, inflammation and inhibiting Fas pathway. Environmental toxicology and pharmacology, 2022, Volume: 93 Topics: Abrin; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Interactions; fas Receptor; Inflammation; Mice; Oxidative Stress; Signal Transduction; Silybin	2022
Silibinin Schiff Base Derivatives Counteract CCl Drug design, development and therapy, 2022, Volume: 16 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Schiff Bases; Silybin; Silymarin	2022
Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry: A metabolomic and mechanistic approach. Biomedical chromatography : BMC, 2022, Volume: 36, Issue:11 Topics: Animals; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Cholesterol; Chromatography, Liquid; Emodin; Fatty Liver; Glycerophospholipids; Liver; Mass Spectrometry; Rats; RNA, Messenger; Silybin; Vitamins	2022
An analysis of silybin meglumine tablets in the treatment of drug-induced liver injury as assessed for causality with the updated Roussel Uclaf Causality Assessment Method using a nationwide database. British journal of clinical pharmacology, 2023, Volume: 89, Issue:4 Topics: Alanine Transaminase; Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Risk Factors; Silybin	2023
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study. Biochemical and biophysical research communications, 2023, 10-08, Volume: 676 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lipids; Liposomes; Liver; Liver Failure; Mice; NIH 3T3 Cells; Reactive Oxygen Species; Silybin	2023
Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation. International journal of pharmaceutics, 2020, Apr-15, Volume: 579 Topics: Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Liberation; Drug Stability; Excipients; Female; In Vitro Techniques; Lipids; Liver; Nanotechnology; Particle Size; Permeability; Rats; Silybin; Solubility; Surface Properties	2020
Current fatality rate of suspected cyclopeptide mushroom poisoning in the United States. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:1 Topics: Antidotes; Cause of Death; Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Mortality; Mushroom Poisoning; Peptides, Cyclic; Poison Control Centers; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Silybin; Silymarin; Time Factors; United States	2021
An Evaluation of the In Vitro Roles and Mechanisms of Silibinin in Reducing Pyrazinamide- and Isoniazid-Induced Hepatocellular Damage. International journal of molecular sciences, 2020, May-25, Volume: 21, Issue:10 Topics: Antitubercular Agents; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Isoniazid; Oxidative Stress; Protective Agents; Protein Carbonylation; Pyrazinamide; Silybin	2020
Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies. Pharmacological research, 2018, Volume: 128 Topics: Animals; ATP-Binding Cassette Transporters; Biological Availability; Caco-2 Cells; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dogs; Flavones; Humans; Madin Darby Canine Kidney Cells; Male; Mice, Inbred C57BL; Rats, Sprague-Dawley; Silybin	2018
A Comparison of the Effectiveness of Silibinin and Resveratrol in Preventing Alpha-Amanitin-Induced Hepatotoxicity. Basic & clinical pharmacology & toxicology, 2018, Volume: 122, Issue:6 Topics: Alanine Transaminase; Alpha-Amanitin; Antioxidants; Aspartate Aminotransferases; Caspase 3; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Humans; Liver; Mushroom Poisoning; Nucleic Acid Synthesis Inhibitors; Protective Agents; Resveratrol; Silybin; Silymarin; Stilbenes	2018
Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Feb-15, Volume: 54 Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzodioxoles; Biological Availability; Caco-2 Cells; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Piperidines; Polyunsaturated Alkamides; Protective Agents; Rats, Sprague-Dawley; Silybin	2019
Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulation. Chinese journal of natural medicines, 2013, Volume: 11, Issue:6 Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Drugs, Chinese Herbal; Liver; Male; Pregnane X Receptor; Rats; Rats, Sprague-Dawley; Receptors, Steroid; Signal Transduction; Silybin; Silybum marianum; Silymarin; Thioacetamide	2013
Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. Chemico-biological interactions, 2014, Jun-05, Volume: 216 Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Curcumin; Gene Expression Regulation; HSP47 Heat-Shock Proteins; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Oxidative Stress; Rats; Rats, Wistar; Silybin; Silymarin; Thioacetamide; Thioctic Acid; Transforming Growth Factor beta1	2014
Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells. Pharmacological reports : PR, 2014, Volume: 66, Issue:5 Topics: Acetaminophen; Administration, Oral; Animals; Biological Availability; Cell Line; Chemical and Drug Induced Liver Injury; Drug Liberation; Hepatocytes; Humans; Hydrogen-Ion Concentration; Lipopolysaccharides; Liposomes; Liver; Macrophages; Male; Mice; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Silybin; Silymarin	2014
Evaluation of the protective effect of silibinin in rats with liver damage caused by itraconazole. Cell biochemistry and biophysics, 2015, Volume: 71, Issue:2 Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytoprotection; Dose-Response Relationship, Drug; Drug Interactions; Female; Itraconazole; Liver; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Silybin; Silymarin; Treatment Outcome	2015
Silibinin mitigates zidovudine-induced hepatocellular degenerative changes, oxidative stress and hyperlipidaemia in rats. Human & experimental toxicology, 2015, Volume: 34, Issue:11 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-HIV Agents; Catalase; Chemical and Drug Induced Liver Injury; Fatty Acids, Nonesterified; Female; Hyperlipidemias; Lipid Peroxidation; Liver; Male; Oxidative Stress; Protective Agents; Rats, Wistar; Silybin; Silymarin; Zidovudine	2015
Acute liver injury and acute liver failure from mushroom poisoning in North America. Liver international : official journal of the International Association for the Study of the Liver, 2016, Volume: 36, Issue:7 Topics: Acetylcysteine; Adult; Amanitins; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Humans; Liver Failure, Acute; Liver Transplantation; Male; Middle Aged; Mushroom Poisoning; North America; Penicillins; Registries; Silybin; Silymarin	2016
Silibinin alleviates N-nitrosodimethylamine-induced glutathione dysregulation and hepatotoxicity in rats. Chinese journal of natural medicines, 2016, Volume: 14, Issue:1 Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Female; Glutathione; Male; Protective Agents; Rats; Rats, Wistar; Silybin; Silymarin	2016
Effect of silibinin and vitamin E on the ASK1-p38 MAPK pathway in D-galactosamine/lipopolysaccharide induced hepatotoxicity. Experimental biology and medicine (Maywood, N.J.), 2016, Volume: 241, Issue:11 Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Histocytochemistry; Lipopolysaccharides; Liver; Liver Function Tests; MAP Kinase Kinase Kinase 5; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Signal Transduction; Silybin; Silymarin; Treatment Outcome; Vitamin E	2016
[Protective effects of silybin · ursodeoxycholic acid evaporated co- precipitate on CCl₄-induced acute liver injury in mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2016, Volume: 32, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Silybin; Silymarin; Ursodeoxycholic Acid	2016
Zidovudine and isoniazid induced liver toxicity and oxidative stress: Evaluation of mitigating properties of silibinin. Environmental toxicology and pharmacology, 2016, Volume: 46 Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Isoniazid; Liver Function Tests; Male; Oxidative Stress; Rats, Wistar; Silybin; Silymarin; Zidovudine	2016
Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium. Chemical & pharmaceutical bulletin, 2008, Volume: 56, Issue:12 Topics: Acetone; Animals; beta-Glucosidase; Cell Survival; Chemical and Drug Induced Liver Injury; Diterpenes; Flowers; Hepatocytes; Hydrolysis; Male; Mice; Molecular Conformation; Multienzyme Complexes; Plant Extracts; Plants, Medicinal; Protective Agents; Silybin; Silymarin; Solvents; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Zingiberaceae	2008
Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum. Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:5 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Liver; Magnetic Resonance Spectroscopy; Male; Rabbits; Silybin; Silymarin	2009
Establishment of a methodology for investigating protectants against ethanol-induced hepatotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:5 Topics: Animals; Antioxidants; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemoprevention; Ethanol; Fenofibrate; Hepatocytes; Hypolipidemic Agents; Male; Malondialdehyde; Nanoparticles; Nanotechnology; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Silybin; Silybum marianum; Silymarin	2010
Silibinin potentially protects arsenic-induced oxidative hepatic dysfunction in rats. Toxicology mechanisms and methods, 2012, Volume: 22, Issue:4 Topics: Animals; Antioxidants; Arsenic; Chemical and Drug Induced Liver Injury; Male; Molecular Structure; Oxidative Stress; Rats; Rats, Wistar; Silybin; Silymarin	2012
Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats. Food chemistry, 2013, May-01, Volume: 138, Issue:1 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Damage; Hep G2 Cells; Humans; Lipid Peroxidation; Liver; Male; Protective Agents; Rats; Rats, Sprague-Dawley; Silybin; Silymarin	2013
Preparation and pharmacological evaluation of silibinin liposomes. Arzneimittel-Forschung, 2003, Volume: 53, Issue:6 Topics: Animals; Antioxidants; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholesterol; Drug Compounding; Drug Stability; Female; Liposomes; Male; Mice; Mice, Inbred BALB C; Particle Size; Rats; Rats, Wistar; Silybin; Silymarin; Sleep; Stomach Ulcer; Time Factors	2003
Silibinin protects mice from T cell-dependent liver injury. Journal of hepatology, 2003, Volume: 39, Issue:3 Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Cytoprotection; Enzyme Induction; Galactosamine; Leukocytes; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Recombinant Proteins; RNA, Messenger; Silybin; Silymarin; T-Lymphocytes; Tumor Necrosis Factor-alpha	2003
Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity. Toxicology, 2003, Sep-30, Volume: 191, Issue:2-3 Topics: Acetaminophen; Acetylcysteine; alpha-Tocopherol; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Northern; Cell Death; Chemical and Drug Induced Liver Injury; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Formazans; Hepatocytes; Lipid Peroxides; Liver Diseases; Male; Neutral Red; Rats; Rats, Wistar; RNA; Silybin; Silymarin; Tetrazolium Salts	2003
Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. Annals of emergency medicine, 2007, Volume: 50, Issue:3 Topics: Acetylcysteine; Alanine Transaminase; Amanitins; Animals; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Male; Mice; Mushroom Poisoning; Penicillin G; Random Allocation; Silybin; Silymarin; Thioctic Acid	2007
Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin. Biochimica et biophysica acta, 2008, Volume: 1780, Issue:5 Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Movement; Cell Survival; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Humans; Hydrogen Peroxide; Keratinocytes; Liver Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Molecular Structure; Reactive Oxygen Species; Silybin; Silymarin	2008
Synthesis and antihepatotoxic activity of silybin 11-O-phosphate. Farmaco (Societa chimica italiana : 1989), 1994, Volume: 49, Issue:1 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Liver; Magnetic Resonance Spectroscopy; Male; Organ Size; Organophosphates; Praseodymium; Rats; Rats, Wistar; Silybin; Silymarin; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet	1994
Acetaminophen hepatotoxicity in rats is attenuated by silybin dihemisuccinate. Progress in clinical and biological research, 1988, Volume: 280 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Glutathione; Liver Diseases; Male; Rats; Rats, Inbred Strains; Silybin; Silymarin	1988