silybin has been researched along with Cancer of Lung in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 16 (48.48) | 24.3611 |
| 2020's | 7 (21.21) | 2.80 |
| Authors | Studies |
|---|---|
| Dadashpour, M; Jafari-Gharabaghlou, D; Lotfi, F; Mousazadeh, H; Salmani Javan, E; Zarghami, N | 1 |
| Airao, V; Bhatt, V; Manvar, A; Patel, P; Raval, M; Shah, P | 1 |
| Bosch-Barrera, J; Cuyàs, E; Encinar, JA; Fernández-Arroyo, S; Joven, J; Menendez, JA; Verdura, S | 1 |
| Chen, D; Chen, Y; Duan, W; Guo, S; Qin, J; Wang, Y; Yin, L | 1 |
| Chen, H; Feng, N; He, Y; Hou, X; Liu, Y; Shen, J; Shi, J; Wang, Z; Xie, X | 1 |
| Gan, Y; Li, G; Ma, Y; Wang, A; Xu, S; Zhang, H | 1 |
| Bae, SW; Jang, KJ; Jo, ES; Kang, DY; Lee, JM; Rugamba, A; Sp, N | 1 |
| Agarwal, R; Mateen, S; Raina, K | 1 |
| Chen, L; Li, Y; Shen, J; Xu, P; Yin, Q; Yu, H; Zhang, Z | 1 |
| Kane, SE; Sadava, D | 1 |
| Barrajón-Catalán, E; Bosch-Barrera, J; Corominas-Faja, B; Cuyàs, E; Joven, J; Martin-Castillo, B; Menendez, JA; Micol, V; Oliveras-Ferraros, C; Segura-Carretero, A | 1 |
| Chen, W; Duan, W; Feng, Y; Jin, Z; Li, Y; Liang, Z; Wang, H; Yan, J; Yan, X; Yang, J; Yang, Y; Yi, W; Yu, S | 1 |
| Dickerson, E; Kassie, F; Khammanivong, A; Qian, X; Song, JM; Teferi, F; Upadhyaya, P | 1 |
| Kassie, F; Luo, X; Molla, K; O Sullivan, G; Qian, X; Song, JM; Teferi, F; Upadhyaya, P | 1 |
| Chung, SY; Kim, JS; Kim, SH; Lee, CG; Lee, HJ; Lee, M; Rho, JK; Shin, IS; Son, Y; Yang, K | 1 |
| Akbarzadeh, A; Askari, S; Rahmati-Yamchi, M; Salehi, R; Zarghami, N | 1 |
| Bosch-Barrera, J; Brunet, J; Cañete, N; Cuyàs, E; Haro, M; Izquierdo, A; Marruecos, J; Menendez, JA; Pedraza, S; Porta, R; Sais, E | 1 |
| Bosch-Barrera, J; Cuyàs, E; Menendez, JA; Micol, V; Pérez-Sánchez, A | 1 |
| Alipour, S; Amirsaadat, S; Ebrahimnezhad, Z; Pilehvar-Soltanahmadi, Y; Zarghami, F; Zarghami, N | 1 |
| Agarwal, C; Agarwal, R; Chittezhath, M; Deep, G; Singh, RP | 1 |
| Agarwal, R; Chittezhath, M; Deep, G; Raina, K; Rajamanickam, S; Singh, RP | 1 |
| Agarwal, R; Dwyer-Nield, LD; Malkinson, AM; Radcliffe, RA; Raina, K; Ramasamy, K; Redente, EF; Singh, RP; Tyagi, A | 1 |
| Agarwal, C; Agarwal, R; Mateen, S; Singh, RP; Tyagi, A | 1 |
| Agarwal, R; Dwyer-Nield, LD; Hasebroock, KM; Malkinson, AM; Raina, K; Ramasamy, K; Serkova, NJ; Singh, RP; Tyagi, A | 1 |
| Dagne, A; Kassie, F; Luo, X; Melkamu, T; Qian, X; Schutten, MM; Upadhyaya, P | 1 |
| Agarwal, C; Agarwal, R; Dwyer-Nield, LD; Malkinson, AM; Singh, RP; Tyagi, A | 1 |
| Chen, PN; Chiou, HL; Chu, SC; Hsieh, YS; Yang, SF | 1 |
| Agarwal, C; Agarwal, R; Chan, DC; Dhanalakshmi, S; Mallikarjuna, GU; Sharma, G; Singh, RP; Tyagi, AK | 1 |
| Chen, PN; Chiou, HL; Chu, SC; Hsieh, YS | 1 |
| Lubet, RA; Tan, Q; Wang, Y; Yan, Y; You, M | 1 |
| Agarwal, R; Chittezhath, M; Deep, G; Dwyer-Nield, LD; Kaur, M; Malkinson, AM; Singh, RP | 1 |
| Gazák, R; Kren, V; Walterová, D | 1 |
| Agarwal, R; Raina, K | 1 |
3 review(s) available for silybin and Cancer of Lung
| Article | Year |
|---|---|
Chemopreventive and anti-cancer efficacy of silibinin against growth and progression of lung cancer.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chemoprevention; Disease Models, Animal; Epigenesis, Genetic; Humans; Lung Neoplasms; Silybin; Silymarin | 2013 |
Silybin and silymarin--new and emerging applications in medicine.
Topics: Angiogenesis Inhibitors; Animal Diseases; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Anticholesteremic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cardiotonic Agents; Cholagogues and Choleretics; Female; Humans; Lung Neoplasms; Male; Prostatic Neoplasms; Receptors, Estrogen; Signal Transduction; Silybin; Silymarin | 2007 |
Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mechanisms.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cytotoxins; Female; Humans; Lung Neoplasms; Male; Neoplasms; Prostatic Neoplasms; Silybin; Silymarin | 2007 |
30 other study(ies) available for silybin and Cancer of Lung
| Article | Year |
|---|---|
Development of a Magnetic Nanostructure for Co-delivery of Metformin and Silibinin on Growth of Lung Cancer Cells: Possible Action Through Leptin Gene and its Receptor Regulation.
Topics: A549 Cells; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Gene Expression Regulation, Neoplastic; Humans; Leptin; Lung Neoplasms; Magnetic Phenomena; Metformin; Nanoparticle Drug Delivery System; Polyethylene Glycols; Polylactic Acid-Polyglycolic Acid Copolymer; Receptors, Leptin; Silybin | 2022 |
Lung cancer targeting efficiency of Silibinin loaded Poly Caprolactone /Pluronic F68 Inhalable nanoparticles: In vitro and In vivo study.
Topics: Animals; Caproates; Drug Carriers; Lactones; Lung Neoplasms; Nanoparticles; Poloxamer; Polyesters; Rats; Silybin; Tissue Distribution | 2022 |
Silibinin Suppresses the Hyperlipidemic Effects of the ALK-Tyrosine Kinase Inhibitor Lorlatinib in Hepatic Cells.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Carcinoma, Non-Small-Cell Lung; Cytochrome P-450 CYP3A; Hepatocytes; Humans; Lactams; Lactams, Macrocyclic; Lipids; Lung Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Silybin; Tandem Mass Spectrometry; Triglycerides | 2022 |
Biodegradable hydrogel from pectin and carboxymethyl cellulose with Silibinin loading for lung tumor therapy.
Topics: Animals; Carboxymethylcellulose Sodium; Hydrogels; Lung Neoplasms; Mice; Pectins; Silybin | 2023 |
Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis.
Topics: Animals; Antineoplastic Agents; Biological Availability; Breast Neoplasms; Caco-2 Cells; Cell Movement; HT29 Cells; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mucus; Nanoparticles; Neoplasms, Experimental; Phenanthrenes; Rats, Sprague-Dawley; Silybin; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2020 |
Silibinin suppresses epithelial-mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1.
Topics: A549 Cells; Aged; Carcinoma, Non-Small-Cell Lung; Cell Movement; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Serine Endopeptidases; Silybin; Survival Rate | 2020 |
Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells.
Topics: Apoptosis; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; ErbB Receptors; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms; Models, Biological; Neoplasm Invasiveness; Neoplastic Stem Cells; Neovascularization, Physiologic; Promoter Regions, Genetic; Protein Binding; Silybin; Spheroids, Cellular; STAT5 Transcription Factor | 2021 |
Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Carriers; Drug Synergism; Female; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Nude; Nanoparticles; Neoplasm Invasiveness; Particle Size; Phosphatidylcholines; Polyethylene Glycols; Silybin; Silymarin; Snail Family Transcription Factors; Solubility; Technology, Pharmaceutical; Time Factors; Tissue Distribution; Transcription Factors; Vitamin E; Wound Healing; Xenograft Model Antitumor Assays | 2013 |
Silibinin reverses drug resistance in human small-cell lung carcinoma cells.
Topics: Antineoplastic Agents; Antioxidants; Caspase 3; Cell Cycle; Cell Line, Tumor; DNA Fragmentation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Silybin; Silymarin; Small Cell Lung Carcinoma; Survivin | 2013 |
Stem cell-like ALDH(bright) cellular states in EGFR-mutant non-small cell lung cancer: a novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin.
Topics: Aldehyde Oxidoreductases; Antineoplastic Agents; Antioxidants; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Genotype; Humans; Lung Neoplasms; Mutation; Neoplastic Stem Cells; Phenotype; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Silybin; Silymarin; Spheroids, Cellular; Tumor Cells, Cultured | 2013 |
Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antioxidants; Apoptosis; Caspase 3; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Survival; Glutathione; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Random Allocation; Reactive Oxygen Species; RNA, Small Interfering; Silybin; Silymarin; Sirtuin 1; Transfection; Xenograft Model Antitumor Assays | 2014 |
RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Female; Gene Expression Regulation, Neoplastic; Indoles; Inflammation; Lipopolysaccharides; Lung; Lung Neoplasms; Mice; Mice, Inbred A; RNA; Sequence Analysis, RNA; Silybin; Silymarin | 2015 |
Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators.
Topics: Animals; Anticarcinogenic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Cyclin D1; Cyclin-Dependent Kinases; Cyclooxygenase 2; Drug Combinations; Female; Humans; I-kappa B Proteins; Indoles; Inflammation; Interleukin-6; Lipopolysaccharides; Lung; Lung Neoplasms; Mice; Mice, Inbred A; NF-KappaB Inhibitor alpha; Nitrosamines; Proto-Oncogene Proteins c-akt; Random Allocation; Retinoblastoma Protein; Silybin; Silymarin; Smoke; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2015 |
The ameliorative effect of silibinin against radiation-induced lung injury: protection of normal tissue without decreasing therapeutic efficacy in lung cancer.
Topics: Acute Lung Injury; Administration, Oral; Animals; Antioxidants; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Radiation Injuries, Experimental; Silybin; Silybum marianum; Silymarin | 2015 |
The anticancer effects of biodegradable nanomagnetic dual natural components on the leptin gene expression in lung cancer.
Topics: Cell Line, Tumor; Coated Materials, Biocompatible; Curcumin; Gene Expression Regulation, Neoplastic; Humans; Leptin; Lung Neoplasms; Magnetite Nanoparticles; Neoplasm Proteins; Polyesters; Polyethylene Glycols; Silybin; Silymarin | 2016 |
Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin.
Topics: Administration, Oral; Aged; Antineoplastic Agents, Phytogenic; Brain Edema; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Compassionate Use Trials; Dietary Supplements; Female; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Silybin; Silymarin; Time Factors; Tomography, X-Ray Computed; Treatment Outcome | 2016 |
STAT3-targeted treatment with silibinin overcomes the acquired resistance to crizotinib in ALK-rearranged lung cancer.
Topics: Anaplastic Lymphoma Kinase; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Crizotinib; Drug Resistance, Neoplasm; Drug Synergism; Epithelial-Mesenchymal Transition; Gene Rearrangement; Humans; Lung Neoplasms; Molecular Targeted Therapy; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Receptor Protein-Tyrosine Kinases; Silybin; Silymarin; STAT3 Transcription Factor | 2016 |
Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells.
Topics: A549 Cells; Cell Proliferation; Drug Carriers; Drug Liberation; Gene Expression Regulation, Neoplastic; Humans; Lactic Acid; Lung Neoplasms; Magnetite Nanoparticles; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Silybin; Silymarin; Telomerase | 2017 |
Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cytokines; Down-Regulation; Enzyme Activation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Signal Transduction; Silybin; Silymarin; STAT1 Transcription Factor; STAT3 Transcription Factor; Time Factors; Transcription Factor AP-1 | 2008 |
Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model.
Topics: Adenocarcinoma; Animals; Antioxidants; Apoptosis; Biomarkers, Tumor; Blotting, Western; Body Weight; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Female; Humans; Immunoenzyme Techniques; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Neoplasm Staging; Neovascularization, Pathologic; Nitric Oxide Synthase Type II; Prostate; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Silybin; Silybum marianum; Silymarin; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2008 |
Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Apoptosis; Cell Proliferation; Cytokines; Enzyme-Linked Immunosorbent Assay; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Lung Neoplasms; Macrophages; Male; Mice; Microvessels; Neovascularization, Pathologic; NF-kappa B; Signal Transduction; Silybin; Silymarin; STAT3 Transcription Factor | 2009 |
Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators.
Topics: Antioxidants; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Humans; Lung Neoplasms; Silybin; Silymarin; Tumor Cells, Cultured | 2010 |
Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies.
Topics: Animals; Anticarcinogenic Agents; Cell Proliferation; Down-Regulation; Gene Deletion; Intermediate Filament Proteins; Lung; Lung Neoplasms; Male; Mice; Mice, Knockout; Neovascularization, Pathologic; Nerve Tissue Proteins; Nestin; NF-kappa B; Nitric Oxide Synthase Type II; Silybin; Silymarin; STAT3 Transcription Factor; Tumor Burden; Urethane; Vascular Endothelial Growth Factor Receptor-2; X-Ray Microtomography | 2011 |
Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Indoles; Lung Neoplasms; Mice; Nitrosamines; Proto-Oncogene Proteins c-akt; Silybin; Silymarin | 2011 |
Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cyclooxygenase 2; Enzyme Inhibitors; Epithelial Cells; Interferon-gamma; Lung Neoplasms; MAP Kinase Kinase Kinases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitric Oxide Synthase Type II; Signal Transduction; Silybin; Silymarin; STAT1 Transcription Factor; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2012 |
Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.
Topics: Antineoplastic Agents; Blotting, Western; Cell Adhesion; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Plasminogen Activators; Reverse Transcriptase Polymerase Chain Reaction; Silybin; Silybum marianum; Silymarin; Time Factors; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2004 |
Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Nucleus; Cell Proliferation; Cytosol; Doxorubicin; Drug Resistance, Neoplasm; Humans; Immunoenzyme Techniques; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Protein Transport; Signal Transduction; Silybin; Silybum marianum; Silymarin; Transplantation, Heterologous; Tumor Cells, Cultured | 2004 |
Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways.
Topics: Anticarcinogenic Agents; Butadienes; Cell Line, Tumor; Cell Movement; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Lung Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Plant Extracts; Silybin; Silybum marianum; Silymarin; Urokinase-Type Plasminogen Activator | 2005 |
Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Topics: Adenoma; Administration, Oral; Animals; Benzo(a)pyrene; Disease Models, Animal; Lung Neoplasms; Mice; Mice, Inbred A; Rotenone; Silybin; Silybum marianum; Silymarin | 2005 |
Effect of silibinin on the growth and progression of primary lung tumors in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Proliferation; Cyclin D1; Cyclooxygenase 2; Disease Models, Animal; Fibroblast Growth Factor 2; Immunohistochemistry; Inflammation; Lung Neoplasms; Mice; Microcirculation; Neovascularization, Pathologic; Nitric Oxide Synthase Type II; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Silybin; Silymarin; Urethane; Vascular Endothelial Growth Factor A | 2006 |