silybin has been researched along with Cancer of Colon in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 20 (76.92) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, SS; Kim, WK; Lee, MA; Lee, SK; Park, HJ | 1 |
| Mehrabani, M; Mohammadi, C; Najafi, R; Sameri, S | 1 |
| Biagi, M; Carrara, M; Catanzaro, D; Cocetta, V; Gabbia, D; Montopoli, M; Ragazzi, E | 1 |
| Mehdi, SH; Nafees, S; Rizvi, MA; Sarwar, T; Zafaryab, M; Zeya, B | 1 |
| Mirza, S; Patel, S; Pathak, C; Rawal, R; Shah, K; Vaidya, F; Waghela, B | 1 |
| Cao, H; Dong, W; Liu, L; Liu, T; Ma, J; Wang, B; Wang, D; Wang, S; Xie, R; Zheng, R | 1 |
| Han, W; Li, W; Lv, X; Wang, H; Zhao, X | 1 |
| Nalini, N; Sangeetha, N | 1 |
| Agarwal, C; Agarwal, R; Kumar, S; Raina, K | 1 |
| Bhatia, V; Falzon, M | 1 |
| Bollati-Fogolin, M; Cadavid-Vargas, JF; Castelli, S; Desideri, A; Etcheverry, SB; Katkar, P; León, IE; Porro, V; Tiscornia, I | 1 |
| Agarwal, R; Singh, RP; Tyagi, A; Velmurugan, B | 1 |
| Aranganathan, S; Nalini, N; Sangeetha, N | 1 |
| Felix, AJ; Nalini, N; Sangeetha, N | 1 |
| Aranganathan, S; Nalini, N; Panneerselvam, J; Rama, G; Sangeetha, N; Shanthi, P | 1 |
| Agarwal, R; Deep, G; Gangar, SC; Kaur, M; Tyagi, A; Velmurugan, B | 1 |
| Agarwal, R; Gu, M; Ravichandran, K; Singh, RP; Velmurugan, B | 1 |
| Bousserouel, S; Gossé, F; Kauntz, H; Raul, F | 2 |
| Balasubramanian, T; Nalini, N; Sangeetha, N; Viswanathan, P | 1 |
| Cho, JK; Park, JW; Song, SC | 1 |
| Bousserouel, S; Gosse, F; Kauntz, H; Marescaux, J; Raul, F | 1 |
| Chen, YH; Chiu, JH; Chua, SK; Lin, CM; Ma, HP; Ong, JR; Shyu, KG; Wang, BW | 1 |
| Chen, WS; Chiu, JH; Lin, JK; Yang, SH | 1 |
| Chen, WS; Chiu, JH; Huang, CJ; Li, SY; Lin, JK; Yang, SH | 1 |
| Hogan, FS; Kahlenberg, MS; Krishnegowda, NK; Mikhailova, M | 1 |
26 other study(ies) available for silybin and Cancer of Colon
| Article | Year |
|---|---|
Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Axin Protein; beta Catenin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Flavonolignans; Humans; Lignans; Lonicera; RNA Interference; RNA, Small Interfering; Wnt Proteins; Wnt Signaling Pathway | 2013 |
Targeting the hallmarks of cancer: the effects of silibinin on proliferation, cell death, angiogenesis, and migration in colorectal cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Mice; Neovascularization, Pathologic; Silybin | 2021 |
Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression.
Topics: Cell Line, Tumor; Colonic Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Glucose Transporter Type 1; Humans; Metabolome; Silybin; Silymarin | 2018 |
Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; HT29 Cells; Humans; Proto-Oncogene Proteins c-bcl-2; Rutin; Silybin; Silymarin | 2018 |
Silibinin, A Natural Blend In Polytherapy Formulation For Targeting Cd44v6 Expressing Colon Cancer Stem Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Colonic Neoplasms; Fluorouracil; G1 Phase; HCT116 Cells; Humans; Hyaluronan Receptors; MAP Kinase Signaling System; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Resting Phase, Cell Cycle; Silybin | 2018 |
Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway.
Topics: Animals; Azoxymethane; Blotting, Western; Colitis; Colonic Neoplasms; Dextran Sulfate; Female; HCT116 Cells; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Silybin; STAT3 Transcription Factor | 2018 |
Silibinin Retards Colitis-associated Carcinogenesis by Repression of Cdc25C in Mouse Model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Carcinogenesis; Carcinogens; cdc25 Phosphatases; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Inbred C57BL; Silybin | 2019 |
Silibinin modulates caudal-type homeobox transcription factor (CDX2), an intestine specific tumor suppressor to abrogate colon cancer in experimental rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Carcinogens; CDX2 Transcription Factor; Colon; Colonic Neoplasms; Homeodomain Proteins; Male; Rats; Rats, Wistar; Receptors, Enterotoxin; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide; RNA, Messenger; Silybin; Silymarin; Transcription Factors; Tumor Suppressor Proteins | 2015 |
Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals.
Topics: Antioxidants; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Interleukin-4; Interleukin-6; Kinetics; Microscopy, Confocal; Neoplastic Stem Cells; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Silybin; Silymarin; Spheroids, Cellular; Transcription Factors | 2014 |
Restoration of the anti-proliferative and anti-migratory effects of 1,25-dihydroxyvitamin D by silibinin in vitamin D-resistant colon cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Movement; Cell Proliferation; Colonic Neoplasms; Drug Synergism; HT29 Cells; Humans; Receptors, Calcitriol; Retinoid X Receptor alpha; Silybin; Silymarin; Snail Family Transcription Factors; Transcription Factors; Tumor Necrosis Factor-alpha; Vitamin D | 2015 |
Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Coordination Complexes; Flavonoids; Humans; Molecular Structure; Silybin; Silymarin; Vanadium | 2015 |
Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Carcinoma; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Intestinal Mucosa; Male; Nitric Oxide Synthase Type II; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Silybin; Silymarin | 2008 |
Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Colonic Neoplasms; Drug Screening Assays, Antitumor; Intestinal Mucosa; Lipid Peroxidation; Male; Oxidative Stress; Precancerous Conditions; Rats; Rats, Wistar; Silybin; Silymarin | 2010 |
Silibinin modulates biotransforming microbial enzymes and prevents 1,2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Bacteria; Body Weight; Colon; Colonic Neoplasms; Disease Models, Animal; Male; Precancerous Conditions; Rats; Rats, Wistar; Silybin; Silymarin | 2009 |
Oral supplementation of silibinin prevents colon carcinogenesis in a long term preclinical model.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; beta Catenin; Cell Proliferation; Chemoprevention; Colonic Neoplasms; Drug Evaluation, Preclinical; Glutathione; Immunohistochemistry; Male; Oxidation-Reduction; Rats; Rats, Wistar; Signal Transduction; Silybin; Silymarin; Time Factors; Wnt Proteins | 2010 |
Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colonic Neoplasms; Humans; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Nude; Silybin; Silymarin; Xenograft Model Antitumor Assays | 2010 |
Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice.
Topics: Angiogenic Proteins; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Azoxymethane; Carcinogens; Carcinoma; Cell Proliferation; Colonic Neoplasms; Cytoprotection; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Inflammation Mediators; Male; Mice; Mice, Inbred Strains; Silybin; Silymarin | 2010 |
Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells.
Topics: Adenocarcinoma; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Autophagy; BH3 Interacting Domain Death Agonist Protein; Caspase 10; Caspase 3; Caspase 8; Caspase Inhibitors; Cell Line, Tumor; Colonic Neoplasms; Humans; Macrolides; Oligopeptides; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Silybin; Silymarin; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2011 |
Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Colon; Colonic Neoplasms; Lipid Peroxidation; Lipids; Liver; Male; Rats; Rats, Wistar; Silybin; Silymarin; Tumor Burden; Xenobiotics | 2012 |
Injectable and biodegradable poly(organophosphazene) gel containing silibinin: its physicochemical properties and anticancer activity.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Humans; Hydrogels; Injections; Mice; Organophosphorus Compounds; Polymers; Silybin; Silybum marianum; Silymarin | 2012 |
The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lymphatic Metastasis; Membrane Potential, Mitochondrial; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Silybin; Silymarin; TNF-Related Apoptosis-Inducing Ligand; Transcription, Genetic; X-Linked Inhibitor of Apoptosis Protein | 2012 |
Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Azoxymethane; Biomarkers, Tumor; Caspase 3; Cell Transformation, Neoplastic; Colonic Neoplasms; Down-Regulation; Interleukin-1beta; Intestinal Mucosa; Male; Matrix Metalloproteinase 7; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Silybin; Silybum marianum; Silymarin; Tumor Necrosis Factor-alpha | 2012 |
Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro.
Topics: Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Humans; Interleukin-6; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Promoter Regions, Genetic; Protein Kinase Inhibitors; Silybin; Silymarin; Transcription Factor AP-1 | 2012 |
Anti-angiogenic effect of silymarin on colon cancer LoVo cell line.
Topics: Angiogenesis Inhibitors; Cell Differentiation; Cell Movement; Colonic Neoplasms; Endothelial Growth Factors; Endothelium, Vascular; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Silybin; Silymarin; Thalidomide; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor up-regulation.
Topics: Angiogenesis Inhibitors; Cell Line; Cell Line, Tumor; Colonic Neoplasms; Endothelial Cells; Gene Expression; Humans; Silybin; Silymarin; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2005 |
Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer.
Topics: Antioxidants; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Humans; Plant Extracts; Silybin; Silymarin | 2007 |