silybin has been researched along with Alzheimer Disease in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 8 (47.06) | 2.80 |
| Authors | Studies |
|---|---|
| Feng, YB; Gong, JX; Huang, KX; Li, HB; Li, XK; Qu, J; Spencer, S; Tao, QF; Wang, F; Wu, XM; Wu, YH; Yang, LX; Zeng, S; Zhao, Y | 1 |
| Huang, L; Huo, Q; Qi, Y; Shi, Y; Sui, H; Zhao, L | 1 |
| Kumaradhas, P; Saravanan, K; Suganya, S; Sugarthi, S | 1 |
| Decker, M; Gutmann, M; Hofmann, J; Maurice, T; Spatz, P; Walther, R | 1 |
| Cao, J; Chen, YX; Dong, Y; Gao, H; Gu, Z; Jin, G; Li, X; Na, X; Su, Y; Wang, S; Wei, P; Wei, X; Yin, H; Yuan, J | 1 |
| Chen, W; Fujisaki, H; Hattori, S; Hayashi, T; Ikejima, T; Kang, Y; Liu, P; Liu, W; Mizuno, K; Qiu, Z; Wang, C | 1 |
| Ahmadian, S; Ebrahim-Habibi, A; Omidi-Shahsavandi, M; Yaghmaei, P | 1 |
| Chen, W; Fujisaki, H; Hattori, S; Hayashi, T; Ikejima, T; Kang, Y; Liu, P; Liu, W; Mizuno, K; Qiu, Z; Wang, C; Wang, X | 1 |
| Luca, A; Paduraru, L; Stanciu, GD; Stefanescu, R; Tamba, BI | 1 |
| Cui, L; Hattori, S; Hayashi, T; Ikejima, T; Liu, B; Liu, W; Song, X; Tashiro, SI; Ushiki-Kaku, Y; Xu, F; Zhou, B | 1 |
| Bai, D; Gan, S; Jin, G; Liu, X; Ren, L; Sun, Y; Yang, Z; Yin, S; Zhu, Q; Zou, D | 1 |
| Bai, D; Chen, X; Cui, Y; Jin, G; Li, W; Liu, X; Sun, Y; Wang, M; Zhang, D; Zhang, L; Zhao, L; Zhu, L; Zhu, Q | 1 |
| Ji, HF; Li, XY; Liu, L; Shen, L | 1 |
| Kim, MH; Kim, SH; Yang, WM | 1 |
| Chen, X; Duan, S; Fang, S; Gu, H; Guan, X; Huang, J; Li, Q; Lin, R; Liu, X; Sun, X; Xu, J; Yan, Y; Yao, Z; Zhang, T | 1 |
| Hiramatsu, M; Ikejima, T; Lu, LL; Lu, P; Mamiya, T; Mouri, A; Nabeshima, T; Nagai, T; Zou, L | 1 |
| Ji, X; Liu, J; Wang, Y; Yin, F; Zhang, J; Zidichouski, J | 1 |
2 review(s) available for silybin and Alzheimer Disease
| Article | Year |
|---|---|
Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biological Products; Catechin; Flavonoids; Fluorescent Dyes; Luteolin; Mice; Mice, Transgenic; Protein Aggregates; Silybin | 2020 |
Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Berberine; Coptis; Curcuma; Curcumin; Ginsenosides; Humans; Isoflavones; Panax notoginseng; Phytochemicals; Plants, Medicinal; Pueraria; Silybin; Silybum marianum; Silymarin | 2014 |
15 other study(ies) available for silybin and Alzheimer Disease
| Article | Year |
|---|---|
Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives.
Topics: Alkenes; Alzheimer Disease; Amides; Animals; Drug Design; Free Radical Scavengers; Humans; Iron Chelating Agents; Lipid Peroxidation; Liver; Male; Models, Molecular; Molecular Conformation; Neurons; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Rats; Silymarin; Structure-Activity Relationship; Xanthine Oxidase | 2009 |
Biomimetic silibinin-loaded macrophage-derived exosomes induce dual inhibition of Aβ aggregation and astrocyte activation to alleviate cognitive impairment in a model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Biomimetics; Cognitive Dysfunction; Disease Models, Animal; Exosomes; Macrophages; Mice; Neurodegenerative Diseases; Silybin | 2021 |
Probing the intermolecular interactions, binding affinity, charge density distribution and dynamics of silibinin in dual targets AChE and BACE1: QTAIM and molecular dynamics perspective.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Catalytic Domain; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Silybin | 2022 |
Synthesis and Biological Evaluation of Flavonoid-Cinnamic Acid Amide Hybrids with Distinct Activity against Neurodegeneration in Vitro and in Vivo.
Topics: Alzheimer Disease; Amides; Animals; Biological Products; Cinnamates; Flavonoids; Mice; Quercetin; Silybin | 2022 |
Silibinin Ameliorates Formaldehyde-Induced Cognitive Impairment by Inhibiting Oxidative Stress.
Topics: Alzheimer Disease; Animals; Antioxidants; Cognitive Dysfunction; Formaldehyde; Glycogen Synthase Kinase 3 beta; Hippocampus; Memory Disorders; Mice; NF-E2-Related Factor 2; Oxidative Stress; Silybin; Silybum marianum; Silymarin | 2022 |
Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats; Receptors, N-Methyl-D-Aspartate; Silybin; Streptozocin | 2023 |
Effect of silibinin and trans-chalcone in an Alzheimer's disease-like model generated by insulin amyloids.
Topics: Alzheimer Disease; Animals; Chalcone; Chalcones; Insulin; Rats; Silybin | 2023 |
Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Down-Regulation; Mice; Neuroinflammatory Diseases; Neuroprotective Agents; Rats; Silybin; Streptozocin | 2023 |
Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Autophagy; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Indans; Male; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Psychotropic Drugs; Rats, Sprague-Dawley; Receptor, trkB; Signal Transduction; Silybin; Silymarin; Up-Regulation | 2017 |
Antioxidative and Anti-Apoptotic Roles of Silibinin in Reversing Learning and Memory Deficits in APP/PS1 Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Hippocampus; Maze Learning; Memory Disorders; Mice, Transgenic; Oxidative Stress; Silybin; Silymarin | 2017 |
Natural silibinin modulates amyloid precursor protein processing and amyloid-β protein clearance in APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Antioxidants; Cognitive Dysfunction; Disease Models, Animal; Down-Regulation; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Silybin; Up-Regulation | 2019 |
Regulation of gut microbiota in Alzheimer's disease mice by silibinin and silymarin and their pharmacological implications.
Topics: Alzheimer Disease; Animals; Antioxidants; Bacteria; Biodiversity; Disease Models, Animal; Gastrointestinal Microbiome; Hippocampus; Learning; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Silybin; Silymarin | 2019 |
Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Dentate Gyrus; Female; Male; Mice, Transgenic; Nerve Regeneration; Phytotherapy; Protein Aggregation, Pathological; Rats, Sprague-Dawley; Silybin; Silybum marianum; Silymarin | 2015 |
Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Exploratory Behavior; Glutathione; Hippocampus; Lipid Peroxidation; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Motor Activity; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Recognition, Psychology; Silybin; Silymarin | 2009 |
Silibinin: a novel inhibitor of Aβ aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cell Line, Tumor; Humans; Neuroprotective Agents; Plaque, Amyloid; Silybin; Silymarin | 2011 |