Page last updated: 2024-08-23

silybin and Acute Liver Injury, Drug-Induced

silybin has been researched along with Acute Liver Injury, Drug-Induced in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.38)	18.7374
1990's	3 (7.14)	18.2507
2000's	9 (21.43)	29.6817
2010's	19 (45.24)	24.3611
2020's	10 (23.81)	2.80

Authors

Authors	Studies
Jung, JH; Kang, SS; Kim, YC; Lee, CO	1
Choi, YH; Huh, H; Kim, J; Kim, SY; Kim, YC; Lee, HS	1
Adnyana, IK; Banskota, AH; Kadota, S; Tezuka, Y; Tran, KQ; Xiong, Q	1
Matsuda, H; Morikawa, T; Ninomiya, K; Xu, F; Yoshikawa, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Imura, K; Matsuda, H; Morikawa, T; Muraoka, O; Ninomiya, K; Pan, Y; Yoshikawa, M; Yuan, D	1
Fujisaki, H; Hattori, S; Hayashi, T; Ikejima, T; Liu, PC; Liu, WW; Mizuno, K; Song, XY	1
Ding, Y; Ge, Y; Sun, Z; Tong, Z; Wang, W; Xu, Q; Zhang, S; Zhou, H; Zhou, L	1
Dhaked, RK; Nagar, DP; Saxena, N	1
Liu, X; Lu, Y; Qiu, S; Wang, M; Xing, H; Xu, R; You, M; Zhang, J; Zhang, L; Zhang, P; Zhu, J	1
Chen, C; Gao, J; Han, X; Jiang, J; Liu, Y; Qian, J; Tang, X; Wen, B; Zhao, X	1
Feng, Y; Han, X; Jiang, G; Kang, W; Li, X; Mao, Y; Raza, HK; Tan, Q; Wang, L; Zhang, B; Zhao, C	1
Alavizadeh, SH; Doagooyan, M; Gheybi, F; Hoseinian, A; Houshangi, K; Jaafari, MR; Khoddamipour, Z; Khooei, A; Papi, A; Sahebkar, A	1
Dhawan, V; Fahr, A; Lokras, A; Nagarsenker, M; Saraf, M; Sutariya, B; Thamm, J; Warawdekar, U	1
Biary, R; De Olano, J; Gosselin, S; Hoffman, RS; Su, MK; Villeneuve, E; Wang, JJ	1
Goh, ZH; Ho, HK; Tee, JK	1
Feng, SL; Li, YZ; Liu, CX; Liu, L; Liu, ZQ; Xie, Y; Yuan, ZW; Zhou, H	1
Arici, MA; Atabey, N; Durmus, N; Ergur, BU; Kalkan, S; Sahin, A; Tuncok, Y; Yakut Aksu, I; Yilmaz, Y	1
Bi, X; Liu, Z; Qu, B; Xie, Y; Yuan, Z; Zhou, H	1
Hao, HP; Wang, GJ; Wang, H; Wang, ZX; Xie, Y	1
Ali, SO; Darwish, HA; Ismail, NA	1
Deshpande, P; Jain, P; Kumar, N; Kutty, NG; Mathew, G; Rai, A; Raj, PV; Rao, CM; Reddy, ND; Udupa, N	1
Aksozek, A; Beydilli, H; Celik, OI; Cetin, ES; Cigerci, IH; Sozen, H; Topal, Y; Yilmaz, N	1
Bhavani, G; Ezhilarasan, D; Jesudas, B; Karthikeyan, S; Raghu, R	1
Fix, OK; Hameed, B; Karvellas, CJ; Lee, WM; Leung, AA; McGuire, BM; Schilsky, ML; Stravitz, RT; Tillman, H	1
Ezhilarasan, D; Karthikeyan, S	1
Hashem, RM; Hassan, MG; Hassanin, KM; Mahmoud, MO; Rashed, LA	1
Chen, H; Lin, F; Liu, DC; Tang, X; Wang, D; Xu, WW; Yang, ZH	1
Karthikeyan, S; Raghu, R	1
Matsuda, H; Morikawa, T; Nakamura, S; Ninomiya, K; Okazaki, Y; Yoshikawa, M	1
Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A	1
Meng, Q; Ruan, X; Shen, C	1
Muthumani, M; Prabu, SM	1
Kostek, H; Lewandowska-Stanek, H; Majewska, M; Szponar, J; Tchórz, M	1
Baek, JY; Byun, EH; Cho, BO; Jeong, IY; Jin, CH; Park, KH; Ryu, HW; So, Y	1
Agarwal, R; Katare, OP; Maheshwari, H; Patil, C	1
Bang, R; Kiemer, AK; Prockl, J; Schümann, J; Tiegs, G; Vollmar, AM	1
El-Bahay, C; Hanelt, S; Kahl, R; Lewerenz, V; Nastevska, C; Röhrdanz, E	1
Betten, DP; Clark, RF; Favata, M; Hernandez, M; Richardson, WH; Riffenburgh, RH; Tanen, DA; Tong, TC	1
Chamulitrat, W; Erben, G; Huber, A; Lehmann, WD; Stremmel, W; Thongphasuk, P; Tuma, S	1
Conti, M; Pace, R; Pifferi, G	1
Campos, R; Garrido, A; Guerra, R; Valenzuela, A	1

Reviews

1 review(s) available for silybin and Acute Liver Injury, Drug-Induced

Article	Year
[Silibinin and its hepatoprotective action from the perspective of a toxicologist]. Przeglad lekarski, 2012, Volume: 69, Issue:8 Topics: Amanita; Amanitins; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Lipid Peroxidation; Liver Diseases; Liver Regeneration; Mushroom Poisoning; Peroxidases; Prostaglandins; Protective Agents; Silybin; Silymarin; Superoxide Dismutase	2012

Other Studies

41 other study(ies) available for silybin and Acute Liver Injury, Drug-Induced

Article	Year
New bioactive cerebrosides from Arisaema amurense. Journal of natural products, 1996, Volume: 59, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cerebrosides; Chemical and Drug Induced Liver Injury; Drug Screening Assays, Antitumor; Humans; Korea; L-Iditol 2-Dehydrogenase; Liver; Magnetic Resonance Spectroscopy; Plant Roots; Plants, Medicinal; Rats; Tumor Cells, Cultured	1996
New antihepatotoxic cerebroside from Lycium chinense fruits. Journal of natural products, 1997, Volume: 60, Issue:3 Topics: Animals; Cells, Cultured; Cerebrosides; Chemical and Drug Induced Liver Injury; Hydrolysis; Liver; Magnetic Resonance Spectroscopy; Plants, Medicinal; Rats; Spectrometry, Mass, Fast Atom Bombardment	1997
Quadranosides I-V, new triterpene glucosides from the seeds of Combretum quadrangulare. Journal of natural products, 2000, Volume: 63, Issue:4 Topics: Africa; Animals; Antineoplastic Agents, Phytogenic; Asia; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, Thin Layer; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Plants, Medicinal; Saponins; Seeds; Spectrophotometry, Ultraviolet; Tumor Necrosis Factor-alpha	2000
Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica. Bioorganic & medicinal chemistry letters, 2003, Mar-24, Volume: 13, Issue:6 Topics: Animals; Brassicaceae; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Egypt; Flavonoids; Hepatocytes; Mice; Molecular Conformation; Plants, Medicinal	2003
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. Bioorganic & medicinal chemistry, 2010, Mar-01, Volume: 18, Issue:5 Topics: Animals; Caffeic Acids; Chemical and Drug Induced Liver Injury; Cistanche; Coumaric Acids; Glucosides; Hepatocytes; Lipopolysaccharides; Mice; Plant Stems; Trisaccharides	2010
Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission. Toxicology in vitro : an international journal published in association with BIBRA, 2022, Volume: 80 Topics: Acetaldehyde; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Chemical and Drug Induced Liver Injury; Ethanol; Humans; Liver; Mitochondrial Dynamics; Mitochondrial Proteins; Protective Agents; Silybin	2022
Preclinical validation of silibinin/albumin nanoparticles as an applicable system against acute liver injury. Acta biomaterialia, 2022, 07-01, Volume: 146 Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Mice; Nanoparticles; Serum Albumin, Bovine; Silybin	2022
Silibinin ameliorates abrin induced hepatotoxicity by attenuating oxidative stress, inflammation and inhibiting Fas pathway. Environmental toxicology and pharmacology, 2022, Volume: 93 Topics: Abrin; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Interactions; fas Receptor; Inflammation; Mice; Oxidative Stress; Signal Transduction; Silybin	2022
Silibinin Schiff Base Derivatives Counteract CCl Drug design, development and therapy, 2022, Volume: 16 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Schiff Bases; Silybin; Silymarin	2022
Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry: A metabolomic and mechanistic approach. Biomedical chromatography : BMC, 2022, Volume: 36, Issue:11 Topics: Animals; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Cholesterol; Chromatography, Liquid; Emodin; Fatty Liver; Glycerophospholipids; Liver; Mass Spectrometry; Rats; RNA, Messenger; Silybin; Vitamins	2022
An analysis of silybin meglumine tablets in the treatment of drug-induced liver injury as assessed for causality with the updated Roussel Uclaf Causality Assessment Method using a nationwide database. British journal of clinical pharmacology, 2023, Volume: 89, Issue:4 Topics: Alanine Transaminase; Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Risk Factors; Silybin	2023
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study. Biochemical and biophysical research communications, 2023, 10-08, Volume: 676 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lipids; Liposomes; Liver; Liver Failure; Mice; NIH 3T3 Cells; Reactive Oxygen Species; Silybin	2023
Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation. International journal of pharmaceutics, 2020, Apr-15, Volume: 579 Topics: Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Liberation; Drug Stability; Excipients; Female; In Vitro Techniques; Lipids; Liver; Nanotechnology; Particle Size; Permeability; Rats; Silybin; Solubility; Surface Properties	2020
Current fatality rate of suspected cyclopeptide mushroom poisoning in the United States. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:1 Topics: Antidotes; Cause of Death; Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Mortality; Mushroom Poisoning; Peptides, Cyclic; Poison Control Centers; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Silybin; Silymarin; Time Factors; United States	2021
An Evaluation of the In Vitro Roles and Mechanisms of Silibinin in Reducing Pyrazinamide- and Isoniazid-Induced Hepatocellular Damage. International journal of molecular sciences, 2020, May-25, Volume: 21, Issue:10 Topics: Antitubercular Agents; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Isoniazid; Oxidative Stress; Protective Agents; Protein Carbonylation; Pyrazinamide; Silybin	2020
Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies. Pharmacological research, 2018, Volume: 128 Topics: Animals; ATP-Binding Cassette Transporters; Biological Availability; Caco-2 Cells; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dogs; Flavones; Humans; Madin Darby Canine Kidney Cells; Male; Mice, Inbred C57BL; Rats, Sprague-Dawley; Silybin	2018
A Comparison of the Effectiveness of Silibinin and Resveratrol in Preventing Alpha-Amanitin-Induced Hepatotoxicity. Basic & clinical pharmacology & toxicology, 2018, Volume: 122, Issue:6 Topics: Alanine Transaminase; Alpha-Amanitin; Antioxidants; Aspartate Aminotransferases; Caspase 3; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Humans; Liver; Mushroom Poisoning; Nucleic Acid Synthesis Inhibitors; Protective Agents; Resveratrol; Silybin; Silymarin; Stilbenes	2018
Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Feb-15, Volume: 54 Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzodioxoles; Biological Availability; Caco-2 Cells; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Piperidines; Polyunsaturated Alkamides; Protective Agents; Rats, Sprague-Dawley; Silybin	2019
Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulation. Chinese journal of natural medicines, 2013, Volume: 11, Issue:6 Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Drugs, Chinese Herbal; Liver; Male; Pregnane X Receptor; Rats; Rats, Sprague-Dawley; Receptors, Steroid; Signal Transduction; Silybin; Silybum marianum; Silymarin; Thioacetamide	2013
Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. Chemico-biological interactions, 2014, Jun-05, Volume: 216 Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Curcumin; Gene Expression Regulation; HSP47 Heat-Shock Proteins; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Oxidative Stress; Rats; Rats, Wistar; Silybin; Silymarin; Thioacetamide; Thioctic Acid; Transforming Growth Factor beta1	2014
Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells. Pharmacological reports : PR, 2014, Volume: 66, Issue:5 Topics: Acetaminophen; Administration, Oral; Animals; Biological Availability; Cell Line; Chemical and Drug Induced Liver Injury; Drug Liberation; Hepatocytes; Humans; Hydrogen-Ion Concentration; Lipopolysaccharides; Liposomes; Liver; Macrophages; Male; Mice; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Silybin; Silymarin	2014
Evaluation of the protective effect of silibinin in rats with liver damage caused by itraconazole. Cell biochemistry and biophysics, 2015, Volume: 71, Issue:2 Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytoprotection; Dose-Response Relationship, Drug; Drug Interactions; Female; Itraconazole; Liver; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Silybin; Silymarin; Treatment Outcome	2015
Silibinin mitigates zidovudine-induced hepatocellular degenerative changes, oxidative stress and hyperlipidaemia in rats. Human & experimental toxicology, 2015, Volume: 34, Issue:11 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-HIV Agents; Catalase; Chemical and Drug Induced Liver Injury; Fatty Acids, Nonesterified; Female; Hyperlipidemias; Lipid Peroxidation; Liver; Male; Oxidative Stress; Protective Agents; Rats, Wistar; Silybin; Silymarin; Zidovudine	2015
Acute liver injury and acute liver failure from mushroom poisoning in North America. Liver international : official journal of the International Association for the Study of the Liver, 2016, Volume: 36, Issue:7 Topics: Acetylcysteine; Adult; Amanitins; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Humans; Liver Failure, Acute; Liver Transplantation; Male; Middle Aged; Mushroom Poisoning; North America; Penicillins; Registries; Silybin; Silymarin	2016
Silibinin alleviates N-nitrosodimethylamine-induced glutathione dysregulation and hepatotoxicity in rats. Chinese journal of natural medicines, 2016, Volume: 14, Issue:1 Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Female; Glutathione; Male; Protective Agents; Rats; Rats, Wistar; Silybin; Silymarin	2016
Effect of silibinin and vitamin E on the ASK1-p38 MAPK pathway in D-galactosamine/lipopolysaccharide induced hepatotoxicity. Experimental biology and medicine (Maywood, N.J.), 2016, Volume: 241, Issue:11 Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Histocytochemistry; Lipopolysaccharides; Liver; Liver Function Tests; MAP Kinase Kinase Kinase 5; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Signal Transduction; Silybin; Silymarin; Treatment Outcome; Vitamin E	2016
[Protective effects of silybin · ursodeoxycholic acid evaporated co- precipitate on CCl₄-induced acute liver injury in mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2016, Volume: 32, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Silybin; Silymarin; Ursodeoxycholic Acid	2016
Zidovudine and isoniazid induced liver toxicity and oxidative stress: Evaluation of mitigating properties of silibinin. Environmental toxicology and pharmacology, 2016, Volume: 46 Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Isoniazid; Liver Function Tests; Male; Oxidative Stress; Rats, Wistar; Silybin; Silymarin; Zidovudine	2016
Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium. Chemical & pharmaceutical bulletin, 2008, Volume: 56, Issue:12 Topics: Acetone; Animals; beta-Glucosidase; Cell Survival; Chemical and Drug Induced Liver Injury; Diterpenes; Flowers; Hepatocytes; Hydrolysis; Male; Mice; Molecular Conformation; Multienzyme Complexes; Plant Extracts; Plants, Medicinal; Protective Agents; Silybin; Silymarin; Solvents; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Zingiberaceae	2008
Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum. Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:5 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Liver; Magnetic Resonance Spectroscopy; Male; Rabbits; Silybin; Silymarin	2009
Establishment of a methodology for investigating protectants against ethanol-induced hepatotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:5 Topics: Animals; Antioxidants; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemoprevention; Ethanol; Fenofibrate; Hepatocytes; Hypolipidemic Agents; Male; Malondialdehyde; Nanoparticles; Nanotechnology; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Silybin; Silybum marianum; Silymarin	2010
Silibinin potentially protects arsenic-induced oxidative hepatic dysfunction in rats. Toxicology mechanisms and methods, 2012, Volume: 22, Issue:4 Topics: Animals; Antioxidants; Arsenic; Chemical and Drug Induced Liver Injury; Male; Molecular Structure; Oxidative Stress; Rats; Rats, Wistar; Silybin; Silymarin	2012
Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats. Food chemistry, 2013, May-01, Volume: 138, Issue:1 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Damage; Hep G2 Cells; Humans; Lipid Peroxidation; Liver; Male; Protective Agents; Rats; Rats, Sprague-Dawley; Silybin; Silymarin	2013
Preparation and pharmacological evaluation of silibinin liposomes. Arzneimittel-Forschung, 2003, Volume: 53, Issue:6 Topics: Animals; Antioxidants; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholesterol; Drug Compounding; Drug Stability; Female; Liposomes; Male; Mice; Mice, Inbred BALB C; Particle Size; Rats; Rats, Wistar; Silybin; Silymarin; Sleep; Stomach Ulcer; Time Factors	2003
Silibinin protects mice from T cell-dependent liver injury. Journal of hepatology, 2003, Volume: 39, Issue:3 Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Cytoprotection; Enzyme Induction; Galactosamine; Leukocytes; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Recombinant Proteins; RNA, Messenger; Silybin; Silymarin; T-Lymphocytes; Tumor Necrosis Factor-alpha	2003
Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity. Toxicology, 2003, Sep-30, Volume: 191, Issue:2-3 Topics: Acetaminophen; Acetylcysteine; alpha-Tocopherol; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Northern; Cell Death; Chemical and Drug Induced Liver Injury; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Formazans; Hepatocytes; Lipid Peroxides; Liver Diseases; Male; Neutral Red; Rats; Rats, Wistar; RNA; Silybin; Silymarin; Tetrazolium Salts	2003
Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. Annals of emergency medicine, 2007, Volume: 50, Issue:3 Topics: Acetylcysteine; Alanine Transaminase; Amanitins; Animals; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Male; Mice; Mushroom Poisoning; Penicillin G; Random Allocation; Silybin; Silymarin; Thioctic Acid	2007
Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin. Biochimica et biophysica acta, 2008, Volume: 1780, Issue:5 Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Movement; Cell Survival; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Hepatocytes; Humans; Hydrogen Peroxide; Keratinocytes; Liver Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Molecular Structure; Reactive Oxygen Species; Silybin; Silymarin	2008
Synthesis and antihepatotoxic activity of silybin 11-O-phosphate. Farmaco (Societa chimica italiana : 1989), 1994, Volume: 49, Issue:1 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Liver; Magnetic Resonance Spectroscopy; Male; Organ Size; Organophosphates; Praseodymium; Rats; Rats, Wistar; Silybin; Silymarin; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet	1994
Acetaminophen hepatotoxicity in rats is attenuated by silybin dihemisuccinate. Progress in clinical and biological research, 1988, Volume: 280 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Glutathione; Liver Diseases; Male; Rats; Rats, Inbred Strains; Silybin; Silymarin	1988