silicon and Uterine-Cervical-Neoplasms

Topics: Algorithms; Breast Neoplasms; Data Interpretation, Statistical; Female; Gold; Humans; Models, Biological; Multivariate Analysis; Nanoparticles; Reproducibility of Results; Silicon; Spectrum Analysis, Raman; Uterine Cervical Neoplasms

This study proposes a vascular endothelial growth factor (VEGF) biosensor for diagnosing various stages of cervical carcinoma. In addition, VEGF concentrations at various stages of cancer therapy are determined and compared to data obtained by computed tomography (CT) and cancer antigen 125 (CA-125). The increase in VEGF concentrations during operations offers useful insight into dosage timing during cancer therapy. This biosensor uses Avastin as the biorecognition element for the potential cancer biomarker VEGF and is based on a n-type polycrystalline silicon nanowire field-effect transistor (poly-SiNW-FET). Magnetic nanoparticles with poly[aniline-co-N-(1-one-butyric acid) aniline]-Fe3O4 (SPAnH-Fe3O4) shell-core structures are used as carriers for Avastin loading and provide rapid purification due to their magnetic properties, which prevent the loss of bioactivity; furthermore, the high surface area of these structures increases the quantity of Avastin immobilized. Average concentrations in human blood for species that interfere with detection specificity are also evaluated. The detection range of the biosensor for serum samples covers the results expected from both healthy individuals and cancer patients.

Topics: Antibodies, Monoclonal, Humanized; Bevacizumab; Biosensing Techniques; CA-125 Antigen; Carcinoma; Female; Ferrosoferric Oxide; Humans; Magnets; Membrane Proteins; Nanowires; Neoplasm Staging; Silicon; Tomography, X-Ray Computed; Transistors, Electronic; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A

We have applied phthalocyaninatosilicon (SiPc) covalently linked to one or two tetramethyl-1-piperidinyloxyl (TEMPO) radicals as fluorescence probes for detecting ascorbic acid in biological systems.

Topics: Ascorbic Acid; Cyclic N-Oxides; Female; Fluorescence; HeLa Cells; Humans; Indoles; Isoindoles; Liposomes; Microscopy, Fluorescence; Molecular Imaging; Silicon; Spectrometry, Fluorescence; Uterine Cervical Neoplasms

The combination of a red light PDT agent and a Pt(ii)-based chemotherapeutic drug at the molecular level maintains the intrinsic functions of each unit; the conjugated complexes exhibit remarkable photocytoxicity and demonstrate potential to serve as agents for DNA-targeting PDT as well as red light photochemotherapy.

Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; HeLa Cells; Humans; Indoles; Isoindoles; Light; Microscopy, Confocal; Molecular Structure; Photochemotherapy; Radiation-Sensitizing Agents; Silicon; Staining and Labeling; Uterine Cervical Neoplasms